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    Implantable device for controlled drug delivery
    4.
    发明授权
    Implantable device for controlled drug delivery 有权
    用于受控药物输送的可植入装置

    公开(公告)号：US09017312B2

    公开(公告)日：2015-04-28

    申请号：US12851494

    申请日：2010-08-05

    申请人： Heejin Lee ,  Michael J. Cima ,  Karen Daniel ,  Cheryl Larrivee-Elkins

    发明人： Heejin Lee ,  Michael J. Cima ,  Karen Daniel ,  Cheryl Larrivee-Elkins

    IPC分类号： A61K9/22 ,  A61M31/00 ,  A61K9/00 ,  A61K31/167

    CPC分类号： A61K9/0092 ,  A61K9/0004 ,  A61K9/0034 ,  A61K31/167 ,  A61M31/002

    摘要： Implantable devices and methods for delivery of lidocaine or other drugs to a patient are provided. In one embodiment, the device includes a first drug portion which has a first drug housing which contains a first drug formulation in a solid form which includes a pharmaceutically acceptable salt of lidocaine; and a second drug portion which includes a second drug housing which contains a second drug formulation which includes lidocaine base. In another embodiment, the device includes a drug reservoir component which has an elastic tube having at least one lumen bounded by a porous sidewall having an open-cell structure, a closed-cell structure, or a combination thereof; and a drug formulation contained within the at least one lumen, wherein the device is deformable between a low-profile deployment shape and a relatively expanded retention shape.

    摘要翻译： 提供了用于将利多卡因或其他药物递送给患者的可植入装置和方法。 在一个实施方案中，该装置包括第一药物部分，其具有第一药物外壳，其包含固体形式的第一药物制剂，其包含利多卡因的药学上可接受的盐; 和第二药物部分，其包括含有包含利多卡因碱的第二药物制剂的第二药物外壳。 在另一个实施方案中，该装置包括药物储存器部件，该药物储存器部件具有弹性管，该弹性管具有由具有开孔结构，闭孔结构或其组合的多孔侧壁限定的至少一个内腔; 以及包含在所述至少一个内腔内的药物制剂，其中所述装置可在低轮廓展开形状和相对扩张的保留形状之间变形。

    Time-selective bioresorbable or collapsible drug delivery systems and methods
    6.
    发明授权
    Time-selective bioresorbable or collapsible drug delivery systems and methods 有权
    时间选择性生物可吸收或可折叠药物递送系统和方法

    公开(公告)号：US08690840B2

    公开(公告)日：2014-04-08

    申请号：US13267560

    申请日：2011-10-06

    申请人： Heejin Lee ,  Michael J. Cima ,  Cheryl Larrivee-Elkins ,  Dennis Giesing ,  Jessica K. Anderson ,  Sarma Duddu

    发明人： Heejin Lee ,  Michael J. Cima ,  Cheryl Larrivee-Elkins ,  Dennis Giesing ,  Jessica K. Anderson ,  Sarma Duddu

    IPC分类号： A61M31/00

    CPC分类号： A61M31/002 ,  A61K9/0034 ,  A61K9/0039 ,  A61L29/148 ,  A61L29/16 ,  A61L31/148 ,  A61L31/16 ,  A61L2300/00

    摘要： Implantable medical devices and treatment methods are provided, particularly for use in the bladder. The device is configured for retention in the bladder for at least a portion of the drug delivery period and includes at least one biodegradable component such that following a biodegradation at a selected time, the retention function is lost and the device or portions thereof are resorbed and/or excreted. The method may include deploying into the bladder of a patient a device having a device structure housing a drug formulation comprising at a drug; releasing drug from the device structure into the bladder; and then, changing the composition of urine in the bladder, e.g., by altering the pH, to trigger degradation of at least part of the device structure to enable the device structure or parts thereof to be excreted from the bladder.

