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    Particle detection auditing system and method
    31.
    发明授权
    Particle detection auditing system and method 有权
    粒子检测审计系统及方法

    公开(公告)号：US07476858B2

    公开(公告)日：2009-01-13

    申请号：US11584950

    申请日：2006-10-23

    申请人： Frederick H. Schamber ,  Cornelis G. van Beek

    发明人： Frederick H. Schamber ,  Cornelis G. van Beek

    IPC分类号： H01J37/26 ,  H01J37/28

    CPC分类号： G01N15/1012 ,  G01N2015/1018 ,  G01N2015/1087 ,  G01N2015/1493 ,  H01J37/28 ,  H01J2237/282

    摘要： A system is presented for evaluating the performance of a particle detecting and measuring instrument wherein the instrument receives a specimen and detects the number of particles on the specimen and measures the descriptive parameters of the particles. The system includes a known specimen received by the instrument and wherein the known specimen has known particles on the specimen, with known parameters of each known particle on the specimen. The instrument detects the known particles and measures the parameters thereof. A matching of individual measured particles is made against individual known particles by means of selected known parameters thereof. A comparison is made of the parameters of each measured particle against the parameters of each known particle to which the measured particle was matched and an indication is provided of the instrument's performance as a function of the matching and the comparison.

    摘要翻译： 提出了一种用于评估颗粒检测和测量仪器的性能的系统，其中仪器接收样品并检测样品上的颗粒数量并测量颗粒的描述参数。 该系统包括由仪器接收的已知样品，其中已知样品在样品上具有已知的颗粒，并且具有样品上每个已知颗粒的已知参数。 仪器检测已知颗粒并测量其参数。 通过其选择的已知参数对各个已知的颗粒进行单个测量的颗粒的匹配。 比较每个测量粒子的参数与测量粒子匹配的每个已知粒子的参数，并且根据匹配和比较的函数提供仪器性能的指示。

    Methods for Controlling One or More Parameters of a Flow Cytometer Type Measurement System
    34.
    发明申请
    Methods for Controlling One or More Parameters of a Flow Cytometer Type Measurement System 有权
    控制流式细胞仪型式测量系统的一个或多个参数的方法

    公开(公告)号：US20080087068A1

    公开(公告)日：2008-04-17

    申请号：US11947116

    申请日：2007-11-29

    申请人： Wayne Roth ,  Douglas Moore

    发明人： Wayne Roth ,  Douglas Moore

    IPC分类号： G12B7/00

    CPC分类号： G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

    摘要： Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.

    摘要翻译： 提供了用于控制流式细胞仪型测量系统的一个或多个参数的各种方法。 一个实施例包括在样品微球的测量期间监测测量系统的参数。 该方法还包括基于监视实时更改参数。 另一种方法包括监测靠近测量系统的温度。 一种这样的方法包括使用经验导出的数据来响应于温度来改变雪崩光电二极管的偏置电压。 不同的这种方法包括使用特性曲线响应于温度改变光电倍增管的输出信号。 一些方法包括监测将流过流式细胞仪类型测量系统的流体样品微球的设置温度。 该方法还包括从该温度下的流体的粘度确定测量系统中的样品微球的速度。

    Flow cytometry system with bubble detection
    35.
    发明申请
    Flow cytometry system with bubble detection 有权
    流式细胞仪检测系统

    公开(公告)号：US20070257215A1

    公开(公告)日：2007-11-08

    申请号：US11430591

    申请日：2006-05-08

    申请人： Collin Rich

    发明人： Collin Rich

    IPC分类号： G01N21/85 ,  G01N1/22

    CPC分类号： G01N15/1404 ,  G01N15/1012 ,  G01N15/1031 ,  G01N15/12 ,  G01N15/1425 ,  G01N15/1427 ,  G01N29/022 ,  G01N35/00623 ,  G01N2015/0011 ,  G01N2015/1018 ,  G01N2015/1025 ,  G01N2015/1068

    摘要： The flow cytometry system of the present invention includes a flow channel including an interrogation zone. A light source and a light detector are connected to the interrogation zone, such that a sample flowing through the interrogation zone can be optically analyzed through methods known in the art of flow cytometry. A bubble detector is connected to the flow channel. A controller is connected to the bubble detector and is adapted to perform a predetermined output in response to the detection of a bubble in the flow channel. The predetermined output may include alerting a user as to the presence of a bubble, flagging potentially corrupted data, and ceasing data collection until the interrogation zone is clear of bubbles.

