公开(公告)号：US20100291146A1

公开(公告)日：2010-11-18

申请号：US12679654

申请日：2008-10-09

Applicant: Martin Pearse ,  Steve Rockman ,  David Ryan

Inventor： Martin Pearse ,  Steve Rockman ,  David Ryan

IPC: A61K39/145 ,  A61P37/04 ,  A61P31/16

CPC classification number: A61K39/145 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/58 ,  A61K2039/70 ,  C12N2760/16134 ,  C12N2760/16234

Abstract: A method for eliciting or inducing a protective immune response in a subject against a pandemic subtype of influenza virus comprises administering to the subject a composition comprising (i) at least one immunogen of an endemic influenza subtype, and (ii) an immunogen-free immunostimulating complex as adjuvant.

Abstract translation: 用于在受试者中引发或诱导针对流感病毒的流行性亚型的保护性免疫应答的方法包括向受试者施用包含（i）至少一种地方性流感亚型免疫原的组合物，和（ii）免疫原免疫刺激 复合物作为佐剂。

公开(公告)号：US07754213B2

公开(公告)日：2010-07-13

申请号：US11875017

申请日：2007-10-19

Applicant: Andrew Donald Nash ,  Manuel Baca ,  Louis Jerry Fabri ,  Dennis Zaller ,  William R. Strohl ,  Zhiqiang An

Inventor： Andrew Donald Nash ,  Manuel Baca ,  Louis Jerry Fabri ,  Dennis Zaller ,  William R. Strohl ,  Zhiqiang An

IPC: A61K39/395

CPC classification number: C07K16/2866 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/71 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2319/43 ,  C12P21/005

Abstract: High affinity antibody antagonists of human interleukin-13 receptor alpha 1 are disclosed. The antibody molecules are effective in the inhibition of IL-13Rα1-mediated activities and, accordingly, present desirable antagonists for the use in the treatment of conditions associated with hIL-13Rα1 activity. The present invention also discloses nucleic acid encoding said antibody molecules, vectors, host cells, and compositions comprising the antibody molecules. Methods of using the antibody molecules for inhibiting or antagonizing IL-13Rα1-mediated activities are also disclosed.

Abstract translation: 公开了人白细胞介素-13受体α1的高亲和力抗体拮抗剂。 抗体分子在抑制IL-13Rα1介导的活性中是有效的，因此，在治疗与hIL-13Rα1活性相关的病症中使用所需的拮抗剂。 本发明还公开了编码所述抗体分子，载体，宿主细胞和包含抗体分子的组合物的核酸。 还公开了使用抗体分子抑制或拮抗IL-13Rα1介导的活性的方法。

公开(公告)号：US20100010193A1

公开(公告)日：2010-01-14

申请号：US12458116

申请日：2009-07-01

Applicant: John Cooper Cox ,  Debbie Pauline Drane ,  Andreas Suhrbier

Inventor： John Cooper Cox ,  Debbie Pauline Drane ,  Andreas Suhrbier

IPC: C07K1/00

CPC classification number: A61K39/39 ,  A61K2039/55511 ,  A61K2039/55561 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/57

Abstract: The present invention relates generally to an immunogenic complex comprising a charged organic carrier and a charged antigen and, more particularly, a negatively charged organic carrier and a positively charged antigen. The complexes of the present invention are useful, inter alia, as therapeutic and/or prophylactic agents for facilitating the induction of a cytotoxic T-lymphocyte response to an antigen.

Abstract translation: 本发明一般涉及包含带电荷的有机载体和带​​电荷的抗原的免疫原性复合物，更具体地说，涉及带负电荷的有机载体和带​​正电荷的抗原。 本发明的复合物尤其可用作促进诱导对抗原的细胞毒性T淋巴细胞应答的治疗和/或预防剂。

公开(公告)号：US07534441B2

公开(公告)日：2009-05-19

申请号：US11027683

申请日：2005-01-03

Applicant: Michael Kerin McNamara

Inventor： Michael Kerin McNamara

IPC: A61K39/385 ,  A61K38/09 ,  A61K31/721 ,  C07K14/59 ,  C07K7/06

CPC classification number: A61K47/4833 ,  A61K38/09 ,  A61K39/0006 ,  A61K47/646 ,  A61K2039/55583 ,  A61K2039/6037

Abstract: The present invention relates generally to an immunogenic LHRH composition and more particularly to an immunogenic LHRH composition comprising a LHRH C-terminal fragment of at least five amino acids. The present invention is useful, inter alia, as a prophylactic and/or therapeutic agent for the modification of fertility and behaviour patterns of animals, the achievement of livestock production gains such as increasing growth, decreasing feed conversion ratios or the control of unwanted organoleptic characteristics or the treatment of disorders of the reproductive organs.

