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    COMBINATION DRUG THERAPY REDUCES PARP-1 RELATED DNA REPAIR AND INCREASES THE EFFICACY OF GENOTOXIC AGENTS
    41.
    发明申请
    COMBINATION DRUG THERAPY REDUCES PARP-1 RELATED DNA REPAIR AND INCREASES THE EFFICACY OF GENOTOXIC AGENTS 审中-公开

    公开(公告)号：US20190350912A1

    公开(公告)日：2019-11-21

    申请号：US16339042

    申请日：2017-10-03

    Applicant: Indiana University Research and Technology Corporation

    Inventor： Jian-Ting Zhang ,  Jian-Yuan Liu

    IPC: A61K31/4439 ,  A61K31/502 ,  A61K31/454 ,  A61K31/137 ,  A61K31/5025 ,  A61K31/4184 ,  A61K31/55 ,  A61P35/00

    Abstract: Various aspects and embodiments disclosed herein relate generally to the modelling, treatment, reduction of resistance to the treatment, prevention, and/or diagnosis of diseases characterized by the formation of cancers. Embodiments include methods of treating cancer, comprising the steps of: providing a patient diagnosed with cancer with a therapeutic regime that includes at least one therapeutically effective dose of at least one agent that reduces the activity of at least one DNA damage/repair pathway. Other embodiments include methods of treating cancer, comprising the steps of: treating a patient diagnosed with cancer with a combination of therapeutic agents that includes at least one therapeutically effective anti-cancer agent and at least one compound that reduces the activity of at least one DNA damage/repair pathway. Yet other embodiments include methods of reducing resistance to a genotoxic therapeutic, comprising the steps of: treating a patient at least one therapeutically effective dose of at least one agent that reduces at least one DNA damage/repair pathway.

    Conduit identification tags
    42.
    发明授权
    Conduit identification tags 有权

    公开(公告)号：US10465823B2

    公开(公告)日：2019-11-05

    申请号：US15519154

    申请日：2015-10-21

    Applicant: Indiana University Research and Technology Corporation

    Inventor： John Finnell ,  Jeff Quinn ,  Brad Wheeler

    IPC: F16L55/00 ,  F16L11/12 ,  B65C3/02

    Abstract: An identifier for a conduit includes a first tag having a body with a first aperture formed therein for receiving the conduit and a first identifying feature, and a second tag having a body with a second aperture formed therein for receiving the conduit and a second identifying feature that matches the first identifying feature. The first tag is attached to the conduit adjacent one end, the second tag is attached to the conduit adjacent another end, and the ends are identified as ends of the same conduit by the matching first and second identifying features.

    REAL TIME TRACKING AND POSITIONING SYSTEM
    47.
    发明申请
    REAL TIME TRACKING AND POSITIONING SYSTEM 审中-公开

    公开(公告)号：US20190230478A1

    公开(公告)日：2019-07-25

    申请号：US16369928

    申请日：2019-03-29

    Applicant: Indiana University Research and Technology Corporation

    Inventor： Kylie Aine Peppler ,  Joshua A. Danish ,  Shenshen Han

    IPC: H04W4/029 ,  H04W24/08 ,  G01S13/87 ,  G01S13/72

    Abstract: A real time tracking and positioning system comprising at least four anchors, at least one actor configured to interact with the at least four anchors, and an electronic device in communication with at least one of the at least four anchors, the electronic device being configured to receive two-way ranging/distance data for each actor and calculate a real-time position of each actor based on the two-way ranging/distance data, the two-way ranging/distance data including a round-trip time of a radio frequency signal between the at least one actor and each of the at least four anchors.

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