公开(公告)号：US20210356543A1

公开(公告)日：2021-11-18

申请号：US17352647

申请日：2021-06-21

Applicant: TECHNION RESEARCH & DEVELOPMENT FOUNDATION LIMITED ,  YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Aharon Blank ,  Itai Katz ,  Akiva Feintuch

IPC: G01R33/56 ,  A61K49/20 ,  G01R33/28 ,  G01R33/62 ,  A61B5/055 ,  A61M5/00

Abstract: A method for the preparation of a highly polarized nuclear spins containing sample of an organic or inorganic material, containing H or OH groups or adsorbed water molecules. Such highly polarized nuclear spins containing samples can be subjected to nuclear magnetic resonance (NMR) measurement and/or can be thawed and immediately administered to an individual undergoing a magnetic resonance imaging (MRI) scan. The method is based on generating unstable radicals on the surface of the sample in the presence of ionized environment followed by cooling the sample to cryogenic temperatures. A device for carrying out a particular step of said method is also disclosed.

公开(公告)号：US20210348179A1

公开(公告)日：2021-11-11

申请号：US17381245

申请日：2021-07-21

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Asaph AHARONI ,  Samuel BOCOBZA ,  Tal DAHAN ,  Avraham A. LEVY

IPC: C12N15/82 ,  C12N15/86 ,  C07K14/08

Abstract: Disclosed herein are methods for gene targeting in a plant cell, as well as recombinant nucleic acid molecules used in these methods. Further disclosed are recombinant nucleic acid molecules comprising a target gene operably linked to a regulatory region of the UBQ10 gene.

公开(公告)号：US11118575B2

公开(公告)日：2021-09-14

申请号：US16495487

申请日：2018-03-07

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Jacob Karni ,  Leon Karni

IPC: F03G6/06 ,  F24S23/77 ,  F24S60/10 ,  F24S10/30

Abstract: The present invention relates to the utilization of solar energy for generation of electricity and/or production of clean fuels or other chemicals, as a means for long term, transportable storage of inherently intermittent solar energy.

公开(公告)号：US20210275545A1

公开(公告)日：2021-09-09

申请号：US17325355

申请日：2021-05-20

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Yosef YARDEN ,  Swati SRIVASTAVA

IPC: A61K31/567 ,  A61K31/496 ,  A61K31/4188 ,  A61K31/03 ,  A61K31/451 ,  A61K31/4174 ,  A61K31/444 ,  A61K31/437 ,  A61P35/00 ,  C12Q1/6886

Abstract: A method of treating a cancer selected from the group consisting of a myeloid malignancy, a lymphoid malignancy and Ewing's sarcoma is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent that inhibits the synthesis and/or activity of cortisol.

公开(公告)号：US20210275473A1

公开(公告)日：2021-09-09

申请号：US17261255

申请日：2019-07-17

Applicant: Yeda Research and Development Co. Ltd. ,  University of Duisburg-Essen

Inventor： Anthony H. FUTERMAN ,  Tammar JOSEPH ,  Walter A. SHAW ,  Stephen W. BURGESS ,  Shengrong LI

IPC: A61K31/167 ,  A61K31/133 ,  A61K31/164

Abstract: Provided herein is a group of sphingosine analogs, useful in the treatment of bacterial infections in mucosal surfaces such as lungs, caused by pathogenic bacteria which are typical to disorders and diseases such as CF and COPD.

公开(公告)号：US20210274631A1

公开(公告)日：2021-09-02

申请号：US17255519

申请日：2019-06-24

Applicant: Ecole Polytechnique ,  Ecole Nationale Supérieure de Techniques Avancées ,  Centre National de La Recherche Scientifique ,  Yeda Research and Development Co. Ltd.

Inventor： Cédric THAURY ,  Slava SMARTSEV

IPC: H05H1/54 ,  H01S3/00

Abstract: A reflective optical system (100) comprising at least one reflective aspheric surface (1) of focal length f0 and optical axis (Z), the surface being configured so that an incident laser beam (2) propagating along an axis (Z′) is focused along the optical axis (Z) with a FWHM ((Full Width at Half Maximum) of the intensity of the reflected beam along the optical axis (Z) being larger, preferably by a factor of at least 10, than the FWHM of the intensity of a focused beam reflected by a parabola having same focal length f0 and same optical axis (Z), receiving same beam.

