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公开(公告)号：US20240226204A9
公开(公告)日：2024-07-11
申请号：US18546690
申请日：2022-02-18
申请人： MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNG DER WISSENSCHAFTEN E.V. , Otto-von-Guericke-Universität Magdeburg , Helmholtz-Zentrum für Infektionsforschung GmbH
发明人： Sascha KUPKE , Udo REICHL , Marc Dominique HEIN , Dunja BRUDER , ulfert RAND
摘要： In The present invention relates in a first aspect to the use of influenza virus defective interfering particles in the prophylactic or therapeutic treatment of coronaviridae infection. In particular, it has been recognized that defective interfering particles of influenza A have beneficial effects in the treatment of SARS coronavirus infection, in particular, SARS-CoV-2 infection. Further, the present invention relates to a pharmaceutical composition for use in treating coronaviridae infection, in particular SARS-CoV-2. In a further aspect, methods for the prophylactic or therapeutic treatments of coronaviridae based on the administration of DIFs are disclosed.
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公开(公告)号：US20230228580A1
公开(公告)日：2023-07-20
申请号：US18010840
申请日：2021-06-15
发明人： Wiard FRUEHLING , Armin HAHN
CPC分类号： G01C21/3453 , G01C21/32 , G01C21/3446
摘要： The present subject matter relates to determine a snapping position in a road network for a destination object by using a cost matrix indicative of accumulative cost values of cells of the matrix. The accumulative cost value of a cell is indicating a cost to travel a path from the cell to a road segment of the road network.
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公开(公告)号：US11530976B2
公开(公告)日：2022-12-20
申请号：US17269174
申请日：2018-09-14
申请人： Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V. , Ludwig-Maximilians-Universitaet Muenchen
IPC分类号： G01N15/14 , G01N33/483 , G01N15/00 , G01N15/10
摘要： A particle analysis method and apparatus, including a spectrometry-based analysis of a fluid sample (1), comprises the steps of creating a sample light beam S and a probe light beam P with a light source device (10) and periodically varying a relative phase between the sample and probe light beams S, P with a phase modulator device (20), irradiating the fluid sample (1) with the sample light beam S, detecting the sample and probe light beams S, P with a detector device (40), and providing a spectral response of the at least one particle (3), wherein the light source device (10) comprises at least one broadband source, which has an emission spectrum covering a mid-infrared MIR frequency range, and the phase modulator device (20) varies the relative phase with a scanning period equal to or below the irradiation period of irradiating the at least one particle (3, 4).
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公开(公告)号：US11505586B2
公开(公告)日：2022-11-22
申请号：US16553536
申请日：2019-08-28
IPC分类号： C07K14/47 , C07K14/475 , C07K14/46 , C07K16/18 , A61K38/00
摘要： This invention relates to extracellular protein-protein interactions and their possible therapeutic uses. More particularly, this invention describes the interaction between Draxin, particularly fragments binding to γ-Netrins comprising SEQ ID NO.:1, 2 or 3, and variants thereof, with γ-Netrins, and the use of this interaction to disrupt γ-Netrin/Netrin receptor interactions. The invention also relates to diagnostic and/or therapeutic uses of Draxin or fragments or variants thereof, as well as to an antibody against Draxin inhibiting binding of Draxin to γ-Netrins. Further, the invention relates to fragments of γ-Netrins, in particular Draxin-binding Netrin1-fragments comprising SEQ ID NO.: 51 and variants thereof, as well as to an antibody against γ-Netrins inhibiting binding of γ-Netrins to Netrin receptors.
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公开(公告)号：US20210397014A1
公开(公告)日：2021-12-23
申请号：US17393690
申请日：2021-08-04
申请人： Max-Planck-Gesellschaft zur Foerderung der Wissenschaften e.V. , Katholieke Universiteit Leuven KU Leuven Research & Development
IPC分类号： G02B27/58 , G02B27/28 , G02B5/30 , G02B26/08 , G02B21/36 , G02B21/00 , G02B21/16 , G01N21/64
摘要： An optical module for imaging light emitting objects on an image sensor comprises a polarizing beam splitter having an entrance face, an exit face, first and a second return faces, a first reflector facing the first return face, a first achromatic quarter-wave retardation plate between the first return face and the first reflector, a second reflector facing the second return face, and a second achromatic quarter-wave retardation plate between the second return face and the second reflector. The first and second reflectors differ in at least one of their orientation with regard to the first and second return faces or their spectral properties. At least one of the first reflector and the second reflector comprises a dichroic mirror arranged between the respective achromatic quarter-wave retardation plate and a further mirror of the respective reflector. The dichroic mirror is tilted with regard to the further mirror of the respective reflector.
