公开(公告)号：US20230174622A1

公开(公告)日：2023-06-08

申请号：US17998447

申请日：2021-05-14

Applicant: Ospedale San Raffaele S.R.L. ,  Fondazione Telethon

Inventor： Luigi Naldini ,  Pietro Genovese ,  Valentina Vavassori

IPC: C07K14/71 ,  C12N15/86 ,  C07K16/28 ,  A61P37/06

CPC classification number: C07K14/71 ,  C12N15/86 ,  C07K16/2863 ,  A61P37/06 ,  C07K2319/03

Abstract: A polynucleotide comprising a nucleotide sequence encoding an epidermal growth factor receptor (EGFR) extracellular epitope operably linked to: (a) a NGFR or GMS SFR alpha signal peptide; (b) a EGFR or NGFR transmembrane domain; and/or (c) a NGFR or EGFR cytosplasmic tail.

公开(公告)号：US11360087B2

公开(公告)日：2022-06-14

申请号：US16342354

申请日：2017-10-17

Applicant: Ospedale San Raffaele S.R.L. ,  Fondazione Telethon

Inventor： Luca Basso-Ricci ,  Luca Biasco ,  Alessandro Aiuti

IPC: G01N33/569 ,  G01N1/28 ,  G01N15/14 ,  G01N33/58 ,  G01N33/49

Abstract: Use of (i) an anti-CD3 antibody, (ii) an anti-CD56 antibody, (iii) an anti-CD14 antibody, (iv) an anti-CD38 antibody, (v) an anti-CD45 antibody, (vi) an anti-CD90 antibody, (vii) an anti-CD135 antibody, (viii) an anti-CD10 antibody, (ix) an anti-CD11c antibody, (x) an anti-CD19 antibody, (xi) an anti-CD34 antibody, (xii) an anti-CD45RA antibody, (xiii) an anti-CD7 antibody, (xiv) an anti-CD71 antibody, (xv) an anti-CD41/CD61 complex antibody or an anti-CD41 antibody and/or an anti-CD61 antibody (xvi) an anti-CD33 antibody and/or an anti-CD66b antibody, for identifying hematopoietic cell subtypes in an isolated sample, determining the relative frequency of hematopoietic cell subtypes in an isolated sample and/or quantifying the number of cells within hematopoietic cell subtypes in an isolated sample, wherein each of (i) to (xvi) is labelled with a different fluorochrome, wherein when (xvi) is an anti-CD33 antibody and an anti-CD66b antibody, the anti-CD33 antibody and anti-CD66b are labelled with the same fluorochrome, and wherein when (xv) is an anti-CD41 antibody and an anti-CD61 antibody, the anti-CD4 antibody and the anti-CD61 antibody are labelled with the same fluorochrome.

公开(公告)号：US20220110943A1

公开(公告)日：2022-04-14

申请号：US17267693

申请日：2019-08-09

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  IRBM S.P.A. ,  PROMIDIS S.R.L. ,  ISTITUTO NAZIONALE Dl GENETICA MOLECOLARE - INGM

Inventor： Raffaele DE FRANCESCO ,  Lorena DONNICI ,  Luca GUIDOTTI ,  Matteo IANNACONE ,  Romano DI FABIO ,  Vincenzo SUMMA ,  Adolfo PRANDI ,  Pietro RANDAZZO ,  Davide GORNATI ,  Alessandro GRILLO ,  Luca FERRANTE ,  Leda Ivanova BENCHEVA ,  Marilenia DE MATTEO ,  Marco FERRARA

IPC: A61K31/554 ,  C07D515/14 ,  C07D515/08 ,  A61K31/407 ,  C07D519/00 ,  C07D513/14 ,  A61P31/20

Abstract: The present invention relates to compounds that are inhibitors of hepatitis B virus (HBV). Compounds of this invention are useful alone or in combination with other agents for treating, ameliorating, preventing or curing HBV infection and related conditions. The present invention also relates to pharmaceutical compositions containing the compounds.

公开(公告)号：US20220025330A1

公开(公告)日：2022-01-27

申请号：US17424825

申请日：2020-01-22

Applicant: Washington University ,  Ospedale San Raffaele S.R.L ,  Fondazione Telethon

Inventor： Christopher Sturgeon ,  Andrea Ditadi

IPC: C12N5/0789

Abstract: The present disclosure provides methods for generating hematopoietic progenitor cells. In some embodiments, the methods involve an in vitro or ex vivo cell culture model utilizing retinoic acid signaling for producing hematopoietic progenitor cells from pluripotent stem cells.

