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公开(公告)号:US11058704B2
公开(公告)日:2021-07-13
申请号:US16338975
申请日:2017-10-02
发明人: Laurent Pierre Paul Debien , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号: A01N43/04 , A61K31/70 , A61K31/7076 , A61K31/706 , A61K31/7064 , A61K39/395 , C07H19/20 , C07H19/207 , C07H19/23
摘要: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号:US10239912B2
公开(公告)日:2019-03-26
申请号:US15400748
申请日:2017-01-06
发明人: Laurent Pierre Paul Debien , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号: A61K31/70 , A01N43/04 , C07H19/23 , A61K31/7052 , A61K31/7076 , C07H19/16 , C07H19/20 , C07H19/207 , A61K31/7064 , C07H19/14 , C07F9/6561 , C07H19/04
摘要: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号:US11407712B2
公开(公告)日:2022-08-09
申请号:US17205273
申请日:2021-03-18
发明人: Joel Worley Beatty , Samuel Lawrie Drew , Matthew Epplin , Jeremy Thomas Andre Fournier , Balint Gal , Tezcan Guney , Karl T. Haelsig , Clayton Hardman , Steven Donald Jacob , Jenna Leigh Jeffrey , Jaroslaw Kalisiak , Kenneth Victor Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Artur Karenovich Mailyan , Debashis Mandal , Guillaume Mata , Hyunyoung Moon , Jay Patrick Powers , Brandon Reid Rosen , Yongli Su , Anh Thu Tran , Zhang Wang , Xuelei Yan , Kai Yu
IPC分类号: C07C317/32 , A61K31/10 , A61K31/277 , A61K31/343 , A61K31/353 , A61K31/365 , A61K31/381 , A61K31/404 , A61K31/415 , A61K31/416 , A61K31/4174 , A61K31/4192 , A61K31/4196 , A61K31/421 , A61K31/423 , A61K31/426 , A61K31/428 , A61K31/437 , A61K31/44 , A61K31/4412 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/4965 , A61K31/50 , A61K31/5025 , A61K31/505 , A61K31/519 , A61K31/538 , A61K39/395 , A61K45/06 , C07C255/53 , C07C317/22 , C07C317/36 , C07D209/34 , C07D211/86 , C07D213/57 , C07D213/71 , C07D213/73 , C07D213/74 , C07D213/84 , C07D215/48 , C07D217/04 , C07D231/12 , C07D231/56 , C07D233/64 , C07D237/20 , C07D239/42 , C07D241/12 , C07D249/06 , C07D249/08 , C07D263/32 , C07D263/57 , C07D265/36 , C07D277/30 , C07D277/56 , C07D277/64 , C07D307/83 , C07D311/22 , C07D333/64 , C07D401/04 , C07D401/10 , C07D409/10 , C07D413/10 , C07D471/04 , C07D487/04
摘要: Compounds that inhibit HIF-2α, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2α.
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公开(公告)号:US10981944B2
公开(公告)日:2021-04-20
申请号:US16273843
申请日:2019-02-12
发明人: Laurent Pierre Paul Debien , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号: A01N43/04 , A61K31/70 , C07H19/23 , A61K31/7076 , C07H19/16 , C07H19/20 , C07H19/207 , C07F9/6561 , C07H19/04 , A61K31/706 , A61K45/06 , A61K31/7052 , A61K31/7064 , C07H19/14
摘要: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号:US11001603B2
公开(公告)日:2021-05-11
申请号:US17009590
申请日:2020-09-01
发明人: Laurent Pierre Paul Debien , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号: A01N43/04 , A61K31/70 , C07H19/23 , A61K31/7076 , C07H19/16 , C07H19/20 , C07H19/207 , C07F9/6561 , C07H19/04 , A61K31/706 , A61K45/06 , A61K31/7052 , A61K31/7064 , C07H19/14
摘要: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号:US11267845B2
公开(公告)日:2022-03-08
申请号:US16461649
申请日:2017-11-17
发明人: Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Ehesan Ul Sharif
摘要: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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公开(公告)号:US20190309010A1
公开(公告)日:2019-10-10
申请号:US16273843
申请日:2019-02-12
发明人: Laurent Pierre Paul DEBIEN , Juan Carlos Jaen , Jaroslaw Kalisiak , Kenneth V. Lawson , Manmohan Reddy Leleti , Erick Allen Lindsey , Dillon Harding Miles , Eric Newcomb , Jay Patrick Powers , Brandon Reid Rosen , Ehesan Ul Sharif
IPC分类号: C07H19/23 , A61K31/706 , A61K45/06 , C07H19/207 , C07H19/20 , C07H19/16 , A61K31/7076 , A61K31/70 , C07F9/6561 , C07H19/14 , A61K31/7064 , A61K31/7052 , C07H19/04
摘要: Compounds that modulate the conversion of AMP to adenosine by 5′-nucleotidase, ecto, and compositions containing the compounds and methods for synthesizing the compounds, are described herein. The use of such compounds and compositions for the treatment and/or prevention of a diverse array of diseases, disorders and conditions, including cancer- and immune-related disorders, that are mediated by 5′-nucleotidase, ecto is also provided.
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