公开(公告)号：US09289468B2

公开(公告)日：2016-03-22

申请号：US14344289

申请日：2011-09-16

Applicant: Shifang Yang ,  Junsheng Cui ,  Bing Zhu ,  Peng Wei

Inventor： Shifang Yang ,  Junsheng Cui ,  Bing Zhu ,  Peng Wei

IPC: A61K38/16 ,  A61K38/12 ,  A61K38/00 ,  A61P35/00 ,  A61P35/02 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K16/00 ,  C12N1/20 ,  C12N15/00 ,  A61K39/00 ,  A61K39/385 ,  A61K38/17 ,  C07K14/715 ,  C07K14/47 ,  C07K14/525 ,  C12N15/63 ,  C12N15/62 ,  C07K14/705 ,  A61K45/06 ,  C07K14/52

CPC classification number: A61K38/1761 ,  A61K38/00 ,  A61K45/06 ,  C07K14/47 ,  C07K14/4747 ,  C07K14/52 ,  C07K14/525 ,  C07K14/70575 ,  C07K14/7151 ,  C07K2319/21 ,  C07K2319/33 ,  C12N15/62 ,  C12N15/63

Abstract: Provided is a fusion protein comprising circularly permuted form of TRAIL, and the fusion protein contains circularly permuted form of TRAIL and oligopeptides located at the N-terminus and/or C-terminus of the permuted form. The oligopeptides contain a repeating sequence consisting of 3-10 histidines. The components of the circularly permuted form of TRAIL from N-terminus to C-terminus are: (a) amino acids 135-281 of TRAIL, (b) a linker, and (c) amino acids 121-135 of TRAIL or amino acids 114-135 of TRAIL or amino acids 95-135 of TRAIL or any fragments of amino acids 95-135 of TRAIL containing amino acids 121-135 of TRAIL. Also provided is a method for treating cancer by using the fusion protein.

Abstract translation: 提供了包含循环形式的TRAIL的融合蛋白，并且融合蛋白包含位于置换形式的N末端和/或C末端的循环形式的TRAIL和寡肽。 寡肽含有由3-10组氨酸组成的重复序列。 从N末端到C末端的循环形式的TRAIL的组分是：（a）TRAIL的氨基酸135-281，（b）接头，和（c）TRAIL或氨基酸的氨基酸121-135 TRAIL的114-135或TRAIL的氨基酸95-135或含有TRAIL的第121-135位氨基酸的TRAIL的任何氨基酸95-135的片段。 还提供了通过使用融合蛋白治疗癌症的方法。

公开(公告)号：US07666989B2

公开(公告)日：2010-02-23

申请号：US10577535

申请日：2003-11-03

Applicant: Bing Zhu

Inventor： Bing Zhu

IPC: C07K14/00

CPC classification number: C07K14/4703 ,  A61K38/00 ,  C07K14/70575

Abstract: The present invention discloses a recombinant protein having an anti-cancer effect, its encoding gene and uses thereof. The recombinant protein having an anti-cancer effect provided by the present invention is one selected from the group consisting of: 1) a protein having the amino acid sequence of SEQ ID No:2 shown in the sequence listing; 2) a protein derived from SEQ ID No:2, which has a sequence homology of more than 90% with SEQ ID No:2 and which has the same activity as that of SEQ ID No:2; 3) a protein derived from SEQ ID No:2, which is obtained by adding or deleting 15 or less amino acid residues at the N-terminus of the amino acid sequence of SEQ ID No:2, and which has the same activity as that of SEQ ID No:2; 4) a protein derived from SEQ ID No:2, which is obtained by adding or deleting 15 or less amino acid residues at the C-terminus of the amino acid sequence of SEQ ID No:2, and which has the same activity as that of SEQ ID No:2; 5) a protein derived from SEQ ID No:2, which is obtained by substitution, deletion, or addition of one or several amino acid residues in the amino acid sequence of SEQ ID No:2, and which has the same activity as that of SEQ ID No:2. The medicament containing above recombinant protein as active component has significant selective inhibitory effect on tumor cells, and does not induce apoptosis of normal tissue cells, and has important applicable value.

Abstract translation: 本发明公开了具有抗癌作用的重组蛋白，其编码基因及其用途。 本发明提供的具有抗癌效果的重组蛋白质选自：1）具有序列表所示的SEQ ID No：2的氨基酸序列的蛋白质; 2）衍生自SEQ ID No：2的蛋白质，其与SEQ ID No：2具有大于90％的序列同源性，并且具有与SEQ ID No：2具有相同的活性; 3）衍生自SEQ ID No：2的蛋白质，其通过在SEQ ID No：2的氨基酸序列的N末端添加或缺失15个或更少的氨基酸残基而获得，并且具有与该序列具有相同的活性 SEQ ID No：2; 4）衍生自SEQ ID No：2的蛋白质，其通过在SEQ ID No：2的氨基酸序列的C末端添加或缺失15个或更少的氨基酸残基获得，并且具有与SEQ ID No：2具有相同的活性 SEQ ID No：2; 5）衍生自SEQ ID No：2的蛋白质，其通过在SEQ ID No：2的氨基酸序列中的一个或几个氨基酸残基的取代，缺失或添加获得，并且具有与 SEQ ID No：2。 含有上述重组蛋白作为活性成分的药物对肿瘤细胞具有显着的选择性抑制作用，不诱导正常组织细胞凋亡，具有重要的适用价值。

