公开(公告)号：US20220168327A1

公开(公告)日：2022-06-02

申请号：US17430756

申请日：2019-02-25

Applicant: The Australian National University ,  Griffith University

Inventor： Christopher Parish ,  Connor O'Meara ,  Lucy Coupland ,  Benjamin Ju Chye Quah ,  Farzaneh Kordbacheh ,  Anna Bezos ,  Anna Browne ,  Ross Stephens ,  Gregory David Tredwell ,  Lee Andrew Philip ,  Karen Knox ,  Laurence Mark von Itzstein ,  Chih-Wei Chang ,  Anne Brüstle ,  David Anak Simon Davis

IPC: A61K31/7028 ,  A61K31/7016 ,  A61P37/06

Abstract: The present invention relates to compounds with high chemical stability and methods for inhibiting the pathological activity of NETs in a subject. In particular, the invention relates to compounds with high chemical stability, uses thereof and methods for inhibiting or ameliorating NET mediated ailments (such as, for example, sepsis, systemic immune response syndrome (SIRS) and ischemia reperfusion injury (IRI)). More particularly, the invention relates to methods and uses of a polyanionic sulfated cellobioside modified with a small uncharged glycosidically linked substituent at its reducing terminus, wherein the presence of the substituent results in a molecule with high chemical stability without affecting the ability of the molecule to be effective in the therapy of NET mediated ailments. For example, the present invention relates to methods and uses of β-O-methyl cellobioside sulfate (mCBS) or a pharmaceutically acceptable salt thereof (e.g., mCBS.Na), in the therapy of a range of NET mediated ailments in subjects.

公开(公告)号：US11313821B2

公开(公告)日：2022-04-26

申请号：US16626888

申请日：2018-06-28

Applicant: GRIFFITH UNIVERSITY

Inventor： Huijun Zhao

IPC: B01L3/00 ,  G01N27/12 ,  B01D63/08 ,  B01D69/02 ,  B01D71/36 ,  G01N33/18 ,  B01D63/02

Abstract: A sensor for the in situ detection of a target chemical species, comprising a gas permeable membrane having a sampling side and an opposing analytical side, wherein the sampling side of the membrane is capable of receiving a sample and the membrane is permeable to target chemical species present in the sample. A weak acid or a weak base is in contact with the analytical side of the membrane, and a conductivity detector is in contact with the weak acid or weak base. In use, target chemical species present in the sample permeate through the membrane and react with the weak acid or weak base, producing ionic species and changing the conductivity.

公开(公告)号：US20220062402A1

公开(公告)日：2022-03-03

申请号：US17416271

申请日：2019-12-20

Applicant: Griffith University

Inventor： Freda E.-C. JEN ,  Kate SEIB ,  Evgeny SEMCHENKO ,  Michael JENNINGS

IPC: A61K39/095 ,  C12N15/86

Abstract: This invention relates generally to polynucleotides, polypeptides, compositions, methods and uses for eliciting an immune response to Neisseria, methods for immunizing a subject against a Neisseria infection, and methods for preventing and/or treating a Neisseria infection in a subject. More particularly, the invention relates to antigenic Neisseria polypeptides and encoding polynucleotides, and related uses and methods, including use for preparing compositions and medicaments for eliciting an immune response to Neisseria, for immunizing a subject against a Neisseria infection, and for preventing and/or treating a Neisseria infection in a subject. The invention also relates to methods for producing therapeutic anti-Neisseria antigen-binding molecules, and therapeutic uses of those antigen-binding molecules.

公开(公告)号：US10971580B2

公开(公告)日：2021-04-06

申请号：US16469809

申请日：2017-12-13

Applicant: GRIFFITH UNIVERSITY

Inventor： Sima Dimitrijev ,  Jisheng Han

IPC: H01L29/872 ,  H01L29/16 ,  H01L29/06 ,  H01L21/3065 ,  H01L21/308 ,  H01L29/66

Abstract: A silicon carbide (SiC) Schottky diode comprises a layer of N-type SiC and a layer of P-type SiC in contact with the layer of N-type SiC creating a P-N junction. An anode is in contact with both the layer of N-type SiC and the layer of P-type SiC creating Schottky contacts between the anode and both the layer of N-type SiC and the layer of P-type SiC. An edge of the layer of P-type SiC is electrically active and comprises a tapered negative charge density at the P-N junction, which can be achieved by a tapered or sloping edge the layer of P-type SiC.

