公开(公告)号：US4988698A

公开(公告)日：1991-01-29

申请号：US434256

申请日：1989-11-13

申请人： Masayuki Kato ,  Shigetaka Nishino ,  Kiyotaka Ito ,  Hisashi Takasugi

发明人： Masayuki Kato ,  Shigetaka Nishino ,  Kiyotaka Ito ,  Hisashi Takasugi

IPC分类号： A61K31/495 ,  A61P9/04 ,  A61P9/06 ,  A61P9/12 ,  C07D215/38 ,  C07D215/40 ,  C07D215/48 ,  C07D401/12 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

CPC分类号： C07D401/12 ,  C07D215/38 ,  C07D215/48 ,  C07D417/12 ,  C07D417/14 ,  C07D471/04

摘要： This invention relates to new 2(1H)-quinolinone compounds having the formula: ##STR1## wherein R.sup.1 is a imidazopyridyl, thiazolyl, indolyl, dihydroindolyl, imidazolyl, benzimidazolyl, quinolyl, isoquinolyl, quinazolinyl, dihydroisoquinolyl, tetrahydroimidazopyridyl or tetrahydroquinolyl, each of which may be substituted with substituents(s) selected from the group consisting of lower alkyl, halogen, lower alkoxy, lower alkylthio, ar(lower)alkoxy, cyano, nitro, amino, lower alkylamino, acylamino, hydroxy and oxo,R.sup.2 is hydrogen, lower alkyl or halogen,A is a single bond or a group of the formula selected from the group consisting of: ##STR2## and --X--CO--, in which X is a single bond or lower alkylene andX.sup.1 is lower alkylene, and a heavy solid line means a single or a double bond,and its pharmaceutically acceptable salt. Said compounds are used in the therapeutic treatment of heart diseases and hypertension in human beings and other animals.

公开(公告)号：US4822805A

公开(公告)日：1989-04-18

申请号：US084862

申请日：1987-08-13

申请人： Hisashi Takasugi ,  Kiyotaka Ito ,  Shigetaka Nishino ,  Akito Tanaka ,  Takao Takaya

发明人： Hisashi Takasugi ,  Kiyotaka Ito ,  Shigetaka Nishino ,  Akito Tanaka ,  Takao Takaya

IPC分类号： C07D401/04 ,  A61K31/44

CPC分类号： C07D401/04

摘要： A compound of the formula: ##STR1## wherein R.sup.1 is pyridyl,R.sup.2 is hydrogen, lower alkyl or hydroxy (lower) alkyl,R.sup.3 is hydrogen, hydroxy or lower alkyl, andR.sup.4 is aryl optionally substituted with substituent(s) selected from the group consisting of lower alkylthio, lower alkylsulfinyl, lower alkylsulfonyl, nitro, amino, substituted amino, hydroxy, lower alkoxy, lower alkynyloxy, substituted or unsubstituted ar(lower)alkoxy, halogen, halo(lower)alkyl, carboxy and esterified carboxy,and a pharmaceutically acceptable salt thereof, processes for the preparation thereof and pharmaceutical composition comprising the same.

公开(公告)号：US4612376A

公开(公告)日：1986-09-16

申请号：US588902

申请日：1984-03-12

申请人： Takao Takaya ,  Masayoshi Murata ,  Kiyotaka Ito

发明人： Takao Takaya ,  Masayoshi Murata ,  Kiyotaka Ito

IPC分类号： C07D239/47 ,  A61K31/513 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D239/46 ,  C07D239/02 ,  A61K31/495

