公开(公告)号：US20080161266A1

公开(公告)日：2008-07-03

申请号：US11961447

申请日：2007-12-20

Applicant: Dharmendra M. Jani ,  Stephen E. Maier

Inventor： Dharmendra M. Jani ,  Stephen E. Maier

IPC: A61K31/717 ,  A61P27/02 ,  A61K47/36 ,  A61K31/155 ,  A61K47/10

CPC classification number: A61L12/141 ,  A61K9/0048 ,  A61K31/155 ,  A61K31/717 ,  A61K36/03 ,  A61L12/142 ,  A61L12/143 ,  A61L12/145

Abstract: The present invention is directed to an ophthalmic composition comprising alginate having a minimum of about 0% and a maximum of about 50% guluronic units bound to an adjacent guluronic unit as a percentage of the total number of monomeric units in the alginate. The composition further includes a cationic antimicrobial agent. The alginate set forth above forms less deactivating complexes with cationic antimicrobial agent, and thus, the composition has improved preservative efficacy.

Abstract translation: 本发明涉及一种眼用组合物，其包含藻酸盐，其具有与藻酸盐中单体单元总数的百分比具有最小约0％和最多约50％的古罗糖醛酸单元的相邻古罗糖醛单元。 组合物还包含阳离子抗微生物剂。 上述藻酸盐与阳离子抗微生物剂形成更少的失活复合物，因此，该组合物具有改善的防腐功效。

公开(公告)号：US20080153908A1

公开(公告)日：2008-06-26

申请号：US11933496

申请日：2007-11-01

Applicant: Dharmendra M. Jani

Inventor： Dharmendra M. Jani

IPC: A61K31/19 ,  A61P27/02

CPC classification number: A61K31/19 ,  A61K9/0048

Abstract: The present invention includes a method of treating a patient suffering from mucin deficiency comprising administering to an eye of a patient suffering from mucin deficiency, a composition comprising an active pharmaceutical selected from the group consisting of acetate, propionate or butyrate in their salt or acid forms and combinations thereof, wherein the active pharmaceutical is present in an amount effective to increase production of mucin in the eye of the mucin deficient patient.

Abstract translation: 本发明包括治疗患有粘蛋白缺乏症的患者的方法，其包括向患有粘蛋白缺乏症的患者的眼睛施用包含其盐或酸形式的选自乙酸盐，丙酸盐或丁酸盐的活性药物的组合物 及其组合，其中活性药物以有效增加粘蛋白缺乏患者眼睛中粘蛋白产生的量存在。

公开(公告)号：US20080153776A1

公开(公告)日：2008-06-26

申请号：US11955418

申请日：2007-12-13

Applicant: Erning Xia ,  Dharmendra M. Jani

Inventor： Erning Xia ,  Dharmendra M. Jani

IPC: A61K31/7016 ,  A61P29/00 ,  A61K31/715 ,  A61P27/14

CPC classification number: A61K31/7016 ,  A61K9/0048 ,  A61K31/715 ,  A61K36/03 ,  Y10S514/914

Abstract: The present invention includes a method of treating inflammation of the eye comprising administering to an eye of a patient suffering from inflammation of the eye, a composition comprising an aqueous solution of alginate having a minimum of about 50% mannuronate residues based upon the total number of saccharide monomeric units.

Abstract translation: 本发明包括治疗眼睛炎症的方法，包括向患有眼睛炎症的患者的眼睛施用包含至少约50％甘露糖醛酸残基的藻酸盐水溶液的组合物， 糖单体单位。

公开(公告)号：US20080140940A1

公开(公告)日：2008-06-12

申请号：US12033105

申请日：2008-02-19

Applicant: Binny Sher Gill ,  Dharmendra Shantilal Modha

Inventor： Binny Sher Gill ,  Dharmendra Shantilal Modha

IPC: G06F12/08

CPC classification number: G06F12/0862 ,  G06F12/0866 ,  G06F12/123

Abstract: A self-tuning, low overhead, simple to implement, locally adaptive, novel cache management policy that dynamically and adaptively partitions the cache space amongst sequential and random streams so as to reduce read misses.

公开(公告)号：US20080061784A1

公开(公告)日：2008-03-13

申请号：US11980910

申请日：2007-10-30

Applicant: Dharmendra Pal ,  Thomas Peterson ,  Tao Song ,  Shu Du

Inventor： Dharmendra Pal ,  Thomas Peterson ,  Tao Song ,  Shu Du

IPC: G01V3/00

CPC classification number: B23B37/00 ,  A61B17/16 ,  A61B17/1604 ,  A61B17/1635 ,  A61B17/320068 ,  A61B2017/1651 ,  A61B2017/320072 ,  A61B2217/005 ,  A61B2217/007 ,  B23B2226/18 ,  B23B2250/12 ,  B23B2260/108 ,  B23B2260/1285 ,  B23B2270/483

Abstract: The present invention relates to a device with an ultrasonic-based probe for drilling and coring. The invention uses ultrasonic and subsonic vibrations produced by a frequency compensation coupler or free mass to produce the hammering action of a partially disengaged probe, with a relatively low axial force required. The invention can also be fitted with irrigation and aspiration capabilities. The invention can furthermore be furnished with a body sensor-feedback apparatus, which provides feedback to the operator as to the optimal frequency and power use of the generator. One embodiment of the invention also has a cooling mechanism to keep the drill or coring apparatus at an optimum temperature.

