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公开(公告)号：US06278111B1
公开(公告)日：2001-08-21
申请号：US09191866
申请日：1998-11-12
IPC分类号： H01J4910
CPC分类号： H01J49/165 , H01J49/049
摘要： An improved electrospray (ES) apparatus has a low pressure ES chamber coupled to a desolvation chamber. The desolvation chamber desolvates the incoming analyte ions of the cone-jet with non-conductive energy. The apparatus stabilizes cone-jet formation in the ES chamber. The apparatus receives solvated ions without pressure reduction, produces desolvated ions with non-conductive energy in a low pressure region, and outputs the desolvated ions towards a mass spectrometer as a substantially solvent-free ion beam suitable for mass spectrometer analysis. The apparatus avoids the degree of pressure reduction featured in prior ES techniques.
摘要翻译： 改进的电喷雾（ES）装置具有耦合到去溶剂化室的低压ES室。 去溶剂化室以非导电能量去除锥形喷射流中的进入分析物离子。 该装置稳定了ES室中的锥形喷射形成。 该装置在没有减压的情况下接收溶剂化离子，在低压区域中产生具有非导电能的脱溶离离子，并将解溶离的离子输出到质谱仪，作为适用于质谱分析的基本上无溶剂的离子束。 该装置避免了先前ES技术中特征的减压程度。
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公开(公告)号：US06396057B1
公开(公告)日：2002-05-28
申请号：US09655577
申请日：2000-09-06
申请人： Joseph A. Jarrell , David M. Strand
发明人： Joseph A. Jarrell , David M. Strand
IPC分类号： B01D5944
CPC分类号： H01J49/165 , H01J49/0018
摘要： An improved method and apparatus for performing Mass spectrometry, in particular, Liquid chromatography/Mass spectrometry (LC/MS) is disclosed. Controlled generation of individual charged droplets enables the subsequent steps of trapping, desolvation and concentration. Miniaturization is also enabled. In contrast, conventional means of forming Electrosprays are chaotic, generating large numbers of charged droplets simultaneously. Additional flows of gas are provided in a nebulization region to effectively remove undesired solvent vapor and concentrate desirable analyte containing droplets and/or analyte ions. A semipermeable structure is used to effectively separate associated gas flow streams. Ions are concentrated or trapped using electrodes which are bound in the nebulization region and are appropriately electrically biased so as to concentrate the ions on one side, or in the center, or in a ring of the laminar gas stream. Additionally, a valve may be used to interrupt the flow gas into a detector region.
摘要翻译： 公开了一种改进的用于进行质谱法的方法和装置，特别是液相色谱/质谱（LC / MS）。 单个带电液滴的受控产生使得随后的捕获，去溶剂化和浓缩步骤成为可能。 小型化也被启用。 相比之下，形成电喷雾的常规手段是混沌的，同时产生大量的带电液滴。 在雾化区域中提供额外的气体流，以有效地去除不需要的溶剂蒸气并浓缩所需的分析物含有液滴和/或分析离子。 使用半透性结构来有效分离相关的气流。 使用结合在雾化区域中并且被适当地电偏压的电极来浓缩或捕获离子，以便将离子集中在层流气流的一侧或中心或环中。 此外，可以使用阀来中断流入气体进入检测器区域。
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公开(公告)号：US09496125B2
公开(公告)日：2016-11-15
申请号：US12919570
申请日：2009-03-03
CPC分类号： H01J49/167 , B01L3/0268 , B01L3/502792 , B01L2200/026 , B01L2300/0819 , B01L2300/089 , B01L2400/0427 , B03C5/024 , B03C2201/26 , G01N30/06 , G01N30/20 , G01N2030/201
摘要： Described are techniques for use in connection with analyzing a droplet. One or more droplets of a sample are formed on a surface of a digital microfluidic device. The droplets are manipulated to perform processing using said one or more droplets generating one or more resulting droplets. The one or more resulting droplets may be transferred from the microfluidic device to another device for analysis. The one or more droplets may also be provided to the digital microfluidic device from yet another device or analysis instrument.