CPC分类号： C07D239/47

摘要： New pyrimidine derivatives of the formula: ##STR1## wherein Z is a group selected from ##STR2## in which R.sup.1 and R.sup.2 are each hydrogen, alkenyl, ar(lower)alkyl or lower alkyl optionally substituted with epoxy, hydroxy, amino and/or lower alkylamino and R.sup.5 is lower alkyl,R.sup.3 is hydrogen, aryl optionally substituted with lower alkyl, lower alkoxy and/or halogen, or pyridyl optionally substituted with lower alkyl,R.sup.4 is hydrogen, lower alkyl or phenyl optionally substituted with lower alkoxy, andY is .dbd.O, .dbd.S or .dbd.N--R.sup.6, in which R.sup.6 is lower alkyl; cyclo(lower)alkyl; ar(lower)alkyl optionally substituted with lower alkoxy; N-containing unsaturated heterocyclic group optionally substituted with lower alkyl; or aryl optionally substituted with hydroxy, lower alkyl, halogen or lower alkoxy, in which lower alkoxy substituent may be substituted with epoxy, hydroxy, amino and/or lower alkylamino,provided that Y is .dbd.N--R.sup.6 when R.sup.3 and R.sup.4 are each hydrogen, and Y is .dbd.S or .dbd.N--R.sup.6 when R.sup.1 and R.sup.2 are each hydrogen or lower alkyl and R.sup.3 is phenyl, and pharmaceutically acceptable salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same.These derivatives and salts thereof are useful as cardiotonic, antihypertensive agent, cerebrovascular vasodilator and anti-platelet agent.

摘要翻译： 其中Z是选自其中R 1和R 2各自为氢的链烯基，芳基（低级）烷基或任选被环氧基，羟基，氨基和/或烷基取代的低级烷基的基团的新的嘧啶衍生物 低级烷基氨基，R5为低级烷基，R3为氢，任选被低级烷基，低级烷氧基和/或卤素取代的芳基，或任选被低级烷基取代的吡啶基，R4为氢，低级烷基或任选被低级烷氧基取代的苯基，Y 是= O，= S或= N-R6，其中R6是低级烷基; 环（低级）烷基; 任选被低级烷氧基取代的芳（低级）烷基; 任选被低级烷基取代的含N的不饱和杂环基; 或任选被羟基，低级烷基，卤素或低级烷氧基取代的芳基，其中低级烷氧基取代基可被环氧基，羟基，氨基和/或低级烷基氨基取代，条件是当R 3和R 4各自为氢时，Y为= ，当R 1和R 2各自为氢或低级烷基且R 3为苯基时，Y为= S或= N-R 6及其药学上可接受的盐，及其制备方法和包含其的药物组合物。 这些衍生物及其盐可用作强心剂，抗高血压剂，脑血管扩张剂和抗血小板剂。

公开(公告)号：US08179760B2

公开(公告)日：2012-05-15

申请号：US12573200

申请日：2009-10-05

申请人： Kiyotaka Ito ,  Yasumori Hino ,  Harumitsu Miyashita ,  Isao Kobayashi

发明人： Kiyotaka Ito ,  Yasumori Hino ,  Harumitsu Miyashita ,  Isao Kobayashi

IPC分类号： G11B5/09 ,  G11B20/10 ,  G11B27/36 ,  G11B7/0045

CPC分类号： G11B7/0037 ,  G11B7/005 ,  G11B7/24038 ,  G11B20/10009 ,  G11B20/10055 ,  G11B20/10296 ,  G11B20/1816 ,  G11B2007/0013

摘要： A reproduction signal evaluation method according to the present invention relates to adjustment of an edge portion between a shortest mark and a shortest space in a data sequence including marks and spaces in combination that is recordable on an information recording medium. In a pattern including a shortest mark and a shortest space adjacent before or after the shortest mark, a shift amount of an edge of the shortest mark is obtained from a differential metric calculated regarding one of a first pattern in which a space adjacent to the shortest mark and not adjacent to the shortest space is longer than the shortest space; and a second pattern in which a mark adjacent to the shortest space and not adjacent to the shortest mark is longer than the shortest mark.

