公开(公告)号：US20230040639A1

公开(公告)日：2023-02-09

申请号：US17783381

申请日：2020-10-30

Applicant: University of South Carolina

Inventor： Mohamad Azhar

IPC: A01K67/027

Abstract: The current disclosure has identified novel developmental, cellular, molecular, and biochemical pathways and developed a unique mouse model which recapitulates age, bicuspid aortic valve-associated, and gender-specific pathological aspects of development and progression of human CAVD, which will be useful in developing novel diagnostic, preventative, and therapeutic strategies for CAVD patients.

公开(公告)号：US11565813B2

公开(公告)日：2023-01-31

申请号：US16589405

申请日：2019-10-01

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Ron Fulbright

IPC: B64C39/02 ,  B64D1/16 ,  B64D47/08 ,  B64D29/04 ,  B60L50/60 ,  B60L53/80 ,  B64D47/00 ,  A62C3/02

Abstract: Presently disclosed subject matter integrates a method of using thousands of semi-autonomous unmanned aerial vehicles, herein called drones, to deliver vastly superior amounts of fire retardant over substantially larger and variably-shaped drop patterns. Each drone is able to swap its own batteries with freshly charged batteries and each drone is able to refill its container with water or fire retardant. Once launched, a swarm of drones can perform repeated trips from the water/retardant source to the fire without human involvement other than the high-level tasking of where to drop the retardant. Once a general drop destination and drop pattern shape is designated, the swarm can transport retardant to that location, form itself into the desired drop shape, and deploy retardant. The drone body is designed to be modular so different components can be attached with ease and no special training or knowledge required.

公开(公告)号：US11557400B2

公开(公告)日：2023-01-17

申请号：US17141436

申请日：2021-01-05

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Julius Fridriksson ,  Christopher Rorden

IPC: G16H50/30 ,  G16H20/40 ,  G16H50/70 ,  G16H50/50 ,  G06N20/00 ,  A61N1/36 ,  A61B5/00 ,  A61B5/369

Abstract: The present disclosure provides systems and methods that include or otherwise leverage a machine-learned brain injury location model to predict locations of brain injury in a patient based on test data associated with the patient, such as, for example, behavioral test data. For example, the machine-learned brain injury location model can be trained on training data associated with a corpus of patients, where the training data includes sets of example test data (e.g., behavioral test data) respectively labeled with ground truth brain injury locations.

公开(公告)号：US20220397531A1

公开(公告)日：2022-12-15

申请号：US17772265

申请日：2019-11-11

Applicant: UNIVERSITY OF SOUTH CAROLINA ,  LAWRENCE LIVERMORE NATIONAL SECURITY, LLC

Inventor： STANLEY MICHAEL ANGEL ,  JERRY CHANCE CARTER

IPC: G01N21/65

Abstract: A hyperspectral imaging apparatus based on a monolithic or free space optical spatial heterodyne spectrometer (SHS) design, array detector, electromagnetic radiation source, and optical collection element is described. The apparatus enables the simultaneous acquisition of spatially isolated Fizeau fringe patterns, each having an encoded light product that is decoded to produce a spectral fingerprint of the interrogated object. Features specific to the SHS, such as a large entrance aperture, large acceptance angle, and no moving parts, enable a variety of optical collection schemes including lens arrays, solid-core and hollow core waveguides, and others. In one example, a microlens array (MLA) is configured with the hyperspectral imaging apparatus to simultaneously image many hundred spatially isolated Fizeau fringe patterns while interrogating an object using an electromagnetic radiation source. Each Fizeau fringe pattern recorded by the array detector is decoded to produce a full Raman or laser-induced breakdown spectroscopy (LIBS) spectrum. Compared to prior art, the hyperspectral imaging apparatus overcomes the primary limitations of needing to trade time resolution for both spectral and spatial data density because the imaging apparatus simultaneously acquires both spectral and special information. Based on the selection and configuration of diffraction gratings, the grating aperture size, Littrow wavelength (i.e., heterodyne wavelength), and optical collection configuration, the apparatus can be tailored to produced low or high spectral resolution with a spectral bandpass that covers a portion or the entire Raman spectral range (up to 4200 cm−1) and for LIBS as well.

公开(公告)号：US20220371756A1

公开(公告)日：2022-11-24

申请号：US17771519

申请日：2020-10-23

Applicant: University of South Carolina ,  Nephron Pharmaceuticals Corporation

Inventor： John Michael Cutler ,  John Perry Diamond ,  Ramy Harik ,  William Sickinger ,  Jon Alan Burgess ,  Luther Joey Vann ,  Charles Gainey

IPC: B65B3/00 ,  B65B7/28

Abstract: An automated syringe handling system that will safely, securely, and quickly assemble syringes or other medical devices under controlled/sterile conditions while maintaining the syringes in a stable orientation and eliminating unnecessary operator contact with the syringes and working area.