Abstract translation: 本发明一般涉及免疫原性LHRH组合物，更具体地涉及包含至少五个氨基酸的LHRH C-末端片段的免疫原性LHRH组合物。 本发明尤其可用作改变动物的生育力和行为模式的预防和/或治疗剂，实现家畜生产增益如增加生长，降低饲料转化率或控制不想要的感官特征 或治疗生殖器官疾病。

公开(公告)号：US20090017021A1

公开(公告)日：2009-01-15

申请号：US12148275

申请日：2008-04-17

Applicant: Heather L. Davis ,  Michael J. McCluskie ,  Debra P. Drane

Inventor： Heather L. Davis ,  Michael J. McCluskie ,  Debra P. Drane

IPC: A61K39/395 ,  A61K31/7052 ,  A61P35/00 ,  A61K33/24

CPC classification number: A61K45/06 ,  A61K31/337 ,  A61K31/7088 ,  A61K47/542 ,  A61K47/549 ,  A61K47/554 ,  A61K2039/55561 ,  A61K2039/57 ,  A61K2300/00

Abstract: The invention relates to TLR ligand formulations that comprise immune stimulating complexes and their use in inducing innate immunity.

Abstract translation: 本发明涉及包含免疫刺激复合物的TLR配体制剂及其在诱导先天免疫中的用途。

公开(公告)号：US07423023B2

公开(公告)日：2008-09-09

申请号：US10185799

申请日：2002-06-28

Applicant: Jeffrey Stephen Boyle ,  Jamie Louise Brady ,  Andrew Mark Lew

Inventor： Jeffrey Stephen Boyle ,  Jamie Louise Brady ,  Andrew Mark Lew

IPC: A61K31/713

CPC classification number: C07K14/005 ,  A61K39/008 ,  A61K39/015 ,  A61K39/05 ,  A61K39/12 ,  A61K39/145 ,  A61K39/385 ,  A61K48/00 ,  A61K2039/53 ,  A61K2039/552 ,  A61K2039/55566 ,  A61K2039/6031 ,  C07K14/34 ,  C07K14/43554 ,  C07K14/44 ,  C07K14/445 ,  C07K14/70521 ,  C07K14/70564 ,  C07K14/70575 ,  C07K14/70578 ,  C07K2319/00 ,  C12N2760/16122 ,  C12N2760/16134

Abstract: The present invention provides methods of enhancing the immune response to an immunogen and to compositions for use in these methods. In particular the present invention provides a DNA molecule for use in raising an immune response to an antigen. The DNA molecule includes a first sequence encoding a targeting molecule, a second sequence encoding the antigen or an epitope thereof, and optionally a third sequence encoding a polypeptide which promotes dimerization or multimerization of the product encoded by the DNA molecule.

Abstract translation: 本发明提供增强对免疫原的免疫应答和用于这些方法的组合物的方法。 特别地，本发明提供了用于提高对抗原的免疫应答的DNA分子。 DNA分子包括编码靶向分子的第一序列，编码抗原或其表位的第二序列，以及编码促进由DNA分子编码的产物的二聚化或多聚化的多肽的第三序列。

公开(公告)号：US20060287263A1

公开(公告)日：2006-12-21

申请号：US11183187

申请日：2005-07-18

Applicant: Heather Davis ,  Michael McCluskie ,  Debra Drane

Inventor： Heather Davis ,  Michael McCluskie ,  Debra Drane

IPC: A61K48/00 ,  A61K31/704 ,  A61K31/56

CPC classification number: A61K39/0011 ,  A61K31/56 ,  A61K31/704 ,  A61K39/12 ,  A61K39/292 ,  A61K39/39 ,  A61K2039/541 ,  A61K2039/55505 ,  A61K2039/55555 ,  A61K2039/55561 ,  A61K2039/55577 ,  C12N2730/10134

Abstract: Vaccine compositions comprising (a) an oligonucleotide, (b) and immune stimulating complex and (c) an antigen induce a strong interferon-gamma immune response. Both oligonucleotides containing immune stimulatory motifs and oligonucleotides lacking immune stimulatory motifs contribute to an interferon-gamma response when administered with an immune stimulating complex.

Abstract translation: 疫苗组合物包含（a）寡核苷酸，（b）和免疫刺激复合物和（c）抗原诱导强的干扰素-γ免疫应答。 含有免疫刺激基序的寡核苷酸和缺乏免疫刺激基序的寡核苷酸当与免疫刺激复合物一起施用时，有助于干扰素-γ反应。

公开(公告)号：US07037507B2

公开(公告)日：2006-05-02

申请号：US10935155

申请日：2004-09-08

Applicant: David Charles Jackson ,  Souravi Ghosh ,  John Walker

Inventor： David Charles Jackson ,  Souravi Ghosh ,  John Walker

IPC: A61K39/175

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K2039/57 ,  C07K2319/00 ,  C12N2760/18422

Abstract: The present invention provides T helper cell epitopes and compositions for use in inducing an immune response comprising at least one of these epitopes. The epitopes are contained within a peptide sequence selected from the group consisting of SSKTQTHTQQDRPPQPS (SEQ ID NO: 1); QPSTELEETRTSRARHS (SEQ ID NO: 2); QSLRTSLEQSNKAIEEI (SEQ ID NO: 18); and DESSCVFVSESAICSQN (SEQ ID NO: 23).