    摘要翻译： 本发明的流式细胞术系统包括一个包括询问区的流路。 光源和光检测器连接到询问区，使得流过询问区的样品可以通过流式细胞术技术中已知的方法进行光学分析。 气泡检测器连接到流动通道。 控制器连接到气泡检测器，并且适于响应于流动通道中的气泡的检测而执行预定的输出。 预定的输出可以包括向使用者发出关于气泡的存在，标记可能损坏的数据，以及停止数据收集，直到询问区清除气泡。

    Method for testing image processing circuit, particle image analyzer, and storage medium
    36.
    发明申请
    Method for testing image processing circuit, particle image analyzer, and storage medium 有权
    图像处理电路，粒子图像分析仪和存储介质的测试方法

    公开(公告)号：US20060047460A1

    公开(公告)日：2006-03-02

    申请号：US11218166

    申请日：2005-08-31

    申请人： Kozo Fujii

    发明人： Kozo Fujii

    IPC分类号： G01R27/28 ,  G01R31/00

    CPC分类号： G01N15/1012 ,  G01N2015/1443 ,  G06T7/0004 ,  G06T2207/30108

    摘要： A particle image analyzer provided with an image processor for executing predetermined image processes on a particle image containing an image of a particle, a reading means for reading test result data from a flash memory card on which are previously recorded test result data equivalent to the processing result of the image processor during normal operation, and a testing means for determining whether or not the image processor is operating normally by comparing the processing result obtained when the test image is used in the image processor, and test result data read from the flash memory card by the reading means.

    摘要翻译： 一种具有用于对包含粒子图像的粒子图像执行预定图像处理的图像处理器的粒子图像分析器，读取装置，用于从先前记录有相当于处理的测试结果数据的闪存卡读取测试结果数据 在正常操作期间图像处理器的结果以及用于通过比较在图像处理器中使用测试图像时获得的处理结果以及从闪存读取的测试结果数据来确定图像处理器是否正常运行的测试装置 卡通过阅读手段。

    Methods for controlling one or more parameters of a flow cytometer type measurement system
    38.
    发明申请
    Methods for controlling one or more parameters of a flow cytometer type measurement system 有权
    用于控制流式细胞仪型测量系统的一个或多个参数的方法

    公开(公告)号：US20050073686A1

    公开(公告)日：2005-04-07

    申请号：US10918647

    申请日：2004-08-13

    申请人： Wayne Roth ,  Douglas Moore

    发明人： Wayne Roth ,  Douglas Moore

    IPC分类号： G01N15/14 ,  G01N21/00

    CPC分类号： G01N15/1404 ,  G01N15/1012 ,  G01N21/645 ,  G01N2015/1415 ,  G01N2015/1477 ,  G01N2201/12746

    摘要： Various methods for controlling one or more parameters of a flow cytometer type measurement system are provided. One embodiment includes monitoring parameter(s) of the measurement system during measurements of sample microspheres. The method also includes altering the parameter(s) in real time based on the monitoring. Another method includes monitoring a temperature proximate to the measurement system. One such method includes altering a bias voltage of an avalanche photo diode in response to the temperature using empirically derived data. A different such method includes altering output signals of a photomultiplier tube in response to the temperature using a characteristic curve. Some methods include monitoring a temperature of a fluid, in which sample microspheres are disposed, that will flow through the flow cytometer type measurement system. This method also includes determining a velocity of the sample microspheres in the measurement system from a viscosity of the fluid at the temperature.

    摘要翻译： 提供了用于控制流式细胞仪型测量系统的一个或多个参数的各种方法。 一个实施例包括在样品微球的测量期间监测测量系统的参数。 该方法还包括基于监视实时更改参数。 另一种方法包括监测靠近测量系统的温度。 一种这样的方法包括使用经验导出的数据来响应于温度来改变雪崩光电二极管的偏置电压。 不同的这种方法包括使用特性曲线响应于温度改变光电倍增管的输出信号。 一些方法包括监测将流过流式细胞仪类型测量系统的流体样品微球的设置温度。 该方法还包括从该温度下的流体的粘度确定测量系统中的样品微球的速度。

    Evaluation method for a particle counter and device for carrying out said method
    39.
    发明授权
    Evaluation method for a particle counter and device for carrying out said method 有权
    用于实施所述方法的粒子计数器和装置的评估方法