摘要翻译： 描述了与分析液滴有关的技术。 在数字微流体装置的表面上形成一个或多个样品液滴。 操纵液滴以使用所述一个或多个液滴产生一个或多个所产生的液滴进行处理。 所产生的一个或多个液滴可以从微流体装置转移到另一装置用于分析。 一个或多个液滴也可以从另一个装置或分析仪器提供给数字微流体装置。
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公开(公告)号：US20120286151A1
公开(公告)日：2012-11-15
申请号：US13105605
申请日：2011-05-11
CPC分类号： H01J49/14 , H01J49/168
摘要： Embodiments of the present invention are directed to devices and methods for performing an analysis of a sample having a sample surface. The device and method feature a frame element affixed to a sample holder, jet element and a charged particle analyzer having an ion receiving orifice. The jet element directs a jet of gas towards the sample surface held by said sample holder focused on less than 2.0 mm2 of the sample surface. Ions formed by the electrode means are received by a charged particle analyzer having a ion receiving orifice for receiving one or more sample ions and performing a charged particle analysis with respect to the sample surface. The sample holder moves with respect to the jet element, and charged particle analyzer to permit scanning of a sample surface.
摘要翻译： 本发明的实施例涉及用于对具有样品表面的样品进行分析的装置和方法。 装置和方法的特征在于固定到样品架，喷射元件和带有离子接收孔的带电粒子分析仪的框架元件。 喷射元件将气体射流引导到聚集在小于2.0mm 2的样品表面上的由所述样品保持器保持的样品表面。 由电极装置形成的离子被具有用于接收一个或多个样品离子并且相对于样品表面进行带电粒子分析的离子接收孔的带电粒子分析仪接收。 样品架相对于喷射元件移动，并且带电粒子分析仪允许扫描样品表面。
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公开(公告)号：US08294091B2
公开(公告)日：2012-10-23
申请号：US12991026
申请日：2009-05-05
申请人： Joseph A. Jarrell
发明人： Joseph A. Jarrell
IPC分类号： H01J49/10
CPC分类号： H01J49/0422 , H01J49/0431
摘要： Embodiments of the present invention feature devices and methods for performing gas chromatography and liquid chromatography with mass spectrometry. The device and method feature a removable housing which housing contains the gas samples when the mass spectrometry receives gas samples. The device fits an atmospheric pressure ionization housing and upon removal, the atmospheric pressure ionization housing receives liquid samples.
摘要翻译： 本发明的实施方案的特征在于用质谱法进行气相色谱和液相色谱的装置和方法。 该装置和方法的特征在于，当质谱接收气体样品时，壳体包含气体样品。 该装置适合大气压电离壳体，并且在去除时，大气压电离壳体接收液体样品。
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公开(公告)号：US07911609B2
公开(公告)日：2011-03-22
申请号：US11814114
申请日：2006-01-11
申请人： Joseph A. Jarrell
发明人： Joseph A. Jarrell
IPC分类号： G01N21/00
CPC分类号： G01N30/74 , G01N30/84 , G01N2030/303 , G01N2030/847 , G01N21/47
摘要： Embodiments of the present invention are directed to evaporation light scattering detectors having an evaporative chamber having a wall that is in good thermal contact with a heat sink. The heat has a high thermal mass such that a change in temperature of the wall during an analysis is minimized.
摘要翻译： 本发明的实施例涉及具有蒸发室的蒸发光散射检测器，其具有与散热器良好热接触的壁。 热量具有高热量，使得在分析期间壁的温度变化最小化。
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公开(公告)号：US07847936B2
公开(公告)日：2010-12-07
申请号：US12113234
申请日：2008-05-01
申请人： Joseph A. Jarrell
发明人： Joseph A. Jarrell
IPC分类号： G01N21/00
CPC分类号： G01N21/53 , G01N15/0205 , G01N30/74 , G01N35/1097 , G01N2030/8447
摘要： Apparatus for the detection of analytes in a fluid, for example the eluant from a liquid chromatography is described. Solvent is evaporated from the eluant to produce a stream of particles when analyte is present in the fluid. The resultant stream of particles is passed through one or more beams of radiation, typically visible light, and radiation scattered by the particles is detected at least at a first angle to a beam of radiation and at a second, different, angle to a radiation beam to produce a signal indicative of the presence of the analyte.Chromatographic apparatus incorporating the detector and methods of operating the detector and chromatographic apparatus are also described.
