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公开(公告)号:US20220339170A1
公开(公告)日:2022-10-27
申请号:US17224368
申请日:2021-04-07
Applicant: KOREA BASIC SCIENCE INSTITUTE , University of Louisville Research Foundation, Inc. , Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V.
Inventor: Kyoung-Seok RYU , Myeongkyu KIM , Christian GRIESINGER , Donghan LEE
IPC: A61K31/655 , A61K31/192 , A61K31/4245 , A61K31/426 , A61K31/4196 , A61K31/44 , A61K31/506 , A61K31/404 , A61K31/343 , A61K31/4184 , A61K31/55 , A61K31/4709 , A61K31/4422 , A61K31/4725 , A61K38/12
Abstract: Method of increasing platelet counts in a subject, the method comprising administering to the subject a therapeutically effective amount of a compound that inhibits Biliverdin reductase B (BLVRB) activity by blocking a binding site of BLVRB or a pharmaceutically acceptable salt thereof, wherein the compound does not contain xanthene or acridine moiety is provided.
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公开(公告)号:US20220175976A1
公开(公告)日:2022-06-09
申请号:US17262503
申请日:2019-07-24
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor: Ki-Yuk CHANG , Chan-Woo KIM , Kwan-Soo HONG , Hyun-Seung LEE , Hyun-Min KIM
IPC: A61K51/10
Abstract: The present invention relates to a neovascular-targeting contrast medium composition and a method for preparing same. The neovascular-targeting contrast medium composition according to the present invention exhibits high binding force to neovascularization-associated αvβ3 integrin, excellent tissue permeability and biostability, enables simple measurement in vitro, in vivo, or ex vivo, and thus is effective in the detection of neovascularization and in diagnosing diseases associated therewith, and therefore may be usefully employed in the relevant industries.
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公开(公告)号:US11300454B2
公开(公告)日:2022-04-12
申请号:US15733806
申请日:2019-05-22
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor: Dong Uk Kim , Ki Soo Chang
Abstract: Disclosed are a multi-mode thermal imaging device and an operation method thereof. According to an embodiment of the present invention, in a first mode, a first sample is scanned with an optical signal from a light source, signals reflected from the first sample by the scanning are detected separately for each wavelength, a reflectance change spectrum according to the wavelength is derived on the basis of the signals detected separately for each wavelength, a wavelength is selected on the basis of the derived reflectance change spectrum, and a thermal image of the first sample is obtained, through a filter, by detecting an optical signal limited to the selected wavelength from among the signals reflected from the first sample. In a second mode, thermal radiation of a second sample is detected to obtain a thermal image of the second sample.
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公开(公告)号:US20210396767A1
公开(公告)日:2021-12-23
申请号:US17287934
申请日:2019-10-25
Applicant: GACHON UNIVERSITY OF INDUSTRY-ACADEMIC COOPERATION FOUNDATION , KOREA BASIC SCIENCE INSTITUTE
Inventor: Bonghee LEE , Bayarsaikhan DELGER , Jaesuk LEE
IPC: G01N33/68
Abstract: The present invention relates to a method for predicting the prognosis of ischemic disease using an AGE-RAGE-based biomarker. The biomarker can be used as an indicator factor of the clinical severity of ischemic disease, can maximize the efficiency of stem-cell treatment by determination of the optimal timing of the stem-cell treatment on the basis of changes in the biomarker according to the severity of ischemic disease, and can also be used as a useful indicator factor for verifying efficacy after the stem-cell treatment.
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45.
公开(公告)号:US20210311125A1
公开(公告)日:2021-10-07
申请号:US17352799
申请日:2021-06-21
Applicant: KOREA BASIC SCIENCE INSTITUTE , THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIVERSITY (IAC) , KOREA RESEARCH INSTITUTE OF STANDARDS AND SCIENCE
Inventor: Joonhee MOON , Cheolho JEON , Jouhahn LEE , Kyoung Soon CHOI , Chunjoong KIM , Jae Yong SONG , Hosun SHIN , Sun Hwa PARK
Abstract: A battery cell measurement module includes a lower housing having a connection part and a fixing part connected to the lower housing. An upper portion of the fixing part has a battery cell accommodation space accommodating a battery cell. The fixing part includes a connection hole that is in communication with the battery cell accommodation space and has the connection part arranged therein. Module includes a height control part that extends from the battery cell accommodation space to the connection part via the connection hole. Module includes an upper housing detachably attached to the lower housing, arranged to surround the fixing part and the height control part, and provided with a transparent window. The battery cell has an opening in an upper surface of the battery cell and is accommodated in the battery cell accommodation space such that the opening is located at a position vertically overlapping the transparent window.
