公开(公告)号：US06464866B2

公开(公告)日：2002-10-15

申请号：US09747080

申请日：2000-12-21

Applicant: James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin

Inventor： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin

IPC: H01J4910

CPC classification number: G01N30/7266 ,  G01N30/6095 ,  H01J49/0018 ,  H01J49/167 ,  Y10T29/49002 ,  Y10T436/25375 ,  Y10T436/255

Abstract: An electrospray device, a liquid chromatography device and an electrosprayliquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may -be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

公开(公告)号：US06461516B2

公开(公告)日：2002-10-08

申请号：US09746866

申请日：2000-12-21

Applicant: James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin

Inventor： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin

IPC: H01J4910

CPC classification number: G01N30/7266 ,  G01N30/6095 ,  H01J49/0018 ,  H01J49/167 ,  Y10T29/49002 ,  Y10T436/25375 ,  Y10T436/255

Abstract: An electrospray device, a liquid chromatography device and an electrosprayliquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may-be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

Abstract translation: 公开了电喷雾装置，液相色谱装置和电喷雾液相色谱系统。 电喷雾装置包括：基材，其限定在喷射表面上的入口孔与喷射表面上的出口孔之间的通道;由从出射孔周围的喷射表面凹陷的部分限定的喷嘴;以及用于施加电 对基板进行优化和产生电喷雾的潜力; 和可选的附加电极以进一步改变电喷雾。 所述液相色谱装置包括分隔衬底，所述分离衬底限定入口孔和贮存器之间的引入通道以及所述储存器和出口孔之间的分离通道，所述分离通道具有垂直于所述流体流动的分离柱; 覆盖基板，其结合到分离基板以封闭储存器和与盖基板相邻的分离通道; 和可选地用于向流体施加电势的电极。 液相色谱装置的出口可以与电喷雾装置的入口孔均匀地接合，以形成一个集成的单一系统。 可以在单个单片芯片中制造多个系统的阵列，用于快速顺序流体处理和产生用于后续分析的电喷雾，例如通过将电喷雾装置的出口孔定位在质谱仪的采样孔附近。

公开(公告)号：US06454938B2

公开(公告)日：2002-09-24

申请号：US09745891

申请日：2000-12-21

Applicant: James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin

Inventor： James E. Moon ,  Timothy J. Davis ,  Gregory J. Galvin

IPC: H01J4910

CPC classification number: G01N30/7266 ,  G01N30/6095 ,  H01J49/0018 ,  H01J49/167 ,  Y10T29/49002 ,  Y10T436/25375 ,  Y10T436/255

Abstract: An electrospray device, a liquid chromatography device and an electrosprayliquid chromatography system are disclosed. The electrospray device comprises a substrate defining a channel between an entrance orifice on an injection surface and an exit orifice on an ejection surface, a nozzle defined by a portion recessed from the ejection surface surrounding the exit orifice, and an electrode for application of an electric potential to the substrate to optimize and generate an electrospray; and, optionally, additional electrode(s) to further modify the electrospray. The liquid chromatography device comprises a separation substrate defining an introduction channel between an entrance orifice and a reservoir and a separation channel between the reservoir and an exit orifice, the separation channel being populated with separation posts perpendicular to the fluid flow; a cover substrate bonded to the separation substrate to enclose the reservoir and the separation channel adjacent the cover substrate; and, optionally, electrode(s) for application of a electric potential to the fluid. The exit orifice of the liquid chromatography device may be homogeneously interfaced with the entrance orifice of the electrospray device to form an integrated single system. An array of multiple systems may -be fabricated in a single monolithic chip for rapid sequential fluid processing and generation of electrospray for subsequent analysis, such as by positioning the exit orifices of the electrospray devices near the sampling orifice of a mass spectrometer.