公开(公告)号：US20210121579A1

公开(公告)日：2021-04-29

申请号：US16606633

申请日：2018-04-20

Applicant: Ospedale San Raffaele S.R.L ,  Fondazione Telethon

Inventor： Anna Christina KAJASTE-RUDNITSKI ,  Carolina PETRILLO ,  Bernhard Rudolf GENTNER ,  Luigi NALDINI ,  Pietro GENOVESE ,  Giulia SCHIROLI

IPC: A61K48/00 ,  C07K7/64 ,  C12N5/0789 ,  C12N15/69 ,  C12N15/86

Abstract: Use of cyclosporin H (CsH) or a derivative thereof for increasing the efficiency of transduction of an isolated population of cells by a viral vector and/or increasing the efficiency of gene editing of an isolated population of cells when transduced by a viral vector.

公开(公告)号：US20210046159A1

公开(公告)日：2021-02-18

申请号：US16978897

申请日：2019-03-08

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  FONDAZIONE CENTRO SAN RAFFAELE

Inventor： Attilio BONDANZA ,  Barbara CAMISA ,  Margherita NORELLI

IPC: A61K38/20 ,  A61P39/00

Abstract: The present invention relates to a IL-1 antagonist alone or in combination with other therapeutic agents and relative pharmaceutical compositions for use for the treatment and/or prevention of toxicity induced by a T cell therapy, wherein the T cell expresses at least one recombinant receptor.

公开(公告)号：US20200338131A1

公开(公告)日：2020-10-29

申请号：US16827708

申请日：2020-03-24

Applicant: Ospedale San Raffaele S.R.L. ,  Fondazione Telethon

Inventor： Luigi Naldini ,  Bernhard Rudolf Gentner ,  Erika Zonari ,  Francesco Boccalatte

IPC: A61K35/28 ,  C12N5/0789 ,  C12N15/86 ,  A61K48/00

Abstract: A method of preparing a therapeutic cell population for clinical use from a starting population of cells comprising haematopoietic stem cells, said method comprising separating a population of cells that substantially do not express CD38 but which express CD34 from the starting population of cells, and transducing the separated cell population with a vector to obtain the therapeutic cell population.

公开(公告)号：US20190032059A1

公开(公告)日：2019-01-31

申请号：US16004394

申请日：2018-06-10

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  Fondazione Telethon

Inventor： Luigi Naldini ,  Brian Brown

IPC: C12N15/113 ,  C12N15/63 ,  C12N15/86

Abstract: A gene vector comprising a miRNA sequence target.

公开(公告)号：US20180333434A1

公开(公告)日：2018-11-22

申请号：US15970945

申请日：2018-05-04

Applicant: OSPEDALE SAN RAFFAELE S.R.L.

Inventor： Maria Chiara Bonini ,  Attilio Bondanza

IPC: A61K35/17 ,  G01N33/68 ,  G01N33/569 ,  C12N5/0783

CPC classification number: A61K35/17 ,  A61K48/0091 ,  A61K2039/5156 ,  C12N5/0636 ,  C12N2501/23 ,  C12N2501/2302 ,  C12N2501/2306 ,  C12N2501/2307 ,  C12N2501/2315 ,  C12N2501/51 ,  C12N2501/515 ,  C12N2506/11 ,  C12N2510/00 ,  G01N33/56972 ,  G01N33/6863 ,  Y02A50/412 ,  Y02A50/58

Abstract: It is described in vitro methods for expanding, detecting or isolating rare populations of antigen specific memory T cells. It is also described an in vitro method for obtaining a genetically modified memory T cell population. Uses of cells so obtained are also disclosed.

公开(公告)号：US20180305432A1

公开(公告)日：2018-10-25

申请号：US15763419

申请日：2016-10-03

Applicant: OSPEDALE SAN RAFFAELE S.R.L. ,  FONDAZIONE CENTRO SAN RAFFAELE

Inventor： Giulia CASORATI ,  Paolo DELLABONA ,  Claudia DE LALLA ,  Claudio GARAVAGLIA ,  Michela CONSONNI

IPC: C07K14/725 ,  A61K39/00 ,  A61P35/02

CPC classification number: C07K14/7051 ,  A61K39/0011 ,  A61K2039/5156 ,  A61P35/02

Abstract: The present invention relates to a TCR or functional variant thereof having antigenic specificity for CD1c molecules associated with a self-lipid, preferably (mLPA) or derivative thereof, to relative polypeptide, protein, nucleic acid, recombinant expression vector, host cell, population of cells, antibody and pharmaceutical composition. The present invention also relates to the uses of said TCR and relative products, in particular for use in the treatment and/or prevention of an hematological disorder.