Abstract translation: 本发明涉及一种具有用于钻孔和取芯的超声波探头的装置。 本发明使用由频率补偿耦合器或自由质量产生的超声波和亚音速振动以产生所需的相对低的轴向力的部分分离的探针的锤击作用。 本发明还可以具有灌溉和抽吸能力。 本发明还可以配备有身体传感器反馈装置，其向操作者提供关于发生器的最佳频率和功率使用的反馈。 本发明的一个实施例还具有将钻孔或取芯装置保持在最佳温度的冷却机构。

公开(公告)号：US20070250150A1

公开(公告)日：2007-10-25

申请号：US11787376

申请日：2007-04-16

Applicant: Dharmendra Pal ,  Jeffry S. Melsheimer

Inventor： Dharmendra Pal ,  Jeffry S. Melsheimer

IPC: A61F2/06

CPC classification number: A61F2/95 ,  A61F2/2436 ,  A61M25/005 ,  A61M25/0053 ,  A61M25/0097 ,  A61M2025/0098 ,  B29B13/025 ,  B29C57/04 ,  B29C65/02 ,  B29C65/04 ,  B29C65/68 ,  B29C66/0342 ,  B29C66/50 ,  B29C66/63 ,  B29C66/91411 ,  B29C66/91445 ,  B29C66/919 ,  B29C66/91931 ,  B29C66/91933 ,  B29C66/91935 ,  B29C66/949 ,  B29K2009/06 ,  B29K2023/00 ,  B29K2023/12 ,  B29K2027/06 ,  B29K2027/16 ,  B29K2055/02 ,  B29K2069/00 ,  B29K2071/00 ,  B29K2071/12 ,  B29K2077/00 ,  B29K2081/04 ,  B29K2096/005 ,  B29K2101/12 ,  B29K2105/0079 ,  B29L2031/605 ,  B29C65/00

Abstract: A flared strain relief member for medical device delivery systems for stents, prosthetic valve devices, and other implantable articles inside a patient's body are provided. An elongate outer sheath has proximal and distal end portions defining a passageway, and the proximal end portion having an outer layer including melt bonding material. A strain relief member has a tubular first end portion of a first outer diameter and a flared second end portion of a greater second outer diameter. The strain relief member has an inner engaging surface that includes melt bonding material, at least a portion of which disposes concentrically about, and melt bonded to, the outer sheath proximal end portion melt bonding outer layer. The strain relief member second end portion is operatively coupled between a handle first connector and handle second connector. Methods of making a flared strain relief member for medical device delivery systems are also provided.

Abstract translation: 提供了一种用于医疗装置输送系统的扩张应变消除构件，用于支架，假体瓣膜装置和患者体内的其它可植入物品。 细长的外护套具有限定通道的近端部分和远端部分，并且近端部分具有包括熔融粘合材料的外层。 应变消除构件具有第一外径的管状第一端部和较大第二外径的扩口第二端部。 所述应变消除部件具有内部接合面，所述内部接合面包括至少一部分熔融粘合材料，所述熔接材料的至少一部分与所述外护套基端部熔融粘合外层同心配置并熔融粘合。 应变消除构件第二端部可操作地联接在手柄第一连接器和手柄第二连接器之间。 还提供了制造用于医疗装置输送系统的扩口应变消除构件的方法。

公开(公告)号：US20070244440A1

公开(公告)日：2007-10-18

申请号：US11728528

申请日：2007-03-26

Applicant: Dharmendra Pal ,  Thomas Osborne

Inventor： Dharmendra Pal ,  Thomas Osborne

IPC: A61M29/00 ,  A61M5/178 ,  A61M25/00

CPC classification number: A61M25/0074 ,  A61M25/0068

Abstract: A catheter for use with at least two different sizes of wire guides is described. The catheter includes a wire guide lumen sized to receive a first wire guide of a first diameter. The catheter may also include a tip lumen that extends in a distal direction from a first opening in communication with the wire guide lumen to a second opening. The first opening is sized to receive the first wire guide, and the second opening is sized to receive a second wire guide of a smaller diameter than the first wire guide. The catheter also includes one or more longitudinal expansion features capable of radially expanding the tip lumen to receive a wire guide of a diameter up to the first diameter through the second opening. An adapter that may be attached to the catheter by a medical professional is also described.

