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公开(公告)号：US12097302B2
公开(公告)日：2024-09-24
申请号：US17729608
申请日：2022-04-26
Applicant: CellSeed Inc. , TOKAI UNIVERSITY EDUCATIONAL SYSTEM
Inventor： Masato Sato , Chikako Sato , Tomomi Kotoku , Tomoko Kawake
IPC: C12N5/077 , A61L27/36 , A61L27/38 , C12N5/0775
CPC classification number: A61L27/3612 , A61L27/3817 , A61L27/3834 , A61L27/3852 , C12N5/0655 , C12N5/0668 , A61L2430/06 , C12N2533/30
Abstract: Provided is a cell sheet suitable for cartilage repair. The present invention provides a cell sheet for cartilage repair, formed from a culture of cells derived from a cartilage tissue, and the cell sheet is negative for immunostaining using an antibody against type II collagen. The present invention also provides a method for producing a cell sheet for cartilage repair, formed from a culture of cells derived from a cartilage tissue, and the method includes culturing cells derived from a cartilage tissue on a surface of a membrane, where a temperature-responsive polymer is immobilized on the surface, to give the cell sheet. The culturing is stopped before the cell sheet becomes positive for immunostaining using an antibody against type II collagen.
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2.发明公开公开(公告)号：US20230167409A1
公开(公告)日：2023-06-01
申请号：US17921180
申请日：2021-04-26
Inventor： Daisuke SAKAI , Yoshihiko NAKAMURA , Erika MATSUSHITA
CPC classification number: C12N5/0655 , A61K35/32 , C07K14/71 , C12N2506/13 , C12N2500/76 , C12N2501/115 , C12N2533/32
Abstract: A method of culturing a cell population containing cartilage-derived cells positive for expression of Tie2 (cartilage-derived Tie2-positive cells), the method including culturing a cell population containing cartilage-derived Tie2-positive cells in a culture medium containing at least one kind of Tie2 expression enhancer other than growth factors (e.g., an extract derived from a plant of the genus Cinnamomum). This culturing method is preferably performed in cultureware having a culture surface coated with a coating agent (e.g., a polylysine-containing agent).
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公开(公告)号：US11555208B2
公开(公告)日：2023-01-17
申请号：US15890561
申请日：2018-02-07
Inventor： Channabasavaiah B. Gurumurthy , Hiromi Miura , Masato Ohtsuka
Abstract: Disclosed are compositions, methods, and kits for modifying DNA within cells as well as compositions and methods for modifying gene expression in a cell. In particular, the invention generally relates to compositions, methods, and kits for DNA editing using single-stranded DNA. Compositions and methods for modifying gene expression using artificial microRNAs (amiRNA) are also contemplated.
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公开(公告)号：US20220296647A1
公开(公告)日：2022-09-22
申请号：US17599396
申请日：2021-07-29
Applicant: Tokai University Educational System
Inventor： Daisuke SAKAI , Jordy SCHOL , Yoshihiko NAKAMURA
Abstract: Provided is reproducible means that enables production of nucleus pulposus progenitor cells (preferably, an active nucleus pulposus progenitor cell phenotype) from desired cells such as terminally differentiated cells and stem cells having pluripotency or multipotency. A nucleus pulposus progenitor cell inducer according to the present invention comprising an effective amount of a gene of Brachyury (T) or a homolog thereof, at least one selected from the group consisting of SRY-box6 (SOX6) or a homolog thereof and Forkhead Box Q1 (FOXQ1) or a homolog thereof, and MYC Proto-Oncogene, BHLH Transcription Factor (cMyc) or a homolog thereof (nucleus pulposus progenitor cell master regulator transcription factor), or a product thereof.
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公开(公告)号：US10456503B2
公开(公告)日：2019-10-29
申请号：US15305460
申请日：2015-04-20
Inventor： Yosuke Okamura , Yu Nagase , Takuya Komachi , Motonori Hochi , Yuki Sekido , Toru Arakane
IPC: B32B27/02 , A61L31/00 , A61L15/16 , B32B27/36 , B32B27/08 , B32B27/30 , A61L31/04 , A61L31/06 , A61L31/14 , A61L15/24 , A61L15/26 , A61L15/28 , A61L15/64 , B32B9/02 , B32B9/04 , B32B7/05
Abstract: A polymer laminate has 2-100 layers each containing a biodegradable resin and having a thickness of 10 nm-400 nm that are laminated, the thickness of at least one of the outermost layers is 10 nm-180 nm, and the outermost layers are joined to each other. A polymer laminate excellent in biocompatibility and mechanical strength and suitable to medical applications such as wound dressings and antiadhesive materials can be obtained.
