公开(公告)号：US07279161B2

公开(公告)日：2007-10-09

申请号：US11093103

申请日：2005-03-28

申请人： Friedrich Scheiflinger ,  Randolf Kerschbaumer ,  Falko-Guenter Falkner ,  Friedrich Dorner ,  Hans-Peter Schwarz

发明人： Friedrich Scheiflinger ,  Randolf Kerschbaumer ,  Falko-Guenter Falkner ,  Friedrich Dorner ,  Hans-Peter Schwarz

IPC分类号： A61K39/395

CPC分类号： C07K16/40 ,  A61K2039/505

摘要： An antibody or antibody derivative against factor IX/activated factor IX (FIXa) which increases the procoagulant activity of FIXa.

摘要翻译： 针对因子IX /活化因子IX（FIXa）的抗体或抗体衍生物，其增加FIXa的促凝血活性。

公开(公告)号：US07241603B2

公开(公告)日：2007-07-10

申请号：US10300388

申请日：2002-11-19

申请人： Thomas Seelich ,  Ralf Broermann

发明人： Thomas Seelich ,  Ralf Broermann

IPC分类号： C12N9/00

CPC分类号： A61L24/106 ,  C07K14/755 ,  C07K14/78

摘要： A method for producing protein compositions comprising fibrinogen and fibronectin is disclosed, wherein a fibrinogen and fibronectin-containing starting solution is treated with a precipitating composition which comprises two different components that modify the solubility of fibrinogen and/or fibronectin, so that in a single-step precipitation a precipitate is formed which comprises fibrinogen and fibronectin, and the precipitate formed optionally is further treated by methods known per se.

摘要翻译： 公开了一种用于生产包含纤维蛋白原和纤连蛋白的蛋白质组合物的方法，其中含有纤维蛋白原和纤连蛋白的起始溶液用沉淀组合物处理，所述沉淀组合物包含改变纤维蛋白原和/或纤连蛋白的溶解度的两种不同组分， 形成沉淀物，其包含纤维蛋白原和纤连蛋白，并且任选地形成的沉淀物通过本身已知的方法进一步处理。

公开(公告)号：US07220569B2

公开(公告)日：2007-05-22

申请号：US10407123

申请日：2003-04-04

申请人： Michele Himmelspach ,  Uwe Schlokat ,  Friedrich Dorner ,  Andreas Fisch ,  Johann Eibl

发明人： Michele Himmelspach ,  Uwe Schlokat ,  Friedrich Dorner ,  Andreas Fisch ,  Johann Eibl

IPC分类号： C07H21/02 ,  C07H21/04 ,  C12N15/63 ,  C12N1/21 ,  A61K35/14

CPC分类号： C12N9/6432 ,  A61K38/00 ,  C12Y304/21006

摘要： Nucleic acids encoding factor X analogues are provided that have a modification in the region of the natural Factor Xa activation cleavage site. The modification results in a processing site for a protease not naturally cleaving in this region of the Factor X sequence.

摘要翻译： 提供编码因子X类似物的核酸，其在天然因子Xa激活切割位点的区域具有修饰。 该修饰导致在因子X序列的该区域中不自然切割的蛋白酶的加工位点。

公开(公告)号：US07091015B1

公开(公告)日：2006-08-15

申请号：US09486516

申请日：1998-08-26

申请人： Heinz Redl ,  Guenther Schlag ,  Johann Eibl

发明人： Heinz Redl ,  Guenther Schlag ,  Johann Eibl

IPC分类号： C12N9/00

CPC分类号： A61L24/106

摘要： The present invention provides a fibrinogen-based tissue adhesive which contains an elastase inhibitor.

摘要翻译： 本发明提供含有弹性蛋白酶抑制剂的纤维蛋白原组织粘合剂。

公开(公告)号：US20060160994A1

公开(公告)日：2006-07-20

申请号：US10986281

申请日：2004-11-12

申请人： Petrus Lenting ,  Jan Van Mourik ,  Koenraad Mertens ,  Hans Pannekoek ,  Peter Turecek ,  Hans-Peter Schwarz ,  Friedrich Scheiflinger

发明人： Petrus Lenting ,  Jan Van Mourik ,  Koenraad Mertens ,  Hans Pannekoek ,  Peter Turecek ,  Hans-Peter Schwarz ,  Friedrich Scheiflinger

IPC分类号： C07K14/775

CPC分类号： C07K14/755 ,  A61K38/00 ,  A61K38/37 ,  C07K14/705 ,  A61K2300/00

摘要： Factor VIII polypeptides having FVIII:C activity that contain modifications in the A3 and/or C1 and/or C2 domains of the sequence of the light chain of Factor VIII, characterized by the binding affinity to low density lipoprotein receptor protein, and methods for producing the same.

公开(公告)号：US06936441B2

公开(公告)日：2005-08-30

申请号：US10170661

申请日：2002-06-12

申请人： Manfred Reiter ,  Wolfgang Mundt ,  Friedrich Dorner

发明人： Manfred Reiter ,  Wolfgang Mundt ,  Friedrich Dorner

IPC分类号： C12N5/00 ,  C12N5/08 ,  C12P21/00 ,  C12N5/10 ,  C12P21/02

CPC分类号： C12N5/0075 ,  C12N5/0043 ,  C12N2500/32 ,  C12N2500/38 ,  C12N2500/46 ,  C12N2500/50 ,  C12N2500/76 ,  C12N2531/00

摘要： Disclosed are a stable recombinant cell clones which are stable in serum- and protein-free medium for at least 40 generations, a biomass obtained by multiplying the stable cell clone under serum- and protein-free culturing conditions, and a method of preparing recombinant proteins by means of the biomass. Furthermore, the invention relates to a method of recovering stable recombinant cell clones.

