公开(公告)号：US08129357B2

公开(公告)日：2012-03-06

申请号：US11999637

申请日：2007-12-06

Applicant: Yijuang Chern ,  Yun-Lian Lin ,  Nai-Kuei Huang ,  Jung-Hsing Lin ,  Jim-Min Fang ,  Chia-I Lin

Inventor： Yijuang Chern ,  Yun-Lian Lin ,  Nai-Kuei Huang ,  Jung-Hsing Lin ,  Jim-Min Fang ,  Chia-I Lin

IPC: A61K36/00 ,  A61K36/8988 ,  A61K31/70

CPC classification number: A61K36/8988 ,  A61K31/7076

Abstract: This document describes compounds, extracts, and pharmaceutical compositions relating to Gastrodia spp., and methods for the treatment subjects having metabolic disorders or medical conditions such as Huntington's disease, a trinucleotide repeat disease or abnormal blood glucose levels.

Abstract translation: 本文件描述了与天麻属相关的化合物，提取物和药物组合物，以及治疗具有代谢紊乱或医学病症如亨廷顿病，三核苷酸重复疾病或异常血糖水平的受试者的方法。

公开(公告)号：US08129140B2

公开(公告)日：2012-03-06

申请号：US13089620

申请日：2011-04-19

Applicant: Tuan-Hua David Ho ,  Su-May Yu ,  I Son Ng ,  Chii-Gong Tong

Inventor： Tuan-Hua David Ho ,  Su-May Yu ,  I Son Ng ,  Chii-Gong Tong

IPC: C12P1/00 ,  C12N9/42

CPC classification number: C12N9/2437 ,  C07H3/02 ,  C07H3/04 ,  C12N15/8246 ,  C12Y302/01004

Abstract: A novel thermophilic endo-glucanase, nucleic acid encoding the endo-glucase, and uses thereof in converting ligocellulosic material to fermentable sugars.

Abstract translation: 一种新型嗜热内切葡聚糖酶，编码内切葡聚糖的核酸，及其用于将纤维素纤维素材料转化成可发酵糖的用途。

公开(公告)号：US20120040420A1

公开(公告)日：2012-02-16

申请号：US13210637

申请日：2011-08-16

Applicant: Jui-Jen Chang ,  Cheng-Yu Ho ,  Chieh-Chen Huang ,  Ming-Che Shih ,  Wen-Hsiung Li

Inventor： Jui-Jen Chang ,  Cheng-Yu Ho ,  Chieh-Chen Huang ,  Ming-Che Shih ,  Wen-Hsiung Li

IPC: C12P7/64 ,  C12P7/22 ,  C12P7/62 ,  C12N1/16

CPC classification number: C12R1/645 ,  C12P7/22 ,  C12P7/62 ,  C12P7/6436

Abstract: Disclosed are a novel flavor compound-producing yeast strain and methods of using the strain to produce flavor compounds.

Abstract translation: 公开了一种新颖的产生风味化合物的酵母菌株和使用该菌株产生风味化合物的方法。

公开(公告)号：US20120036597A1

公开(公告)日：2012-02-09

申请号：US13197187

申请日：2011-08-03

Applicant: Su-May Yu ,  Chin-Fen Su

Inventor： Su-May Yu ,  Chin-Fen Su

IPC: A01H5/00 ,  C40B30/04 ,  C12Q1/68 ,  C12N15/82

CPC classification number: C12N15/8273

Abstract: Disclosed are chill- or cold-tolerant plants and methods of making the plants. Also disclosed are methods for identifying a plant that is tolerant to chill.

Abstract translation: 公开了冷或冷耐受植物和制造植物的方法。 还公开了用于鉴定耐寒的植物的方法。

公开(公告)号：US08105636B2

公开(公告)日：2012-01-31

申请号：US12212607

申请日：2008-09-17

Applicant: Chi-Huey Wong ,  Yih-Shyun E. Cheng ,  Hui-Ming Yu ,  Ting-Jen R. Cheng ,  Chung-Yi Wu ,  Jim-Min Fang

Inventor： Chi-Huey Wong ,  Yih-Shyun E. Cheng ,  Hui-Ming Yu ,  Ting-Jen R. Cheng ,  Chung-Yi Wu ,  Jim-Min Fang

IPC: A61K36/00 ,  A61K31/045 ,  A61K31/05

CPC classification number: A61K36/53 ,  A61K31/215 ,  A61K31/235

Abstract: The crude extract of Plectranthus Amboinicus (PA) has anti-inflammatory effects and can inhibit AP-1 binding in vitro. The incubation with PA crude extract resulted in significant inhibition of the LPS-induced expression of IL-6, IL-12, MCP-1, and RANTES in HUVEC cells. After the crude extract was further fractionated using preparative HPLC, fraction 8, 9, 10 and 11 were identified to inhibit the AP-1 binding activity. The active component of fraction 8 is Mena 987; fraction 9 is Mena 998; fraction 10 is Mena 9102; and fraction 11 is rosmarinic acid and the synthetic rosmarinic acid analogues. Other compounds showed inhibitory activities as well. These compounds have inhibitory effects on AP-1 activity and are useful as preventive or therapeutic agent for diseases in which excessive expression or activities of AP-1 are involved.