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Patent Agency Ranking
公开(公告)号：US10286014B2
公开(公告)日：2019-05-14
申请号：US14431791
申请日：2013-09-30
Applicant: Foundation for Biomedical Research and Innovation , Tokai University Educational System , StemMed Inc. , JUNTENDO EDUCATIONAL FOUNDATION
Inventor： Takayuki Asahara , Haruchika Masuda , Rika Tanaka
Abstract: Simplification of a preparation step of a cell population used for the treatment of ischemic diseases, and provision of a cell population that shows more effective treatment are shown. A method of producing a cell population wherein a vascular endothelial progenitor cell and/or an anti-inflammatory macrophage are/is enriched, including cultivating a mononuclear cell derived from bone marrow, cord blood or peripheral blood in a serum-free medium containing stem cell factor, interleukin-6, FMS-like tyrosine kinase 3 ligand, thrombopoietin and vascular endothelial cell growth factor, and proliferating vascular endothelial progenitor cell from the cell; and a cell population obtained by the method are shown.
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公开(公告)号：US20140031710A1
公开(公告)日：2014-01-30
申请号：US13787928
申请日：2013-03-07
Inventor： Muneshige KURAHASHI , Naofumi Kobayashi , Sunao Takeda , Takashi Nagaoka , Tadashi Abe , Tetsuya Urano , Takuya Aoki , Chizuko Tsuji
IPC: A61B5/00
CPC classification number: A61B5/4818 , A61B5/082 , A61B5/0826
Abstract: An apparatus for determining sleep apnea includes: an expiratory gas collector which is configured to collect an expiratory gas of a subject; an analyzer which is configured to analyze a constituent and a concentration of the constituent in the collected expiratory gas; and a determiner which is configured to determine whether the subject is in sleep apnea or not, based on a concentration of at least VOC in the analyzed expiratory gas.
Abstract translation: 一种用于确定睡眠呼吸暂停的装置，包括：呼气集气器，被配置成收集受试者的呼气气体; 分析器，其被配置为分析所收集的呼气中的成分和浓度; 以及确定器，其被配置为基于所分析的呼气中的至少VOC的浓度来确定所述受试者是否处于睡眠呼吸暂停中。
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公开(公告)号：US20190255121A1
公开(公告)日：2019-08-22
申请号：US16279341
申请日：2019-02-19
Inventor： Daisuke SAKAI , Tomoko NAKAI , Mitsuru NAIKI , Yoji SHIBAYAMA
IPC: A61K35/36 , A61K9/00 , C12Q1/6876
Abstract: An object of the present invention is to provide an agent for promoting expression of N-acetylgalactosaminyltransferase that contains an extract from inflamed tissues inoculated with vaccinia virus. The present invention demonstrated that the extract from inflamed tissues inoculated with vaccinia virus promotes the expression of N-acetylgalactosaminyltransferase in intervertebral disc cells. Thus, the extract from inflamed tissues inoculated with vaccinia virus or a preparation containing the extract is useful as an agent for promoting the expression of N-acetylgalactosaminyltransferase in intervertebral disc cells.
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公开(公告)号：US10314834B2
公开(公告)日：2019-06-11
申请号：US15758582
申请日：2016-09-09
Inventor： Kanji Sugita , Kiyoshi Ando
IPC: A61K31/454 , A61K45/00 , A61K31/122 , A61K31/167 , A61K31/404 , A61K31/437 , A61K31/4439 , A61K31/444 , A61K31/496 , A61K31/502 , A61K31/5025 , A61K31/506 , A61K31/517 , A61K31/553
Abstract: According to the present invention, there is provided a pharmaceutical composition for treating Philadelphia chromosome positive lymphocytic leukemia, including a thalidomide derivative and BCR-ABL tyrosine kinase inhibitor. According to the present invention there is also provided a method of treating Philadelphia chromosome positive lymphocytic leukemia, including administering a thalidomide derivative and a BCR-ABL tyrosine kinase inhibitor to a patient suffering from Philadelphia chromosome positive lymphocytic leukemia.
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公开(公告)号：US10254649B2
公开(公告)日：2019-04-09
申请号：US15030894
申请日：2014-10-16
Inventor： Osamu Mikami , Kentaro Ohmori , Hideyuki Nawata
IPC: G03F7/075 , G03F7/09 , G03F7/16 , G03F7/20 , G03F7/30 , G02B6/138 , G02B6/122 , G02B6/26 , C08F290/14 , C08G77/16 , C09D183/04 , C08G77/20 , C08G77/00 , G02B1/111 , B29D11/00 , G03F7/00 , G03F7/32
Abstract: A method for producing an optical waveguide composing an optical path conversion component having an extremely low signal loss, allowing a high surface packaging density and high speed operation, and allowing high productivity. A method for producing an optical waveguide that propagates light from a surface of a support to an oblique direction not vertical to the surface, the method for producing an optical waveguide comprising the steps of: (1) providing an anti-reflective coating on the support; (2) placing a photosensitive resin composition on the anti-reflective coating, and exposing the photosensitive resin composition to a light ray entering from a direction non-vertical to the surface of the support through a photomask for curing the composition; and (3) removing the unexposed photosensitive resin composition by development; and an optical waveguide obtained by the method.
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