公开(公告)号：US6130203A

公开(公告)日：2000-10-10

申请号：US243539

申请日：1999-02-03

申请人： Johannes J. Voorberg

发明人： Johannes J. Voorberg

IPC分类号： G01N33/68 ,  A61K38/00 ,  A61K38/43 ,  A61K38/55 ,  C07K14/755 ,  C07K14/81 ,  C07K14/815 ,  C07K16/36 ,  C07K19/00 ,  C12N5/10 ,  C12N15/02 ,  C12N15/09 ,  C12P21/08 ,  G01N33/86 ,  A01N37/18 ,  A61K35/14

CPC分类号： C07K14/755 ,  C07K14/8121 ,  C07K14/815 ,  A61K38/00 ,  C07K2319/00 ,  Y10S514/834 ,  Y10S930/10

摘要： Hybrid proteins which affect blood coagulation comprise a region from a donor anticoagulant or antithrombotic protein, and the resulting hybrid protein has a modified biological activity. Information concerning the hybrid proteins implicates DNA sequences encoding the proteins and hosts, including transgenic animals, that possess these DNA sequences; antibodies directed against hybrid proteins; methods of modifying the properties of proteins; and treatment methods employing hybrid proteins.

摘要翻译： 影响血液凝固的杂交蛋白质包括来自供体抗凝血剂或抗血栓形成蛋白质的区域，所得杂交蛋白质具有改良的生物活性。 关于杂交蛋白质的信息涉及编码具有这些DNA序列的蛋白质和宿主（包括转基因动物）的DNA序列; 针对杂交蛋白的抗体; 改变蛋白质性质的方法; 和使用杂合蛋白的治疗方法。

公开(公告)号：US6124255A

公开(公告)日：2000-09-26

申请号：US8583

申请日：1998-01-16

申请人： Guenther Schlag ,  Seth Hallstroem ,  Harald Gasser

发明人： Guenther Schlag ,  Seth Hallstroem ,  Harald Gasser

IPC分类号： A61K38/00 ,  A61K38/17 ,  A61K38/38 ,  A61K38/49 ,  C07K14/765 ,  A01N37/18 ,  C07K1/00

CPC分类号： C07K14/765 ,  A61K38/1709 ,  A61K38/38 ,  A61K38/49

摘要： There is disclosed a stable, virus-safe, pharmaceutical preparation comprising thiol-group-containing proteins which are heat-treated and processed such that at least 40% of the thiol groups are capable of being nitrosated, a method of preparing such preparations as well as the use of these preparations.

公开(公告)号：US6013620A

公开(公告)日：2000-01-11

申请号：US926845

申请日：1997-09-11

申请人： Peter Turecek ,  Hans-Peter Schwarz ,  Gerda Redl

发明人： Peter Turecek ,  Hans-Peter Schwarz ,  Gerda Redl

IPC分类号： A61K38/04 ,  A61K38/43 ,  A61K38/46 ,  A61K38/48 ,  A61P7/02 ,  C12N9/64 ,  A61K35/14 ,  A61K38/16 ,  C07K14/745

CPC分类号： C12N9/6437 ,  A61K38/4846 ,  C12N9/647 ,  C12Y304/21021 ,  Y10S514/834

摘要： The invention relates to a pharmaceutical composition for the treatment of patients with blood coagulation diseases which are caused by coagulation factor deficiency and/or inhibitors of coagulation factors, whereby the composition as a FEIB-activity and is characterized in that it has Factor VIIa and at least one further active ingredient and the activity of at least 10 Factor VIIa units per unit FEIBA. Additionally, the invention comprises a method for the production of the pharmaceutical preparation and its use.

摘要翻译： 本发明涉及一种用于治疗由凝血因子缺乏引起的凝血疾病患者和/或凝血因子抑制剂的药物组合物，其中组合物作为FEIB活性，其特征在于其具有因子VIIa和 至少一种其他活性成分和至少10个因子VIIa单位每单位FEIBA的活性。 此外，本发明包括制备药物制剂及其用途的方法。

公开(公告)号：US6004561A

公开(公告)日：1999-12-21

申请号：US797629

申请日：1997-02-07

申请人： Friedrich Dorner ,  Michael Pfleiderer ,  Falko-Gunter Falkner

发明人： Friedrich Dorner ,  Michael Pfleiderer ,  Falko-Gunter Falkner

IPC分类号： A61K39/00 ,  C07K14/02 ,  C12N7/01 ,  C12N15/51 ,  C12P21/08 ,  G01N33/576 ,  C12Q1/70 ,  A61K39/29 ,  G01N33/53

CPC分类号： C07K14/005 ,  G01N33/5764 ,  A61K2039/525 ,  A61K39/00 ,  C12N2730/10122 ,  Y10S435/975 ,  Y10S436/82

摘要： The present invention relates to methods of producing recombinant molecules including the nucleotide sequence for the structure of the preS1 region of the surface glycoprotein of the hepatitis B virus, and to compositions of the molecules. Compositions of the recombinant molecules may include a promoter and a marker gene. Cloning vectors are used to incorporate the recombinant molecules into hosts. Cells infected with the chimeric vaccinia produce high levels of preS1 protein. Isolation and purification of the preS1-containing protein is facilitated by the use of a recombinant molecule in which the myristylation site has been deleted by a modification of the nucleotide sequence. The purified preS1-containing protein is useful for development of vaccines, diagnostic kits and therapies.