公开(公告)号：US09289468B2

公开(公告)日：2016-03-22

申请号：US14344289

申请日：2011-09-16

Applicant: Shifang Yang ,  Junsheng Cui ,  Bing Zhu ,  Peng Wei

Inventor： Shifang Yang ,  Junsheng Cui ,  Bing Zhu ,  Peng Wei

IPC: A61K38/16 ,  A61K38/12 ,  A61K38/00 ,  A61P35/00 ,  A61P35/02 ,  C07K1/00 ,  C07K14/00 ,  C07K17/00 ,  C07K16/00 ,  C12N1/20 ,  C12N15/00 ,  A61K39/00 ,  A61K39/385 ,  A61K38/17 ,  C07K14/715 ,  C07K14/47 ,  C07K14/525 ,  C12N15/63 ,  C12N15/62 ,  C07K14/705 ,  A61K45/06 ,  C07K14/52

CPC classification number: A61K38/1761 ,  A61K38/00 ,  A61K45/06 ,  C07K14/47 ,  C07K14/4747 ,  C07K14/52 ,  C07K14/525 ,  C07K14/70575 ,  C07K14/7151 ,  C07K2319/21 ,  C07K2319/33 ,  C12N15/62 ,  C12N15/63

Abstract: Provided is a fusion protein comprising circularly permuted form of TRAIL, and the fusion protein contains circularly permuted form of TRAIL and oligopeptides located at the N-terminus and/or C-terminus of the permuted form. The oligopeptides contain a repeating sequence consisting of 3-10 histidines. The components of the circularly permuted form of TRAIL from N-terminus to C-terminus are: (a) amino acids 135-281 of TRAIL, (b) a linker, and (c) amino acids 121-135 of TRAIL or amino acids 114-135 of TRAIL or amino acids 95-135 of TRAIL or any fragments of amino acids 95-135 of TRAIL containing amino acids 121-135 of TRAIL. Also provided is a method for treating cancer by using the fusion protein.

Abstract translation: 提供了包含循环形式的TRAIL的融合蛋白，并且融合蛋白包含位于置换形式的N末端和/或C末端的循环形式的TRAIL和寡肽。 寡肽含有由3-10组氨酸组成的重复序列。 从N末端到C末端的循环形式的TRAIL的组分是：（a）TRAIL的氨基酸135-281，（b）接头，和（c）TRAIL或氨基酸的氨基酸121-135 TRAIL的114-135或TRAIL的氨基酸95-135或含有TRAIL的第121-135位氨基酸的TRAIL的任何氨基酸95-135的片段。 还提供了通过使用融合蛋白治疗癌症的方法。

公开(公告)号：US07666989B2

公开(公告)日：2010-02-23

申请号：US10577535

申请日：2003-11-03

Applicant: Bing Zhu

Inventor： Bing Zhu

IPC: C07K14/00

CPC classification number: C07K14/4703 ,  A61K38/00 ,  C07K14/70575

Abstract: The present invention discloses a recombinant protein having an anti-cancer effect, its encoding gene and uses thereof. The recombinant protein having an anti-cancer effect provided by the present invention is one selected from the group consisting of: 1) a protein having the amino acid sequence of SEQ ID No:2 shown in the sequence listing; 2) a protein derived from SEQ ID No:2, which has a sequence homology of more than 90% with SEQ ID No:2 and which has the same activity as that of SEQ ID No:2; 3) a protein derived from SEQ ID No:2, which is obtained by adding or deleting 15 or less amino acid residues at the N-terminus of the amino acid sequence of SEQ ID No:2, and which has the same activity as that of SEQ ID No:2; 4) a protein derived from SEQ ID No:2, which is obtained by adding or deleting 15 or less amino acid residues at the C-terminus of the amino acid sequence of SEQ ID No:2, and which has the same activity as that of SEQ ID No:2; 5) a protein derived from SEQ ID No:2, which is obtained by substitution, deletion, or addition of one or several amino acid residues in the amino acid sequence of SEQ ID No:2, and which has the same activity as that of SEQ ID No:2. The medicament containing above recombinant protein as active component has significant selective inhibitory effect on tumor cells, and does not induce apoptosis of normal tissue cells, and has important applicable value.

