公开(公告)号：US20240193782A1

公开(公告)日：2024-06-13

申请号：US18433704

申请日：2024-02-06

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Natalia A. TRAYANOVA ,  Rheeda ALI ,  Julie SHADE

IPC分类号： G06T7/11 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/50

CPC分类号： G06T7/11 ,  G16H30/20 ,  G16H30/40 ,  G16H50/20 ,  G16H50/50 ,  G06T2207/10088 ,  G06T2207/20021 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30048

摘要： A device may receive images of a patient, and may perform segmentation of surfaces on the images to create a 3D model. The device may identify normal tissue regions and atrial fibrosis (AF) regions in the 3D model, and may divide the 3D model into the normal tissue regions and the AF regions. The device may assign first cell and tissue properties to the normal tissue regions, and may assign second cell and tissue properties to the AF regions. The device may perform simulations on the normal tissue regions and the AD regions, based on the first and second cell and tissue properties, to generate simulation results, and may extract first features from the simulation results. The device may extract second features from the images, and may process the first and second features, with a model, to select a feature that is predictive of atrial fibrillation recurrence.

公开(公告)号：US20240189277A1

公开(公告)日：2024-06-13

申请号：US18554928

申请日：2022-04-14

申请人： The Johns Hopkins University

发明人： Laura Ensign ,  Justin Hanes ,  Yoo Chun Kim ,  Tung Heng Hsueh

IPC分类号： A61K31/404 ,  A61K9/00 ,  A61K31/192 ,  A61P27/02

CPC分类号： A61K31/404 ,  A61K9/0019 ,  A61K9/0048 ,  A61K31/192 ,  A61P27/02

摘要： Administration of therapeutic, prophylactic, or diagnostic agents that bind to a receptor or ligand in the eye or to the skin in microcrystalline form leads to increased delivery and long-lasting activity within the eye as compared with administration of the agent in non-crystalline form. Compositions and methods for delivery of active agents in microcrystalline form to the eye for the treatment, prevention and diagnosis of eye diseases and disorders are provided. In preferred embodiments, microcrystals include sunitinib malate in complex with pamoic acid. Administration of microcrystals of sunitinib malate/pamoic acid to the eye provides protection from glaucoma for up to 6 months or longer without retinal toxicity, following a single injection into the eye.

公开(公告)号：US11992348B2

公开(公告)日：2024-05-28

申请号：US17634597

申请日：2020-09-04

申请人： The Johns Hopkins University

发明人： Mathias Unberath ,  Jan-Nico Zaech

IPC分类号： A61B6/03 ,  A61B6/00 ,  A61B6/12 ,  A61B6/40 ,  A61B6/50 ,  G16H20/40 ,  G16H30/20 ,  G16H30/40

CPC分类号： A61B6/032 ,  A61B6/12 ,  A61B6/4085 ,  A61B6/4441 ,  A61B6/505 ,  A61B6/5258 ,  A61B6/563 ,  G16H20/40 ,  G16H30/20 ,  G16H30/40

摘要： A device may receive an X-ray image captured by a C-arm CBCT device at a particular position defined by a six-degree of freedom pose relative to an anatomy, and may process the X-ray image, with a machine learning model, to determine a predicted quality of next possible X-ray images provided by the C-arm CBCT device. The device may utilize the machine learning model, to identify a particular X-ray image, of the next possible X-ray images, with a greatest predicted quality and to update the six-degree of freedom pose based on the particular X-ray image. The device may provide, to the C-arm CBCT device, data that identifies the updated six-degree of freedom pose to cause the C-arm CBCT device to adjust to a new position based on the updated six-degree of freedom pose.

公开(公告)号：US11992015B2

公开(公告)日：2024-05-28

申请号：US17388392

申请日：2021-07-29

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： George Dimopoulos ,  Sarah M. Short ,  Jose L. Ramirez

IPC分类号： A01N63/20 ,  A61K31/7004 ,  A61K35/74 ,  C12N1/20 ,  C12R1/01

CPC分类号： A01N63/20 ,  A61K31/7004 ,  A61K35/74 ,  C12N1/20 ,  C12N1/205 ,  A61K2300/00 ,  C12R2001/01 ,  Y02A50/30

摘要： The present invention relates to the fields of malaria and dengue virus. More specifically, the present invention provides compositions and methods useful for the treatment and prevention of malaria and dengue virus. In particular embodiments, a composition comprises mosquito nectar feed and Chromobacterium sp_Panamam (Csp_P).

公开(公告)号：US20240165155A1

公开(公告)日：2024-05-23

申请号：US18283887

申请日：2022-03-31

申请人： The Johns Hopkins University

发明人： Kellie N. Smith ,  Justina Caushi ,  Emily Han-Chung Hsiue ,  Andrew M. Pardoll ,  Shibin Zhou ,  Bert Vogelstein ,  Kenneth W. Kinzler ,  Nickolas Papadopoulos

IPC分类号： A61K35/17 ,  A61K39/00 ,  A61K45/06 ,  C07K14/47 ,  C07K14/725 ,  C12N15/86

CPC分类号： A61K35/17 ,  A61K39/4611 ,  A61K39/4632 ,  A61K39/464411 ,  A61K39/464451 ,  A61K45/06 ,  C07K14/4746 ,  C07K14/7051 ,  C12N15/86

摘要： This document relates to methods and materials for treating a mammal having cancer. For example, this document provides T cell receptors (TCRs) that can bind to a modified peptide (e.g., a tumor antigen). In some cases, methods of using T cells expressing one or more TCRs that can bind to a modified peptide (e.g., a tumor antigen) to treat a mammal having cancer are provided.