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6.发明申请公开(公告)号：US20210376322A1
公开(公告)日：2021-12-02
申请号：US16968107
申请日：2019-02-06
发明人： Feixiang WU , Yan YU , Joachim MAIER
IPC分类号： H01M4/58 , H01M4/583 , H01M10/052 , H01M4/38 , H01M4/04
摘要： The present invention relates to an electrode material comprising at least one sulfur-limonene sulfide component or a composite of the sulfur-limonene sulfide component with a first conductive component; electrodes, in particular cathodes, containing the electrode material; half-cells, cells, and batteries containing the electrodes; and processes for obtaining the electrode material, the electrode, the half-cell, the cell, and the battery comprising electrode material and/or electrodes of the present invention.
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公开(公告)号：US11167144B2
公开(公告)日：2021-11-09
申请号：US16447218
申请日：2019-06-20
摘要： An apparatus for terminating or unpinning rotating electric activity in a cardiac tissue analyzes an electric parameter for rotating electric activity in the cardiac tissue, and generates electric pulses in response to the rotating electric activity. The electric pulses are applied as electric field pulses and include a plurality of rotating electric activity synchronization pulses arranged at first intervals and a rotating electric activity termination or unpinning pulse following to the last synchronization pulse at a second interval which is similar to one of the first intervals. A maximum electric field strength caused the synchronization pulses is not more than 82% of a maximum electric field strength caused by the termination or unpinning pulse, and an electric pulse energy delivered to the cardiac tissue by each of the synchronization pulses is not more than 67% of an electric pulse energy delivered by the termination or unpinning pulse.
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公开(公告)号：US11052367B2
公开(公告)日：2021-07-06
申请号：US16679912
申请日：2019-11-11
摘要： Each of monodisperse spherical microcapsules for seeding a transparent fluid to track movements of the fluid both in translational and rotational directions comprises a core; a shell; and 1 to 5 light reflecting solid integral particles. Each of the particles reflects incoming light in a defined direction; and each of the particles is embedded in the core and fixed in its orientation with regard to the shell. The shell and the core are transparent for the incoming light to be reflected by the particles entering and exiting the microcapsule. The shell has a thickness of not more than λ, λ being a wavelength of the incoming light, so that the shell does essentially not deflect the incoming light entering and exiting the microcapsule. The core includes a main component of the fluid such that a refraction index of the core essentially matches a refraction index of the fluid.
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公开(公告)号：US10962479B2
公开(公告)日：2021-03-30
申请号：US16377575
申请日：2019-04-08
摘要： For spatial high resolution determining a position of a singularized molecule, which is excitable with excitation light for emission of luminescence light, in n spatial dimensions in a sample, the excitation light is directed onto the sample with an intensity distribution, which has a zero point and intensity increasing regions adjoining the zero point on both sides in each of the n spatial dimensions. The zero point is arranged at not more than n×3 different positions. The luminescence light emitted by the singularized molecule is separately registering for each of the different positions of the zero point. The position of the singularized molecule in the n spatial dimensions in the sample is deduced from intensities of the luminescence light separately registered for the not more than n×3 different positions of the zero point.
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公开(公告)号：US10955348B2
公开(公告)日：2021-03-23
申请号：US16123280
申请日：2018-09-06
摘要： For high spatial resolution imaging a structure marked with luminescence markers, light that has an effect on the emission of luminescence light by the luminescence markers is directed onto a sample with an intensity distribution having a central zero point. Scan areas of the sample are scanned with the zero point. Luminescence light emitted out of a local area including the zero point is registered and assigned to the respective location of the zero point in the sample. Several copies of an object of interest are arranged in the scan areas and subjected to varying surrounding conditions. The individual scan areas are scanned with the respective zero point at least two times at two different stages of reactions to the varying surrounding conditions. Dimensions of the scan areas are limited such that they are not larger than 75% of a distance of intensity maxima delimiting the zero point.
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