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    Method for producing tricyclodecandialdehyde
    31.
    发明申请
    Method for producing tricyclodecandialdehyde 失效
    三环癸二醛生产方法

    公开(公告)号：US20070100168A1

    公开(公告)日：2007-05-03

    申请号：US10581802

    申请日：2004-12-14

    Applicant: Rainer Papp ,  Rocco Paciello ,  Christoph Benisch

    Inventor： Rainer Papp ,  Rocco Paciello ,  Christoph Benisch

    IPC: C07C45/49

    CPC classification number: C07C209/26 ,  C07C29/141 ,  C07C47/347 ,  C07C2603/68 ,  C07C211/19 ,  C07C31/278

    Abstract: Process for preparing tricyclodecanedialdehyde by hydroformylation of dicyclopentadiene by means of a CO/H2 mixture at elevated temperature and under superatmospheric pressure in the presence of a rhodium catalyst which has not been modified by means of a ligand and is homogeneously dissolved in the hydroformylation medium, wherein the hydroformylation is carried out at a pressure of from 200 to 350 bar in at least two reaction zones, with a reaction temperature of from 80 to 120° C. being set in a first reaction zone and a reaction temperature of from 120 to 150° C. being set in a reaction zone following this reaction zone, with the proviso that the reaction temperature in the subsequent reaction zone is at least 5° C. higher than in the preceding reaction zone.

    Abstract translation: 在高温和超大气压下，在没有通过配体修饰的铑催化剂存在下，通过二环戊二烯加氢甲酰化二环戊二烯制备三环癸二醛的方法， 均匀地溶解在加氢甲酰基化介质中，其中加氢甲酰化在至少两个反应区中在200-350巴的压力下进行，反应温度为80-120℃设定在第一反应区和 在该反应区之后的反应区中设置120至150℃的反应温度，条件是后续反应区中的反应温度比前述反应区高至少5℃。

    Utilization of tricyclic aldehydes as odoriferous agents
    34.
    发明授权
    Utilization of tricyclic aldehydes as odoriferous agents 失效
    三环醛作为气味剂的利用

    公开(公告)号：US06541445B1

    公开(公告)日：2003-04-01

    申请号：US09673367

    申请日：2000-10-16

    Applicant: Thomas Markert

    Inventor： Thomas Markert

    IPC: A61K746

    CPC classification number: C11B9/0042 ,  C07C45/50 ,  C11B9/0003 ,  C07C47/347

    Abstract: The use of tricyclic aldehydes as odorous materials, which can be produced through partial or total hydroformylation of tricyclo[5.2.1.02,6]-dec(adi)enes, except saturated monoaldehydes, is described. The fragrance enhancing capacity of the compounds is described in methods for their use both as perfumes and perfume enhancers or boosters.

    Abstract translation: 描述了使用三环醛作为气味材料，其可以通过部分或全部加氢甲酰化三环[5.2.1.02,6] - 癸（adi）烯，但饱和单醛除外。 在其用作香料和香料增强剂或增效剂的方法中描述了化合物的香味增强能力。

    8-exo-formyl-2,6-exo-tricyclo(5.2.1.02,6)decane, method of preparing it and use of the same
    39.
    发明授权
    8-exo-formyl-2,6-exo-tricyclo(5.2.1.02,6)decane, method of preparing it and use of the same 失效
    8-外 - 甲酰基-2,6-二 - 三环（5.2.1.02,6）癸烷，其制备方法及其用途

    公开(公告)号：US5492887A

    公开(公告)日：1996-02-20

    申请号：US960431

    申请日：1992-12-11

    Applicant: Ernst-Joachim Brunke ,  Claus-Hermann Kappey ,  Bernd Holscher ,  Hartmut Struwe

    Inventor： Ernst-Joachim Brunke ,  Claus-Hermann Kappey ,  Bernd Holscher ,  Hartmut Struwe

    IPC: A61K8/00 ,  A61Q13/00 ,  B01J23/44 ,  C07B61/00 ,  C07C45/62 ,  C07C45/67 ,  C07C47/347 ,  C11B9/00 ,  C11D3/50 ,  A61K7/46

    CPC classification number: C11B9/0042 ,  C07C47/347 ,  C11D3/50 ,  C07C2103/68

    Abstract: It was found that 8-exo-formyl-2,6-exo-tricyclo[5.2.1.0.sup.2,6 ]decane having the constitution and stereochemistry of formula (I) possesses particularly useful olfactory properties which are clearly superior to those of the 8-endo-epimer and which already have an effect if compound (I) is enriched with mixtures of 8-exo- and 8-endo-epimers. Compound (I) can therefore be advantageously used, in pure or enriched form, as a scent or as a component of perfume compositions. To prepare an enriched epimer mixture, a mixture obtained in a known manner (U.S. Pat. No. 3,270,061) and having an exo/endo ratio of 1.45:1 is brought into equilibrium by base catalysis, preferably by the action of alkali hydroxides in alcoholic solution, to give an exo/endo ratio of 5.25:1. Alternatively, the enriched epimer mixture can be prepared starting from 8-formyl-2,6-exo-tricyclo[5.2.1.0.sup.2,6 ]decene-3(4), catalytically hydrogenated for example with palladium coal and then optionally brought into equilibrium. Or 2,6-exo-tricyclo[5.2.1.0.sup.2,6 ]decene-8 can be hydroformylated and also optionally brought into equilibrium. The pure compound (I) is prepared by reducing preferably a mixture of 8-exo- and 8-endo-epimers obtained in the manner known per se to a mixture of the corresponding alcohols, from which the 8-exo-configured methylol is isolated by chromatography or distillation and oxidized to obtain the aldehyde (compound I) again.

    Abstract translation: PCT No.PCT / DE92 / 00307 Sec。 371日期：1992年12月11日 102（e）日期1992年12月11日PCT提交1992年4月10日PCT公布。 WO92 / 18451 PCT出版物 日期为1992年10月26日。发现具有式（I）的构成和立体化学的8-外 - 甲酰基-2,6-二三环[5.2.1.0 2,6]癸烷具有特别有用的嗅觉性质 优于8-内差 - 差向异构体的那些，并且如果化合物（I）富含8-外消旋和8-内消旋异构体的混合物，其已经具有效果。 因此，化合物（I）可有利地以纯的或富集的形式用作香料或香料组合物的组分。 为了制备富集的差向异构体混合物，通过碱催化，优选通过碱金属氢氧化物在醇中的作用，以已知方式获得的混合物（美国专利3,270,061）并且具有1.45:1的外/内比 溶液，得到5.25:1的外/内比。 或者，可以从8-甲酰基-2,6-外三环[5.2.1.0 2,6]癸烯-3（4）开始制备富集的差向异构体混合物，催化氢化，例如用钯煤，然后任选地平衡。 或2,6-二三环[5.2.1.02,6]癸烯-8可以加氢甲酰化，也可任选地达到平衡。 纯化合物（I）通过将本身已知的方式获得的8-外消旋和8-内消旋异构体的混合物优选地还原为相应的醇的混合物，从其中分离出8-外型配位的羟甲基 通过色谱法或蒸馏法氧化得到醛（化合物I）。

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