公开(公告)号：US20160354111A1

公开(公告)日：2016-12-08

申请号：US15116562

申请日：2015-02-04

Applicant: NIPRO CORPORATION

Inventor： KATSUYA MIYAGAWA ,  MISA MATSUMOTO ,  TOMONORI NAKAMURA

IPC: A61B17/3207 ,  A61B8/00 ,  A61B8/12

CPC classification number: A61B17/320783 ,  A61B8/12 ,  A61B8/445 ,  A61B17/320758 ,  A61B2017/22069 ,  A61B2017/22071 ,  A61B2017/320716 ,  A61B2090/3735 ,  A61B2090/3784

Abstract: [Object] To provide a catheter having a simple structure capable of excising an atheroma in a blood vessel and capable of obtaining ultrasonic images of a blood vessel.[Solution] A catheter 10 has a shaft 11 having an opening 20 in a part of the side wall on the distal end side, a cutter 12 which is located in the vicinity of the opening 20 in the internal space of the shaft 11 and which can move in the axial direction 101 of the shaft 11, a balloon 23 which is disposed on the side opposite to the opening 20 with respect to the axis of the shaft 11 and which outwardly expands from the side wall of the shaft 11, and a phased array ultrasound probe 17 disposed along the circumferential direction 102 of the outer peripheral surface of the side wall in the vicinity of the opening 20 at least on the same side as the side where the opening 20 is provided with respect to the axis of the shaft 11.

Abstract translation: 导管10具有在前端侧的侧壁的一部分中具有开口20的轴11，位于轴11的内部空间内的开口20附近的切割器12， 可以沿着轴11的轴向101移动，气球23相对于轴11的轴线设置在与开口20相对的一侧上并且从轴11的侧壁向外扩展，并且 相对阵列超声波探头17至少在与开口20相对于轴的轴线设置的一侧至少在同一侧沿着侧壁的外周表面的周向方向102设置在开口20附近 11。

公开(公告)号：US20160326165A1

公开(公告)日：2016-11-10

申请号：US15108506

申请日：2014-12-18

Applicant: KINKI UNIVERSITY ,  EDUCATIONAL CORPORATION MUKOGAWA GAKUIN ,  NIPRO CORPORATION

Inventor： Kenji MATSUYAMA ,  Toru OTORI ,  Tetsutaro KIMACHI

IPC: C07D471/04 ,  A61K31/5383 ,  A61K33/06 ,  A61K31/496 ,  A61K33/08 ,  C07D498/06 ,  A61K9/00

CPC classification number: C07D471/04 ,  A61K9/0053 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/5383 ,  A61K33/06 ,  A61K33/08 ,  C07D498/06

Abstract: The present invention provides a hemiacetal ester prodrug of the pyridone carboxylic acid antibacterial drug, wherein the prodrug is characterized in that, (i) it is hydrolyzed promptly after intestinal absorption and regenerates the pyridone carboxylic acid antibacterial drug as a drug substance, (ii) a one-dose package is possible by preventing chelate-formation in intestines in an oral administration, and (iii) the normal bacterial flora of the intestinal bacterial flora is not influenced at all until the ester is absorbed, because the hemiacetal-type esterification is executed on the carboxylic acid which is a center of the antibacterial action, resulting in prevention of the pseudomembranous colitis. The prodrug is an alkoxy carbonyl hemiacetal-type ester represented by the chemical formula (I), which is useful as a prodrug for inhibiting the enteric-bacterium-shift side effect, and can be used in combination with polyvalent metal-containing medicines.

公开(公告)号：US20160303332A1

公开(公告)日：2016-10-20

申请号：US15099064

申请日：2016-04-14

Applicant: NIPRO CORPORATION

Inventor： Yoshiharu IWASE ,  Yutaka EIZUMI ,  Isao SASAKI

IPC: A61M5/32 ,  A61L31/14 ,  A61L31/02

CPC classification number: A61M5/3286 ,  A61L31/022 ,  A61L31/14 ,  A61M5/329 ,  A61M2207/00 ,  F04C2270/0421

Abstract: An injection needle 1 made of an alloy containing cobalt and molybdenum is manufactured as follows. First, a lancet cut is carried out to a pipe-like metallic material composed of the alloy containing cobalt and molybdenum to form a blade tip 3 and a blade part 5. Then, a distal end part 1A including the blade tip 3 is mechanically polished, and thereafter, the distal end part 1A is immersed in an electrolytic solution and electrolytically polished. Thus, burrs at the blade tip 3 or the like generated during mechanical polishing are removed. Since the injection needle 1 is composed of the alloy containing cobalt and molybdenum, compared to a conventional injection needle made of stainless steel, an injection needle in which the surface roughness of an inner peripheral surface of the injection needle is low and smooth can be provided.

