PHARMACEUTICAL COMBINATIONS
    42.
    发明申请
    PHARMACEUTICAL COMBINATIONS 有权
    药物组合

    公开(公告)号:US20100179145A1

    公开(公告)日:2010-07-15

    申请号:US12445180

    申请日:2007-10-12

    CPC classification number: A61K31/403 A61K31/4035 A61K45/06 A61K2300/00

    Abstract: The invention provides combinations comprising (or consisting essentially of) one or more ancillary compound(s) and a compound of the formula (I): or salts, tautomers, solvates and N-oxides thereof; wherein R1 is hydroxy or hydrogen; R2 is hydroxy; methoxy or hydrogen; provided that at least one of R1 and R2 is hydroxy; R3 is selected from hydrogen; halogen; cyano; optionally substituted C1-5 hydrocarbyl and optionally substituted C1-5 hydrocarbyloxy; R4 is selected from hydrogen; a group —(O)n—R7 where n is 0 or 1 and R7 is an optionally substituted acyclic C1-5 hydrocarbyl group or a monocyclic carbocyclic or heterocyclic group having 3 to 7 ring members; halogen; cyano; hydroxy; amino; and optionally substituted mono- or di-C1-5 hydrocarbyl-amino; or R3 and R4 together form a monocyclic carbocyclic or heterocyclic ring of 5 to 7 ring members; and NR5R6 forms an optionally substituted bicyclic heterocyclic group having 8 to 12 ring members of which up to 5 ring members are heteroatoms selected from oxygen, nitrogen and sulphur. The combinations have activity as Hsp90 and/or glycogen synthase kinase-3 and/or cyclin dependent kinase inhibitors.

    Abstract translation: 本发明提供包含(或基本上由)一种或多种辅助化合物和式(I)化合物或其盐,互变异构体,溶剂合物和N-氧化物的组合; 其中R1是羟基或氢; R2是羟基; 甲氧基或氢; 条件是R 1和R 2中的至少一个是羟基; R3选自氢; 卤素; 氰基; 任选取代的C 1-5烃基和任选取代的C 1-5烃氧基; R4选自氢; 其中n为0或1,R7为任选取代的无环C 1-5烃基或具有3至7个环成员的单环碳环或杂环基团 - (O)n -R 7基团; 卤素; 氰基; 羟基; 氨基; 和任选取代的单或二-C 1-5烃基 - 氨基; 或R 3和R 4一起形成5至7个环成员的单环碳环或杂环; 并且NR 5 R 6形成具有8至12个环成员的任选取代的双环杂环基,其中多达5个环成员是选自氧,氮和硫的杂原子。 这些组合具有作为Hsp90和/或糖原合酶激酶-3和/或细胞周期蛋白依赖性激酶抑制剂的活性。

    COMBINATIONS OF PYRAZOLE DERIVATIVES FOR THE INHIBITION OF CDKS AND GSK'S
    43.
    发明申请
    COMBINATIONS OF PYRAZOLE DERIVATIVES FOR THE INHIBITION OF CDKS AND GSK'S 审中-公开
    用于抑制CDKS和GSK'S的吡唑衍生物的组合

    公开(公告)号:US20100021420A1

    公开(公告)日:2010-01-28

    申请号:US12373827

    申请日:2007-07-13

    CPC classification number: A61K31/454 A61K45/06 A61K2300/00

    Abstract: A combination comprising (a) a compound of formula (0): or salts or tautomers or N-oxides or solvates thereof; wherein X is R1-A-NR4— or a 5- or 6-membered carbocyclic or heterocyclic ring; A is a bond, SO2, C═O, NR9(C═O) or 0(C═O) wherein R9 is hydrogen or C1-4 hydrocarbyl optionally substituted by hydroxy or C1-4 alkoxy; Y is a bond or an alkylene chain of 1 to 3 carbon atoms; R1 is hydrogen; a carbocyclic or heterocyclic group having from 3 to 12 ring members; or an optionally substituted C1-8 hydrocarbyl group wherein 1 or 2 of the carbon atoms of the hydrocarbyl group may optionally be replaced by an atom or group selected from O, S, NH, SO, SO2; R2 is hydrogen; halogen; C1-4 alkoxy; or a C1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C1-4 alkoxy; R3 is selected from hydrogen and carbocyclic and heterocyclic groups having from 3 to 12 ring members; and R4 is hydrogen or a C1-4 hydrocarbyl group optionally substituted by halogen, hydroxyl or C1-4 alkoxy; and (b) a compound of formula (I′″) or salts, tautomers, solvates and N-oxides thereof: wherein R1 is 2,6-dichlorophenyl; R2a and R2b are both hydrogen; and R3 is a group: formula (A) where R4 is C1-4 alkyl.