Abstract translation: 描述了与至少两种不同尺寸的导线器一起使用的导管。 导管包括尺寸适于接收第一直径的第一线引导件的线引导腔。 导管还可以包括尖端腔，其从远离方向延伸，与第一开口连通，该第一开口与导线管腔连通到第二开口。 第一开口的尺寸被设计成接收第一线引导件，并且第二开口的尺寸被设计成接纳直径小于第一线引导件的第二线引导件。 该导管还包括一个或多个纵向膨胀特征，其能够径向扩张尖端内腔，以通过第二开口接纳直径直到第一直径的线引导件。 还描述了可由医学专业人员附接到导管的适配器。

公开(公告)号：US20070225738A1

公开(公告)日：2007-09-27

申请号：US11726495

申请日：2007-03-22

Applicant: Dharmendra Pal

Inventor： Dharmendra Pal

IPC: A61B17/08 ,  A61M29/00

CPC classification number: A61B17/12022 ,  A61B17/12113 ,  A61B17/1214 ,  A61B17/12181 ,  A61B2017/1205

Abstract: An occlusion device for occluding blood flow in a vessel is provided, having a generally helical member with a pair of end portions and an intermediate portion therebetween. The intermediate portion defines a varying coil pitch so that the helical member has a varying stiffness along the intermediate portion.

Abstract translation: 提供了一种用于阻塞血管中的血流的闭塞装置，其具有大致螺旋形的构件，其具有一对端部和中间部分。 中间部分限定变化的线圈节距，使得螺旋构件沿着中间部分具有变化的刚度。

公开(公告)号：US20070037119A1

公开(公告)日：2007-02-15

申请号：US11502310

申请日：2006-08-10

Applicant: Dharmendra Pal ,  Jeffry Melsheimer

Inventor： Dharmendra Pal ,  Jeffry Melsheimer

IPC: A61C3/03

CPC classification number: A61B17/22012 ,  A61B17/320758 ,  A61B2017/320004

Abstract: A system includes a generator with a grinder subgenerator and an ultrasonic subgenerator, a grinder handpiece, and an ultrasonic handpiece. The grinder handpiece is connected in electrical communication with the grinder subgenerator. The grinder handpiece includes a motor and a grinding tool connected mechanically to the motor. The rotational speed of the grinding tool is associated with electrical energy provided by the grinder subgenerator to the motor. The ultrasonic handpiece is connected in electrical communication with the ultrasonic subgenerator. The ultrasonic handpiece includes a transducer and a ball tip connected mechanically to the transducer. The amplitude of the vibrations at the ball tip is associated with electrical energy provide by the ultrasonic subgenerator to the transducer.

Abstract translation: 一种系统包括具有磨床子发电机和超声波副发电机的发电机，磨床机头和超声波机头。 研磨机手机与研磨机子发电机电连接。 研磨机的手持件包括电动机和与电机机械连接的研磨工具。 研磨工具的转速与研磨机副发电机向电动机提供的电能相关联。 超声波手持件与超声波副发生器电连接。 超声波手持件包括与换能器机械连接的换能器和球头。 球尖处振动的振幅与超声波发生器提供给换能器的电能有关。

公开(公告)号：US07107403B2

公开(公告)日：2006-09-12

申请号：US10676464

申请日：2003-09-30

Applicant: Dharmendra Shantilal Modha ,  Divyesh Jadav ,  Pawan Goyal ,  Renu Tewari

Inventor： Dharmendra Shantilal Modha ,  Divyesh Jadav ,  Pawan Goyal ,  Renu Tewari

IPC: G06F12/00 ,  G06F13/00

CPC classification number: G06F9/5016 ,  G06F12/0871 ,  G06F12/12 ,  G06F2212/282 ,  G06F2212/6042

Abstract: A method and system for dynamically allocating cache space in a storage system among multiple workload classes each having a unique set of quality-of-service (QoS) requirements. The invention dynamically adapts the space allocated to each class depending upon the observed response time for each class and the observed temporal locality in each class. The dynamic allocation is achieved by maintaining a history of recently evicted pages for each class, determining a future cache size for the class based on the history and the QoS requirements where the future cache size might be different than a current cache size for the class, determining whether the QoS requirements for the class are being met, and adjusting the future cache size to maximize the number of classes in which the QoS requirements are met. The future cache sizes are increased for the classes whose QoS requirements are not met while they are decreased for those whose QoS requirements are met.

Abstract translation: 一种用于在多个工作负载类别中动态地分配存储系统中的高速缓存空间的方法和系统，每个工作负载类别具有唯一的服务质量（QoS）要求。 本发明根据每个类的观察到的响应时间和每个类中观察到的时间局部性动态地适应分配给每个类的空间。 通过维护每个类别的最近被逐出的页面的历史来实现动态分配，基于历史和QoS要求确定将来的高速缓存大小，其中将来的高速缓存大小可能与该类的当前高速缓存大小不同， 确定是否满足该类的QoS要求，以及调整未来的高速缓存大小以最大化满足QoS要求的类的数量。 对于满足QoS要求的类，对于满足QoS要求的用户而言，对于不满足QoS要求的类，对于未来的高速缓存大小会有所增加。