公开(公告)号：US11284815B2

公开(公告)日：2022-03-29

申请号：US14242953

申请日：2014-04-02

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Eric S. Carlsgaard ,  Paul J. Galley ,  Mark G. Mears ,  Benoit P. Menez ,  Hemlata Nayee ,  Jose Salazar-Galindo

IPC: A61B5/145 ,  G06F16/27 ,  G16H40/63 ,  G16H40/67

Abstract: A diabetes management system includes a handheld medical device, a mobile computing device, and a diabetes management application. The handheld medical device is configured to measure glucose in a sample of fluid residing in a test strip and associate a measurement time with the glucose measurement. The diabetes management application is configured to request a current device time from the RTC, determine a first device delta time by determining a difference between the current device time and an internal clock time, and associate a first timestamp with a glucose measurement, wherein the first timestamp is equal to the measurement time plus the first device delta time.

公开(公告)号：US11278883B2

公开(公告)日：2022-03-22

申请号：US16474942

申请日：2017-12-29

Applicant: Roche Diagnostics Hematology, Inc. ,  Roche Diagnostics Operations, Inc.

Inventor： Ertan Ergezen ,  Stephen Conroy ,  Rijk Edwin Oosterbroek ,  Claudio Cherubini

IPC: B01L1/00 ,  B01L3/02 ,  B01L9/00 ,  G01N1/31 ,  G01N35/00

Abstract: The disclosure features methods, fluid delivery platforms, and apparatus for preparing a sample on a substrate that includes a substrate handler configured to move a substrate between a first position and a second position, and a platform positioned so that when the substrate is in the second position, the platform faces the substrate, where the platform includes a fluid delivery area having a second surface formed from a hydrophilic material for which a water contact angle is 40 degrees or less, and a first surface facing the substrate when the substrate is in the second position, formed from a hydrophobic material for which a water contact angle is 100 degrees or more.

公开(公告)号：US11275065B2

公开(公告)日：2022-03-15

申请号：US16718296

申请日：2019-12-18

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Uwe Kobold ,  Hubert Paul ,  Martin Rempt

IPC: G01N30/72 ,  G01N30/86 ,  G01N30/88 ,  G01N33/487 ,  G01N30/02

Abstract: A diagnostic system and method and an interconnected laboratory system comprising clinical diagnostic systems are presented. The diagnostic system comprises a sample preparation module, a liquid chromatography (LC) separation module coupled to the sample preparation module via a sample preparation/LC interface, a mass spectrometer (MS) module coupled to the LC separation module via an LC/MS interface, and a result calculation module for identifying and/or quantifying analytes or substances of interest contained in the samples and passed through the LC separation and MS modules. The diagnostic system comprises a controller programmed to monitor operational parameters (1-n) indicative of a performance status of the diagnostic system, to trigger a quality control procedure and/or a maintenance procedure whenever one or more parameters (1-n) of the operational parameters (1-n) is out of specification, and to minimize the quality control and/or maintenance procedures as long as the operational parameters (1-n) remains within specification.

公开(公告)号：US11267827B2

公开(公告)日：2022-03-08

申请号：US16284346

申请日：2019-02-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Hans-Peter Josel ,  Tobias Oelschlaegel ,  Giuseppe Prencipe ,  Luisa De Cola ,  Elena Longhi ,  Chien-Wei Hsu

IPC: C07F7/08 ,  C09K11/06 ,  B82Y15/00 ,  B82Y30/00 ,  B82Y40/00

Abstract: The present disclosure relates to novel multifunctionalized silicon nanoparticles, to processes for their preparation and to compositions comprising the novel multifunctionalized silicon nanoparticles. The disclosure also relates to the use of the novel multifunctionalized silicon nanoparticles in electrochemiluminescence based detection methods and in the in vitro detection of an analyte. In particular, the disclosure relates to methods for measuring an analyte by in vitro methods employing the novel multifunctionalized silicon nanoparticles.

公开(公告)号：US11236386B2

公开(公告)日：2022-02-01

申请号：US16598685

申请日：2019-10-10

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Frank Bergmann ,  Tobias Oelschlaegel ,  Sebastian Johannes Pomplun

IPC: C12Q1/6869 ,  C07D295/13 ,  C07D487/04 ,  C07H21/02 ,  C07H21/04 ,  A61K47/68

Abstract: The present description relates to a method for binding to a target molecule having an aldehyde compound derived from N-(2-aminoethyl)pyrrole, which compound also has a moiety of interest, to compounds (conjugates) obtained by this method, having both the target molecule and the moiety of interest and to novel substances derived from N-(2-aminoethyl)pyrrole. In one embodiment, the compound has the formula of Formula II wherein R1, R2 and R3 independently are H, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl, wherein R4, R5, R6, R7 and R8 independently are H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl, substituted or unsubstituted heteroaryl, or -LM, wherein L is absent or is a linker and M is a moiety of interest selected from a nucleotide, an oligonucleotide, a peptide, a label, a cytotoxic agent, a partner of a binding pair and a functional group, wherein two of R4, R5, R6, R7, and R8 optionally are linked to form a substituted or unsubstituted cycloalkyl or a substituted or unsubstituted heterocycloalkyl, and T is a target molecule selected from the group consisting of a solid phase, a polypeptide, a protein, a carbohydrate, a nucleotide and a nucleic acid, with the proviso that at least one of R4, R5, R6, R7 or R8 is -LM.