    Abstract translation: 包含(a)式(O)化合物或其盐或互变异构体或其N-氧化物或溶剂合物的组合; 其中X为R 1 -A-NR 4 - 或5或6元碳环或杂环; A为键,SO 2,C-O,NR 9(C-O)或O(C-O),其中R 9为氢或任选被羟基或C 1-4烷氧基取代的C 1-4烃基; Y是1〜3个碳原子的键或亚烷基链; R1是氢; 具有3至12个环成员的碳环或杂环基; 或任选取代的C 1-8烃基,其中烃基中的1或2个碳原子可以任选地被选自O,S,NH,SO,SO 2的原子或基团取代; R2是氢; 卤素; C 1-4烷氧基; 或任选被卤素,羟基或C 1-4烷氧基取代的C 1-4烃基; R 3选自具有3至12个环成员的氢和碳环和杂环基; R4是氢或任选被卤素,羟基或C 1-4烷氧基取代的C 1-4烃基; 和(b)式(I“)的化合物或其盐,互变异构体,溶剂化物和N-氧化物:其中R1是2,6-二氯苯基; R2a和R2b都是氢; 并且R 3是下式:其中R 4是C 1-4烷基的式(A)。

    Intuitive labeling schemes for structured cabling solutions
    44.
    发明授权
    Intuitive labeling schemes for structured cabling solutions 有权
    结构化布线解决方案的直观标签方案

    公开(公告)号:US07585191B2

    公开(公告)日:2009-09-08

    申请号:US11779827

    申请日:2007-07-18

    CPC classification number: H05K7/186 H04Q1/021 H04Q1/062 H04Q1/064

    Abstract: Structured cabling solutions may include techniques and systems usable to route, organize, and otherwise manage wires, optical fibers, and other cables. Structured cabling solutions may include one or more chassis coupled to and movable relative to a frame to provide access to signal connectors on the chassis. Structured cabling solutions may also include labeling schemes that identify patch connectors that correspond to outlets in a structured cabling installation.

    Abstract translation: 结构化布线解决方案可以包括可用于路由,组织和以其他方式管理电线,光纤和其它电缆的技术和系统。 结构化布线解决方案可以包括耦合到框架并相对于框架可移动的一个或多个底板,以提供对底盘上的信号连接器的访问。 结构化布线解决方案还可以包括识别对应于结构化布线设备中的插座的贴片连接器的标签方案。

    Structured Cabling Solutions
    45.
    发明申请
    Structured Cabling Solutions 有权
    结构化布线解决方案

    公开(公告)号:US20080298762A1

    公开(公告)日:2008-12-04

    申请号:US11779824

    申请日:2007-07-18

    CPC classification number: H05K7/186 H04Q1/021 H04Q1/062 H04Q1/064

    Abstract: Structured cabling solutions may include techniques and systems usable to route, organize, and otherwise manager wires, optical fibers, and other cables. Structured cabling solutions may include one or more chassis coupled to and movable relative to a frame to provide access to signal connectors on the chassis. Structured cabling solutions may also include labeling schemes that identify patch connectors that correspond to outlets in a structured cabling installation.

    Abstract translation: 结构化布线解决方案可以包括可用于路由,组织和以其他方式管理电线,光纤和其他电缆的技术和系统。 结构化布线解决方案可以包括耦合到框架并相对于框架可移动的一个或多个底板,以提供对底盘上的信号连接器的访问。 结构化布线解决方案还可以包括识别对应于结构化布线设备中的插座的贴片连接器的标签方案。

    SYSTEMS AND METHODS FOR MAXIMIZING THE OUTPUT OF A VEHICLE ALTERNATOR
    46.
    发明申请
    SYSTEMS AND METHODS FOR MAXIMIZING THE OUTPUT OF A VEHICLE ALTERNATOR 审中-公开
    用于最大化车辆输出的系统和方法