Abstract translation: 本发明公开了具有抗癌作用的重组蛋白，其编码基因及其用途。 本发明提供的具有抗癌效果的重组蛋白质选自：1）具有序列表所示的SEQ ID No：2的氨基酸序列的蛋白质; 2）衍生自SEQ ID No：2的蛋白质，其与SEQ ID No：2具有大于90％的序列同源性，并且具有与SEQ ID No：2具有相同的活性; 3）衍生自SEQ ID No：2的蛋白质，其通过在SEQ ID No：2的氨基酸序列的N末端添加或缺失15个或更少的氨基酸残基而获得，并且具有与该序列具有相同的活性 SEQ ID No：2; 4）衍生自SEQ ID No：2的蛋白质，其通过在SEQ ID No：2的氨基酸序列的C末端添加或缺失15个或更少的氨基酸残基获得，并且具有与SEQ ID No：2具有相同的活性 SEQ ID No：2; 5）衍生自SEQ ID No：2的蛋白质，其通过在SEQ ID No：2的氨基酸序列中的一个或几个氨基酸残基的取代，缺失或添加获得，并且具有与 SEQ ID No：2。 含有上述重组蛋白作为活性成分的药物对肿瘤细胞具有显着的选择性抑制作用，不诱导正常组织细胞凋亡，具有重要的适用价值。

公开(公告)号：US20050247893A1

公开(公告)日：2005-11-10

申请号：US11184291

申请日：2005-07-18

Applicant: Monty Fu ,  Bing Zhu

Inventor： Monty Fu ,  Bing Zhu

IPC: G21F5/018

CPC classification number: G21F5/018 ,  A61M5/1785 ,  G21Y2002/501 ,  G21Y2004/30 ,  Y10T29/49826 ,  Y10T29/49904

Abstract: A method and apparatus for transporting radiopharmaceuticals. Typically, the apparatus is a two-part assembly, each part having an exterior shell, a radiation shield and a non-porous lining. Additionally, the assembled apparatus has a sealed internal chamber suitable for carrying a syringe or a sharps container containing a syringe. The internal chamber of the radiopharmaceutical pig is lined with a non-porous lining, typically a durable plastic, that prevents contamination of the radiopharmaceutical doses, the radiation shield, or the environment. Additionally, the non-porous lining can be quickly and easily cleaned and sterilized, avoiding the often difficult, to impossible, task of cleaning and sterilizing the radiation shield of the radiopharmaceutical pig. The non-porous lining is surrounded by a radiation shield that is typically comprised of elemental lead. The radiation shield prevents radiation from the radiopharmaceutical from contaminating the user or environment. The radiation shield is surrounded by an exterior shell that absorbs impact and prevents the radiopharmaceutical pig from breaking. Additionally, the exterior shell prevents environmental exposure to the potentially hazardous material of the radiation shield. Generally, a method of transporting a radiopharmaceutical by filling the container with a radiopharmaceutical, inserting the container into the internal chamber of the radiopharmaceutical pig having a non-porous lining, and assembling the radiopharmaceutical pig so the that the container is in the internal chamber and is encapsulated by the radiation shield, is also provided.

Abstract translation: 用于运输放射性药物的方法和装置。 通常，该设备是两部分组件，每个部件具有外壳，辐射屏蔽和无孔衬里。 此外，组装的装置具有适于携带注射器或含有注射器的锐器容器的密封内部腔室。 放射性药物猪的内部室内衬有无孔衬里，通常是耐用的塑料，其防止放射性药物剂量，辐射屏蔽或环境的污染。 此外，无孔衬里可以快速且容易地清洁和消毒，避免了对放射性药物猪的辐射屏蔽进行清洁和消毒的常常困难的，不可能的任务。 无孔衬里由通常由元素铅构成的辐射屏蔽围绕。 辐射屏蔽防止放射性药物的辐射污染用户或环境。 辐射屏蔽被外壳包围，吸收冲击并防止放射性药物猪破裂。 此外，外壳防止环境暴露于辐射屏蔽层的潜在危险物质。 通常，通过用放射性药剂填充容器来输送放射性药物的方法，将容器插入具有无孔衬里的放射性药物猪的内部室中，并且组装放射性药物猪使得容器处于内部室中， 被辐射屏蔽封装，也被提供。