摘要翻译： 描述了用于检测流体中分析物的装置，例如液相色谱的洗脱液。 当分析物存在于流体中时，溶剂从洗脱液蒸发以产生颗粒物流。 所得到的颗粒流通过一个或多个辐射束，通常是可见光，并且至少与辐射束成一定角度地检测由颗粒散射的辐射，并以与辐射束成第二个不同角度 以产生指示分析物存在的信号。 还描述了结合检测器的色谱装置和操作检测器和色谱装置的方法。
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公开(公告)号：US6140640A
公开(公告)日：2000-10-31
申请号：US257871
申请日：1999-02-25
CPC分类号： H01J49/167
摘要： A non-reactive electrospray needle structure that can be used with relatively low electrical potential introduced externally at a selectable location along the length of the needle structure. The electrospray device or apparatus includes a non-conductive tube with an inner diameter, with one end of the tube having a reduced inner diameter thereby forming a tip. The tube is configured to have a fracture in it, positioned a predetermined or selectable distance from the tip. An electrically conductive path, such as a wire or electrode, is provided external to the tube and proximate to the fracture. A collar surrounds the tube proximate the fracture. The electrically conductive path provides a voltage potential to charge the spray. The collar maintains the conductive path in place, seals the tube at the fracture, and provides structural strength. In one embodiment, the tube is packed with a binding material to form a column bed.
摘要翻译： 可以使用具有相对低的电位的非反应性电喷射针结构，其外部沿着针结构的长度的可选择位置引入。 电喷雾装置或设备包括具有内径的非导电管，管的一端具有减小的内径，从而形成尖端。 该管被配置为在其中具有位于与尖端预定的或可选择的距离处的断裂。 导电路径（例如线或电极）设置在管的外部并且靠近断裂。 衣领围绕骨折附近围绕管。 导电路径提供电压以对喷雾进行充电。 轴环将导电路径保持在适当位置，在断裂处密封管，并提供结构强度。 在一个实施例中，管装有粘合材料以形成柱床。
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9.发明授权Systems and methods for coupling molecule separation devices to analytical instruments 有权将分子分离装置耦合到分析仪器的系统和方法公开(公告)号：US08449746B2
公开(公告)日：2013-05-28
申请号：US13178041
申请日：2011-07-07
申请人： Joseph A. Jarrell
发明人： Joseph A. Jarrell
CPC分类号： B01D57/02 , H01J49/0404
摘要： Described is a capillary that interfaces with an analysis system. The capillary comprises a non-conductive tubing and a conductive region proximate to an output end of the non-conductive tubing. The conductive region comprises a plurality of porous regions and non-porous regions positioned about a circumference of the non-conductive tubing. The porous regions separated from each other by the non-porous regions. Advantageously, the arrangement of porous regions provides mechanical stability about the conductive region.
摘要翻译： 描述了与分析系统接口的毛细管。 毛细管包括非导电管和靠近非导电管的输出端的导电区。 导电区域包括围绕非导电管道的圆周定位的多个多孔区域和非多孔区域。 多孔区域通过无孔区域彼此分离。 有利地，多孔区域的布置提供关于导电区域的机械稳定性。
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10.发明申请APPARATUS FOR PHOTOIONIZATION OF AN ANALYTE IN AN ELUENT OF A CHROMATOGRAPHY COLUMN 审中-公开用于在色谱柱的荧光体中分析分析仪的装置公开(公告)号：US20130020483A1
公开(公告)日：2013-01-24
申请号：US13636447
申请日：2011-04-06
申请人： Joseph A. Jarrell
发明人： Joseph A. Jarrell
IPC分类号： H01J49/16
摘要： Described is an apparatus for photoionization of an analyte in an eluent of a chromatography column. The apparatus includes a laser to generate a beam of optical radiation, a mass spectrometer and one or more optical components to receive the beam and to generate a concentrated region of optical radiation near an orifice of the mass spectrometer so that an analyte in the vapor phase of the eluent is ionized. Alternatively, the apparatus includes a laser driven light source, a mass spectrometer and an optical imaging system. The laser driven light source includes an optical enclosure having an ionizable medium, an ignition source and a laser for pumping optical radiation into the ionizable medium. The optical imaging system generates an image of the pumped region of the ionized medium proximate to the orifice of the mass spectrometer to thereby photoionize an analyte in the vapor phase of the eluent.
摘要翻译： 描述了用于色谱柱的洗脱液中的分析物的光电离的装置。 该装置包括用于产生光辐射束的激光器，质谱仪和一个或多个光学部件以接收光束并且在质谱仪的孔口附近产生光辐射的集中区域，使得气相中的分析物 的洗脱液被电离。 或者，该装置包括激光驱动光源，质谱仪和光学成像系统。 激光驱动光源包括具有可电离介质的光学外壳，点火源和用于将光辐射泵入可离子化介质的激光器。 光学成像系统产生靠近质谱仪的孔口的离子化介质的泵送区域的图像，从而使洗脱液的气相中的分析物光电离。
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