公开(公告)号：US20220345830A1

公开(公告)日：2022-10-27

申请号：US17719485

申请日：2022-04-13

Applicant: University of South Carolina

Inventor： Sourav Banerjee ,  Mohammad Sadegh Saadatzi

IPC: H04R25/02 ,  H04R25/00 ,  H04R31/00

Abstract: Described herein are bio-inspired acoustic bandpass sensors with a user-defined range of frequencies mimicking the geometric structure of a human's basilar membrane to capture infrasonic, sonic or ultrasonic waves per design with a target frequency range for a specific application and methods of making same.

公开(公告)号：US11482721B2

公开(公告)日：2022-10-25

申请号：US16570253

申请日：2019-09-13

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Brian C. Benicewicz ,  Laura Murdock ,  Lihui Wang ,  Fei Huang ,  Andrew Pingitore

IPC: H01M8/1081 ,  H01M8/1086 ,  H01M8/18 ,  H01M8/1032 ,  H01M8/1044 ,  H01M8/1067 ,  H01M8/1027

Abstract: Disclosed are redox flow battery membranes, redox flow batteries incorporating the membranes, and methods of forming the membranes. The membranes include a densified polybenzimidazole gel membrane that is capable of incorporating a high liquid content without loss of structure that is formed according to a process that includes in situ hydrolysis of a polyphosphoric acid solvent followed by densification of the gel membrane. The densified membranes are then imbibed with a redox flow battery supporting electrolyte such as sulfuric acid and can operate at very high ionic conductivities of about 50 mS/cm or greater and with low permeability of redox couple ions, e.g. vanadium ions, of about 10−7 cm2/s or less. Redox flow batteries incorporating the membranes can operate at current densities of about 50 mA/cm2 or greater.

公开(公告)号：US20220258131A1

公开(公告)日：2022-08-18

申请号：US17617113

申请日：2020-04-07

Applicant: UNIVERSITY OF SOUTH CAROLINA ,  COLUMBIA UNIVERSITY

Inventor： BRIAN C. BENICEWICZ ,  YUCHENG HUANG ,  CONNOR R. BILCHAK ,  SANAT K. KUMAR

IPC: B01J20/28 ,  C08F292/00 ,  B01J20/26 ,  B01J20/30 ,  B01D71/78 ,  B01D69/02 ,  B01D69/10 ,  B01D69/14 ,  B01D69/08 ,  B01D63/10 ,  B01D67/00 ,  B01D53/22 ,  B01D71/40 ,  B01D71/02

Abstract: Gas separation membranes as may be used in separating gaseous materials from one another and methods of forming the membranes are described. The separation membranes include polymer-grafted nanoparticles (GNPs) as a platform and a relatively small amount of free polymer. The free polymer and the polymer grafted to the nanoparticles have the same chemical structure and similar number average molecular weights. The gas separation membranes can exhibit high ideal selectivity and can be used in a variety of applications, such as carbon capture.

公开(公告)号：US20220257711A1

公开(公告)日：2022-08-18

申请号：US17630662

申请日：2020-07-31

Applicant: University of South Carolina ,  Board of Trustees of the University of Arkansas

Inventor： Jay D. Potts ,  Ambrish Kumar ,  Donald Dipette ,  Shannon Servoss

IPC: A61K38/17 ,  A61P9/00 ,  A61K9/50 ,  A61P9/12

Abstract: NMEG-αCGRP, a biologically active molecule, and systems and methods of use therefore, subcutaneous administration of NMEG-αCGRP, a non-toxic peptoid-peptide hybrid that possesses hypotensive action, employed as a therapeutic agent to treat and prevent various cardiovascular diseases, including, heart failure (pressure. as well as volume, overload), myocardial infarction, cardiomyopathy, and hypertension.

公开(公告)号：US11414348B2

公开(公告)日：2022-08-16

申请号：US15674645

申请日：2017-08-11

Applicant: University of South Carolina

Inventor： Dimitris Rizos

IPC: C04B14/04 ,  C04B28/08 ,  C04B28/02 ,  E01B3/28 ,  C04B111/00

Abstract: Concrete that exhibits increased flexibility (i.e., low modulus of elasticity) and high compressive strength is described. High aspect ratio structures as may be formed of the concrete are described. Structures formed of the concrete can have the same high compressive strength as similar structures formed from a more conventional concrete but can be significantly more flexible, which can allow for better load distribution in the structure and associated assembly. The concrete includes a weathered granite as coarse aggregate. The materials can be particularly beneficial in forming concrete components of a rail infrastructure, such as railroad ties and slabs.