Abstract translation: 本发明提供了用于诱导包含这些表位中的至少一个的免疫应答的T辅助细胞表位和组合物。 表位包含在选自SSKTQTHTQQDRPPQPS（SEQ ID NO：1）的肽序列中; QPSTELEETRTSRARHS（SEQ ID NO：2）; QSLRTSLEQSNKAIEEI（SEQ ID NO：18）; 和DESSCVFVSESAICSQN（SEQ ID NO：23）。

公开(公告)号：US20040191270A1

公开(公告)日：2004-09-30

申请号：US10622470

申请日：2003-07-21

Applicant: CSL LIMITED and CHIRON CORPORATION

Inventor： Debbi Drane ,  John Cox ,  Michael Houghton ,  Xavier Pallard

IPC: A61K039/29

CPC classification number: A61K39/29 ,  A61K39/12 ,  A61K2039/55544 ,  A61K2039/55566 ,  A61K2039/55572 ,  A61K2039/55577 ,  A61K2039/57 ,  C12N2770/24234

Abstract: The present invention relates generally to an immunogenic complex comprising a charged organic carrier and a charged antigen and, more particularly, a negatively charged organic carrier and a positively charged antigen, wherein the charged antigen is a polyprotein of Hepatitis C Virus (HCV), particularly the core protein of HCV, or a fragment thereof, or a fusion protein comprising the polyprotein or a fragment thereof. The complexes of the present invention are useful, inter alia, in vaccine compositions as therapeutic and/or prophylactic agents for facilitating the induction of immune responses, and in particular a cytotoxic T-lymphocyte response, in the treatment of a disease condition which results from an HCV infection.

Abstract translation: 本发明一般涉及包含带电荷的有机载体和带​​电荷的抗原的免疫原性复合物，更具体地，涉及带负电荷的有机载体和带​​正电荷的抗原，其中带电的抗原是丙型肝炎病毒（HCV）的多蛋白，特别是 HCV的核心蛋白或其片段，或包含该多聚蛋白或其片段的融合蛋白。 本发明的复合物尤其可用于疫苗组合物中，作为促进免疫应答诱导的治疗和/或预防剂，特别是细胞毒性T淋巴细胞应答，用于治疗由 HCV感染。

公开(公告)号：US20020150590A1

公开(公告)日：2002-10-17

申请号：US09920174

申请日：2001-08-01

Applicant: The Council of the Queensland Institute of Medical Research, CSL Limited

Inventor： Rajiv Khanna ,  Beverley Mavis Kerr ,  Ihor Stephan Misko ,  Denis James Moss ,  Scott Renton Burrows

IPC: A61K048/00 ,  A61K039/12 ,  A61K031/70 ,  A01N043/04 ,  A61K039/395 ,  A61K039/40 ,  A61K039/42 ,  A61K039/245 ,  A61K039/25 ,  C12N005/06 ,  C12N005/16

CPC classification number: C07K14/005 ,  A61K39/00 ,  A61K2039/51 ,  C12N2710/16222 ,  Y02A50/466

Abstract: The present invention provides cytotoxic Epstein-Barr virus T-cell epitopes. These epitopes are QVKWRMTTL, VFSDGRVAC, VPAPAGPIV, TYSAGIVQI, LLDFVRFMGV, QNGALAINTF, VSSDGRVAC, VSSEGRVAC, VSSDGRVPC, VSSDGLVAC, VSSDGQ-VAC, VSSDGRVVC, VPAPPVGPIV, VEITPYEPIG, VEITPYEPTW, VELTPYKPTW, RRIYDLIKL, RKIYDLIEL and PYLFWLAGI. The present invention further provides vaccines including one or more of these epitopes, optionally with additional epitopes.

Abstract translation: 本发明提供细胞毒性的爱泼斯坦 - 巴尔病毒T细胞表位。 这些表位是QVKWRMTTL，VFSDGRVAC，VPAPAGPIV，TYSAGIVQI，LLDFVRFMGV，QNGALAINTF，VSSDGRVAC，VSSEGRVAC，VSSDGRVPC，VSSDGLVAC，VSSDGQ-VAC，VSSDGRVVC，VPAPPVGPIV，VEITPYEPIG，VEITPYEPTW，VELTPYKPTW，RRIYDLIKL，RKIYDLIEL和PYLFWLAGI。 本发明进一步提供包含一种或多种这些表位的疫苗，任选具有另外的表位。