公开(公告)号：US11981957B2

公开(公告)日：2024-05-14

申请号：US16107246

申请日：2018-08-21

申请人： The Johns Hopkins University

发明人： Akira Sawa ,  Koko Ishizuka ,  YeeWen Candace Wu ,  Youjin Chung ,  Nao J. Gamo

IPC分类号： C12Q1/6827 ,  A61B10/02 ,  C12Q1/6883 ,  G16B40/10

CPC分类号： C12Q1/6827 ,  A61B10/02 ,  C12Q1/6883 ,  C12Q2539/10 ,  C12Q2600/106 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/156 ,  C12Q2600/158 ,  G16B40/10

摘要： Biomarkers relevant to neurons in the brain, in particular at single cell levels, are identified by using olfactory neurons as the best surrogates from subjects so as to establish diagnosis, prognosis, and treatment of brain conditions.

公开(公告)号：US20240142435A1

公开(公告)日：2024-05-02

申请号：US18300014

申请日：2023-04-13

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Ho Lam Tang ,  Ho Man Holly Tang

IPC分类号： G01N33/50 ,  C12N9/96

CPC分类号： G01N33/5005 ,  C12N9/96 ,  C07K2319/03 ,  C07K2319/50 ,  C07K2319/60 ,  G01N2510/00

摘要： The present invention relates to the field of anastasis, i.e., the process of reversal of apoptosis. More specifically, the present invention provides methods and compositions useful for studying anastasis. The present invention also provides a biosensor comprising (a) a split transcription factor complex comprising one half of a split transcription factor linked to a transmembrane domain via an enzyme cleavable linker; (b) a split transcription factor comprising the other half of the split transcription factor linked to a MTS via an enzyme-cleavable linker; and (c) a reporter system comprising (1) a first nucleic acid encoding a site specific recombinase operably linked to the site specific sequence for the transcription factor; and (2) a second nucleic acid comprising a stop codon cassette flanked by site specific recombination sequences, wherein the split transcription factor is Gal 4 or split Q. In other embodiments, the recombinase is Cre or FLP.

公开(公告)号：US20240140971A1

公开(公告)日：2024-05-02

申请号：US18209798

申请日：2023-06-14

申请人： The Johns Hopkins University ,  Duke University

发明人： Martin G. Pomper ,  Ronnie C. Mease ,  Ying Chen ,  Sangeeta Ray ,  Michael Zalutsky ,  Ganesan Vaidyanathan

IPC分类号： C07F13/00 ,  A61P35/00

CPC分类号： C07F13/00 ,  A61P35/00 ,  C07B2200/05

摘要： PSMA binding scaffolds with radioiodinated, radiobrominated and radioastatinated labeled prosthetic groups are disclosed. Pharmaceutical compositions and methods of treating PSMA expressing cells or tumors also are disclosed.

公开(公告)号：US11969402B2

公开(公告)日：2024-04-30

申请号：US17611752

申请日：2020-05-14

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Luis Garza ,  Dongwon Kim

IPC分类号： A61K31/203 ,  A61K8/36 ,  A61K8/60 ,  A61K31/5585 ,  A61K31/713 ,  A61K38/17 ,  A61P17/02 ,  A61P17/14 ,  A61Q19/08

CPC分类号： A61K31/203 ,  A61K8/361 ,  A61K8/606 ,  A61K31/5585 ,  A61K31/713 ,  A61K38/1729 ,  A61P17/02 ,  A61P17/14 ,  A61Q19/08 ,  A61K2800/91

摘要： The present invention relates to the field of skin rejuvenation. Specifically, the present invention provides compositions and methods for promoting skin rejuvenation using a toll-like receptor 3 (TLR3) agonist and retinoic acid or derivatives thereof. In a specific embodiment, a method for treating wrinkles in a subject comprises the steps of (a) administering to the area of the subject comprising a wrinkle a composition comprising an effective amount of retinoic acid or a derivative thereof; and administering to the area of the subject comprising a wrinkle a composition comprising an effective amount of a TLR3 agonist.

公开(公告)号：US20240131006A1

公开(公告)日：2024-04-25

申请号：US18548423

申请日：2022-03-01

申请人： THE JOHNS HOPKINS UNIVERSITY

发明人： Florin M. Selaru ,  Laura Ensign-Hodges ,  Ling Li ,  Min Kyung Joo

IPC分类号： A61K31/4174 ,  A61P1/00

CPC分类号： A61K31/4174 ,  A61P1/00

摘要： The present disclosure provides methods, uses, and pharmaceutical compositions comprising and azole derivative (e.g., sulconazole) in the treatment or prevention of fibrotic disease or disorder or fibrosis, including Crohn's disease.