摘要:
The invention relates to compounds of formula 1 and formula 10 and to compositions comprising these compounds and methods of treating gastrointestinal disorders by administering these compounds.
摘要:
The invention relates to a novel process for preparing mixtures of enantiomers of PPI's having a sulphinyl structure using a mixture of enantiomers of chiral zirconium complexes or chiral hafnium complexes.
摘要:
An apparatus applies a liquid or viscid coating medium onto a moving material web, especially one made of paper or cardboard. A coating mechanism first applies the coating medium onto an applicator element or an applicator roll, which subsequently transfers the coating medium at a coating location onto the material web in the form of a coating layer. Furthermore, if so desired, a doctoring device can be positioned at a doctor station, adjacent to the coating location, on the downstream side relative to the movement of the material web for the purpose of smoothing and/or metering the coating. The coating apparatus incorporates an apparatus for the generation and/or supplying of a fluid, preferably steam. This apparatus is positioned adjacent to the coating location or to the doctor station on the downstream side relative to the movement L of the material web.
摘要:
A method and apparatus for coating a traveling layer of material, in particular paper and/or cardboard. An applicator implement applies a predetermined and proper amount of a liquid or pasty medium onto an outer surface of a first rotating applicator roller which in turn transfers the liquid or pasty medium onto a first side of the moving layer of material just as it is moving through a press nip. A second layer of coating medium is applied indirectly with a second applicator implement onto an outer surface of a second rotating applicator roller from where it is transferred onto the previously coated side of the moving material layer while the first coat of coating medium is still wet.
摘要:
A method for the treatment of chronic obstructive pulmonary disease (COPD), including administering to a patient suffering from COPD, a therapeutically effective amount of roflumilast having a purity of greater than or equal to 99% by weight, and N-(3,5-dichloropyrid-4-yl)-3-cyclopropylmethoxy-4-hydroxybenzamide present (relative to roflumilast) in an amount greater than zero and less than 0.1% by weight.
摘要:
The invention relates to compounds of formula 1 and formula 10 and to compositions comprising these compounds and methods of treating gastrointestinal disorders by administering these compounds.
摘要:
The invention relates to a method for directly or indirectly applying a liquid or pasty application medium (2) onto one or both sides of a continuous surface (4), wherein the application medium (2) is applied to the surface (4) in a plurality of single application regions by means of a plurality of single application nozzles (12) spaced apart from one another side by side and/or in succession in the direction of width (B) and/or longitudinal direction of the surface (4) and clearly distanced (D) from the surface (4), the application medium (2) emerging from each of these nozzles, wherein adjacent single application regions each intersect (U) at least in part in their respective edge regions, causing a layer of application medium to be produced across substantially the entire width (B) of the surface (4) to be coated. The invention also relates to an apparatus for performing this method.