公开(公告)号：US11583438B1

公开(公告)日：2023-02-21

申请号：US16865245

申请日：2020-05-01

申请人： Zeltiq Aesthetics, Inc.

发明人： Mitchell E. Levinson ,  Jesse Nicasio Rosen ,  Corydon A. Hinton ,  Kevin S. Springer

IPC分类号： A61F7/10 ,  A61F7/00 ,  A61F7/02 ,  A61H23/02 ,  A61H9/00 ,  A61B17/00

摘要： A system and method of monitoring, controlling and/or detecting events during the removal of heat from subcutaneous lipid-rich tissue is described. In some examples, the system detects an increase in temperature at a treatment device in contact with the skin of a subject, determines that the increase in temperature is related to a treatment event, and performs an action based on the determination. In some examples, the system shuts off the treatment device, alerts an operator, or reduces the cooling in response to a determined treatment event.

公开(公告)号：US20230051638A1

公开(公告)日：2023-02-16

申请号：US17873064

申请日：2022-07-25

申请人： Zeltiq Aesthetics, Inc.

发明人： Joel N. Jimenez Lozano ,  Like Zeng ,  Linda Pham ,  George Frangineas, JR.

IPC分类号： A61F7/00

摘要： Provided herein are systems, compositions, and methods for improving one or more skin characteristics in a subject. These systems, compositions, and methods are configured to cool the subject's skin at a target site to a degree that alters adipocyte signaling but does not produce significant destruction of subcutaneous lipid-rich cells. In some embodiments, alteration of adipocyte signaling produces an improvement in one or more skin characteristics.

公开(公告)号：US20220387211A1

公开(公告)日：2022-12-08

申请号：US17719889

申请日：2022-04-13

申请人： Zeltiq Aesthetics, Inc.

发明人： Mitchell E. Levinson ,  Jesse N. Rosen ,  William P. Pennybacker

IPC分类号： A61F7/00 ,  A61F7/10

摘要： A cooling device for removing heat from subcutaneous lipid-rich cells of a subject having skin is provided. The cooling device includes a plurality of cooling elements movable relative to each other to conform to the contour's of the subject's skin. The cooling elements have a plurality of controllable thermoelectric coolers. The cooling elements can be controlled to provide a time-varying cooling profile in a predetermined sequence, can be controlled to provide a spatial cooling profile in a selected pattern, or can be adjusted to maintain constant process parameters, or can be controlled to provide a combination thereof.

公开(公告)号：US11076879B2

公开(公告)日：2021-08-03

申请号：US15962811

申请日：2018-04-25

申请人： Zeltiq Aesthetics, Inc.

发明人： Peter Yee ,  George Frangineas, Jr. ,  Austin Root

IPC分类号： A61B17/30 ,  A61F7/02 ,  A61B18/02 ,  A61B18/00 ,  A61B17/00 ,  A61F7/00

摘要： Systems for treating a subject's tissue can include a thermally conductive cup with vacuum features configured to facilitate removal of air located between the cup and the subject's skin. The vacuum features can extend along cup to provide airflow paths to a vacuum port. The applicator can cool and/or heat the retained tissue to affect targeted tissue. After the treat period, the vacuum can be reduced or stop and the applicator can be removed from the subject.

公开(公告)号：US20210146150A1

公开(公告)日：2021-05-20

申请号：US17100725

申请日：2020-11-20

申请人： ZELTIQ Aesthetics, Inc.

发明人： George FRANGINEAS, JR. ,  Theodorus Johannes Virginia CABERG

IPC分类号： A61N2/00 ,  A61N2/02

摘要： A method for strengthening, toning, and firming muscle tissues, the method includes receiving parameters for operating a magnetic muscle stimulation device. The parameters include: a first waveform frequency; one or more pulse durations; a second waveform frequency that is non-zero; causing, a first alternating current having one or more first pulses to flow for a first length of time through a coil according to the first waveform frequency; causing, a second alternating current having one or more second pulses to flow through the coil for a second length of time according to the second waveform frequency lower than the first waveform frequency. The method includes repeating the causing of the first and second alternating currents for a plurality of iterations to provide a continuously pulsed time-varying magnetic field that alternates between the first and the second waveform frequencies to generate a treatment session.

公开(公告)号：US10675176B1

公开(公告)日：2020-06-09

申请号：US14662181

申请日：2015-03-18

申请人： Zeltiq Aesthetics, Inc.

发明人： Joseph Coakley ,  William P. Pennybacker ,  Bryan J. Weber

IPC分类号： A61F7/00

摘要： Treatment systems include conformable applicators for performing cryotherapy are described. Aspects of the technology are further directed to methods and conformable applicators capable of affecting target regions. The conformable applicators can be applied a wide range of treatment sites. A strap assembly can hold applicator against the treatment site, and a holder assembly can be adhered to the subject's skin to inhibit, limit, or substantially prevent movement of the applicator along the subject's skin.

公开(公告)号：US09861421B2

公开(公告)日：2018-01-09

申请号：US14610807

申请日：2015-01-30

申请人： Zeltiq Aesthetics, Inc.

发明人： Michael P. O'Neil ,  Leonard C. DeBenedictis ,  George Frangineas, Jr.