公开(公告)号：US07268359B2

公开(公告)日：2007-09-11

申请号：US11184291

申请日：2005-07-18

Applicant: Monty Mong Chen Fu ,  Bing Bing Zhu

Inventor： Monty Mong Chen Fu ,  Bing Bing Zhu

IPC: G21F5/00

CPC classification number: G21F5/018 ,  A61M5/1785 ,  G21Y2002/501 ,  G21Y2004/30 ,  Y10T29/49826 ,  Y10T29/49904

Abstract: A method and apparatus for transporting radiopharmaceuticals. Typically, the apparatus is a two-part assembly, each part having an exterior shell, a radiation shield and a non-porous lining. Additionally, the assembled apparatus has a sealed internal chamber suitable for carrying a syringe or a sharps container containing a syringe. The internal chamber of the radiopharmaceutical pig is lined with a non-porous lining, typically a durable plastic, that prevents contamination of the radiopharmaceutical doses, the radiation shield, or the environment. Additionally, the non-porous lining can be quickly and easily cleaned and sterilized, avoiding the often difficult, to impossible, task of cleaning and sterilizing the radiation shield of the radiopharmaceutical pig. The non-porous lining is surrounded by a radiation shield that is typically comprised of elemental lead. The radiation shield prevents radiation from the radiopharmaceutical from contaminating the user or environment. The radiation shield is surrounded by an exterior shell that absorbs impact and prevents the radiopharmaceutical pig from breaking. Additionally, the exterior shell prevents environmental exposure to the potentially hazardous material of the radiation shield. Generally, a method of transporting a radiopharmaceutical by filling the container with a radiopharmaceutical, inserting the container into the internal chamber of the radiopharmaceutical pig having a non-porous lining, and assembling the radiopharmaceutical pig so the that the container is in the internal chamber and is encapsulated by the radiation shield, is also provided.

Abstract translation: 用于运输放射性药物的方法和装置。 通常，该设备是两部分组件，每个部件具有外壳，辐射屏蔽和无孔衬里。 此外，组装的装置具有适于携带注射器或含有注射器的锐器容器的密封内部腔室。 放射性药物猪的内部室内衬有无孔衬里，通常是耐用的塑料，其防止放射性药物剂量，辐射屏蔽或环境的污染。 此外，无孔衬里可以快速且容易地清洁和消毒，避免了对放射性药物猪的辐射屏蔽进行清洁和消毒的常常困难的，不可能的任务。 无孔衬里由通常由元素铅构成的辐射屏蔽围绕。 辐射屏蔽防止放射性药物的辐射污染用户或环境。 辐射屏蔽被外壳包围，吸收冲击并防止放射性药物猪破裂。 此外，外壳防止环境暴露于辐射屏蔽层的潜在危险物质。 通常，通过用放射性药剂填充容器来输送放射性药物的方法，将容器插入具有无孔衬里的放射性药物猪的内部室中，并且组装放射性药物猪使得容器处于内部室中， 被辐射屏蔽封装，也被提供。

公开(公告)号：US20050247893A1

公开(公告)日：2005-11-10

申请号：US11184291

申请日：2005-07-18

Applicant: Monty Fu ,  Bing Zhu

Inventor： Monty Fu ,  Bing Zhu

IPC: G21F5/018

CPC classification number: G21F5/018 ,  A61M5/1785 ,  G21Y2002/501 ,  G21Y2004/30 ,  Y10T29/49826 ,  Y10T29/49904

Abstract: A method and apparatus for transporting radiopharmaceuticals. Typically, the apparatus is a two-part assembly, each part having an exterior shell, a radiation shield and a non-porous lining. Additionally, the assembled apparatus has a sealed internal chamber suitable for carrying a syringe or a sharps container containing a syringe. The internal chamber of the radiopharmaceutical pig is lined with a non-porous lining, typically a durable plastic, that prevents contamination of the radiopharmaceutical doses, the radiation shield, or the environment. Additionally, the non-porous lining can be quickly and easily cleaned and sterilized, avoiding the often difficult, to impossible, task of cleaning and sterilizing the radiation shield of the radiopharmaceutical pig. The non-porous lining is surrounded by a radiation shield that is typically comprised of elemental lead. The radiation shield prevents radiation from the radiopharmaceutical from contaminating the user or environment. The radiation shield is surrounded by an exterior shell that absorbs impact and prevents the radiopharmaceutical pig from breaking. Additionally, the exterior shell prevents environmental exposure to the potentially hazardous material of the radiation shield. Generally, a method of transporting a radiopharmaceutical by filling the container with a radiopharmaceutical, inserting the container into the internal chamber of the radiopharmaceutical pig having a non-porous lining, and assembling the radiopharmaceutical pig so the that the container is in the internal chamber and is encapsulated by the radiation shield, is also provided.