Abstract translation: 如下制造由含有钴和钼的合金制成的注射针1。 首先，对由含有钴和钼的合金构成的管状金属材料进行刺血针切割，以形成刀片尖端3和刀片部分5.然后，将包括刀尖3的前端部1A机械抛光 然后将前端部1A浸渍在电解液中进行电解抛光。 因此，在机械抛光期间产生的叶片尖端3等处的毛刺被去除。 由于注射针1由含有钴和钼的合金构成，所以与现有的不锈钢注射针相比，可以提供注射针的内周面的表面粗糙度低且平滑的注射针 。

公开(公告)号：USD761421S1

公开(公告)日：2016-07-12

申请号：US29521617

申请日：2015-03-25

Applicant: NIPRO CORPORATION

Designer： Hiroyuki Nakagami ,  Tatsuya Kudo ,  Shingo Sakamoto

公开(公告)号：US20160128903A1

公开(公告)日：2016-05-12

申请号：US14895533

申请日：2014-06-12

Applicant: Ken KODAI ,  Kazuaki Uketake ,  Nipro Corporation

Inventor： Kazuaki Uetake ,  Ken KODAI

IPC: A61J1/03 ,  B65B41/10 ,  B65D75/32 ,  B65B1/04 ,  B65B61/26 ,  B65B47/04 ,  B65B51/02

Abstract: A PTP sheet for pharmaceutical packaging has a first sheet in which pockets each capable of housing a solid pharmaceutical are projected to the side of a first surface which is one of a back surface and a front surface and a second sheet which is pasted to a second surface opposite to the first surface in the first sheet and covers an opening of the pocket. The second sheet has a first region having mesh-shaped grooves having a first depth in a third surface opposite to the surface to be pasted to the second surface and a second region having mesh-shaped grooves having a second depth smaller than the first depth or not having a groove.

Abstract translation: 用于药物包装的PTP片材具有第一片，其中能够容纳固体药物的口袋投射到作为背表面和前表面之一的第一表面的侧面上，第二片材被粘贴到第二片材 表面与第一片中的第一表面相对并且覆盖口袋的开口。 所述第二片具有第一区域，所述第一区域具有网状凹槽，所述第一区域具有与要粘贴到所述第二表面的表面相对的第三表面中的第一深度，以及具有第二深度小于所述第一深度的网状凹槽的第二区域， 没有凹槽

公开(公告)号：US20160106561A1

公开(公告)日：2016-04-21

申请号：US14787972

申请日：2014-05-12

Applicant: TOKAI UNIVERSITY EDUCATIONAL SYSTEM ,  NIPRO CORPORATION

Inventor： Yuji IKARI ,  Kuniaki MATSUMOTO

IPC: A61F2/89

CPC classification number: A61F2/89 ,  A61F2/915 ,  A61F2002/825 ,  A61F2002/91558 ,  A61F2002/91575 ,  A61F2002/91583 ,  A61F2230/0054 ,  A61F2250/0018

Abstract: Provided is a stent having a novel structure, the stem simultaneously having both the stability of shape against the action of external force, such as compression force, tensile force, or torsional force, and high flexibility in the direction of twisting of the stem. Connection groups are provided at three or more positions set at circumferentially equally-spaced intervals, the connection groups each including connection sections which are disposed circumferentially close to each other between axially adjacent tubular divided bodies. The connection groups on both sides axially of each of the tubular divided bodies are provided at positions circumferentially offset from each other while at least one turning portion is present between the connection groups.

Abstract translation: 提供了一种具有新颖结构的支架，所述杆同时具有形状抵抗外力作用的稳定性，例如压缩力，拉力或扭转力，以及在杆的扭转方向上的高柔性。 连接组设置在设置在周向等间隔的间隔处的三个或更多个位置处，每个连接组包括在轴向相邻的管状分隔体之间彼此周向地设置的连接部分。 每个管状分隔体的两侧的连接组在彼此周向地偏移的位置处设置，而在连接组之间存在至少一个转动部。

公开(公告)号：US20160032354A1

公开(公告)日：2016-02-04

申请号：US14768331

申请日：2014-02-18

Applicant: NIPRO CORPORATION

Inventor： Kenta Tatsumi ,  Daisuke Nakamura

IPC: C12Q1/44

CPC classification number: C12Q1/44 ,  C07K2319/21 ,  C12N9/16 ,  G01N2333/916 ,  G01N2800/347

Abstract: It is an object of this invention to provide a simple measurement method capable of detecting indoxyl sulfuric acid in a sample rapidly and at high sensitivity. By causing sulfatase and tetrazolium salt to act on indoxyl sulfuric acid in a sample to generate a formazan dye, and then calculating the generation amount of the formazan dye, indoxyl sulfuric acid in the sample can be measured more simply, more rapidly, and at higher sensitivity as compared with former methods.

