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114 条记录 (耗时 0.035 秒)

    Method for operating microchip reservoir device
    42.
    发明授权
    Method for operating microchip reservoir device 有权
    操作微芯片储液装置的方法

    公开(公告)号：US07901397B2

    公开(公告)日：2011-03-08

    申请号：US11930406

    申请日：2007-10-31

    申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer

    发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Robert S. Langer

    IPC分类号： A61K9/22

    CPC分类号： A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  A61M5/14276 ,  A61M37/00 ,  A61M2205/0244 ,  C25F5/00 ,  C25F7/00 ,  Y10T137/8242

    摘要： A method is provided for operating a device for the containment and controlled release or exposure of a chemical substance. The method includes (i) providing a device which includes a substrate having a plurality of reservoirs, at least one chemical substance stored in the reservoirs, a plurality of metal reservoir caps, each of which closes an opening of one of said reservoir caps, and power and electrode means for disintegrating each of said reservoir caps; and (ii) disintegrating at least one of said reservoir caps, using said power and electrode means, to expose or release the chemical substance, wherein said disintegration comprises using potentiostatic or galvanostatic control to a voltage potential at said at least one reservoir cap.

    摘要翻译： 提供了一种用于操作用于化学物质的容纳和控制释放或暴露的装置的方法。 该方法包括（i）提供一种装置，其包括具有多个储存器的基板，存储在储存器中的至少一种化学物质，多个金属储存器盖，每个金属储存器盖封闭其中一个储存器盖的开口，以及 功率和电极装置，用于分解每个所述储存器盖; 以及（ii）使用所述功率和电极装置分解至少一个所述储存器盖以暴露或释放所述化学物质，其中所述分解包括对所述至少一个储存器盖的电压电位进行恒电位或恒电流控制。

    Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form
    43.
    发明授权
    Method and form of a drug delivery device, such as encapsulating a toxic core within a non-toxic region in an oral dosage form 有权
    药物递送装置的方法和形式，例如以口服剂型将毒性核心包封在无毒区域内

    公开(公告)号：US07875290B2

    公开(公告)日：2011-01-25

    申请号：US11246910

    申请日：2005-10-07

    申请人： Francis C. Payumo ,  Jill K. Sherwood ,  Donald C. Monkhouse ,  Jaedeok Yoo ,  Christopher M. Gaylo ,  Chen-Chao Wang ,  Michael J. Cima

    发明人： Francis C. Payumo ,  Jill K. Sherwood ,  Donald C. Monkhouse ,  Jaedeok Yoo ,  Christopher M. Gaylo ,  Chen-Chao Wang ,  Michael J. Cima

    IPC分类号： A61K31/4745 ,  A61K31/198 ,  A61K9/48

    CPC分类号： A61K9/2893 ,  A61K9/209 ,  A61K9/2886 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00

    摘要： A drug delivery device such as an oral dosage form (ODF) with a toxic or potent core encapsulated by a non-toxic region. The non-toxic region may be a region including multiple layers, coatings, shells, and combinations thereof, which provides protection to and isolation from the toxic or potent core. The drug in the toxic or potent core is incorporated into the dosage form via, for example, three-dimensional printing, as a solution, solubilization or suspension of solid particles in liquid, rather than by the more conventional handling and compressing of dry powder. This minimizes the likelihood of creating airborne particles of the toxic drug during manufacturing, hence controlling and minimizing the exposure of manufacturing personnel to the hazardous substance. Wet dispensing of the toxic or potent drug further provides greater bioavailability of the drug to the patient.

    摘要翻译： 药物递送装置，例如具有由无毒区域包封的毒性或有效核心的口服剂型（ODF）。 无毒区域可以是包括多层，涂层，壳及其组合的区域，其提供对有毒或有效的核心的保护和分离。 有毒或有效的核心中的药物通过例如三维印刷作为溶液，固体颗粒在液体中的溶解或悬浮而不是通过更常规的干粉处理和压缩而被并入到剂型中。 这最小化在制造过程中产生毒性药物的空气中颗粒的可能性，从而控制和最小化制造人员对有害物质的暴露。 有毒或有效的药物的湿分配进一步提供药物对患者更大的生物利用度。

    METHOD FOR MAKING HIGH JC SUPERCONDUCTING FILMS AND POLYMER-NITRATE SOLUTIONS USED THEREFORE
    45.
    发明申请
    METHOD FOR MAKING HIGH JC SUPERCONDUCTING FILMS AND POLYMER-NITRATE SOLUTIONS USED THEREFORE 审中-公开
    制备高JC超导膜的方法及其所用的聚合物 - 硝酸盐溶液

    公开(公告)号：US20100093545A1

    公开(公告)日：2010-04-15

    申请号：US12306415

    申请日：2007-06-29

    申请人： Michael J. Cima ,  Masateru Yoshizumi ,  Daniel E. Wesolowski ,  Yoda R. Patta

    发明人： Michael J. Cima ,  Masateru Yoshizumi ,  Daniel E. Wesolowski ,  Yoda R. Patta

    IPC分类号： H01L39/24 ,  H01L39/12

    CPC分类号： H01L39/2425 ,  C23C18/1216 ,  C23C18/1241 ,  C23C18/1245 ,  C23C18/1295 ,  H01L21/31691

    摘要： 100-800 nm ReBCO films with critical current density (Jc) values in excess of 1 MA/cm2 were fabricated from aqueous nitrate precursor solutions with additives. Additives such as polyethylene glycol (PEG) and sucrose were selected to suppress crystallization of barium nitrate. This produces higher concentration solutions resulting in thicker crack-free single layers. Additional water-soluble viscosity modifiers, such as polyvinyl alcohol (PVA) or cellulose-derivatives, were used to increase thickness and allow wetting of ceramic surfaces. Water vapor present at higher temperatures during heat-treatment damaged the films, while the role of water vapor at lower temperatures is still under investigation.