IPC分类号： A61B18/02 ,  A61F7/00 ,  A61H1/00 ,  A61N7/00 ,  A61K31/045 ,  A61K31/047 ,  A61B18/00 ,  A61B90/00

CPC分类号： A61B18/02 ,  A61B18/0206 ,  A61B90/04 ,  A61B2018/00291 ,  A61B2018/00464 ,  A61B2018/00714 ,  A61B2018/00791 ,  A61B2018/00875 ,  A61B2018/00994 ,  A61B2018/0237 ,  A61B2018/0262 ,  A61B2090/0463 ,  A61B2090/065 ,  A61F7/00 ,  A61F7/007 ,  A61F2007/0003 ,  A61F2007/0004 ,  A61F2007/0019 ,  A61F2007/0036 ,  A61F2007/0045 ,  A61F2007/0047 ,  A61F2007/0052 ,  A61F2007/0056 ,  A61F2007/0075 ,  A61F2007/0087 ,  A61F2007/0093 ,  A61F2007/0096 ,  A61H1/006 ,  A61H1/008 ,  A61K31/045 ,  A61K31/047 ,  A61N7/00

摘要： Compositions and formulations for use with devices and systems that enable tissue cooling, such as cryotherapy applications, for alteration and reduction of adipose tissue are described. Aspects of the technology are further directed to methods, compositions and devices that provide protection of non-targeted cells (e.g., non-lipid-rich cells) from freeze damage during dermatological and related aesthetic procedures that require sustained exposure to cold temperatures. Further aspects of the technology include systems for enhancing sustained and/or replenishing release of cryoprotectant to a treatment site prior to and during cooling applications.

公开(公告)号：US09844461B2

公开(公告)日：2017-12-19

申请号：US13013603

申请日：2011-01-25

申请人： Mitchell E. Levinson ,  John W. Allison ,  Joseph Coakley ,  Bryan Weber

发明人： Mitchell E. Levinson ,  John W. Allison ,  Joseph Coakley ,  Bryan Weber

IPC分类号： A61F7/12 ,  A61F7/02 ,  A61F7/00 ,  F28F7/00

CPC分类号： A61F7/02 ,  A61F2007/0056 ,  A61F2007/0096 ,  A61F2007/029 ,  A61F2007/0292

摘要： Home-use applicators for non-invasively removing heat from subcutaneous, lipid-rich cells via phase change coolants, and associated devices, systems and methods. A device in accordance with a particular embodiment includes an applicator releasably positionable in thermal communication with human skin, and a coolant vessel having a coolant. The device further includes a heat transfer conduit operatively coupled to the applicator and housing a heat transfer fluid that is isolated from fluid contact with the coolant. A heat exchanger is operatively coupled between the coolant vessel and the heat transfer conduit to transfer heat between the heat transfer fluid and the coolant, and a fluid driver is operatively coupled to the heat transfer conduit to direct the heat transfer fluid between the applicator and the heat exchanger.

公开(公告)号：US20160051401A1

公开(公告)日：2016-02-25

申请号：US14705868

申请日：2015-05-06

申请人： Peter Yee ,  Joseph Coakley ,  George Frangineas, JR. ,  Tamara Hilton

发明人： Peter Yee ,  Joseph Coakley ,  George Frangineas, JR. ,  Tamara Hilton

IPC分类号： A61F7/00

摘要： Systems for treating a subject's tissue can include a thermally conductive cup, a tissue-receiving cavity, and a vacuum port. The vacuum port is in fluid communication with the tissue-receiving cavity to provide a vacuum for drawing the submental tissue, or other targeted tissue, into the tissue-receiving cavity. A thermal device can cool and/or heat the conductive cup such that the conductive cup non-invasively controls the temperature of subcutaneous lipid-rich cells in the tissue. A restraint apparatus can hold a the conductive cup in thermal contact with the target region.

摘要翻译： 用于治疗受试者组织的系统可以包括导热杯，组织接收腔和真空口。 真空端口与组织接收腔流体连通，以提供用于将颏下组织或其它目标组织拉入组织接收腔的真空。 热装置可以冷却和/或加热导电杯，使得导电杯非侵入地控制组织中皮下富含脂质的细胞的温度。 约束装置可以将导电杯保持与目标区域热接触。

公开(公告)号：US20140277302A1

公开(公告)日：2014-09-18

申请号：US13830027

申请日：2013-03-14

申请人： ZELTIQ AESTHETICS, INC.

发明人： Bryan J. Weber ,  Joseph Coakley ,  Mark William Baker ,  Thomas Burnell Reeve, III

IPC分类号： A61F7/00

CPC分类号： A61F7/0085 ,  A61F2007/0054 ,  A61F2007/0093 ,  A61F2007/0095 ,  A61F2007/029 ,  A61F2007/0295

摘要： A treatment system for cooling subcutaneous lipid-rich cells in a human subject includes an applicator and a control unit. The treatment system has a cooling mode for cooling tissue and a heating mode for warming tissue. The control unit includes a circulation circuit in fluid communication with the applicator, a chiller apparatus configured to chill fluid from the applicator circulation circuit, and a heater apparatus to warmed fluid from the applicator circulation circuit. The control unit mixes the chilled fluid and/or the warmed with fluid in the applicator circulation circuit control the temperature of the fluid circulated in the applicator.

摘要翻译： 用于冷却人受试者中皮下富含脂质细胞的治疗系统包括施用器和控制单元。 处理系统具有用于冷却组织的冷却模式和用于加热组织的加热模式。 所述控制单元包括与所述施加器流体连通的循环回路，构造成使来自所述施加器循环回路的流体冷却的冷却器装置，以及来自所述施加器循环回路的加热器装置。 控制单元将冷却的流体和/或加热的流体与施加器循环回路中的流体混合，控制在施用器中循环的流体的温度。