公开(公告)号：US20080045900A1

公开(公告)日：2008-02-21

申请号：US10543714

申请日：2004-01-30

申请人： Paul G. Alchas ,  Peter W. Heyman ,  Marina S. Korisch ,  William A. Easterbrook ,  Robert E. West ,  Todd M. Chelak

发明人： Paul G. Alchas ,  Peter W. Heyman ,  Marina S. Korisch ,  William A. Easterbrook ,  Robert E. West ,  Todd M. Chelak

IPC分类号： A61M5/46

CPC分类号： A61M5/3129 ,  A61M5/3134 ,  A61M5/3243 ,  A61M5/3257 ,  A61M5/326 ,  A61M5/425 ,  A61M5/46 ,  A61M2205/583 ,  A61M2205/6063

摘要： A medication delivery device, particularly an intradermal delivery device, having a needle cannula, with a sharpened distal end having a forward tip, and a limiter disposed about the needle cannula. The limiter has a distal end defining a skin engaging surface which is disposed transversely to, and at least partially about, the needle cannula. The skin engaging surface is generally non-flat with generally coplanar portions, and a recess being defined in the skin engaging surface which defines a void in or adjacent to the coplanar portions into which portions of a patient's skin can be deformed into when the skin engaging surface is pressed against the patient's skin. The forward tip of the needle cannula is spaced apart from a plane defined by the coplanar portions a distance ranging from about 0.5 mm to 3.0 mm such that the skin engaging surface limits penetration of the forward tip of the needle cannula to the dermis layer of the patient's skin.

摘要翻译： 药物输送装置，特别是具有针插管的皮内递送装置，其具有尖锐的远端具有前部尖端，以及围绕针管设置的限制器。 限制器具有限定皮肤接合表面的远端，其横向于并且至少部分地围绕针插管设置。 皮肤接合表面通常是非平坦的，具有大致共面的部分，并且在皮肤接合表面中限定凹部，该凹槽限定了共面部分中或邻近共面部分的空隙，当皮肤接合时，患者皮肤的部分可以变形 表面被压在患者的皮肤上。 针插管的前端与由共面部分限定的平面间隔开，距离范围为约0.5mm至3.0mm，使得皮肤接合表面限制针插管的前尖端穿透到针管的真皮层 病人的皮肤。

公开(公告)号：US06730059B2

公开(公告)日：2004-05-04

申请号：US10140950

申请日：2002-05-09

申请人： Richard James Caizza ,  Paul G. Alchas ,  Alfred Wesley Prais

发明人： Richard James Caizza ,  Paul G. Alchas ,  Alfred Wesley Prais

IPC分类号： A61M500

CPC分类号： A61B17/205 ,  Y10S128/919

摘要： A medical needle device which is reusable and cooperates with a disposable needle assembly. The medical needle device includes a holder, a needle assembly, and an ejector rod cooperating with the holder. The needle assembly includes a needle hub and needle. The holder has a proximal end and a distal end and defines an opening extending therethrough. The distal end has a hub socket for receiving the hub of the needle, with the needle hub received in the socket. The ejector extends into the opening from the proximal end of the holder. The ejector rod is slidably received in the holder and has a distal end configured to engage the needle hub, and a proximal end extending outward from the holder. The ejector rod is used to eject the needle assembly from the holder.

摘要翻译： 一种医疗针装置，其可重复使用并与一次性针组件协作。 医疗针装置包括保持器，针组件和与保持器配合的顶出杆。 针组件包括针座和针。 保持器具有近端和远端并限定延伸穿过其中的开口。 远端具有用于接收针的轮毂的轮毂插座，针座被容纳在插座中。 喷射器从保持器的近端延伸到开口中。 顶出杆可滑动地容纳在保持器中，并且具有构造成接合针座的远端以及从保持器向外延伸的近端。 推杆用于将针组件从保持器中排出。

公开(公告)号：US06689118B2

公开(公告)日：2004-02-10

申请号：US10071665

申请日：2002-02-08

申请人： Paul G. Alchas ,  Philippe Emile Fernand Laurent

发明人： Paul G. Alchas ,  Philippe Emile Fernand Laurent

IPC分类号： A61M3100

CPC分类号： A61M5/46 ,  A61B17/205 ,  A61K39/00 ,  A61K2039/53 ,  A61K2039/54 ,  A61M5/158 ,  A61M5/282 ,  A61M5/3202 ,  A61M5/3278 ,  A61M37/00 ,  A61M2202/0445 ,  Y02A50/388 ,  Y02A50/39 ,  Y02A50/396 ,  Y02A50/401 ,  Y02A50/412 ,  Y02A50/464 ,  Y02A50/466 ,  Y02A50/472 ,  Y02A50/484

摘要： A method of making an intradermal injection using a drug delivery device containing the substance to be injected. A device for practicing the method includes a needle cannula having a forward tip and a limiter portion having a skin engaging surface surrounding the needle cannula. The needle cannula is in fluid communication with the substance and the tip of the needle cannula extends beyond the skin engaging surface a distance equal to approximately 0.5 mm to 3.0 mm. The needle cannula includes a fixed angle of orientation relative to the plane of the skin engaging surface. The skin engaging surface limits penetration of the needle tip into the skin so that the substance can be expelled through the needle tip into the dermis layer. Preferably, the fixed angle of orientation of the needle cannula is generally perpendicular relative to the skin surface, and the skin engaging surface is generally flat.

