公开(公告)号：US20140120161A1

公开(公告)日：2014-05-01

申请号：US14140274

申请日：2013-12-24

Applicant: CENTRE EUROPEEN D'ETUDE DU DIABETE (30% PARTIAL INTEREST) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

Inventor： YVES FRERE ,  LOUIS DANICHER ,  ALAIN BELCOURT

IPC: A61K38/28 ,  A61K9/00 ,  A61K9/48

CPC classification number: A61K9/4808 ,  A61K9/0053 ,  A61K9/4866 ,  A61K9/5153 ,  A61K9/5161 ,  A61K9/5192 ,  A61K38/28

Abstract: A vector for the oral administration of at least one pharmacologically active substance enabling the active substance to move from the intestinal lumen to the blood, optionally via interstitial liquid, without any substantial degradation of the substance, includes an essentially hydrophilic matrix having an outer surface which is modified by one or several chemical species providing the vector with an essentially lipophilic quality and containing one or several active substances. The vector is associated with a gastroresistant vehicle enabling it to pass into the stomach without any denaturation and/or degradation of the active substance. The invention also relates to pharmaceutical compositions containing the vector. The vectors can be used to produce medicaments used in human or veterinary medicine.

Abstract translation: 用于口服给予至少一种药理活性物质的载体，其使活性物质能够任选地经由间质液体从肠腔移动到血液，而不会明显地降解物质，包括基本上亲水的基质，其具有外表面， 由一种或多种化学物质修饰，提供具有基本上亲油性质量且含有一种或几种活性物质的载体。 载体与胃阻抗性载体相关联，使其能够进入胃中，而不会使活性物质发生任何变性和/或降解。 本发明还涉及含有载体的药物组合物。 载体可用于生产用于人或兽药的药物。

公开(公告)号：US20130164250A1

公开(公告)日：2013-06-27

申请号：US13739421

申请日：2013-01-11

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

Inventor： YASEMIN ATAMAN-ONAL ,  THIERRY DELAIR ,  GENEVIEVE INCHAUSPE ,  PASCALE JEANNIN ,  GLAUCIA PARANHOS-BACCALA ,  BERNARD VERRIER

IPC: A61K47/48

CPC classification number: C07K16/40 ,  A61K9/167 ,  A61K9/5153 ,  A61K9/5192 ,  A61K39/00 ,  A61K47/34 ,  A61K47/6935 ,  A61K2039/6093 ,  C07K14/005 ,  C07K16/1054 ,  C07K16/1072 ,  C12N2740/16222 ,  C12N2740/16322 ,  C12N2770/24222 ,  G01N33/54346

Abstract: Nonlamellar bioresorbable microparticles to which protein substances are bonded, and a method for preparing the microparticles, comprising: (i) preparing the microparticles from at least one bioresorbable polymer without stabilizer and without surfactant; and (ii) bonding the protein substances to the microparticles obtained in step (i) without surfactant.

Abstract translation: 蛋白质物质结合的非平面生物可再吸收微粒及其制备方法，其特征在于，包括：（i）从不含稳定剂和无表面活性剂的至少一种生物可再吸收聚合物制备微粒; 和（ii）将蛋白质物质结合到没有表面活性剂的步骤（i）中获得的微粒子。

公开(公告)号：US20240355415A1

公开(公告)日：2024-10-24

申请号：US18688211

申请日：2021-09-03

Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITE CÔTE D'AZUR ,  CHU DE NICE

Inventor： Silvia BOTTINI ,  David PRATELLA ,  Marco MILANESIO ,  Véronique DUBOC ,  Véronique PAQUIS-FLUCKLINGER

IPC: G16B20/10 ,  C12Q1/6827 ,  G16B40/20 ,  G16H10/40 ,  G16H50/20

CPC classification number: G16B20/10 ,  C12Q1/6827 ,  G16B40/20 ,  G16H10/40 ,  G16H50/20

Abstract: Here, a suite of methods and devices is provided, allowing the implementation of a strategy for Non-Invasive Prenatal Testing (NIPT) results validation in clinical practice: a package to perform NIPT analysis, a semi-supervised approach to create synthetic sequences and to estimate confidence intervals for aneuploidies prediction and a package to test the reliability of NIPT results based on confidence intervals. These new tools were validated on 2 cohorts including confirmed ancuploidies, demonstrating sensitivity and specificity of 100%. Thus, the invention relates to a method for assessing the fetal fraction (ff) and sequencing depth (sd) in NIPT; devices for implementing the method, computer program products and computer readable mediums. This result yields the conclusion that thresholds of ff, sd and E value need to be assessed for each data analysis pipeline, chromosome and cohort. The provided devices and methods are thus of wide interest as it allows to identify these thresholds in a laboratory—specific fashion to improve NIPT performances.