    公开(公告)号：US06573696B1

    公开(公告)日：2003-06-03

    申请号：US09807286

    申请日：2001-04-11

    申请人： Paul Sahner

    发明人： Paul Sahner

    IPC分类号： G01N2700

    CPC分类号： G01N15/1429 ,  G01N15/1012 ,  G01N2015/1486 ,  G01N2015/1493 ,  G06M1/108

    摘要： In an evaluation method for a particle counter, a detector generates a signal in response to the presence of particles in a measuring area in which a liquid flow is conveyed. The sensor signal is treated by a signal processing device and is converted into a display value, taking into account at least one calibration factor. The sensor signal is treated in such a way that the individual residence times of the particles in the measuring zone are determined within a given lapse of time and a summated signal is formed by summating the residence times. The signal is used to represent the display value, taking into account the at least one calibration factor. A device for carrying out this includes a signal processing unit with a comparator circuit, a clock-pulse generator and a summation device in the form of a pulse counter, for example, in order to form the summated signal.

    摘要翻译： 在颗粒计数器的评估方法中，检测器响应于在其中输送液体流的测量区域中存在颗粒而产生信号。 传感器信号由信号处理装置处理，并考虑到至少一个校准因子而被转换成显示值。 处理传感器信号，使得在给定的时间内确定颗粒在测量区域中的单独停留时间，并且通过将停留时间相加来形成求和信号。 该信号用于表示显示值，考虑到至少一个校准因子。 用于实现这一点的装置包括具有比较器电路的信号处理单元，时钟脉冲发生器和脉冲计数器形式的求和装置，以形成加和信号。

    Monodisperse fluorine-containing synthetic polymer particles having a defined refractive index for use as standards and calibrators in flow cytometry
    40.
    发明授权
    Monodisperse fluorine-containing synthetic polymer particles having a defined refractive index for use as standards and calibrators in flow cytometry 失效
    具有限定折射率的单分散含氟合成聚合物颗粒用作流式细胞术中的标准物和校准物

    公开(公告)号：US06521729B1

    公开(公告)日：2003-02-18

    申请号：US09432905

    申请日：1999-11-02

    申请人： David Zelmanovic ,  William Moskalski ,  Ronny DeClercq ,  Frank Louwet ,  Eberhard Kuckert ,  Wolfgang Podszun

    发明人： David Zelmanovic ,  William Moskalski ,  Ronny DeClercq ,  Frank Louwet ,  Eberhard Kuckert ,  Wolfgang Podszun

    IPC分类号： C08F12024

    CPC分类号： G01N15/1012 ,  G01N2015/1062 ,  G01N2015/1486 ,  G01N2015/149 ,  Y10T436/10 ,  Y10T436/101666

    摘要： The invention describes novel methods for calibrating or standardizing flow cytometry instruments using synthetic polymer particles or beads having physical properties which provide advantages for their use in such instruments. The polymer particles or beads employed in the calibration methods are spherical, have an average particle diameter of from about 1 to about 8 microns, a relatively narrow particle distribution, and a low refractive index, i.e., from about 1.35 to about 1.45. The particles are safe, stable for long time periods and are particularly suitable for employment as hematology analyzer calibration substances. The invention provides an advantageous improvement over the types of standards currently used to calibrate a variety of instruments that rely on light scatter combined with other parameters to identify and measure biological particles or cells, as well as nonbiological particles. In particular, using the calibration/standardization method and polymer particles according to the present invention allows hematology instruments to be calibrated and standardized for subsequent accurate and reliable determinations of red blood cells, reticulocytes, white blood cells and platelets in whole blood samples.

    摘要翻译： 本发明描述了使用具有物理性质的合成聚合物颗粒或珠粒来校准或标准化流式细胞仪器的新方法，其提供了在这些仪器中使用的优点。 在校准方法中使用的聚合物颗粒或珠粒是球形的，平均粒径为约1至约8微米，相对较窄的颗粒分布和低折射率，即约1.35至约1.45。 颗粒安全，长时间稳定，特别适合用作血液分析仪校准物质。 本发明提供了相对于目前用于校准依赖于光散射的各种仪器与其他参数相结合以识别和测量生物颗粒或细胞以及非生物颗粒的标准类型的有利改进。 特别地，使用根据本发明的校准/标准化方法和聚合物颗粒允许血液仪器被校准和标准化，用于随后准确可靠地测定全血样品中的红细胞，网织红细胞，白细胞和血小板。