公开(公告)号：US20210230687A1

公开(公告)日：2021-07-29

申请号：US17228477

申请日：2021-04-12

Applicant: ILLUMINA CAMBRIDGE LIMITED

Inventor： Elena Cressina ,  Antoine Francais ,  Xiaohai Liu

IPC: C12Q1/6869 ,  C07H19/06 ,  C07H21/00 ,  C07H19/16 ,  C07H19/20 ,  C07H19/10 ,  C07H19/073 ,  C07H19/14 ,  C07H21/04 ,  C12Q1/6809 ,  C12Q1/6816

Abstract: The present disclosure relates to new nucleotide and oligonucleotide compounds and their use in nucleic acid sequencing applications.

公开(公告)号：US11059849B2

公开(公告)日：2021-07-13

申请号：US15507853

申请日：2015-09-01

Applicant: DNA Script

Inventor： Thomas Ybert ,  Sylvain Gariel

IPC: C07H21/04 ,  C07H19/10 ,  C07H19/20 ,  C12P19/34

Abstract: A modified nucleotide, intended for the synthesis of long chain nucleic acids by enzymatic processes, comprising a “natural” nitrogenous base or a natural nitrogenous base analogue, a ribose or deoxyribose carbohydrate, and at least one phosphate group, characterized in that said nucleotide comprises at least one R group, termed the modifier group, carried by said nitrogenous base or analogue and/or by the oxygen in position 3′ of the ribose or deoxyribose molecule, making it possible to block the polymerization of said nucleotide and/or to allow the interaction of said nucleotide with another molecule, such as a protein, during the nucleic acid synthesis, R comprising at least one functional terminal group.

公开(公告)号：US20210207192A1

公开(公告)日：2021-07-08

申请号：US17209398

申请日：2021-03-23

Applicant: ABBOTT MOLECULAR INC.

Inventor： Dae Hyun Kim

IPC: C12Q1/6806 ,  C12N15/10 ,  C07H19/20 ,  C07H19/10 ,  C07H21/04 ,  C12Q1/6869

Abstract: Provided herein is technology relating to the manipulation and detection of nucleic acids, including but not limited to compositions, methods, and kits related to nucleotides comprising a chemically reactive linking moiety.

公开(公告)号：US20210196741A1

公开(公告)日：2021-07-01

申请号：US17077267

申请日：2020-10-22

Applicant: GILEAD PHARMASSET LLC

Inventor： Jinfa Du ,  Dhanapalan Nagarathnam ,  Michael Joseph Sofia ,  Peiyuan Wang

IPC: A61K31/7072 ,  A61K31/706 ,  A61K31/7064 ,  A61K31/7076 ,  C07H19/04 ,  C07H19/20 ,  C07H19/06 ,  C07H19/10 ,  A61K45/06 ,  C07H17/02 ,  C07D417/14

Abstract: Disclosed herein are phosphoramidate prodrugs of nucleoside derivatives for the treatment of viral infections in mammals, which is a compound, its stereoisomer, salt (acid or basic addition salt), hydrate, solvate, or crystalline form thereof, represented by the following structure: Also disclosed are methods of treatment, uses, and processes for preparing each of which utilize the compound represented by formula I.

公开(公告)号：US20210139525A1

公开(公告)日：2021-05-13

申请号：US16959901

申请日：2019-01-07

Applicant: CERECOR, INC.

Inventor： Stephen B. Thomas ,  Patrick J. Crutcher ,  Fabrizio Pertusati ,  Elisa Pileggi

IPC: C07H19/20 ,  C07H19/10

Abstract: The invention relates to nucleotide prodrugs and pharmaceutical preparations thereof. The invention further relates using the prodrugs of the invention in the treatment of mitochondrial DNA (mtDNA) depletion syndrome (MDS).