摘要翻译： 使用含有待注射物质的药物输送装置进行皮内注射的方法。 用于实施该方法的装置包括具有前端的针插管和具有围绕针插管的皮肤接合表面的限制器部分。 针插管与物质流体连通，并且针插管的尖端延伸超过皮肤接合表面等于大约0.5mm至3.0mm的距离。 针套管包括相对于皮肤接合表面的平面的固定定向角度。 皮肤接合表面限制针尖进入皮肤的穿透，使得物质可以通过针尖排出到真皮层中。 优选地，针插管的固定定向角度通常相对于皮肤表面垂直，并且皮肤接合表面通常是平坦的。

公开(公告)号：US5372945A

公开(公告)日：1994-12-13

申请号：US923384

申请日：1992-07-31

申请人： Paul G. Alchas ,  Alfred W. Prais ,  Bruce E. Jarrell ,  Stuart K. Williams ,  Joseph A. DiPisa, Jr.

发明人： Paul G. Alchas ,  Alfred W. Prais ,  Bruce E. Jarrell ,  Stuart K. Williams ,  Joseph A. DiPisa, Jr.

IPC分类号： C12M3/00 ,  A61F2/06 ,  A61L27/34 ,  A61L27/38 ,  A61L27/50 ,  C12M3/08 ,  C12N5/00 ,  C12N5/06 ,  C12S3/00 ,  C12M1/40

CPC分类号： A61F2/062 ,  A61L27/34 ,  A61L27/38 ,  A61L27/507 ,  C12M45/09 ,  C12N5/0068 ,  A61M2202/08 ,  A61M2202/097

摘要： Methods and apparatus for collecting and processing tissue to produce an endothelial cell product having a vessel for rinsing, draining, digesting and isolating tissue. The vessel has a rinsing and digesting chamber for containing tissue during processing. An inlet in the rinsing and digesting chamber allows entry of rinsing solution and tissue from a liposuction device. A waste chamber in fluid communication with the rinsing and digesting chamber preferably connects with a vacuum source. An isolation chamber is separated from the rinsing and digesting chamber by a screen. An ampule in fluid communication with the isolation chamber includes a pair of ports controlled by valve devices to be selectively in fluid communication with the isolation chamber. After processing, the ampule isolates a pellet of endothelial cells and the valve devices permit the pellet to be in fluid communication with the ports. The method includes providing the vessel, introducing tissue to be processed, orienting the vessel to screen the tissue, introducing an enzyme and agitating to digest the tissue, centrifuging the vessel to transfer the cells from the digested tissue, and isolating the cells for retrieval.

摘要翻译： 用于收集和处理组织以产生具有用于冲洗，排干，消化和分离组织的血管的内皮细胞产品的方法和装置。 该容器具有用于在加工期间容纳组织的冲洗和消化室。 冲洗和消化室中的入口允许从吸脂装置进入冲洗溶液和组织。 与冲洗和消化室流体连通的废物室优选与真空源连接。 隔离室通过筛网与冲洗和消化室分离。 与隔离室流体连通的安瓿包括由阀装置控制的一对端口，以选择性地与隔离室流体连通。 加工后，安瓿将内皮细胞颗粒分离，并且阀门装置允许颗粒与端口流体连通。 该方法包括提供容器，引入待处理组织，定向容器筛选组织，引入酶并搅拌消化组织，离心容器以从消化的组织转移细胞，并分离细胞进行检索。

公开(公告)号：US5312380A

公开(公告)日：1994-05-17

申请号：US951353

申请日：1992-09-25

申请人： Paul G. Alchas ,  Frank A. Augello ,  Christopher J. Brooks ,  Tony A. Cutshall ,  Joseph A. DiPisa, Jr. ,  Stuart K. Williams ,  Jonathan B. Gabel ,  Paul J. Mulhauser ,  Wes Prais ,  Bruce E. Jarrell ,  Deborah G. Rose

发明人： Paul G. Alchas ,  Frank A. Augello ,  Christopher J. Brooks ,  Tony A. Cutshall ,  Joseph A. DiPisa, Jr. ,  Stuart K. Williams ,  Jonathan B. Gabel ,  Paul J. Mulhauser ,  Wes Prais ,  Bruce E. Jarrell ,  Deborah G. Rose

