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公开(公告)号：US09097644B2
公开(公告)日：2015-08-04
申请号：US12673866
申请日：2008-08-15
申请人： Lee Josephson , Rui Hong , Michael J. Cima , Ralph Weissleder
发明人： Lee Josephson , Rui Hong , Michael J. Cima , Ralph Weissleder
IPC分类号： G01N24/08 , G01R33/465 , G01R33/50 , G01N27/74 , G01R33/56
CPC分类号： G01N24/08 , G01N27/745 , G01R33/465 , G01R33/50 , G01R33/5601
摘要： This invention relates generally to magnetic resonance (MR)-based methods and kits for measuring the viscosity of liquid samples.
摘要翻译： 本发明一般涉及基于磁共振（MR）的方法和用于测量液体样品粘度的试剂盒。
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公开(公告)号：US20110124744A1
公开(公告)日：2011-05-26
申请号：US12673866
申请日：2008-08-15
申请人： Lee Josephson , Rui Hong , Michael J. Cima , Ralph Weissleder
发明人： Lee Josephson , Rui Hong , Michael J. Cima , Ralph Weissleder
CPC分类号： G01N24/08 , G01N27/745 , G01R33/465 , G01R33/50 , G01R33/5601
摘要： This invention relates generally to magnetic resonance (MR)-based methods and kits for measuring the viscosity of liquid samples.
摘要翻译： 本发明一般涉及基于磁共振（MR）的方法和用于测量液体样品粘度的试剂盒。
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公开(公告)号：US08486373B2
公开(公告)日：2013-07-16
申请号：US10979755
申请日：2004-11-01
CPC分类号： A61K49/0056 , A61B5/0068 , A61B5/0071 , A61B5/0084 , A61B5/0086 , A61K47/60 , A61K49/0032 , A61K49/0054 , A61K49/0058 , C12Q1/6841 , C12Q1/6883 , C12Q2565/30 , C12Q2565/1015 , C12Q2525/301
摘要： An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.
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公开(公告)号：US20100120174A1
公开(公告)日：2010-05-13
申请号：US12612126
申请日：2009-11-04
申请人： Lee Josephson , Yi Sun , Ralph Weissleder
发明人： Lee Josephson , Yi Sun , Ralph Weissleder
IPC分类号： G01N33/553
CPC分类号： G01N27/745 , A61B5/14503 , G01N33/54326 , G01N33/54366 , G01R33/465 , G01R33/50
摘要： This invention relates to magnetic resonance-based sensors and related methods.
摘要翻译： 本发明涉及基于磁共振的传感器及相关方法。
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公开(公告)号：US07829350B2
公开(公告)日：2010-11-09
申请号：US12194475
申请日：2008-08-19
申请人： Lee Josephson , Ralph Weissleder , J. Manuel Perez
发明人： Lee Josephson , Ralph Weissleder , J. Manuel Perez
IPC分类号： G01N33/00 , G01N33/48 , G01N33/50 , G01N33/543 , G01N33/553 , G01N33/86 , B01L3/00
CPC分类号： G01N33/54346 , A61K49/1851 , B82Y5/00 , C07F15/02 , C07H21/02 , C07K1/22 , C12Q1/37 , C12Q1/44 , C12Q1/6816 , G01N33/54326 , G01N33/5434 , G01N33/577 , Y10S435/969 , Y10S977/773 , Y10S977/918 , Y10S977/92 , Y10T436/143333
摘要： The present invention provides novel compositions of binding moiety-nanoparticle conjugates, aggregates of these conjugates, and novel methods of using these conjugates, and aggregates. The nanoparticles in these conjugates can be magnetic metal oxides, either monodisperse or polydisperse. Binding moieties can be, e.g., oligonucleotides, polypeptides, or polysaccharides. Oligonucleotide sequences are linked to either non-polymer surface functionalized metal oxides or with functionalized polymers associated with the metal oxides. The novel compositions can be used in assays for detecting target molecules, such as nucleic acids and proteins, in vitro or as magnetic resonance (MR) contrast agents to detect target molecules in living organisms.
摘要翻译： 本发明提供结合部分 - 纳米颗粒共轭物的新组合物，这些缀合物的聚集体，以及使用这些共轭物和聚集体的新方法。 这些共轭物中的纳米颗粒可以是单分散或多分散的磁性金属氧化物。 结合部分可以是例如寡核苷酸，多肽或多糖。 寡核苷酸序列与非聚合物表面官能化金属氧化物或与金属氧化物相关的官能化聚合物连接。 该新型组合物可用于体外检测靶分子（例如核酸和蛋白质）或作为磁共振（MR）造影剂检测活体中靶分子的测定。
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公开(公告)号：US20110046004A1
公开(公告)日：2011-02-24
申请号：US12772747
申请日：2010-05-03
申请人： Lee Josephson , Ralph Weissleder , J. Manuel Perez
发明人： Lee Josephson , Ralph Weissleder , J. Manuel Perez
CPC分类号： G01N33/54346 , A61K49/1851 , B82Y5/00 , C07F15/02 , C07H21/02 , C07K1/22 , C12Q1/37 , C12Q1/44 , C12Q1/6816 , G01N33/54326 , G01N33/5434 , G01N33/577 , Y10S435/969 , Y10S977/773 , Y10S977/918 , Y10S977/92 , Y10T436/143333
摘要： The present invention provides novel compositions of binding moiety-nanoparticle conjugates, aggregates of these conjugates, and novel methods of using these conjugates, and aggregates. The nanoparticles in these conjugates can be magnetic metal oxides, either monodisperse or polydisperse. Binding moieties can be, e.g., oligonucleotides, polypeptides, or polysaccharides. Oligonucleotide sequences are linked to either non-polymer surface functionalized metal oxides or with functionalized polymers associated with the metal oxides. The novel compositions can be used in assays for detecting target molecules, such as nucleic acids and proteins, in vitro or as magnetic resonance (MR) contrast agents to detect target molecules in living organisms.