    摘要翻译： 由具有添加剂的硝酸盐前体溶液制备具有超过1MA / cm 2的临界电流密度（Jc）值的100-800nm ReBCO膜。 选择添加剂如聚乙二醇（PEG）和蔗糖以抑制硝酸钡的结晶。 这产生更高的浓度溶液，导致更厚的无裂纹单层。 使用额外的水溶性粘度调节剂，例如聚乙烯醇（PVA）或纤维素衍生物来增加厚度并允许陶瓷表面的润湿。 在热处理过程中，较高温度下的水蒸汽会损坏膜，而在较低温度下的水蒸汽作用仍在调查之中。

    Thermally-activated reservoir devices
    47.
    发明授权
    Thermally-activated reservoir devices 有权
    热活化储罐装置

    公开(公告)号：US07473248B2

    公开(公告)日：2009-01-06

    申请号：US10747900

    申请日：2003-12-29

    申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Scott Albert Uhland

    发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Scott Albert Uhland

    IPC分类号： A61M37/00

    CPC分类号： B01L3/50853 ,  A61K9/0009 ,  A61K9/0024 ,  A61K9/0097 ,  B01L2300/0819 ,  B01L2400/0677

    摘要： Methods are provided for controlled reservoir opening, including the steps of (a) providing a biocompatible implantable device which comprises at least one substrate, a plurality of reservoirs in the substrate, reservoir caps each of which covers one of the reservoirs, and molecules sealed inside the reservoirs; and (b) selectively heating each reservoir cap in an amount effective to rupture the reservoir cap and open the reservoir. In another embodiment, the method steps include (a) implanting into a patient a biocompatible device which comprises at least one substrate, a plurality of reservoirs in the substrate, reservoir caps each of which covers one of the reservoirs, and molecules sealed inside the reservoirs; and (b) selectively heating each reservoir cap in an amount effective to rupture the reservoir cap and open the reservoir.

    摘要翻译： 提供了用于受控储存器开口的方法，包括以下步骤：（a）提供生物相容的可植入装置，其包括至少一个基底，基底中的多个储存器，每个盖子中的一个储存器的储存器盖，以及密封在其中的分子 水库; 和（b）以有效地使储存器盖破裂并打开储存器的量选择性地加热每个储存器盖。 在另一个实施例中，方法步骤包括（a）向生物相容性装置植入生物相容性装置，生物相容性装置包括至少一个基底，基底中的多个储存器，每个储存器覆盖其中一个储存器，以及密封在贮存器内的分子 ; 和（b）以有效地使储存器盖破裂并打开储存器的量选择性地加热每个储存器盖。

    Microchip devices with improved reservoir opening
    50.
    发明授权
    Microchip devices with improved reservoir opening 失效
    具有改进水箱开口的Microchip器件

    公开(公告)号：US06875208B2

    公开(公告)日：2005-04-05

    申请号：US10159550

    申请日：2002-05-31

    申请人： John T. Santini, Jr. ,  Michael J. Cima ,  Norman F. Sheppard, Jr. ,  Nolan T. Flynn ,  Scott A. Uhland ,  Zouhair Sbiaa ,  John M. Maloney

    发明人： John T. Santini, Jr. ,  Michael J. Cima ,  Norman F. Sheppard, Jr. ,  Nolan T. Flynn ,  Scott A. Uhland ,  Zouhair Sbiaa ,  John M. Maloney

    IPC分类号： A61K9/00 ,  A61K9/22 ,  A61M31/00 ,  A61M37/00

    CPC分类号： A61K9/0097 ,  A61K9/0009 ,  Y10T137/8242

    摘要： Microchip devices and methods of manufacture thereof are provided to increase the uniformity and reliability of active exposure and release of microchip reservoir contents. In one embodiment, the microchip device for the controlled release or exposure of molecules or secondary devices comprises: (1) a substrate having a plurality of reservoirs; (2) reservoir contents comprising molecules, a secondary device, or both, located in the reservoirs; (3) reservoir caps positioned on the reservoirs over the reservoir contents; (4) electrical activation means for disintegrating the reservoir cap to initiate exposure or release of the reservoir contents in selected reservoirs; and (5) a current distribution means, a stress induction means, or both, operably engaged with or integrated into the reservoir cap, to enhance reservoir cap disintegration.

    摘要翻译： Microchip的器件及其制造方法被提供以增加微芯片储存器内容物的主动曝光和释放的均匀性和可靠性。 在一个实施例中，用于分子或次要装置的受控释放或暴露的微芯片装置包括：（1）具有多个储存器的基板; （2）位于储层中的包含分子，次要装置或二者的储层内容物; （3）位于油藏内的油藏内的储层盖; （4）电活化装置，用于使贮存器盖分解以开始在所选择的储存器中暴露或释放储存器内容物; 和（5）电流分配装置，应力感应装置或两者，可操作地与储存器盖接合或集成到储存器盖中，以增强储存器盖分解。