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46.
公开(公告)号:US11061170B2
公开(公告)日:2021-07-13
申请号:US16164925
申请日:2018-10-19
Applicant: Korea Basic Science Institute
Inventor: Ki Soo Chang , Kye Sung Lee , Dong Uk Kim , Jung Dae Kim
Abstract: Disclosed is a broadband objective lens and a method of manufacturing the objective lens. The objective lens includes a plurality of lenses, and each of the lenses includes a coating layer on which a nanopattern is formed.
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公开(公告)号:US20210199377A1
公开(公告)日:2021-07-01
申请号:US17126036
申请日:2020-12-18
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor: Yeon Suk Choi , Myung Su Kim
Abstract: Disclosed are a helium gas liquefier and a method for liquefying a helium gas. The disclosed helium gas liquefier includes: a first cooling part including a first cooling column; a first cold head installed on the first cooling column, and a first cylinder in which the first cooling column and the first cold head are built; a second cooling part including a second cooling column, a second cold head installed on the second cooling column, and a second cylinder in which the second cooling column and the second cold head are built; and a liquid helium storage disposed under the second cooling part.
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公开(公告)号:US20210090873A1
公开(公告)日:2021-03-25
申请号:US16937862
申请日:2020-07-24
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor: Ji Young Baek , Myoung Choul Choi , Chang Min Choi , Sang Ju Lee , Boo Ki Min
Abstract: A mass spectrometry system includes a sample holder provided in a vacuum changer and on which a sample is disposed, an irradiator configured to perform sputtering or ionization on the sample, an analyzer configured to analyze an ionized sample generated from the sample by the irradiator, and a controller configured to control the irradiator or the analyzer and perform a first process and a second process. The first process is to determine position information of materials in the sample by irradiating a laser or ion beam to a portion of the sample, and the second process is to irradiate a laser or ion beam of a first output value to another portion of the sample in a section in which the materials in the sample change and irradiate a laser or ion beam of a second output value in other sections.
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公开(公告)号:US10935470B2
公开(公告)日:2021-03-02
申请号:US16671099
申请日:2019-10-31
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor: Hwan Hur , Hee-Seok Kweon , Kye-Sung Lee
Abstract: Provided is an ultra microtome device including: a specimen restraint part having a sample holder formed on one side in a length direction, wherein a specimen is mounted on the sample holder; a power part for providing power for implementing a motion of the specimen restraint part; an up and down motion implementing part including a first cam rotated by a force transmitted from the power part and a first shaft for implementing an up and down motion of the specimen restraint part in response to the rotation of the first cam; and a forward and backward motion implementing part including a second cam rotated by the force transmitted from the power part and a second shaft for implementing a forward and backward motion of the specimen restraint part in response to the rotation of the second cam, thereby implementing a more precise motion.
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公开(公告)号:US10761309B2
公开(公告)日:2020-09-01
申请号:US16659655
申请日:2019-10-22
Applicant: KOREA BASIC SCIENCE INSTITUTE
Inventor: Dong Uk Kim , Ki Soo Chang
Abstract: Disclosed is a laser scanning based microscope apparatus including a light source configured to output a laser signal, a scanning unit configured to scan a heating sample with a first laser signal corresponding to a portion of the output laser signal, and output an optical signal reflected from the sample by the scanning to a first detector, the first detector configured to generate a first electrical signal through the reflected optical signal, a second detector configured to generate a second electrical signal through a second laser signal corresponding to a remaining portion of the output laser signal, and a controller configured to acquire a thermal image of the sample by performing a frequency domain analysis based on the first electrical signal and a differential electrical signal.
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