公开(公告)号：US20140317222A1

公开(公告)日：2014-10-23

申请号：US13818360

申请日：2012-02-15

Applicant: Hui Li ,  Xianxia Huang ,  Hanxu Hou ,  Tai Zhou ,  Bing Zhu ,  Changmin Chen ,  Jingbang Zhou

Inventor： Hui Li ,  Xianxia Huang ,  Hanxu Hou ,  Tai Zhou ,  Bing Zhu ,  Changmin Chen ,  Jingbang Zhou

IPC: H04L29/08

CPC classification number: H04L67/1097 ,  G06F11/1092 ,  H03M13/033 ,  H03M13/1515 ,  H04L67/1095

Abstract: A method, device and system disclosed used in storage technique, comprising: splitting a file of size M into k blocks, that is to say, each block is of size M/k; issuing the above k blocks across k different storage nodes in the distributed network storage system in a distributed manner; using the k blocks, constructing n−k independent blocks via linear coding method, and satisfying the property that any k of the n encoded blocks can be used to reconstruct the original data in the file, which means the linear coding method is a kind of Maximum-Distance Separable (MDS) code; distribute the n−k encoded blocks to the rest n−k different storage codes in the distributed network storage systems.

Abstract translation: 一种在存储技术中使用的方法，装置和系统，包括：将大小为M的文件分割成k个块，也就是说，每个块的大小为M / k; 以分布式方式在分布式网络存储系统中的k个不同存储节点上发布上述k个块; 使用k个块，通过线性编码方法构造n-k个独立块，并满足n个编码块的任何k可以用于重构文件中的原始数据的属性，这意味着线性编码方法是一种 最大距离可分离（MDS）代码; 将n-k个编码块分布到分布式网络存储系统中的其余n-k个不同存储码。

公开(公告)号：US20140006877A1

公开(公告)日：2014-01-02

申请号：US13993257

申请日：2012-06-29

Applicant: Bing Zhu ,  Peng Zou ,  Madhukar Tallam ,  Luhai Chen ,  Kai Wang

Inventor： Bing Zhu ,  Peng Zou ,  Madhukar Tallam ,  Luhai Chen ,  Kai Wang

IPC: G06F11/34

CPC classification number: G06F11/3466 ,  G06F11/0712 ,  G06F11/0778

Abstract: Methods and apparatus are disclosed to capture error conditions in lightweight virtual machine managers. A disclosed example method includes defining a shared memory structure between the VMM and a virtual machine (VM), when the VM is spawned by the VMM, installing an abort handler on the VM associated with a vector value, in response to detecting an error, transferring VMM state information to the shared memory structure, and invoking the abort handler on the VM to transfer contents of the shared memory structure to a non-volatile memory.

Abstract translation: 公开了在轻量级虚拟机管理器中捕获错误状况的方法和装置。 所公开的示例性方法包括当VM由VMM产生时，在VMM和虚拟机（VM）之间定义共享存储器结构，响应于检测到错误，在与向量值相关联的VM上安装中止处理程序， 将VMM状态信息传送到共享存储器结构，并且调用VM上的中止处理程序以将共享存储器结构的内容传送到非易失性存储器。

公开(公告)号：US08453086B2

公开(公告)日：2013-05-28

申请号：US11422314

申请日：2006-06-05

Applicant: Tung-Sun Tung ,  Tsair-Chin Lin ,  Bing Zhu

Inventor： Tung-Sun Tung ,  Tsair-Chin Lin ,  Bing Zhu

IPC: G06F17/50

CPC classification number: G06F17/5022 ,  G06F17/5027 ,  G06F2217/78

Abstract: The invention described here is the methods of using a hardware-based functional verification system to mimic a design under test (DUT), under intended application environment and software, to record or derive the transition activities of all circuits of the DUT, then calculate the total or partial power consumption during the period of interest. The period of interest is defined by the user in terms of “events” which are the arbitrary states of the DUT. Furthermore, the user can specify the number of sub-divisions required between events thus vary the apparent resolution of the power consumption profile.

