公开(公告)号：US07615643B2

公开(公告)日：2009-11-10

申请号：US11754653

申请日：2007-05-29

Applicant: Kevin Kuntz ,  Kyle Allen Emmitte ,  Tara Renae Rheault ,  Stephon Smith ,  Keith Hornberger ,  Hamilton Dickson ,  Mui Cheung

Inventor： Kevin Kuntz ,  Kyle Allen Emmitte ,  Tara Renae Rheault ,  Stephon Smith ,  Keith Hornberger ,  Hamilton Dickson ,  Mui Cheung

IPC: A61K31/445 ,  A61K31/4184 ,  C07D401/14 ,  C07D409/04

CPC classification number: C07D409/04 ,  C07D409/14 ,  C07D413/14

Abstract: The present invention provides benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

公开(公告)号：US07465807B2

公开(公告)日：2008-12-16

申请号：US10575210

申请日：2004-10-12

Applicant: Mui Cheung ,  Kyle Allen Emmitte

Inventor： Mui Cheung ,  Kyle Allen Emmitte

IPC: C07D409/04

CPC classification number: C07D491/04 ,  C07D409/04 ,  C07D409/14

Abstract: The present invention provides a process for preparing benzimidazole thiophene compounds.

Abstract translation: 本发明提供一种制备苯并咪唑噻吩化合物的方法。

公开(公告)号：US07462614B2

公开(公告)日：2008-12-09

申请号：US10550434

申请日：2004-03-29

Applicant: Mui Cheung ,  Nigel Paul King ,  Kevin Wayne Kuntz ,  Robert Anthony Mook, Jr. ,  Mark Andrew Pobanz ,  James Michael Salovich ,  Brian John Wilson

Inventor： Mui Cheung ,  Nigel Paul King ,  Kevin Wayne Kuntz ,  Robert Anthony Mook, Jr. ,  Mark Andrew Pobanz ,  James Michael Salovich ,  Brian John Wilson

IPC: C07D487/04 ,  C07D401/04 ,  C07D401/06 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/14 ,  A61K31/53 ,  A61P35/00

CPC classification number: C07D487/04

Abstract: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract translation: 本发明提供式（I）化合物：其中所有变量如本文所定义，含有该化合物的药物组合物，其制备方法及其作为药剂的用途。

公开(公告)号：US20080249301A1

公开(公告)日：2008-10-09

申请号：US12065655

申请日：2006-08-28

Applicant: Keith Hornberger ,  Mui Cheung ,  Mark Andrew Pobanz ,  Kyle Allen Emmitte ,  Kevin Wayne Kuntz ,  Jennifer Gabriel Badiang

Inventor： Keith Hornberger ,  Mui Cheung ,  Mark Andrew Pobanz ,  Kyle Allen Emmitte ,  Kevin Wayne Kuntz ,  Jennifer Gabriel Badiang

IPC: C07D235/04 ,  C07D401/10 ,  C07D413/14 ,  C07D403/10 ,  C07D243/08

CPC classification number: C07D333/40 ,  C07D409/04

Abstract: The present invention provides a process for preparing benzimidazole thiophene compounds of formula (I). Intermediates used in the process are also claimed.

Abstract translation: 本发明提供制备式（I）的苯并咪唑噻吩化合物的方法。 还要求用于该方法中的中间体。

公开(公告)号：US20080214563A1

公开(公告)日：2008-09-04

申请号：US12065684

申请日：2006-08-28

Applicant: Mui Cheung ,  Jennifer Gabriel Badiang ,  Horne Donaldson ,  Tara Renae Rheault

Inventor： Mui Cheung ,  Jennifer Gabriel Badiang ,  Horne Donaldson ,  Tara Renae Rheault

IPC: A61K31/496 ,  C07D409/14 ,  A61K31/4545 ,  A61K31/4439 ,  A61K31/4184 ,  C12N5/06 ,  A61P35/00 ,  A61P35/04

CPC classification number: C07D409/14

Abstract: The present invention provides 5-heteroaryl substituted benzimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract translation: 本发明提供5-杂芳基取代的苯并咪唑噻吩化合物，其含有它们的药物组合物，其制备方法及其作为药剂的用途。

公开(公告)号：US07338959B2

公开(公告)日：2008-03-04

申请号：US10506447

申请日：2003-02-28

Applicant: Stanley Dawes Chamberlain ,  Mui Cheung ,  Holly Kathleen Emerson ,  Neil W. Johnson ,  Kristen Elizabeth Nailor ,  Douglas McCord Sammond ,  Marcus Semones