摘要翻译： 根据本发明的再现信号评估方法涉及在包括可记录在信息记录介质上的组合的数据序列中的最短标记和最短空间之间的边缘部分的调整。 在包括最短标记和在最短标记之前或之后相邻的最短空格的图案中，从针对与最短标记相邻的空格的第一图案之一计算的差分度量获得最短标记的边缘的偏移量 标记与不相邻的最短空间长于最短空间; 以及第二图案，其中与最短空间相邻并且不与最短标记相邻的标记比最短标记长。

公开(公告)号：US20120057448A1

公开(公告)日：2012-03-08

申请号：US13318722

申请日：2011-03-07

申请人： Kiyotaka Ito ,  Yasumori Hino ,  Naoyasu Miyagawa ,  Atsushi Nakamura

发明人： Kiyotaka Ito ,  Yasumori Hino ,  Naoyasu Miyagawa ,  Atsushi Nakamura

IPC分类号： G11B7/125 ,  G11B7/139

CPC分类号： G11B7/00456 ,  G11B7/0062

摘要： A writing method according to the present invention is a method for writing a data sequence as a combination of marks and spaces on an information recording medium by condensing a laser beam through a lens. The writing method is characterized in that a cooling pulse for recording a mark that is even shorter than the limit of optical resolution of the laser beam and another cooling pulse for recording a mark that is still longer than the limit of the optical resolution of the laser beam are applied under mutually different conditions.

摘要翻译： 根据本发明的写入方法是通过将激光束通过透镜聚焦来将数据序列作为标记和间隔的组合写入信息记录介质的方法。 写入方法的特征在于，用于记录比激光束的光学分辨率的极限更短的标记的冷却脉冲和用于记录比激光的光学分辨率的极限更长的标记的另一个冷却脉冲 光束在相互不同的条件下施加。

公开(公告)号：US20050213285A1

公开(公告)日：2005-09-29

申请号：US11084101

申请日：2005-03-21

申请人： Fumio Tatezono ,  Seiji Omura ,  Kiyotaka Ito ,  Tsuyoshi Komatsu ,  Makoto Hashimoto

发明人： Fumio Tatezono ,  Seiji Omura ,  Kiyotaka Ito ,  Tsuyoshi Komatsu ,  Makoto Hashimoto

IPC分类号： H01G9/00 ,  H01G9/008 ,  H01G9/08 ,  H01G9/10 ,  H01G11/00 ,  H01G11/02 ,  H01G11/66 ,  H01G11/68 ,  H01G11/70 ,  H01G11/78 ,  H01G11/80 ,  H01G11/82 ,  H01G11/84 ,  H01M2/08 ,  H01M2/30 ,  H01M10/05 ,  H01M10/0585 ,  H01M10/30 ,  H01M10/34

CPC分类号： H01M10/345 ,  H01G9/016 ,  H01G9/10 ,  H01G9/155 ,  H01G11/68 ,  H01G11/70 ,  H01G11/80 ,  H01M2/08 ,  H01M10/38 ,  Y02E60/13

摘要： An electric double layer capacitor is provided with a cell, in which a pair of polarizable electrodes, which are impregnated with an electrolyte, are disposed in opposition on either side of a separator; wherein the polarizable electrodes are provided with collector electrodes, and a peripheral portion of the cell is sealed by a sealing member composed of synthetic resin. The collector electrodes are composed of an alloy made of crystal grains of differing components and the collector electrodes pass through the sealing member while in intimate contact with the sealing member, extending to the outside of the sealing member. A metal plated layer made of crystal grains of a single component is formed on those locations on the collector electrodes that pass through the sealing member.

摘要翻译： 电双层电容器设置有电池，其中浸渍有电解质的一对可极化电极相对于隔板的任一侧设置; 其中可极化电极设置有集电极，并且电池的周边部分由由合成树脂构成的密封构件密封。 集电极由不同成分的晶粒构成的合金构成，集电体通过密封部件与密封部件紧密接触而延伸到密封部件的外部。 在通过密封构件的集电极上的那些位置上形成由单一成分的晶粒构成的金属镀层。