公开(公告)号：US20210269860A1

公开(公告)日：2021-09-02

申请号：US17258477

申请日：2019-07-08

Applicant: Yeda Research and Development Co. Ltd. ,  The Medical Research, Infrastructure and Health Services Fund of the Tel Aviv Medical Center

Inventor： Eran SEGAL ,  Eran ELINAV ,  Zamir HALPERN

IPC: C12Q1/689 ,  C12Q1/04 ,  A61K45/06 ,  A61K35/74 ,  A61P1/00 ,  A61P31/04

Abstract: A method of assessing whether a candidate subject is suitable for probiotic treatment is disclosed. The method comprises determining a signature of the gut microbiome of the candidate subject, wherein when the signature of the microbiome of the candidate subject is statistically significantly similar to a signature of a gut microbiome of a control subject known to be responsive to probiotic treatment, it is indicative that the subject is suitable for probiotic treatment.

公开(公告)号：US20210251955A1

公开(公告)日：2021-08-19

申请号：US17242530

申请日：2021-04-28

Applicant: Yeda Research and Development Co. Ltd. ,  Memorial Sloan Kettering Cancer Center

Inventor： Liran SHLUSH ,  Omar ABDEL-WAHAB

IPC: A61K31/40 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/506 ,  A61K31/4178 ,  A61K31/34 ,  A61K31/167 ,  A61K31/454 ,  A61K31/445 ,  A61K31/4545 ,  A61K31/351 ,  A61K31/404 ,  A61K45/06 ,  A61P35/02

Abstract: A method of preventing a hematopoietic disorder or malignancy in a high risk subject, the subject being positive for one or more mutation in a splicing factor, is disclosed. The method comprising administering to the subject an agent capable of inhibiting spliceosomal activity, with the proviso that said agent does not inhibit RBM39 activity.

公开(公告)号：US20210242648A1

公开(公告)日：2021-08-05

申请号：US17048711

申请日：2019-04-29

Applicant: YEDA RESEARCH AND DEVELOPMENT CO. LTD.

Inventor： Nir DAVIDSON ,  Asher FRIESEM ,  Oren RAZ ,  Chene TRADONSKY

IPC: H01S3/00 ,  H01S3/06 ,  H01S3/08 ,  H01S3/083 ,  H01S3/105 ,  H01S3/106 ,  H01S3/10

Abstract: Laser systems and methods configured to reconstruct an image of an object from an input comprising: the objects scattered intensity distribution (SID) and the objects compact support; the system comprising: a first lens and a second lens, in a four-focal telescope configuration; a gain with a minor at one end, at first end of the telescope, configured to amplify and reflect a received beam; a reflective spatial light modulator, at second end of the telescope, configured to selectively reflect intensity distributions of a received beam, according to their spatial location, the selective reflection is configured to maintain the intensity distributions of the objects SID; a spatial intensity binary mask, located between the telescope's lenses, comprising an aperture in the form of the objects compact support; the mask is configured to transfer only beams passing through the aperture. The reconstructed objects image is provided at least at the mask's aperture.

公开(公告)号：US11077128B2

公开(公告)日：2021-08-03

申请号：US16847737

申请日：2020-04-14

Applicant: Yeda Research and Development Co. Ltd.

Inventor： Steven J. D. Karlish ,  Adriana Katz ,  Daniel M. Tal ,  Arie Marcovich

IPC: A61K31/7052 ,  C07H17/00 ,  C07J43/00 ,  A61P27/06 ,  A61P9/00 ,  C07J19/00

Abstract: Provided herein are alpha2-selective Na,K-ATPase inhibitors and prodrugs thereof, characterized by having a cyclic moiety attached to a digoxin or digitoxin derivative, as well as uses thereof in lowering intraocular pressure and in treating glaucoma and heart conditions.