Abstract:
An apparatus has a housing with an internal passage. When deployed, a barrier positions in an upward direction in an annular space between a sleeve and the housing and folds towards one of its sides to conform to the annular space. When debris collection is desired, operators lift the sleeve with a tool, the barrier rotates down and positions across the internal passage, and the tool releases the sleeve. In this stage, the barrier can collect debris to protect a downhole valve. In further stages, operators open the downhole valve, and flow moves the barrier, cage body, and sleeve together in upward direction. Eventually, the sleeve is biased downward again, and the barrier positions within the annular space by reversibly folding towards its opposing side. In this position, barrier points in a downward direction and folds towards its opposing side to conform to the annular space.
Abstract:
A method of injecting a substance into an eye is disclosed. A connection between a disposable tip segment and a limited reuse assembly is recognized. A temperature control device is activated to alter the temperature of a substance contained in a dispensing chamber. Dosage information is read. In response to the dosage information, a mechanical linkage interface is advanced to advance a plunger to expel the substance from the dispensing chamber. The mechanical linkage interface is retracted without substantially retracting the plunger to prevent reflux of the substance. Reuse of the disposable tip segment is prevented. The removal of the disposable tip segment from the limited reuse assembly is recognized.
Abstract:
An injection device has a dispensing chamber housing, a plunger, and a temperature control device. The dispensing chamber housing has a first part and a second part. The first part is thermally coupled to a needle. The second part is thermally coupled to the first part. The second part has an inner surface and an outer surface. The inner surface partially defines a dispensing chamber for holding a quantity of a substance. The plunger is engaged with an inner surface of the dispensing chamber housing, is capable of sliding in the dispensing chamber housing, and is fluidly sealed to the inner surface of the dispensing chamber housing. The temperature control device at least partially surrounds the dispensing chamber housing and is capable of altering a temperature of the substance in the dispensing chamber. The second part has a greater thermal coefficient than the first part.
Abstract:
An ophthalmic injection device has a dispensing chamber housing, a plunger, a needle fluidly coupled to a dispensing chamber, a temperature control device, a power source for providing power to the temperature control device, a controller for controlling the temperature control device, and a mechanical linkage mechanism. The interior surface of the dispensing chamber housing partially defines a dispensing chamber for holding a quantity of a substance. The plunger is engaged with the inner surface of the dispensing chamber housing, is capable of sliding in the dispensing chamber housing, and is fluidly sealed to the inner surface of the dispensing chamber housing. A plunger shaft is coupled to the plunger. The temperature control device can alter the temperature of the substance contained therein. The mechanical linkage mechanism has at least two pivots and at least two shafts and transfers force from a lever to the plunger.
Abstract:
A process is provided to produce an aqueous dispersion wherein the aqueous dispersion enhances the water and oil repellency of materials. The process comprises: 1) contacting at least one fluoroalkyl monomer, at least one water-dispersible polyester, water, and optionally an ethylenically unsaturated monomer to form a pre-emulsion; and 2) polymerizing the pre-emulsion in a polymerization zone in the presence of an initiator to produce the aqueous dispersion.In another embodiment, a process to produce an aqueous dispersion is provided. The process comprises: 1) contacting at least one fluoroalkyl monomer, at least one water-dispersible polyester, water, and optionally an ethylenically unsaturated monomer to form a pre-emulsion; 2) shearing the pre-emulsion to produce a mini-emulsion; and 3) polymerizing the miniemulsion in a polymerization zone to produce the aqueous dispersion.
Abstract:
An endoluminal prosthesis comprises a prosthetic trunk comprising a trunk lumen extending therethrough, a wall, and an anastomosis in the wall, wherein the prosthetic trunk has a circumference. The endoluminal prosthesis further comprises a prosthetic branch comprising a branch lumen extending therethrough. The branch lumen is in fluid communication with the trunk lumen through the anastomosis. The prosthetic branch is disposed longitudinally along and circumferentially about the prosthetic trunk.
Abstract:
The present disclosure provides embodiments of a method for characterizing microbial populations. Exemplified by methods for characterizing microbiota in vaginal samples, the methods provided herein are widely applicable to the characterization of microbial communities. Also provided are probiotic regimens and methods for selecting appropriate probiotic regimens based on the normal vaginal microbiota of a subject. Reagents and kits for detecting normal vaginal microbiota and diagnosing pathogenic microorganisms in the vagina are also provided.
Abstract:
The invention relates to the isolation of the fibrinogen binding protein gene from Staphylococcus aureus and to the use of the fibrinogen binding protein and antibodies generated against it for wound healing, blocking adherence to indwelling medical devices, immunization or diagnosis of infection.
Abstract:
The isolation of the S. aureus fibrinogen binding protein gene is described and a minimal fibrinogen binding protein is identified. The protein finds use as a vaccine or a pharmaceutical composition for application to prevent infection, promotion of wound healing, blocking adherence to indwelling medical devices, or diagnosis of infection.
Abstract:
The isolation of the S. aureus fibrinogen binding protein gene is described and a minimal fibrinogen binding protein is identified. The protein finds use as a vaccine or a pharmaceutical composition for application to prevent infection, promotion of wound healing, blocking adherence to indwelling medical devices, or diagnosis of infection.