公开(公告)号：US5173493A

公开(公告)日：1992-12-22

申请号：US495119

申请日：1990-03-19

申请人： Masayuki Kato ,  Kiyotaka Ito ,  Hisashi Takasugi

发明人： Masayuki Kato ,  Kiyotaka Ito ,  Hisashi Takasugi

IPC分类号： A61K31/435 ,  A61K31/437 ,  A61P1/00 ,  A61P1/04 ,  A61P1/08 ,  A61P3/04 ,  A61P9/00 ,  A61P9/04 ,  A61P9/06 ,  A61P9/08 ,  A61P9/10 ,  A61P11/02 ,  A61P25/04 ,  A61P25/18 ,  A61P25/20 ,  A61P25/22 ,  A61P25/24 ,  A61P25/26 ,  A61P25/28 ,  A61P43/00 ,  C07D471/04

CPC分类号： C07D471/04 ,  Y02P20/55

摘要： The invention relates to compounds for treatment of nausea and vomiting, of the formula ##STR1## wherein R.sup.1 is hydrogen, lower alkyl, lower alkenyl or N,N-di(lower)alkylaminomethyl,R.sup.2 is hydrogen, lower alkyl or halogen,R.sup.3 is imidazolyl or pyridyl, each of which may have substituent(s) selected from lower alkyl and imino-protective group, andR.sup.4 is hydrogen, lower alkyl, lower alkenyl or hydroxy(lower)alkyl and R.sup.5 is hydrogen, hydroxy or lower alkanoyloxy, orR.sup.4 and R.sup.5 are linked together to form an additional bond,or a pharmaceutically acceptable salt thereof.

摘要翻译： 本发明涉及用于治疗恶心和呕吐的化合物，其中R1是氢，低级烷基，低级烯基或N，N-二（低级）烷基氨基甲基，R2是氢，低级烷基或卤素，R3是 咪唑基或吡啶基，其各自可以具有选自低级烷基和亚氨基保护基的取代基，并且R4是氢，低级烷基，低级烯基或羟基（低级）烷基，R5是氢，羟基或低级烷酰氧基，或 R4和R5连接在一起形成另外的键，或其药学上可接受的盐。

公开(公告)号：US4824851A

公开(公告)日：1989-04-25

申请号：US173584

申请日：1988-03-25

申请人： Takao Takaya ,  Masayoshi Murata ,  Kiyotaka Ito

发明人： Takao Takaya ,  Masayoshi Murata ,  Kiyotaka Ito

IPC分类号： C07D239/47 ,  A61K31/513 ,  A61P7/02 ,  A61P9/04 ,  A61P9/12 ,  C07D239/46 ,  A61K31/495 ,  C07D239/24

CPC分类号： C07D239/47

摘要： New pyrimidine derivatives of the formula: ##STR1## wherein Z is a group selected from ##STR2## in which R.sup.1 and R.sup.2 are each hydrogen, alkenyl, ar(lower)alkyl or lower alkyl optionally substituted with epoxy, hydroxy, amino and/or lower alkylamino and R.sup.5 is lower alkyl,R.sup.3 is hydrogen, aryl optionally substituted with lower alkyl, lower alkoxy and/or halogen, or pyridyl optionally substituted with lower alkyl,R.sup.4 is hydrogen, lower alkyl or phenyl optionally substituted with lower alkoxy, andY is.dbd.O, .dbd.S or .dbd.N--R.sup.6, in which R.sup.6 is lower alkyl; cyclo(lower)alkyl; ar(lower)alkyl optionally substituted with lower alkoxy; N-containing unsaturated heterocyclic group optionally substituted with lower alkyl; or aryl optionally substituted with hydroxy, lower alkyl, halogen or lower alkoxy, in which lower alkoxy substituent may be substituted with epoxy, hydroxy, amino and/or lower alkylamino,provided that Y is.dbd.N--R.sup.6 when R.sup.3 and R.sup.4 are each hydrogen, and Y is.dbd.S or.dbd.N--R.sup.6 when R.sup.1 and R.sup.2 are each hydrogen or lower alkyl and R.sup.3 is phenyl, and pharmaceutically acceptable salts thereof, and processes for preparation thereof and pharmaceutical composition comprising the same.These derivatives and salts thereof are useful as cardiotonic, antihypertensive agent, cerebrovascular vasodilator and anti-platelet agent.