Abstract translation: 这里描述的发明是使用基于硬件的功能验证系统在预期的应用环境和软件下模拟被测设计（DUT）来记录或导出DUT的所有电路的转换活动的方法，然后计算 在兴趣期间的全部或部分功耗。 感兴趣的时期由用户根据DUT的任意状态的“事件”定义。 此外，用户可以指定事件之间所需的子分割的数量，从而改变功耗简档的视在分辨率。

公开(公告)号：US08467862B2

公开(公告)日：2013-06-18

申请号：US13049805

申请日：2011-03-16

Applicant: Jay Snell ,  Bing Zhu ,  Katie Hoberman ,  Harish Krishnaswamy

Inventor： Jay Snell ,  Bing Zhu ,  Katie Hoberman ,  Harish Krishnaswamy

IPC: A61B5/04

CPC classification number: A61B5/0452 ,  A61B5/7264

Abstract: Cardiac activity is sensed over a plurality of heart beats defining a beat set. For each beat in the set, it is determined whether the beat is a non-classified beat (e.g., paced beat, a beat outside of a specified heart rate range or a PVC), or a classified beat. For each classified beat, it is determined whether the beat is a non-detect beat, a minor beat or a major beat. Counts of classified beats, non-classified beats, major beats, minor beats, and non-detect beats are maintained. The beat set is declared to be one of a non-classified set, a major set, a minor set or a non-detect set based on the relative counts of classified beats, non-classified beats, major beats, minor beats, and non-detect beats. Over a period of time, counts of beat-set types are maintained and entry into and exit from ST episodes are determined based on these beat-set counts.

Abstract translation: 在定义拍子组的多个心跳上感测到心脏活动。 对于集合中的每个节拍，确定节拍是否是非分类节拍（例如，节奏拍子，指定心率范围或PVC之外的节拍）或分类节拍。 对于每个分类的节拍，确定节拍是否是非检测节拍，小节奏或主要节拍。 维持分类节拍，非分类节拍，主要节拍，次要节拍和非检测节拍的数量。 基于分类节拍，非分类节拍，主要节拍，次要节拍和非节奏组合的相对计数，节拍组被宣布为非分类集，主要集，未成年集或未检测集之一。 检测节拍 在一段时间内，基于这些节拍设置计算确定节拍类型的计数，并且进入和退出ST剧集。

公开(公告)号：US08331797B2

公开(公告)日：2012-12-11

申请号：US10588042

申请日：2004-08-19

Applicant: Zhengfu Han ,  Bing Zhu ,  Xiaofan Mo ,  Guangcan Guo

Inventor： Zhengfu Han ,  Bing Zhu ,  Xiaofan Mo ,  Guangcan Guo

IPC: H04B10/04 ,  H04B10/00

CPC classification number: H04L9/0858

Abstract: The invention relates to a polarization-controlled encoding method, encoder and quantum key distribution system, which is characterized in that polarization maintaining light path or 90 degree rotation Faraday mirror are used inside the encoder to keep the polarization of the output pulses same, and that in the quantum key distribution system employing the polarization-controlled encoder the pulse emitted from transmitter is unidirectional-transmitted to receiver and then quantum key distribution is implemented using interference in the pulses according to the quantum key distribution protocol. The quantum key distribution system using the polarization-controlled encoder of the invention has the ability of avoiding the wiretapping to transmitter, receiver and quantum channel. Detection units each of which separates reversed photon from other photons are added at the out port of the transmitter and the in port of receiver, respectively, so that Trojan horse is prevented from entering and photons with phase modulated information are prevented from leaving the safe area in receiver. Unconditionally safe key distribution can be accomplished by using the quantum key distribution system of the invention.

