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    CARBON NANOTUBE ELECTROCHEMICAL SET AS LAB-ON-A-CHIP
    32.
    发明公开
    CARBON NANOTUBE ELECTROCHEMICAL SET AS LAB-ON-A-CHIP 审中-公开

    公开(公告)号：US20240118235A1

    公开(公告)日：2024-04-11

    申请号：US18274284

    申请日：2022-01-28

    Applicant: University of Cincinnati

    Inventor： Noe Alvarez ,  Pankaj Gupta

    IPC: G01N27/30 ,  C01B32/168 ,  G01N27/327

    CPC classification number: G01N27/308 ,  C01B32/168 ,  G01N27/3278 ,  C01B2202/22 ,  C01B2202/36

    Abstract: The present disclosure concerns open-end carbon nanotubes assembled as a microelectrode array in electrode sets/micro-electrode sets (ES/micro-ES). The ES/micro-ES includes three electrodes that are made of highly densified multi-walled carbon nanotubes fibers (HD-CNTfs) sectioned into rods embedded in an inert polymer film with exposed open ends of CNTs at the electrode-electrolyte interface. The ES/micro-ES provide miniature electrochemical sensing devices in which all electrodes are based on carbon nanomaterials. The combination of dimensions and orientation provides for highly sensitive electrochemical determination (picomolar) of different electroactive analytes in different electrolyte mediums, where even a single drop of desired analyte solution will be enough for electrochemical characterization.

    Method for manufacturing microneedle biosensor
    33.
    发明授权
    Method for manufacturing microneedle biosensor 有权

    公开(公告)号：US11945164B2

    公开(公告)日：2024-04-02

    申请号：US17944216

    申请日：2022-09-14

    Applicant: Peking University

    Inventor： Yue Cui

    IPC: B33Y10/00 ,  B29C64/30 ,  B33Y40/20 ,  B33Y80/00 ,  B41M3/00 ,  G01N27/30 ,  G01N27/327 ,  B29L31/00

    CPC classification number: B29C64/30 ,  B33Y10/00 ,  B33Y40/20 ,  B33Y80/00 ,  B41M3/006 ,  G01N27/308 ,  G01N27/3271 ,  B29L2031/752

    Abstract: A microneedle biosensor includes a microneedle and a substrate. One end of the microneedle is connected to the substrate, an outer surface of the microneedle is provided with a working electrode and a first electrode, an outer surface of the working electrode is provided with an enzyme, and an outer surface of the microneedle biosensor is covered with a biocompatible film. A method for manufacturing a microneedle biosensor includes: manufacturing the substrate and the microneedle in an additive mode simultaneously; spray-printing and curing the working electrode and the first electrode on the outer surface of the microneedle; spray-printing and drying the enzyme on the outer surface of the working electrode; and using biocompatible liquid for spray-printing, and drying the biocompatible liquid to form the biocompatible film. The substrate, the microneedle, the working electrode, the first electrode, the enzyme and the biocompatible film are all manufactured through a full printing method.

    CIRCUITRY FOR ANALYTE MEASUREMENT
    34.
    发明公开
    CIRCUITRY FOR ANALYTE MEASUREMENT 审中-公开

    公开(公告)号：US20240085370A1

    公开(公告)日：2024-03-14

    申请号：US17940225

    申请日：2022-09-08

    Applicant: Cirrus Logic International Semiconductor Ltd.

    Inventor： John P. LESSO

    IPC: G01N27/416 ,  G01N27/00 ,  G01N27/30

    CPC classification number: G01N27/4161 ,  G01N27/002 ,  G01N27/30

    Abstract: Circuitry for measuring a characteristic of an electrochemical cell, the electrochemical cell comprising at least one working electrode and a counter electrode, the circuitry comprising: driver circuitry configured to apply a working bias voltage to the at least one working electrode and a counter bias voltage at the counter electrode to produce a first voltage bias between the at least one working electrode and the counter electrode; control circuitry configured to adjust the first voltage bias over a first bias range by varying the working bias voltage and the counter bias voltage.

    REFERENCE ELECTRODE & ION SELECTIVE MEMBRANE
    35.
    发明公开
    REFERENCE ELECTRODE & ION SELECTIVE MEMBRANE 审中-公开

    公开(公告)号：US20240041364A1

    公开(公告)日：2024-02-08

    申请号：US18265580

    申请日：2021-11-25

    Applicant: University of Southampton

    Inventor： Roeland Hubertus Gerardus MINGELS ,  Hywel MORGAN

    IPC: A61B5/1473 ,  G01N27/333 ,  G01N27/30

    CPC classification number: A61B5/1473 ,  G01N27/3335 ,  G01N27/301 ,  A61B2503/40 ,  A61B2562/125

    Abstract: An integrated reference electrode for use in an electrochemical measurement system, comprising: a reference electrode in combination with a hygroscopic hydrogel electrolyte impregnated and contained in a porous framework, wherein the hygroscopic hydrogel electrolyte is adapted to contact the reference electrode when in a hydrated state. Also, an ion selective membrane with an aromatic epoxy polymer made from one or more monomers having at least one epoxide group, and a chloride salt or a silver—silver chloride physically trapped in the aromatic epoxy polymer. On contact with water the aromatic epoxy polymer forms a network of channels for ion exchange. The membrane may be used between an electrolyte and an external fluid environment; or the membrane may be coated upon the surface of a reference electrode.