Abstract translation: 用于运输放射性药物的方法和装置。 通常，该设备是两部分组件，每个部件具有外壳，辐射屏蔽和无孔衬里。 此外，组装的装置具有适于携带注射器或含有注射器的锐器容器的密封内部腔室。 放射性药物猪的内部室内衬有无孔衬里，通常是耐用的塑料，其防止放射性药物剂量，辐射屏蔽或环境的污染。 此外，无孔衬里可以快速且容易地清洁和消毒，避免了对放射性药物猪的辐射屏蔽进行清洁和消毒的常常困难的，不可能的任务。 无孔衬里由通常由元素铅构成的辐射屏蔽围绕。 辐射屏蔽防止放射性药物的辐射污染用户或环境。 辐射屏蔽被外壳包围，吸收冲击并防止放射性药物猪破裂。 此外，外壳防止环境暴露于辐射屏蔽层的潜在危险物质。 通常，通过用放射性药剂填充容器来输送放射性药物的方法，将容器插入具有无孔衬里的放射性药物猪的内部室中，并且组装放射性药物猪使得容器处于内部室中， 被辐射屏蔽封装，也被提供。

公开(公告)号：US5927351A

公开(公告)日：1999-07-27

申请号：US866733

申请日：1997-05-30

Applicant: Bing Bing Zhu ,  Monty Mong Chen Fu ,  Richard L. Green ,  Haig S. Bagerdjian

Inventor： Bing Bing Zhu ,  Monty Mong Chen Fu ,  Richard L. Green ,  Haig S. Bagerdjian

IPC: A61M5/178 ,  G21F5/018 ,  B65B1/04

CPC classification number: G21F5/018 ,  A61M5/1785

Abstract: An improved drawing station system for handling radioactive material for use in syringes in the health care industry. The system includes a drawing station, a syringe shield and two different radiopharmaceutical pigs. The drawing station has a base with a support and two arms mounted thereto to support a first radiopharmaceutical pig enclosing a container of radioactive material. The radiopharmaceutical pig is releasably mounted to the second arm so that the radiopharmaceutical pig is pivotable about two predetermined axes to position the container for penetration by the syringe needle to draw radioactive material from the container into the syringe.

Abstract translation: 一种用于处理放射性物质的改进绘图工位系统，用于保健行业的注射器。 该系统包括绘图台，注射器护罩和两种不同的放射性药物猪。 绘图工位具有一个支架底座和两个手臂，以支撑包围放射性物质容器的第一放射性药物猪。 放射性药物猪被可释放地安装到第二臂上，使得放射性药物猪可围绕两个预定轴线枢转，以将容器定位以通过注射器针头穿透，以将放射性物质从容器吸入注射器。

公开(公告)号：US5834788A

公开(公告)日：1998-11-10

申请号：US866919

申请日：1997-05-30

Applicant: Monty Mong Chen Fu ,  Bing Bing Zhu ,  Richard L. Green ,  Chris K. Fitz

Inventor： Monty Mong Chen Fu ,  Bing Bing Zhu ,  Richard L. Green ,  Chris K. Fitz

IPC: G21F5/015 ,  G21F5/00

CPC classification number: G21F5/015

Abstract: An improved radiation dense container for transporting radioactive iodine and the like, including a cup-shaped base having a cavity with an opening that is sized to receive radioactive iodine in the form of either one or more iodine capsules or a vial of iodine solution. The vial has a cap with a septum through which the radioactive iodine solution can be withdrawn from the vial in situ by an oral radioisotope administration set. A lid threadedly engages the base over the cavity opening to substantially seal it when threaded in place and to allow the insertion and removal of the radioactive iodine when removed. The base and the lid are both formed of tungsten. The container includes one or more activated charcoal filters to absorb any gases given off by the radioactive iodine when sealed in the cavity. An inner cup-shaped container and cap, made of plastic and sized and configured for a close fit within the base cavity, may be utilized to conveniently hold the capsules or, optionally, the vial.

Abstract translation: 用于输送放射性碘等的改进的辐射密集容器，包括具有开口的杯形基座，杯形基座的尺寸适于接纳一种或多种碘胶囊或一小瓶碘溶液形式的放射性碘。 小瓶具有带有隔膜的帽，放射性碘溶液可以通过口腔放射性同位素给药装置从原位取出。 一个盖子螺纹地接合在空腔开口上的基座上，以便当螺纹就位时基本上将其密封，并且允许在移除时插入和移除放射性碘。 基座和盖都由钨形成。 容器包括一个或多个活性炭过滤器，用于吸收当密封在空腔中时由放射性碘释放的任何气体。 可以利用由塑料制成的尺寸和构造用于紧密配合在基座腔内的内杯形容器和帽，以方便地保持胶囊或任选的小瓶。