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41.发明授权公开(公告)号：US10758526B2
公开(公告)日：2020-09-01
申请号：US15317079
申请日：2015-06-09
申请人： BIOMED VALLEY DISCOVERIES, INC. , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES
发明人： Saurabh Saha , Xiaoyan M. Zhang , Dimiter Dimitrov , Zhongyu Zhu , Brad St. Croix , Enrique Zudaire
IPC分类号： A61K31/4745 , A61K39/395 , C07K16/28 , A61K47/68 , A61K39/00
摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a disease, such as cancer in a subject. The methods include: administering to a subject in need thereof (a) a therapeutically effective amount of a molecularly targeted agent; and (b) a therapeutically effective amount of a monoclonal antibody or antigen binding fragment thereof, wherein the monoclonal antibody contains: (i) a heavy chain variable region (VH), which includes an amino acid sequence selected from SEQ ID NO:1, SEQ ID NO:3, SEQ ID NO:5, and SEQ ID NO:7; and (ii) a light chain variable region (VL), which includes an amino acid sequence selected from SEQ ID NO:2, SEQ ID NO:4, SEQ ID NO:6, and SEQ ID NO:8. Compositions, including pharmaceutical compositions, and kits for treating diseases, such as cancer, are also provided herein.
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公开(公告)号：US10604582B2
公开(公告)日：2020-03-31
申请号：US15512000
申请日：2015-09-16
申请人： THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH , BIOMED VALLEY DISCOVERIES, INC.
发明人： Dimiter S. Dimitrov , Zhongyu Zhu , Bradley St. Croix , Steven Seaman , Saurabh Saha , Xiaoyan Michelle Zhang , Gary A. DeCrescenzo , Dean Welsch
IPC分类号： C07K16/30 , C07K16/28 , A61K39/395 , A61K47/68 , A61K35/00 , A61K39/00 , G01N33/574 , A61P35/00
摘要： Polypeptides and proteins that specifically bind to and immunologically recognize CD276 are disclosed. Chimeric antigen receptors (CARs), anti-CD276 binding moieties, nucleic acids, recombinant expression vectors, host cells, populations of cells, pharmaceutical compositions, and conjugates relating to the polypeptides and proteins are also disclosed. Methods of detecting the presence of (a) cancer or (b) tumor vasculature in a mammal and methods of (a) treating or preventing cancer or (b) reducing tumor vasculature in a mammal are also disclosed.
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公开(公告)号：US10196443B2
公开(公告)日：2019-02-05
申请号：US15680177
申请日：2017-08-17
申请人： THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES , BIOMED VALLEY DISCOVERIES, INC.
发明人： Dimiter Dimitrov , Zhongyu Zhu , Brad St. Croix , Enrique Zudaire , Saurabh Saha , Xiaoyan Michelle Zhang , Gary Decrescenzo , Dean Welsch
IPC分类号： C07H21/04 , C12N15/09 , C12N15/63 , A61P35/00 , G01N33/574 , A61P31/04 , C07K16/30 , A61K39/395 , C07K16/28 , A61K47/68 , A61K9/00 , A61K45/06 , A61K49/16 , C07K14/725 , C07K14/705 , A61K39/00
摘要： Antibodies that specifically bind TEM8 protein, conjugates thereof, and their use, are disclosed herein. In some examples the conjugates and antibodies are useful for methods of detecting and treating pathogenic angiogenesis. In other examples the conjugates and antibodies are useful for methods of detecting and treating cancer. In additional examples, the conjugates and antibodies are useful for methods of decreasing binding of Anthrax protective antigen to a cell.
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公开(公告)号：US09861621B2
公开(公告)日：2018-01-09
申请号：US15195723
申请日：2016-06-28
IPC分类号： A61K31/44 , A61K31/444 , C07K16/28 , A61K39/395 , A61K45/06 , A61K39/00
CPC分类号： A61K31/444 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/507 , C07K16/2818 , C07K2317/76 , A61K2300/00
摘要： The present invention provides, inter alia, a composition containing a compound of formula (I): or a pharmaceutically acceptable salt thereof, optionally, in combination with at least one immune checkpoint inhibitor compound. Kits containing the composition, and methods of using the composition for ameliorating or treating the effects of a disease such as a cancer, in a subject, are also provided herein.