    公开(公告)号:US20070268003A1

    公开(公告)日:2007-11-22

    申请号:US11751500

    申请日:2007-05-21

    CPC classification number: H02H7/06 H02P9/006 H02P29/60

    Abstract: Systems and method for mixing the output of a vehicle alternator throughout any operating temperature range include a first temperature sensor for measuring a first temperature and a second temperature sensor for measuring a first temperature. A first temperature module compares the first temperature with a first temperature reference to determine a first temperature error, and to calculate a first duty cycle reference based on the first temperature error. A second temperature module compares the second temperature with a second temperature reference based on the second temperature error, and to calculate a second duty cycle reference based on the second temperature error. A duty cycle selection module selects the lesser of the first duty cycle reference or the second duty cycle reference as a maximum system duty cycle. A duty cycle control module regulates a field current of the vehicle alternator based on the maximum system duty cycle.

    Abstract translation: 用于在任何工作温度范围内混合车辆交流发电机的输出的系统和方法包括用于测量第一温度的第一温度传感器和用于测量第一温度的第二温度传感器。 第一温度模块将第一温度与第一温度参考值进行比较以确定第一温度误差,并且基于第一温度误差来计算第一占空比参考。 第二温度模块基于第二温度误差将第二温度与第二温度参考值进行比较,并且基于第二温度误差来计算第二占空比参考。 占空比选择模块选择第一占空比参考值或第二占空比参考值中较小的一个作为最大系统占空比。 占空比控制模块基于最大系统占空比来调节车辆交流发电机的励磁电流。

    End-to-end data integrity protection for PCI-Express based input/output adapter
    48.
    发明申请
    End-to-end data integrity protection for PCI-Express based input/output adapter 失效
    基于PCI-Express的输入/输出适配器的端到端数据完整性保护

    公开(公告)号:US20060090116A1

    公开(公告)日:2006-04-27

    申请号:US10960607

    申请日:2004-10-07

    CPC classification number: H03M13/09 H04L1/004 H04L1/0061 H04L2001/0094

    Abstract: Method, system and computer program product for protecting the integrity of data transferred between an input/output bus of a data processing system and an external network. A method for protecting the integrity of data transferred between an input/output bus and a network includes generating a Cyclic Redundancy Check (CRC) value on an interface between the input/output bus and an adapter for data being transferred from the input/output bus to the network, and checking a CRC value on the interface between the input/output bus and the adapter for data being transferred from the network to the input/output bus. By adding a CRC generator and a CRC checker on the interface between the input/output bus and the adapter, end-to-end data integrity protection is provided for data transferred between the input/output bus and the network.

    Abstract translation: 用于保护在数据处理系统的输入/输出总线与外部网络之间传送的数据完整性的方法,系统和计算机程序产品。 一种用于保护在输入/输出总线和网络之间传输的数据的完整性的方法包括在输入/输出总线与适配器之间的接口上产生循环冗余校验(CRC)值,以便从输入/输出总线 并且检查输入/输出总线和适配器之间的接口上的CRC值,以便数据从网络传输到输入/输出总线。 通过在输入/输出总线和适配器之间的接口上添加CRC生成器和CRC校验器,为输入/输出总线和网络之间传输的数据提供端到端的数据完整性保护。

    Apparatus for filtering ultrasonic noise within a fluid flow system

    公开(公告)号:US20060006022A1

    公开(公告)日:2006-01-12

    申请号:US11179158

    申请日:2005-07-12

    CPC classification number: F16L55/0331

    Abstract: A method is employed to attenuate ultrasonic noise propagating in a flow stream of a fluid flow system. In particular, the method attenuates the noise propagating between a noise source and a reference point in the flow stream (wherein the reference point and the noise source are positioned in the flow stream in direct acoustic line of sight relation). The method includes positioning an absorbent element in the flow stream between the noise source and the reference point. Then, the ultrasonic noise is directed past vicinity of the absorbent element such that indirect ultrasonic noise is absorbed by the absorbent element. Preferably, the method also includes deflecting the ultrasonic noise to convert direct noise to indirect noise prior to directing the ultrasonic noise past the vicinity of the absorbent material in the flow stream. Such a method may be employed to attenuate ultrasonic noise by up to about 20 dB to 45 dB.

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