Abstract translation: 本发明的目的是提供一种能够快速且高灵敏度地检测样品中的吲哚硫酸的简单测量方法。 通过使硫酸酯酶和四唑鎓盐作用于样品中的吲哚硫酸以产生甲an染料，然后计算甲an染料的产生量，样品中的茚满硫酸可以更简单，更快速，更高 灵敏度与以前的方法相比。

公开(公告)号：US20150313797A1

公开(公告)日：2015-11-05

申请号：US14650120

申请日：2013-11-25

Applicant: NIPRO CORPORATION

Inventor： Tomohiko KUBO

IPC: A61J1/20

CPC classification number: A61J1/2096 ,  A61J1/2013 ,  A61J1/2055

Abstract: In a connection device, when a cannula holding member is in a use state, a position of an end portion of an outer cylindrical portion on a retracted position side does not protrude to the retracted position side, with respect to a position of an end portion of an inner cylindrical portion on the retracted position side. Thereby, a connection device including a structure capable of holding a vial by holding means irrespective of the size of the vial can be provided.

Abstract translation: 在连接装置中，当套管保持构件处于使用状态时，缩回位置侧的外筒部的端部的位置不向缩回位置侧突出，相对于端部的位置 在缩回位置侧的内圆柱形部分。 因此，可以提供一种连接装置，其包括能够通过保持装置保持小瓶而不考虑小瓶的尺寸的结构。

公开(公告)号：US09010150B2

公开(公告)日：2015-04-21

申请号：US13846453

申请日：2013-03-18

Applicant: Nipro Corporation

Inventor： Hideo Kuwabara ,  Hideki Yamauchi ,  Yoshitaka Ishimi ,  Shinichiro Senga

IPC: C03B29/00 ,  C03B21/00 ,  C03B25/00 ,  C03B31/00 ,  C03B33/00 ,  C03B29/02 ,  C03B23/09 ,  A61J1/14

CPC classification number: C03B23/099 ,  A61J1/14 ,  C03B23/006 ,  C03B23/0093 ,  C03B23/09 ,  C03B29/02 ,  C03C23/007

Abstract: A method for producing a vial with low alkali elution by removing a deteriorated region caused by processing on an internal surface of a vial is disclosed. The method is for forming vials from borosilicate glass tubes with a bottom wherein an internal surface of the tube is fire-blasted with a flame.

Abstract translation: 公开了一种通过除去由小瓶的内表面上的加工引起的恶化区域来生产低碱洗脱的小瓶的方法。 该方法用于从具有底部的硼硅酸盐玻璃管形成小瓶，其中管的内表面用火焰喷射。

公开(公告)号：US20150073356A1

公开(公告)日：2015-03-12

申请号：US14386461

申请日：2013-01-29

Applicant: NIPRO CORPORATION

Inventor： Norihisa Sasayama ,  Yui Hagiwara ,  Naoko Ishihara

IPC: A61M39/10

CPC classification number: A61M39/10 ,  A61M1/029 ,  A61M5/178 ,  A61M5/31515 ,  A61M5/3202 ,  A61M5/3275 ,  A61M2005/3268

Abstract: To prevent a user from accidentally pricking the user with a hollow needle when separating blood components using a syringe and a connection device. A blood component separation apparatus has three syringes and a connection device. The connection device is attached to one syringe and is inserted into other syringes. The connection device has a first member to which a base end of a hollow needle is joined and a second member which is connected to the first member in such a manner as to be able to move relative to the first member. The second member is moved back and forth between a first position where a tip of the hollow needle is accommodated and a second position where the tip of the hollow needle is exposed. The second member has elastic portions which are elastically deformed in the movement from the first position to the second position. The elastically deformed elastic portions elastically energize the second member at the second position to the first position side with respect to the first member.

Abstract translation: 为了防止用户使用注射器和连接装置分离血液成分时用中空针不慎地刺穿使用者。 血液成分分离装置具有三个注射器和连接装置。 连接装置连接到一个注射器，并插入其他注射器。 连接装置具有第一构件，中空针的基端与该第一构件接合，第二构件以能够相对于第一构件移动的方式连接到第一构件。 第二构件在容纳空心针的前端的第一位置和中空针的前端露出的第二位置之间来回移动。 第二构件具有在从第一位置到第二位置的运动中弹性变形的弹性部分。 弹性变形的弹性部分在第二位置将第二构件弹性激励到相对于第一构件的第一位置侧。