公开(公告)号：US20220020489A1

公开(公告)日：2022-01-20

申请号：US17365464

申请日：2021-07-01

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Stephen Martin ,  Jakub Winiarz ,  Alexandra Paun

IPC: G16H40/67 ,  G16H10/40

Abstract: A computer-implemented method for inferring a condition of at least one analytical device based on at least one automatic notification received over a network from the analytical device is disclosed. The method comprises receiving, at a data processing agent, at least one automatic notification from at least one analytical device, processing, at the data processing agent, the at least one automatic notification, to thus identify one or more characteristics of the at least one automatic notification from the at least one analytical device, inferring, at the data processing agent, the condition of the at least one analytical device, by applying the one or more identified characteristics to a model; and generating, at the data processing agent, a notification reporting the inferred condition of the analytical device.

公开(公告)号：US11211152B2

公开(公告)日：2021-12-28

申请号：US15989976

申请日：2018-05-25

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Ralf Bauer ,  Werner Schönenberger ,  Roger Iten

IPC: G01N35/10 ,  G01N35/00 ,  G16H10/40

Abstract: A system and method for managing information relating to requests for a number of tests to be made of at least one sample within a laboratory environment are disclosed. The system may include a sample reception unit, a pre-analytical unit to scan, sort and/or aliquot the sample on request according to respective test requirements included within a respective sample order, an analytical unit to run at least one test on a sorted and/or aliquoted sample, and at least one decision unit. The decision unit acts as a connecting component for interconnecting the sample reception unit, the pre-analytical unit and the analytical unit as both an intermediary and coordinator such that tests can be performed via a recursive workflow until the sample is completely measured. The decision unit is further configured to collate the test results appropriately with the sample and to give a respective report towards a host component.

公开(公告)号：US11204360B2

公开(公告)日：2021-12-21

申请号：US15995209

申请日：2018-06-01

Applicant: Roche Diagnostics Operations, Inc.

Inventor： David Huber ,  Daniel Arnold

IPC: G01N35/04 ,  B65G47/76

Abstract: A switch for a conveying line for transporting a laboratory diagnostic vessel carrier is presented. The conveying line comprises a first line portion and a second line portion. The switch comprises a curved first guiding surface and a second guiding surface. The switch is moveable between a first position, in which the laboratory diagnostic vessel carrier is transportable along the curved first guiding surface from the first line portion to the second line portion, and a second position, in which the laboratory diagnostic vessel carrier is further transportable along the second guiding surface on the first line portion. A switch assembly and a conveying line are also disclosed.

公开(公告)号：US11200326B2

公开(公告)日：2021-12-14

申请号：US16174972

申请日：2018-10-30

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Richard Edward Salin

IPC: G06F11/14 ,  G06F21/60 ,  G16H10/60 ,  G01N35/00 ,  G06F8/65 ,  G06F11/00 ,  G06F21/51 ,  G06F9/455 ,  G06F21/57 ,  G06F21/64 ,  G16H40/63 ,  G16H10/40 ,  G16Z99/00 ,  G06F9/4401 ,  H04L9/32

Abstract: A method for saving and/or restoring settings of an instrument for processing a sample or reagent is disclosed. The instrument comprises a control unit and an operating system. A storage medium is provided to the instrument. The storage medium comprises a script. The script restores data for restoring settings of the instrument. The script is encrypted and/or digitally signed. The method verifies an identity and/or integrity of the script and executes the script upon starting the instrument by the operating system with the storage medium when the identity and/or integrity of the script correspond to an identity and/or integrity of the instrument. The control unit provides an input menu for allowing a user to input a saving and/or restoring command. The instrument saves settings on the storage medium and/or restores settings of the instrument from the storage medium by the restoring data corresponding to the saving and/or restoring command.

公开(公告)号：US20210364540A1

公开(公告)日：2021-11-25

申请号：US17317181

申请日：2021-05-11

Applicant: Roche Diagnostics Operations, Inc.

Inventor： Christopher William Bates

IPC: G01N35/04

Abstract: A laboratory sample container carrier cleaning apparatus is provided comprising a revolving device, being adapted to move a sample container carrier supplied to the revolving device along a circular path, and a cleaning device, being adapted to clean the sample container carrier being moved along the circular path.