公开(公告)号：US11427796B2

公开(公告)日：2022-08-30

申请号：US16335390

申请日：2017-09-19

Applicant: INRIA INSTITUT NATIONAL DE RECHERCHE EN INFORMATIQUE ET EN AUTOMATIQUE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFQUE (C.N.R.S) ,  UNIVERSITE NICE SOPHIA ANITPOLIS

Inventor： Olivier Bernard ,  Hubert Bonnefond ,  Antoine Sciandra ,  Éric Pruvost ,  Ghjuvan Grimaud

IPC: C12M3/00 ,  C12M1/00 ,  C12M1/34 ,  C12N5/00 ,  C12M1/36 ,  C12N1/12 ,  C12M1/42

Abstract: The invention relates to a bioreactor comprising a tank (100) capable of being operated for a working period, said tank (100) being intended to receive a culture medium comprising a cellular culture of photosynthetic microorganisms, a light source (200) arranged to emit incident light having a chosen incoming light intensity (Iin) in the direction of the tank, a temperature probe (400) for measuring the temperature of said culture medium in the tank, and a temperature regulator (500) capable of raising and lowering the temperature of said culture medium in the tank, and further comprising a control (700) of the temperature regulator arranged to adjust the temperature of the culture medium to a low setpoint value (VCB) during a first period, and to adjust the temperature of the culture medium to a high setpoint value (VCH) during a second period, the succession of said first and second periods making it possible to induce a cellular stress in at least some of said photosynthetic microorganisms during the working period.

公开(公告)号：US11312863B2

公开(公告)日：2022-04-26

申请号：US14900901

申请日：2014-06-26

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.) ,  UNIVERSITE PAUL SABATIER TOULOUSE III

Inventor： Christophe Le Roux ,  Francois Martin ,  Pierre Micoud ,  Angela Dumas

IPC: C09C1/30 ,  C01B33/44 ,  C09C1/00

Abstract: A method for preparing a composition including mineral particles functionalized by at least one organic group and having a specific surface defined according to the BET method greater than 500 m2/g, involves: —choosing a phyllosilicate composition, including mineral particles having a thickness of less than 100 nm, a largest dimension of less than 10 μm and belonging to the family of lamellar silicates; —choosing at least one functionalizing agent, from the group formed from the oxysilanes and oxygermanes having at least one organic group, —bringing the phyllosilicate composition into contact with a functionalizing solution including the functionalizing agent, so as to obtain a phyllosilicate composition including mineral particles functionalized by the organic group, while choosing the organic group from the group formed from the cationic heteroaryl groups, the quaternary ammonium groups and the salts of same. The phyllosilicate composition obtained by the method is also described.

公开(公告)号：US11045907B2

公开(公告)日：2021-06-29

申请号：US15762482

申请日：2016-09-22

Applicant: Manutech-USD ,  Ecole Nationale d'Ingenieurs de Saint-Etienne ,  Ecole Centrale de Lyon ,  Centre National de la Recherche Scientifique (C.N.R.S.)

Inventor： Emmanuel Baubeau ,  Florent Missemer ,  Philippe Bertrand

IPC: B33Y10/00 ,  B33Y30/00 ,  B33Y40/00 ,  B29C64/153 ,  B23K26/354 ,  B29C64/30 ,  B23K26/34 ,  B28B1/00

Abstract: A system of additive-manufacturing by laser melting of a powder bed. The system includes a first laser unit selectively emitting a first laser beam to form at least one layer of material by melting the powder bed; a second laser unit selectively emitting a second laser beam to machine at least a portion of the layer of material; and an optical unit enabling to focus the first laser beam on the powder bed to be melted and the second laser beam on the layer of material to be machined. The system is able to produce a part by successive stacking of melted then machined layers of material. A process of additive-manufacturing by laser melting of a powder bed is also contemplated.