    SENSING ELECTRODE, ELECTROCHEMICAL SENSING SYSTEM COMPRISING THE SAME, AND METHODS THEREOF
    36.
    发明公开
    SENSING ELECTRODE, ELECTROCHEMICAL SENSING SYSTEM COMPRISING THE SAME, AND METHODS THEREOF 审中-公开

    公开(公告)号：US20240035998A1

    公开(公告)日：2024-02-01

    申请号：US18357129

    申请日：2023-07-23

    Applicant: 2WITECH SOLUTIONS LLC

    Inventor： Qingwu Wang ,  Yufeng Ma

    IPC: G01N27/30

    CPC classification number: G01N27/30

    Abstract: The present invention provides a sensing electrode, an electrochemical sensing system using the sensing electrode, methods of preparing and using the sensing electrode and the electrochemical sensing system. The sensing electrode includes a base electrode having a conductive surface, and a coating layer formed on the conductive surface. The coating layer has cavities or holes, each of which can be filled with, bound to, or occupied by, an analyte molecule. A decrease of conductivity of the sensing electrode is correlated to the number of cavities or holes that are filled with, bound to, or occupied by, the molecules of the analyte. The invention exhibits numerous technical merits such as suitability for field application, high sensitivity to analyte such as PFOA or PFAS at 1 ppt level, rapid response within minutes, and superior selectivity against interferences such as PFDA, PFOS, PFOSA, and PFHxA, among others.

    AUTO-CALIBRATION PH SENSOR
    37.
    发明公开
    AUTO-CALIBRATION PH SENSOR 审中-公开

    公开(公告)号：US20240027388A1

    公开(公告)日：2024-01-25

    申请号：US18224878

    申请日：2023-07-21

    Applicant: Sensorex Corporation

    Inventor： Alex D. Smith ,  Albert Haizhen Zhou ,  Jose Tafolla ,  Michael Francis Ross ,  Hamed Shadpour

    IPC: G01N27/30 ,  G01N27/416

    CPC classification number: G01N27/302 ,  G01N27/301 ,  G01N27/4167 ,  G01N27/4165

    Abstract: A pH sensor comprising pH sensing instrumentation, reference sensing instrumentation, an electrochemical junction, and a pH determination unit. The pH sensing instrumentation comprises a pH fluid, a pH fluid chamber, a pH sensing chamber, and a measuring electrode extending through the pH fluid chamber and comprising a tip that resides in the pH sensing chamber. The reference sensing instrumentation comprises a reference fluid, a reference chamber filled with the reference fluid, a reference electrode immersed in the reference fluid, and monitoring instrumentation. The monitoring instrumentation comprises a monitoring fluid, a monitoring fluid chamber, a monitoring sensing chamber filled with the monitoring fluid, and a monitoring electrode extending through the monitoring fluid chamber and comprising a tip that resides in the monitoring sensing chamber. The monitoring fluid chamber and the monitoring sensing chamber are immersed in the reference fluid.

    ELECTROCHEMICAL SENSOR SYSTEM AND METHOD FOR URIC ACID MEASUREMENT
    38.
    发明公开
    ELECTROCHEMICAL SENSOR SYSTEM AND METHOD FOR URIC ACID MEASUREMENT 审中-公开

    公开(公告)号：US20240019393A1

    公开(公告)日：2024-01-18

    申请号：US18373412

    申请日：2023-09-27

    Applicant: Purdue Research Foundation

    Inventor： Wenzhuo Wu ,  Jing Jiang

    IPC: G01N27/30

    CPC classification number: G01N27/30

    Abstract: An electrochemical sensor that includes a substrate and a piezoelectric semiconductor which is configured to detect uric acid using piezo-electrocatalysis. The piezoelectric semiconductor is coupled to the substrate. The piezoelectric semiconductor includes a nanostructured semiconducting ZnO catalyst. The nanostructured semiconducting ZnO catalyst has a noncentrosymmetric wurtzite configuration. The nanostructured semiconducting ZnO catalyst is shaped as a nanorod and/or a nanosheet.

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