Abstract translation: 本发明涉及一种偏振控制编码方法，编码器和量子密钥分发系统，其特征在于在编码器内部使用偏振保持光路或90度旋转法拉第镜，以保持输出脉冲的极化相同， 在使用偏振控制编码器的量子密钥分配系统中，从发射机发射的脉冲是单向传输到接收机，然后根据量子密钥分配协议在脉冲中使用干扰来实现量子密钥分配。 使用本发明的偏振控制编码器的量子密钥分发系统具有避免对发射机，接收机和量子信道的窃听的能力。 检测单元分别将反向光子与其他光子分离，分别在发射机的出口和接收机的入口端口分别加入，防止特洛伊木马进入，防止具有相位调制信息的光子离开安全区域 在接收器。 通过使用本发明的量子密钥分发系统可以实现无条件的安全密钥分发。

公开(公告)号：US08187606B2

公开(公告)日：2012-05-29

申请号：US12446382

申请日：2007-10-19

Applicant: Bing Zhu ,  Shifang Yang ,  Junsheng Cui

Inventor： Bing Zhu ,  Shifang Yang ,  Junsheng Cui

IPC: A61K39/00

CPC classification number: A61K39/12 ,  A61K2039/585 ,  A61K2039/6031 ,  C07K14/005 ,  C07K14/4725 ,  C07K2319/00 ,  C12N7/00 ,  C12N2710/20022 ,  C12N2710/20034

Abstract: The present invention provides a fusion protein comprising an immunostimulatory polypeptide and a mutant E7 protein of a human papilloma virus. The present invention also provides a gene encoding the fusion protein, expression vectors containing the gene, a pharmaceutical composition comprising the fusion protein, a method for treating or preventing a human papilloma virus related disease by using the fusion protein and uses of the fusion protein in the preparation of a medicament for the treatment or prevention of the human papilloma virus related disease.

Abstract translation: 本发明提供了包含免疫刺激多肽和人乳头瘤病毒的突变E7蛋白的融合蛋白。 本发明还提供了编码融合蛋白的基因，含有该基因的表达载体，包含该融合蛋白的药物组合物，通过使用融合蛋白治疗或预防人乳头状瘤病毒相关疾病的方法以及融合蛋白的用途 制备用于治疗或预防人乳头状瘤病毒相关疾病的药物。

公开(公告)号：US20080037998A1

公开(公告)日：2008-02-14

申请号：US10588042

申请日：2004-08-19

Applicant: Han Zhengfu ,  Bing Zhu ,  Xiaofan Mo ,  Guangcan Guo

Inventor： Han Zhengfu ,  Bing Zhu ,  Xiaofan Mo ,  Guangcan Guo

IPC: H04L9/08

CPC classification number: H04L9/0858

Abstract: The invention relates to a polarization-controlled encoding method, encoder and quantum key distribution system, which is characterized in that polarization maintaining light path or 90 degree rotation Faraday mirror are used inside the encoder to keep the polarization of the output pulses same, and that in the quantum key distribution system employing the polarization-controlled encoder the pulse emitted from transmitter is unidirectional-transmitted to receiver and then quantum key distribution is implemented using interference in the pulses according to the quantum key distribution protocol. The quantum key distribution system using the polarization-controlled encoder of the invention has the ability of avoiding the wiretapping to transmitter, receiver and quantum channel. Detection units each of which separates reversed photon from other photons are added at the out port of the transmitter and the in port of receiver, respectively, so that Trojan horse is prevented from entering and photons with phase modulated information are prevented from leaving the safe area in receiver. Unconditionally safe key distribution can be accomplished by using the quantum key distribution system of the invention.

Abstract translation: 本发明涉及一种偏振控制编码方法，编码器和量子密钥分发系统，其特征在于在编码器内部使用偏振保持光路或90度旋转法拉第镜，以保持输出脉冲的极化相同， 在使用偏振控制编码器的量子密钥分配系统中，从发射机发射的脉冲是单向传输到接收机，然后根据量子密钥分配协议在脉冲中使用干扰来实现量子密钥分配。 使用本发明的偏振控制编码器的量子密钥分发系统具有避免对发射机，接收机和量子信道的窃听的能力。 检测单元分别将反向光子与其他光子分离，分别在发射机的出口和接收机的入口端口分别加入，防止特洛伊木马进入，防止具有相位调制信息的光子离开安全区域 在接收器。 通过使用本发明的量子密钥分发系统可以实现无条件的安全密钥分发。