公开(公告)号：US10301362B2

公开(公告)日：2019-05-28

申请号：US15304462

申请日：2015-04-15

Applicant: Griffith University

Inventor： Manisha Pandey ,  Michael Batzloff ,  Michael Good

IPC: C07K14/315 ,  C07K16/12 ,  A61K39/09 ,  A61K38/48 ,  A61K39/395 ,  C07K16/40 ,  A61K39/00

Abstract: A method and composition for eliciting an immune response to group A streptococcal bacteria in a mammal is provided, which includes administering to the mammal an M protein fragment, variant or derivative thereof and a SpyCEP protein or peptide fragment, or an antibody to the SpyCEP protein or fragment to facilitate restoring or enhancing neutrophil activity. Also provided is an immunodominant peptide fragment of SpyCEP.

公开(公告)号：US10028938B2

公开(公告)日：2018-07-24

申请号：US15508055

申请日：2015-09-07

Applicant: Griffith University

Inventor： Mark Von Itzstein ,  Ibrahim El-Deeb ,  Larissa Dirr ,  Patrice Guillon ,  Moritz Winger

IPC: A61K31/4192 ,  A61K31/351 ,  A61K31/36 ,  A61K31/4025 ,  A61K31/403 ,  A61K31/41

CPC classification number: A61K31/4192 ,  A61K31/351 ,  A61K31/36 ,  A61K31/4025 ,  A61K31/403 ,  A61K31/41 ,  A61K2300/00 ,  C07D405/04

Abstract: The present invention relates to compounds which are found to exhibit an antiviral effect. The compounds are modulators of the activity of the viral haemagglutinin and/or neuraminidase enzymes.

公开(公告)号：US09962412B2

公开(公告)日：2018-05-08

申请号：US14397293

申请日：2013-04-29

Applicant: Griffith University

Inventor： Ming Wei

IPC: G01N33/554 ,  A61K35/74 ,  C12N1/20 ,  C12N1/36 ,  C12R1/145 ,  A61K39/395 ,  A61K39/00

CPC classification number: A61K35/74 ,  A61K39/39558 ,  A61K2039/505 ,  C12N1/20 ,  C12N1/36 ,  C12R1/145

Abstract: The present invention relates to a derivative bacterial strain of an avirulent, non-pathogenic Clostridium ghonii that is capable of arresting the growth of, regressing or destroying one or more solid tumors. The present invention further relates to a composition comprising the derivative bacterial strain for targeted lysis of solid tumors. The present invention further relates to methods of producing derivative strains of C. ghonii by serial culturing in tumor bearing animals.

公开(公告)号：US20250101525A1

公开(公告)日：2025-03-27

申请号：US18730665

申请日：2023-01-23

Applicant: Griffith University

Inventor： Chamindie PUNYADEERA ,  Chameera WEERAMANGE

IPC: C12Q1/6886 ,  C12Q1/48

Abstract: Disclosed herein are biomarkers of cancer. More particularly, the present disclosure relates to miRNA biomarkers and their use in methods, compositions, apparatuses, devices and kits for determining an indicator that is useful for assessing a likelihood that oropharyngeal cancer is present or absent in a human subject, or for assessing a likelihood of a human subject with OPC having a poor survival prognosis or good survival prognosis.

公开(公告)号：US20240366936A1

公开(公告)日：2024-11-07

申请号：US18686330

申请日：2022-08-22

Applicant: Griffith University

Inventor： Adrian McCormack ,  Claudio Pizzolato ,  Sam Canning ,  Kyle Mulholland

IPC: A61N1/36 ,  A61N1/04

Abstract: The present invention relates to an applicator for applying functional electrical stimulation (FES) to rehabilitate a person. The applicator includes a surround for surrounding a portion of the person. One or more electrodes are locating within the surround. The electrodes may be borne by the surround, when attaching the surround to the portion, to greatly reduce set-up time.

公开(公告)号：US20240239846A1

公开(公告)日：2024-07-18

申请号：US18560354

申请日：2022-05-16

Applicant: THE UNIVERSITY OF ADELAIDE ,  GRIFFITH UNIVERSITY

Inventor： Michael Paul JENNINGS ,  Christopher DAY ,  Adrienne Webster PATON ,  James Cleland PATON ,  Lucy SHEWELL

IPC: C07K14/245 ,  G01N33/574

CPC classification number: C07K14/245 ,  G01N33/57415 ,  G01N33/57488 ,  G01N2333/245 ,  G01N2400/10 ,  G01N2800/52

Abstract: The present disclosure relates to compositions, kits and methods for preparing and/or analysing biological samples from a subject. These compositions, kits and methods may be useful in applications, such as diagnosing cancer and/or or determining a prognosis therefor.