Abstract translation: 芍药（Plectranthus Amboinicus，PA）的粗提物具有抗炎作用，能体外抑制AP-1结合。 与PA粗提取物的孵育导致LPS诱导的HUVEC细胞中IL-6，IL-12，MCP-1和RANTES的表达的显着抑制。 在使用制备型HPLC进一步分馏粗提取物后，鉴定出8,9,10和11级分抑制AP-1结合活性。 级分8的活性组分是Mena 987; 9级是Mena 998; 级分10是Mena 9102; 并且级分11是迷迭香酸和合成的迷迭香酸类似物。 其他化合物也显示抑制活性。 这些化合物对AP-1活性具有抑制作用，可用作涉及AP-1过度表达或活性的疾病的预防或治疗剂。

公开(公告)号：US20110288409A1

公开(公告)日：2011-11-24

申请号：US13195201

申请日：2011-08-01

Applicant: Yeu-Kuang Hwu ,  Giorgio Margaritondo ,  Jung Ho Je

Inventor： Yeu-Kuang Hwu ,  Giorgio Margaritondo ,  Jung Ho Je

IPC: A61B6/00

CPC classification number: A61B6/482 ,  A61B6/4092 ,  A61B6/481 ,  A61B6/484 ,  A61B6/504 ,  A61B6/508

Abstract: Images of blood vessels of a body are obtained by injecting a refraction enhancement contrast agent into the blood vessels to increase a difference in refractive indices of the blood vessels and surrounding material. The blood vessels are irradiated with a penetrating radiation, and an image of the blood vessels is generated based on detected radiation. The image has visible edge enhancement features indicating boundaries of the blood vessels.

Abstract translation: 通过将折射增强造影剂注射到血管中以增加血管和周围材料的折射率差异来获得身体血管的图像。 用穿透性辐射照射血管，并且基于检测到的辐射产生血管的图像。 该图像具有指示血管边界的可见边缘增强特征。

公开(公告)号：US20110281323A1

公开(公告)日：2011-11-17

申请号：US12777569

申请日：2010-05-11

Applicant: Lie-Fen Shyur ,  Chih-An Hsu

Inventor： Lie-Fen Shyur ,  Chih-An Hsu

IPC: C12N9/02 ,  C12N15/63 ,  C12N5/10 ,  C07H21/00

CPC classification number: C12N9/0061 ,  C12Y110/03002

Abstract: Novel laccases from Cerrena sp. WR1 and Lentinus sp. and uses thereof.

Abstract translation: Cerrena sp。的新型漆酶 WR1和香菇属 及其用途。

公开(公告)号：US20110281288A1

公开(公告)日：2011-11-17

申请号：US12778619

申请日：2010-05-12

Applicant: Yit-Tsong Chen ,  Chien-Yuan Pan ,  Tsung-Wu Lin

Inventor： Yit-Tsong Chen ,  Chien-Yuan Pan ,  Tsung-Wu Lin

IPC: C12Q1/48 ,  C12M1/34 ,  G01N33/566 ,  G01N27/00

CPC classification number: G01N27/4145 ,  G01N27/4146 ,  G01N33/5438

Abstract: A reusable nanowire field effect transistor for detecting biomolecular interactions. The field effect transistor contains nanowire covalently linked to a docking molecule, which is capable of binding to an anchor molecule in a reversible manner, i.e., at an association constant of 105 to 109 M−1.

Abstract translation: 用于检测生物分子相互作用的可重复利用的纳米线场效应晶体管。 场效应晶体管包含与对接分子共价连接的纳米线，其能够以可逆方式结合锚定分子，即105至109M-1的缔合常数。

公开(公告)号：US20110250192A1

公开(公告)日：2011-10-13

申请号：US13056043

申请日：2009-08-03

Applicant: Alice L. Yu ,  You-Chin Lin ,  Ruey-Jen Lin

Inventor： Alice L. Yu ,  You-Chin Lin ,  Ruey-Jen Lin

IPC: A61K38/46 ,  A61K48/00 ,  A61P35/00 ,  C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/136 ,  C12Q2600/178

Abstract: Methods for assessing the risk level or survival/death probability of a neuroblastoma patient based on a number of microRNA signatures, optionally in combination with Dicer, Drosha, and age at diagnosis. Also disclosed herein is use of Dicer, Drosha, or both in suppressing neuroblastoma cell growth

Abstract translation: 基于许多微小RNA标记来评估神经母细胞瘤患者的风险水平或存活/死亡概率的方法，任选地与Dicer，Drosha和诊断年龄组合。 本文还公开了使用Dicer，Drosha或两者来抑制神经母细胞瘤细胞生长

公开(公告)号：US07964351B2

公开(公告)日：2011-06-21

申请号：US12123700

申请日：2008-05-20

Applicant: Yuan-Tsong Chen ,  Shuen-Iu Hung ,  Wen-Hung Chung ,  Jer-Yuarn Wu

Inventor： Yuan-Tsong Chen ,  Shuen-Iu Hung ,  Wen-Hung Chung ,  Jer-Yuarn Wu

IPC: C12Q1/68 ,  C12P19/34 ,  C07H21/02

CPC classification number: C12Q1/6881 ,  C12Q1/6883 ,  C12Q2600/156 ,  G01N33/94

Abstract: The present invention provides a method of predicting the risk of a patient for developing adverse drug reactions, particularly SJS or TEN. It was discovered that an HLA-B allele, HLA-B* 1502, is associated with SJS/TEN that is induced by a variety of drugs. The correlation with HLA-B* 1502 is most significant for carbamazepine-induced SJS/TEN, wherein all the patients tested have the HLA-B* 1502 allele. In addition, another HLA-B allele, HLA-B*5801, is particularly associated with SJS/TEN induced by allopurinol. Milder cutaneous reactions, such as maculopapular rash, erythema multiforme (EM), urticaria, and fixed drug eruption, are particularly associated with a third allele, HLA-B *4601. For any of the alleles, genetic markers (e.g., HLA markers, microsatellite, or single nucleotide polymorphism markers) located between DRB1 and HLA-A region of the specific HLA-B haplotype can also be used for the test.