摘要翻译： 本发明提供结合部分 - 纳米颗粒共轭物的新组合物，这些缀合物的聚集体，以及使用这些共轭物和聚集体的新方法。 这些共轭物中的纳米颗粒可以是单分散或多分散的磁性金属氧化物。 结合部分可以是例如寡核苷酸，多肽或多糖。 寡核苷酸序列与非聚合物表面官能化金属氧化物或与金属氧化物相关的官能化聚合物连接。 该新型组合物可用于体外检测靶分子（例如核酸和蛋白质）或作为磁共振（MR）造影剂检测活体中靶分子的测定。
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公开(公告)号：US20080305048A1
公开(公告)日：2008-12-11
申请号：US10581417
申请日：2004-12-09
CPC分类号： B82Y5/00 , A61K47/555 , A61K49/10 , A61K49/1833 , C12Q1/00 , C12Q1/28 , C12Q1/37
摘要： This invention relates to magnetic nanoparticle conjugates and related compositions and methods of use.
摘要翻译： 本发明涉及磁性纳米颗粒共轭物及其相关组合物和使用方法。
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公开(公告)号：US20060275775A1
公开(公告)日：2006-12-07
申请号：US10979755
申请日：2004-11-01
CPC分类号： A61K49/0056 , A61B5/0068 , A61B5/0071 , A61B5/0084 , A61B5/0086 , A61K47/60 , A61K49/0032 , A61K49/0054 , A61K49/0058 , C12Q1/6841 , C12Q1/6883 , C12Q2565/30 , C12Q2565/1015 , C12Q2525/301
摘要： An intramolecularly-quenched, near infrared fluorescence probe that emits substantial fluorescence only after interaction with a target tissue (i.e., activation) is disclosed. The probe includes a polymeric backbone and a plurality of near infrared fluorochromes covalently linked to the backbone at fluorescence-quenching interaction-permissive positions separable by enzymatic cleavage at fluorescence activation sites. The probe optionally includes protective chains or fluorochrome spacers, or both. Also disclosed are methods of using the intramolecularly-quenched, near infrared fluorescence probes for in vivo optical imaging.
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公开(公告)号：US20060269965A1
公开(公告)日：2006-11-30
申请号：US11431247
申请日：2006-05-09
申请人： Lee Josephson , Yi Sun , Ralph Weissleder
发明人： Lee Josephson , Yi Sun , Ralph Weissleder
CPC分类号： G01N27/745 , A61B5/14503 , G01N33/54326 , G01N33/54366 , G01R33/465 , G01R33/50
摘要： This invention relates to magnetic resonance-based sensors and related methods.
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公开(公告)号：US08569078B2
公开(公告)日：2013-10-29
申请号：US12772747
申请日：2010-05-03
申请人： Lee Josephson , Ralph Weissleder , J. Manuel Perez
发明人： Lee Josephson , Ralph Weissleder , J. Manuel Perez
IPC分类号： G01N33/00
CPC分类号： G01N33/54346 , A61K49/1851 , B82Y5/00 , C07F15/02 , C07H21/02 , C07K1/22 , C12Q1/37 , C12Q1/44 , C12Q1/6816 , G01N33/54326 , G01N33/5434 , G01N33/577 , Y10S435/969 , Y10S977/773 , Y10S977/918 , Y10S977/92 , Y10T436/143333
摘要： The present invention provides novel compositions of binding moiety-nanoparticle conjugates, aggregates of these conjugates, and novel methods of using these conjugates, and aggregates. The nanoparticles in these conjugates can be magnetic metal oxides, either monodisperse or polydisperse. Binding moieties can be, e.g., oligonucleotides, polypeptides, or polysaccharides. Oligonucleotide sequences are linked to either non-polymer surface functionalized metal oxides or with functionalized polymers associated with the metal oxides. The novel compositions can be used in assays for detecting target molecules, such as nucleic acids and proteins, in vitro or as magnetic resonance (MR) contrast agents to detect target molecules in living organisms.
摘要翻译： 本发明提供结合部分 - 纳米颗粒共轭物的新组合物，这些缀合物的聚集体，以及使用这些共轭物和聚集体的新方法。 这些共轭物中的纳米颗粒可以是单分散或多分散的磁性金属氧化物。 结合部分可以是例如寡核苷酸，多肽或多糖。 寡核苷酸序列与非聚合物表面官能化金属氧化物或与金属氧化物相关的官能化聚合物连接。 该新型组合物可用于体外检测靶分子（例如核酸和蛋白质）或作为磁共振（MR）造影剂检测活体中靶分子的测定。
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