公开(公告)号：US20200308544A1

公开(公告)日：2020-10-01

申请号：US16869232

申请日：2020-05-07

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N5/0789 ,  C08K5/5399 ,  C12N5/074 ,  H01L31/048 ,  C12N15/87 ,  C12P21/00 ,  C12N9/16 ,  C12N5/077 ,  C12N15/90 ,  C12N9/22 ,  A61K35/28

Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US10767195B2

公开(公告)日：2020-09-08

申请号：US16655766

申请日：2019-10-17

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C07H21/04 ,  C12N15/63 ,  C12N15/90 ,  A61K31/7115 ,  C12N9/22 ,  C07K14/195 ,  C12N15/10 ,  A61K35/14 ,  A61K38/46 ,  A61K48/00 ,  C12N15/86 ,  G01N33/50 ,  A01K67/00 ,  A61K35/12

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US10752917B2

公开(公告)日：2020-08-25

申请号：US16654536

申请日：2019-10-16

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C07H21/04 ,  C12N15/63 ,  C12N15/90 ,  A61K31/7115 ,  C12N9/22 ,  C07K14/195 ,  C12N15/10 ,  A61K35/14 ,  A61K38/46 ,  A61K48/00 ,  C12N15/86 ,  G01N33/50 ,  A01K67/00 ,  A61K35/12

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US20200040365A1

公开(公告)日：2020-02-06

申请号：US16657325

申请日：2019-10-18

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N15/90 ,  C12N15/86 ,  A61K35/14 ,  C12N9/22 ,  A61K38/46 ,  G01N33/50 ,  C12N15/10 ,  A61K48/00 ,  A61K31/7115 ,  C07K14/195

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US20200032299A1

公开(公告)日：2020-01-30

申请号：US16657321

申请日：2019-10-18

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N15/90 ,  C12N15/86 ,  A61K35/14 ,  C12N9/22 ,  A61K38/46 ,  G01N33/50 ,  C12N15/10 ,  A61K48/00 ,  A61K31/7115 ,  C07K14/195

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US20200032296A1

公开(公告)日：2020-01-30

申请号：US16654536

申请日：2019-10-16

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N15/90 ,  C12N15/86 ,  A61K35/14 ,  C12N9/22 ,  A61K38/46 ,  G01N33/50 ,  C12N15/10 ,  A61K48/00 ,  A61K31/7115 ,  C07K14/195

Abstract: The present invention relates in part to nucleic acids encoding proteins, therapeutics comprising nucleic acids encoding proteins, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods and products for altering the DNA sequence of a cell are described, as are methods and products for inducing cells to express proteins using synthetic RNA molecules. Therapeutics comprising nucleic acids encoding gene-editing proteins are also described.

公开(公告)号：US20190390174A1

公开(公告)日：2019-12-26

申请号：US16567059

申请日：2019-09-11

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: C12N5/074 ,  C12N9/16 ,  C12N15/90 ,  C12N9/22 ,  C08K5/5399 ,  C12N15/87 ,  C12P21/00 ,  A61K35/28 ,  H01L31/048 ,  C12N5/077 ,  C12N5/0789

Abstract: The present invention relates in part to nucleic acids encoding proteins, nucleic acids containing non-canonical nucleotides, therapeutics comprising nucleic acids, methods, kits, and devices for inducing cells to express proteins, methods, kits, and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, and therapeutics produced using these methods, kits, and devices. Methods for inducing cells to express proteins and for reprogramming and gene-editing cells using RNA are disclosed. Methods for producing cells from patient samples, cells produced using these methods, and therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US10369233B2

公开(公告)日：2019-08-06

申请号：US16030675

申请日：2018-07-09

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: A61K48/00 ,  A61K31/7115 ,  A61P1/16 ,  A61P3/06 ,  A61P11/00 ,  A61P3/00 ,  A61P9/00 ,  A61P29/00 ,  A61P35/00 ,  A61P3/10 ,  C07K14/00 ,  C12N9/22 ,  A61K9/00

Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.

公开(公告)号：US20190225944A1

公开(公告)日：2019-07-25

申请号：US16374482

申请日：2019-04-03

Applicant: Factor Bioscience Inc.

Inventor： Matthew Angel ,  Christopher Rohde

IPC: C12N5/074 ,  C12N5/071 ,  C12N5/077 ,  C12N5/0789 ,  C12N5/095

CPC classification number: C12N5/0696 ,  C12N5/0018 ,  C12N5/0625 ,  C12N5/0647 ,  C12N5/0656 ,  C12N5/0657 ,  C12N5/0676 ,  C12N5/0695 ,  C12N2500/25 ,  C12N2500/33 ,  C12N2500/36 ,  C12N2500/84 ,  C12N2501/602 ,  C12N2501/603 ,  C12N2501/604 ,  C12N2501/606 ,  C12N2501/608 ,  C12N2501/998 ,  C12N2506/09 ,  C12N2506/45

Abstract: The present invention relates in part to methods for producing tissue-specific cells from patient samples, and to tissue-specific cells produced using these methods. Methods for reprogramming cells using RNA are disclosed. Therapeutics comprising cells produced using these methods are also disclosed.

公开(公告)号：US20190000997A1

公开(公告)日：2019-01-03

申请号：US16030675

申请日：2018-07-09

Applicant: Factor Bioscience Inc.

Inventor： Matthew ANGEL ,  Christopher ROHDE

IPC: A61K48/00 ,  A61P3/10 ,  A61P35/00 ,  A61P29/00 ,  A61P9/00 ,  A61P3/00 ,  A61P11/00 ,  A61P1/16 ,  A61K31/7115 ,  C12N9/22 ,  C07K14/00 ,  A61P3/06

CPC classification number: A61K48/005 ,  A61K9/0019 ,  A61K31/7115 ,  A61K48/0058 ,  A61K48/0066 ,  A61P1/16 ,  A61P3/00 ,  A61P3/06 ,  A61P3/10 ,  A61P9/00 ,  A61P11/00 ,  A61P29/00 ,  A61P35/00 ,  C07K14/001 ,  C07K14/003 ,  C12N9/22 ,  C12N2310/20 ,  C12Y301/21

Abstract: The present invention relates in part to nucleic acids, including nucleic acids encoding proteins, therapeutics and cosmetics comprising nucleic acids, methods for delivering nucleic acids to cells, tissues, organs, and patients, methods for inducing cells to express proteins using nucleic acids, methods, kits and devices for transfecting, gene editing, and reprogramming cells, and cells, organisms, therapeutics, and cosmetics produced using these methods, kits, and devices.