公开(公告)号：US06278111B1

公开(公告)日：2001-08-21

申请号：US09191866

申请日：1998-11-12

Applicant: Edward W. Sheehan ,  Ross C. Willoughby ,  Joseph A. Jarrell ,  David M. Strand

Inventor： Edward W. Sheehan ,  Ross C. Willoughby ,  Joseph A. Jarrell ,  David M. Strand

IPC: H01J4910

CPC classification number: H01J49/165 ,  H01J49/049

Abstract: An improved electrospray (ES) apparatus has a low pressure ES chamber coupled to a desolvation chamber. The desolvation chamber desolvates the incoming analyte ions of the cone-jet with non-conductive energy. The apparatus stabilizes cone-jet formation in the ES chamber. The apparatus receives solvated ions without pressure reduction, produces desolvated ions with non-conductive energy in a low pressure region, and outputs the desolvated ions towards a mass spectrometer as a substantially solvent-free ion beam suitable for mass spectrometer analysis. The apparatus avoids the degree of pressure reduction featured in prior ES techniques.

Abstract translation: 改进的电喷雾（ES）装置具有耦合到去溶剂化室的低压ES室。 去溶剂化室以非导电能量去除锥形喷射流中的进入分析物离子。 该装置稳定了ES室中的锥形喷射形成。 该装置在没有减压的情况下接收溶剂化离子，在低压区域中产生具有非导电能的脱溶离离子，并将解溶离的离子输出到质谱仪，作为适用于质谱分析的基本上无溶剂的离子束。 该装置避免了先前ES技术中特征的减压程度。

公开(公告)号：US06252225B1

公开(公告)日：2001-06-26

申请号：US09492352

申请日：2000-01-27

Applicant: Yasuaki Takada ,  Minoru Sakairi ,  Atsumu Hirabayashi ,  Takayuki Nabeshima ,  Hideaki Koizumi

Inventor： Yasuaki Takada ,  Minoru Sakairi ,  Atsumu Hirabayashi ,  Takayuki Nabeshima ,  Hideaki Koizumi

IPC: H01J4910

CPC classification number: H01J49/165 ,  G01N30/7266 ,  H01J49/168

Abstract: A mass spectrometer including a sprayer for spraying a sample solution, a needle electrode for ionizing the sample contained in the sample solution, an aperture for introducing the ions of the sample into a lower pressure region having a pressure lower than the pressure of a region in which the needle electrode is disposed, and a mass spectrometric apparatus for analyzing the ions introduced from the aperture. A direction of a spray caused by the sprayer is almost perpendicular to a center axis of the aperture and a tip of the needle is disposed facing to an electrode having the aperture.

Abstract translation: 一种质谱仪，包括用于喷射样品溶液的喷雾器，用于使包含在样品溶液中的样品电离的针状电极，用于将样品的离子引入低于区域压力的低压区域的孔 设置针状电极的质谱仪和用于分析从孔径引入的离子的质谱仪。 由喷雾器引起的喷雾方向几乎垂直于孔的中心轴线，并且针的尖端面向具有孔的电极设置。

公开(公告)号：US06211516B1

公开(公告)日：2001-04-03

申请号：US09247646

申请日：1999-02-09

Applicant: Jack A. Syage ,  Karl A. Hanold ,  Mark A. Hanning-Lee

Inventor： Jack A. Syage ,  Karl A. Hanold ,  Mark A. Hanning-Lee

IPC: H01J4910

CPC classification number: H01J49/162 ,  H01J49/107 ,  H01J49/147

Abstract: A monitor that can detect at least one trace molecule in a gas sample. The monitor may include a photoionizer that is coupled to an electron-ionization mass spectrometer. The photoionizer may ionize the gas sample at a wavelength(es) which ionizes the trace molecules without creating fragmentation. The inclusion of the electron-ionizer may allow alternate or additional ionization to detect trace molecules not ionized by the photoionizer. The gas sample may be ionized at atmospheric pressure which increases the yield of the ionized trace molecules and the sensitivity of the mass spectrometer.