Inventor： Stanley Dawes Chamberlain ,  Mui Cheung ,  Holly Kathleen Emerson ,  Neil W. Johnson ,  Kristen Elizabeth Nailor ,  Douglas McCord Sammond ,  Marcus Semones

IPC: C07D239/48 ,  C07D403/12 ,  C07D403/14 ,  A61K31/506 ,  A61K31/4184 ,  A61P35/00

CPC classification number: C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D405/14 ,  C07D409/14 ,  C07D413/14

Abstract: Benzimidazole derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such benzimidazole derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

Abstract translation: 本文描述了可用作TIE-2和/或VEGFR-2抑制剂的苯并咪唑衍生物。 所述的发明还包括制备这种苯并咪唑衍生物的方法以及使用它们在治疗过度增殖性疾病中的方法。

公开(公告)号：US07141569B2

公开(公告)日：2006-11-28

申请号：US10473491

申请日：2002-03-21

Applicant: Mui Cheung ,  Kristjan Gudmundsson ,  Brian A. Johns

Inventor： Mui Cheung ,  Kristjan Gudmundsson ,  Brian A. Johns

IPC: C07D471/04 ,  A61K31/435 ,  C07D401/04

CPC classification number: C07D471/04

Abstract: The present invention provides compounds of formula (I): pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract translation: 本发明提供式（I）化合物：含有该化合物的药物组合物，其制备方法及其作为药剂的用途。

公开(公告)号：US07034030B2

公开(公告)日：2006-04-25

申请号：US10473196

申请日：2002-03-20

Applicant: Michael John Alberti ,  Stanley D. Chamberlain ,  Mui Cheung ,  Kristjan Gudmundsson ,  Philip Anthony Harris ,  Brian A. Johns ,  David Kendall Jung ,  Michael Robert Peel ,  Jennifer Badiang Stanford

Inventor： Michael John Alberti ,  Stanley D. Chamberlain ,  Mui Cheung ,  Kristjan Gudmundsson ,  Philip Anthony Harris ,  Brian A. Johns ,  David Kendall Jung ,  Michael Robert Peel ,  Jennifer Badiang Stanford

IPC: C07D403/04 ,  A61K31/505

CPC classification number: C07D471/04

Abstract: The present invention provides compounds of formula (I): wherein all variables are as defined herein, pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract translation: 本发明提供式（I）化合物：其中所有变量如本文所定义，含有该化合物的药物组合物，其制备方法及其作为药剂的用途。

公开(公告)号：US20050085637A1

公开(公告)日：2005-04-21

申请号：US10503874

申请日：2003-02-07

Applicant: Mui Cheung ,  Kristen Nailor ,  Douglas Sammond ,  James Veal

Inventor： Mui Cheung ,  Kristen Nailor ,  Douglas Sammond ,  James Veal

IPC: A61K31/505 ,  A61K31/506 ,  A61K45/00 ,  A61P9/00 ,  A61P9/10 ,  A61P17/02 ,  A61P27/02 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  C07D239/02 ,  C07D239/48 ,  C07D251/48

CPC classification number: C07D239/48

Abstract: Pyrimidine derivatives, which are useful as TIE-2 and/or VEGFR-2 inhibitors are described herein. The described invention also includes methods of making such pyrimidine derivatives as well as methods of using the same in the treatment of hyperproliferative diseases.

Abstract translation: 本文描述了可用作TIE-2和/或VEGFR-2抑制剂的嘧啶衍生物。 所述的发明还包括制备此类嘧啶衍生物的方法以及使用该嘧啶衍生物的方法来治疗过度增殖性疾病。

公开(公告)号：US20100075960A1

公开(公告)日：2010-03-25

申请号：US12303118

申请日：2007-05-29

Applicant: Kevin Kuntz ,  Kyle Allen Emmitte ,  Tara Renae Rheault ,  Stephon Smith ,  Keith Hornberger ,  Hamilton Dickson ,  Mui Cheung

Inventor： Kevin Kuntz ,  Kyle Allen Emmitte ,  Tara Renae Rheault ,  Stephon Smith ,  Keith Hornberger ,  Hamilton Dickson ,  Mui Cheung

IPC: A61K31/454 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/4545 ,  C07D413/14 ,  C07D409/14 ,  A61P35/00

CPC classification number: C07D409/04 ,  C07D409/14

Abstract: The present invention provides bezimidazole thiophene compounds pharmaceutical compositions containing the same, processes for preparing the same and their use as pharmaceutical agents.

Abstract translation: 本发明提供苯扎咪唑噻吩化合物含有其的药物组合物，其制备方法及其作为药剂的用途。