公开(公告)号：US10899019B2

公开(公告)日：2021-01-26

申请号：US16314959

申请日：2017-07-03

Applicant: PERCIPIO ROBOTICS ,  SORBONNE UNIVERSITE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)

Inventor： Stephane Regnier ,  Thomas Daunizeau ,  Dogan Sinan Haliyo ,  Tianming Lu ,  Marie Lutringer ,  David Heriban

IPC: B25J15/02 ,  B25J7/00 ,  B25B9/02 ,  A61B17/30 ,  A61B17/00 ,  A61B34/00 ,  A61B90/00

Abstract: A mechatronic device includes two arms extending from a base in a first direction and shaped to be handheld by an operator, the two arms having free ends forming a gripper and arranged to move closer together by rotation from a rest position to an active position, a motor housed in the base, an actuator mounted between the arms, and a means for controlling said actuator, the actuator connected to the motor so as to be driven in movement in translation in the first direction. The actuator also has a first contact surface that forms a cam with a respective second contact surface on each arm, the first contact surface remaining engaged with the second contact surface. The control means controls the movement in translation of the actuator to produce a movement in rotation of the arms that applies a chosen force of the gripper in its active position.

公开(公告)号：US20200308652A1

公开(公告)日：2020-10-01

申请号：US16758644

申请日：2018-10-24

Applicant: UNIVERSITE PARIS DESCARTES ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)

Inventor： Sandrine BOURDOULOUS ,  Anaïs DOMINGOT ,  Camille FAURE

IPC: C12Q1/6886

Abstract: This invention relates to a method for diagnosing and/or prognosticating HER2-dependent cancer in a subject, comprising a) measuring the amount of moesin in a sample from the subject; b) comparing the amount of moesin measured in step a) to a reference value; c) finding a deviation or no deviation of the amount of moesin measured in step a) from the reference value; and d) attributing said finding of deviation or no deviation to a particular diagnosis and/or prognosis of HER2-dependent cancer in the subject.

公开(公告)号：US10772930B2

公开(公告)日：2020-09-15

申请号：US15937416

申请日：2018-03-27

Applicant: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S) ,  UNIVERSITE DE RENNES 1 ,  UNIVERSITE DE BRETAGNE OCCIDENTALE

Inventor： Florie Desriac ,  Yannick Fleury ,  Patrick Le Chevalier ,  Delphine Destoumieux ,  Matthieu Simon

IPC: C07K7/56 ,  A61K38/12 ,  C11D3/28 ,  C11D3/32 ,  C11D3/38 ,  C11D3/48 ,  C12R1/01 ,  A23K10/18 ,  A23K20/195 ,  A23K50/80 ,  A61K35/74 ,  A61K35/741 ,  C07K7/64 ,  A61K38/00 ,  A61K35/00

Abstract: The present invention relates to an isolated bacterium from the genus Pseudoalteromonas for its use as a probiotic, the use of said strain as a preservative, cyclolipopeptides which may be obtained from this bacterium, a composition comprising at least such a cyclolipopeptide, as well as to their uses.

公开(公告)号：US10711232B2

公开(公告)日：2020-07-14

申请号：US15559947

申请日：2016-03-18

Applicant: Inria Institut National De Recherche En Informatique Et En Automatique ,  Centre National De La Recherche Scientifique (C.N.R.S.) ,  Universite Pierre Et Marie Curie (Paris 6)

Inventor： Francis Mairet ,  Olivier Bernard ,  Antoine Sciandra ,  Eric Pruvost ,  Charlotte Combe

IPC: C12M1/00

Abstract: The invention relates to a bioreactor comprising a tank containing a culture medium in which a cell culture composed of algae cells is dispersed. The cell culture of algae has a concentration greater than 0.1 g/L in the culture medium, and each algal cell has a minimum absorption in a specific range of wavelengths of light. The bioreactor comprises a light source that is capable of emitting incident light in the direction of the tank, 60% of the photons of the incident light having a wavelength which is included in said specific range of wavelengths of light. The invention also relates to the use of the bioreactor for the production of biomass.