公开(公告)号：US11001602B2

公开(公告)日：2021-05-11

申请号：US16171970

申请日：2018-10-26

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Klaus-Peter Stengele

IPC: C07H19/20 ,  C07C323/19 ,  C07C323/32 ,  C07H19/02 ,  C07D231/12 ,  C07D235/28 ,  C07D207/16 ,  C07D213/70 ,  C07C319/14 ,  C07H1/00 ,  C07H19/06 ,  C07H19/10 ,  C07H19/16 ,  C07K1/04 ,  C07K7/08

Abstract: The present disclosure relates to photoactivable protecting groups containing a diarylsulfide chromophore, a method for the synthesis thereof and their use as photoactivable protecting groups using maskless photolithography based array synthesis.

公开(公告)号：US10982277B2

公开(公告)日：2021-04-20

申请号：US16563443

申请日：2019-09-06

Applicant: Illumina Cambridge Limited

Inventor： Xiaohai Liu ,  Xiaolin Wu ,  Geoffrey Paul Smith

IPC: C12Q1/68 ,  C07H19/073 ,  C07H19/10 ,  C07H19/14 ,  C07H19/173 ,  C07H19/20 ,  C12Q1/6869 ,  C12Q1/6876

Abstract: Some embodiments described herein relate to modified nucleotide and nucleoside molecules with novel 3′-hydroxy protecting groups. Also provided herein are methods to prepare such modified nucleotide and nucleoside molecules and sequencing by synthesis processes using such modified nucleotide and nucleoside molecules.

公开(公告)号：US10981944B2

公开(公告)日：2021-04-20

申请号：US16273843

申请日：2019-02-12

Applicant: ARCUS BIOSCIENCES, INC.

Inventor： Laurent Pierre Paul Debien ,  Juan Carlos Jaen ,  Jaroslaw Kalisiak ,  Kenneth V. Lawson ,  Manmohan Reddy Leleti ,  Erick Allen Lindsey ,  Dillon Harding Miles ,  Eric Newcomb ,  Jay Patrick Powers ,  Brandon Reid Rosen ,  Ehesan Ul Sharif

IPC: A01N43/04 ,  A61K31/70 ,  C07H19/23 ,  A61K31/7076 ,  C07H19/16 ,  C07H19/20 ,  C07H19/207 ,  C07F9/6561 ,  C07H19/04 ,  A61K31/706 ,  A61K45/06 ,  A61K31/7052 ,  A61K31/7064 ,  C07H19/14

Abstract: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.

公开(公告)号：US20210087219A1

公开(公告)日：2021-03-25

申请号：US17111096

申请日：2020-12-03

Applicant: Alnylam Pharmaceuticals, Inc.

Inventor： Muthiah MANOHARAN ,  Kallanthottathil G. RAJEEV ,  Jeremy LACKEY ,  Jayaprakash K. NAIR

IPC: C07H21/02 ,  C07H21/00 ,  C07F9/6512 ,  C07F9/655 ,  C07F9/6558 ,  C07H19/20

Abstract: This invention relates to an oligonucleotide comprising one or more abasic nucleoside monomers of formula IV′: These monomers are useful for modifying of oligonucleotides at one or more positions. This invention also relates to a method of inhibiting the expression of a target gene in a cell. The method comprises contacting the cell with an oligonucleotide having one or more of the above formula (IV′).

公开(公告)号：US10953030B2

公开(公告)日：2021-03-23

申请号：US16532210

申请日：2019-08-05

Applicant: RIBOSCIENCE LLC

Inventor： Mark Smith ,  Klaus G. Klumpp

IPC: C07H19/20 ,  A61K31/7072 ,  A61K31/7056 ,  A61K31/4709 ,  A61K31/4184 ,  A61K31/4188 ,  A61K45/06 ,  A61P1/16 ,  A61K31/4178 ,  A61P31/14 ,  A61K31/683

Abstract: Cytidine nucleoside analogues of Formula I, wherein the variables are as described herein, in combination with uridine nucleoside analogues of Formula II, wherein the variables are as described herein, produce a synergistic effect on the inhibition of HCV polymerase.