    摘要翻译： 提供了可植入的医疗装置和治疗方法，特别用于膀胱。 该装置构造成在膀胱中保留药物递送期的至少一部分，并且包括至少一种可生物降解的组分，使得在选定时间内经过生物降解后，保留功能丧失并且其装置或部分被吸收， /或排泄。 该方法可以包括向患者的膀胱中部署具有容纳包含药物的药物制剂的装置结构的装置; 将药物从装置结构释放到膀胱中; 然后，例如通过改变pH来改变膀胱中尿液的组成，以触发装置结构的至少一部分的降解，使装置结构或其部分能够从膀胱排出。

    Electrochemical actuator
    7.
    发明授权
    Electrochemical actuator 有权

    公开(公告)号：US07999435B2

    公开(公告)日：2011-08-16

    申请号：US12035406

    申请日：2008-02-21

    申请人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

    发明人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

    IPC分类号： H01L41/08

    CPC分类号： F03G7/005 ,  H01M10/052

    摘要： The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example.

    ELECTROCHEMICAL ACTUATOR
    9.
    发明申请
    ELECTROCHEMICAL ACTUATOR 有权
    电化学执行器

    公开(公告)号：US20110098643A1

    公开(公告)日：2011-04-28

    申请号：US12960224

    申请日：2010-12-03

    申请人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

    发明人： Yet-Ming Chiang ,  Michael J. Cima ,  Timothy E. Chin

    IPC分类号： A61M5/14

    CPC分类号： F03G7/005 ,  H01M2/16 ,  H01M4/485 ,  H01M4/505 ,  H01M4/525 ,  H01M4/587 ,  H01M6/30 ,  H01M2004/021 ,  H01M2010/4292

    摘要： The present invention provides systems, devices, and related methods, involving electrochemical actuation. In some cases, application of a voltage or current to a system or device of the invention may generate a volumetric or dimensional change, which may produce mechanical work. For example, at least a portion of the system may be constructed and arranged to be displaced from a first orientation to a second orientation. Systems such as these may be useful in various applications, including pumps (e.g., infusion pumps) and drug delivery devices, for example.

    摘要翻译： 本发明提供涉及电化学致动的系统，装置和相关方法。 在一些情况下，将电压或电流施加到本发明的系统或装置可能产生容积或尺寸变化，这可能产生机械作业。 例如，系统的至少一部分可以被构造和布置成从第一取向向第二取向移位。 诸如这些的系统可用于各种应用，例如泵（例如输注泵）和药物输送装置。

    System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form
    10.
    发明授权
    System and method for uniaxial compression of an article, such as a three-dimensionally printed dosage form 有权
    用于单轴压缩制品的系统和方法，例如三维印刷的剂型

    公开(公告)号：US07931914B2

    公开(公告)日：2011-04-26

    申请号：US10284430

    申请日：2002-10-29

    申请人： Wendy E. Pryce Lewis ,  Charles William Rowe ,  Michael J. Cima ,  Peter A. Materna

    发明人： Wendy E. Pryce Lewis ,  Charles William Rowe ,  Michael J. Cima ,  Peter A. Materna

    IPC分类号： A61K9/20 ,  A61K9/28 ,  A61K9/14 ,  A61K9/16 ,  A61K9/48 ,  A61F13/00

    CPC分类号： A61K9/20 ,  A61J3/10 ,  A61K9/2095 ,  B29C64/00 ,  B29C64/165 ,  B29C67/0051 ,  B29C67/0081 ,  B29L2031/753 ,  B33Y70/00 ,  B33Y80/00

    摘要： A uniaxially compressed dosage form manufactured by three-dimensional printing that preserves the predetermined internal architecture of the dosage form while producing an improved surface finish. The compression compacts the dosage form, eliminating at least some of the void space that remains at the end of conventional three-dimensional printing. Surface finish obtained as a result of the uniaxial compression process can be essentially equal to that obtained from conventional tablet pressing. Additionally, the internal structure or spatial variation of composition of the dosage form is preserved during the pressing operation, with geometric shrinkage occurring mostly in the direction of the axis of pressing. Further, as a result of compression, a greater quantity of API can be packed into a given final volume of dosage form.

    摘要翻译： 通过三维印刷制造的单轴压缩剂型，其保持了剂型的预定内部结构，同时产生改进的表面光洁度。 压缩压缩剂型，消除了在传统三维印刷结束时保留的至少一些空隙空间。 作为单轴压缩方法的结果获得的表面光洁度可以基本上等于从常规压片获得的表面光洁度。 此外，在压制操作期间保留了剂型的组成的内部结构或空间变化，几何收缩主要发生在按压轴的方向上。 此外，作为压缩的结果，可以将更大量的API包装在给定的最终体积的剂型中。