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公开(公告)号：US09757424B2
公开(公告)日：2017-09-12
申请号：US14347339
申请日：2012-09-25
发明人： Reza Halse , Saurabh Saha , Jeffrey James Roix
IPC分类号： A61K31/4184 , A61K38/08 , A61K45/06 , A61K31/41 , A61K31/4188 , A61K38/13 , A61K31/137 , A61K31/155 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/197 , A61K31/235 , A61K31/401 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/4168 , A61K31/4178 , A61K31/42 , A61K31/433 , A61K31/4422 , A61K31/472 , A61K31/517 , A61K31/5415 , A61K31/55 , A61K31/554 , A61K31/675 , A61K38/12
CPC分类号： A61K38/08 , A61K31/137 , A61K31/155 , A61K31/165 , A61K31/166 , A61K31/167 , A61K31/197 , A61K31/235 , A61K31/401 , A61K31/403 , A61K31/404 , A61K31/4045 , A61K31/41 , A61K31/4168 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/42 , A61K31/433 , A61K31/4422 , A61K31/472 , A61K31/517 , A61K31/5415 , A61K31/55 , A61K31/554 , A61K31/675 , A61K38/12 , A61K38/13 , A61K45/06 , A61K2300/00
摘要： The present invention provides, inter alia, methods for treating or ameliorating the effects of a glioma. Methods of this invention include administering to a subject in need thereof an effective amount of a first active agent, such as e.g., an angiotensin receptor blocker, an antifungal agent, a bisphosphonate, an oxytocin inhibitor, an interleukin-1 (IL-1) inhibitor, a cyclooxygenase inhibitor, an α2δ voltage-dependent calcium channel (VDCC) inhibitor, a dihydroorotate dehydrogenase inhibitor, a calcium channel blocker, a renal sodium-chloride symporter inhibitor, an a2 adrenergic agonist, a phenothiazine antipsychotic, a calcineurin inhibitor, a 5-HT agonist, an angiotensin-converting enzyme (ACE) inhibitor, a direct rennin inhibitor, or combinations thereof, and a second active agent, which is a chemotherapeutic agent. Compositions for treating or ameliorating the effects of a glioma are also provided.
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公开(公告)号：US09670177B2
公开(公告)日：2017-06-06
申请号：US15011420
申请日：2016-01-29
IPC分类号： A61K31/4439 , C07D401/04 , C07C55/08 , A61K45/06
CPC分类号： C07D401/04 , A61K31/4439 , A61K45/06 , C07B2200/13 , C07C55/08
摘要： The present invention provides a malonate salt of a compound of formula (I): which is a crystalline salt. Also provided are pharmaceutical compositions that include the provided malonate salt and methods of using the provided crystalline forms and pharmaceutical compositions for the treatment of cancer.
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公开(公告)号：US20160045556A1
公开(公告)日：2016-02-18
申请号：US14781270
申请日：2014-03-28
发明人： Saurabh SAHA , Shibin ZHOU , Bert VOGELSTEIN , Kenneth W. KINZLER
摘要： The present invention provides, inter alia, methods for treating or ameliorating an effect of a solid tumor present in a non-human animal. These methods include administering intratumorally to the non-human animal a unit dose of C. novyi, preferably C. novyi NT, colony forming units (CFUs), which contains about 1×106-1×1010 CFUs suspended in a pharmaceutically acceptable carrier or solution. Methods for debulking a solid tumor present in a non-human animal, a method for microscopically precise excision of tumor cells in a non-human animal, methods for treating or ameliorating an effect of a solid tumor that has metastasized to one or more sites in a non-human animal, methods for ablating a solid tumor present in a non-human animal, unit doses of C. novyi, preferably C. novyi NT, CFUs, and kits for treating or ameliorating an effect of a solid tumor present in a non-human animal are also provided.
摘要翻译： 本发明尤其提供了用于治疗或改善存在于非人动物中的实体瘤的作用的方法。 这些方法包括向非人动物内瘤内给予单位剂量的C. novyi，优选C. novyi NT，集落形成单位（CFU），其含有悬浮在药学上可接受的载体中的约1×10 6 -1×10 10 CFU或 解。 存在于非人动物中的实体瘤的减数目的方法，非人动物中微观上精确切除肿瘤细胞的方法，用于治疗或改善已经转移到一个或多个部位的实体瘤的作用的方法 一种非人类动物，用于消融存在于非人动物中的实体瘤的方法，单位剂量的C.novyi，优选C.novyi NT，CFU和用于治疗或改善存在于 还提供非人类动物。
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