IPC分类号： A61F2/06 ,  A61L27/34 ,  A61L27/38 ,  A61L27/50 ,  A61J1/00 ,  A61M1/00

CPC分类号： A61L27/507 ,  A61F2/062 ,  A61L27/34 ,  A61L27/38 ,  A61M2202/08

摘要： The invention is an endothelial cell procurement and deposition kit for collecting fat from a patient, processing said fat to produce an endothelial cell deposition product, and depositing said product on the surface of a graft, all under sterile conditions established and maintained within the components of said kit comprised of: fat collection means for collecting subcutaneous fat from a patient; digestion means connectable to said fat collection means to maintain sterility during reception of said fat and for retaining said fat under sterile conditions during rinsing and digestion to produce a digested product; endothelial cell isolation means connectable to said digestion means for maintaining sterile conditions during reception of said digested product and for separating and isolating microvessel endothelial cells from said digested product to produce an endothelial cell product; cell deposition means connectable to said isolation means for maintaining sterile conditions during reception of said endothelial cell product and for depositing said cells on the surface of a graft to be implanted in a patient and facilitating implantation of said endothelial graft into a patient.

摘要翻译： 本发明是用于从患者收集脂肪的内皮细胞采购和沉积试剂盒，处理所述脂肪以产生内皮细胞沉积产物，并将所述产物沉积在移植物的表面上，所有这些在无菌条件下建立并保持在 所述试剂盒包括：用于从患者收集皮下脂肪的脂肪收集装置; 消化装置可连接到所述脂肪收集装置以在接收所述脂肪期间保持不育，并且在漂洗和消化期间在无菌条件下保持所述脂肪以产生消化产物; 内皮细胞分离装置可连接到所述消化装置，用于在接收所述消化产物期间维持无菌条件，并用于从所述消化产物中分离和分离微血管内皮细胞以产生内皮细胞产物; 细胞沉积装置可连接到所述隔离装置，用于在接收所述内皮细胞产物期间维持无菌条件，并将所述细胞沉积在待植入患者体内的移植物表面上，并便于将所述内皮移植物植入患者体内。

公开(公告)号：US5035708A

公开(公告)日：1991-07-30

申请号：US356431

申请日：1989-05-24

申请人： Paul G. Alchas ,  Frank A. Augello ,  Christopher J. Brooks ,  Tony A. Cutshall ,  Joseph A. DiPisa, Jr. ,  Stuart K. Williams ,  Jonathan B. Gabel ,  Paul J. Mulhauser ,  Wes Prais ,  Bruce E. Jarrell ,  Deborah G. Rose

发明人： Paul G. Alchas ,  Frank A. Augello ,  Christopher J. Brooks ,  Tony A. Cutshall ,  Joseph A. DiPisa, Jr. ,  Stuart K. Williams ,  Jonathan B. Gabel ,  Paul J. Mulhauser ,  Wes Prais ,  Bruce E. Jarrell ,  Deborah G. Rose

IPC分类号： A61B10/02 ,  A01N1/02 ,  A61F2/06 ,  A61L27/00 ,  A61L27/34 ,  A61L27/50

CPC分类号： A61L27/34 ,  A61F2/062 ,  A61L27/507 ,  C12M45/09 ,  A61M2202/08 ,  C12M47/04 ,  Y10S604/902

摘要： The invention is an endothelial cell procurement and deposition kit for collecting fat from a patient, processing said fat to produce an endothelial cell deposition product, and depositing said product on the surface of a graft, all under sterile conditions established and maintained within the components of said kit comprised of: fat collection means for collecting subcutaneous fat from a patient; digestion means connectable to said fat collection means to maintain sterility during reception of said fat and for retaining said fat under sterile conditions during rinsing and digestion to produce a digested product; endothelial cell isolation means connectable to said digestion means for maintaining sterile conditions during reception of said digested product and for separating and isolating microvessel endothelial cells from said digested product to produce an endothelial cell product; cell deposition means connectable to said isolation means for maintaining sterile conditions during reception of said endothelial cell product and for depositing said cells on the surface of a graft to be implanted in a patient and facilitating implantation of said endothelial graft into a patient.

摘要翻译： 本发明是用于从患者收集脂肪的内皮细胞采购和沉积试剂盒，处理所述脂肪以产生内皮细胞沉积产物，并将所述产物沉积在移植物的表面上，所有这些在无菌条件下建立并保持在 所述试剂盒包括：用于从患者收集皮下脂肪的脂肪收集装置; 消化装置可连接到所述脂肪收集装置以在接收所述脂肪期间保持不育，并且在漂洗和消化期间在无菌条件下保持所述脂肪以产生消化产物; 内皮细胞分离装置可连接到所述消化装置，用于在接收所述消化产物期间维持无菌条件，并用于从所述消化产物中分离和分离微血管内皮细胞以产生内皮细胞产物; 细胞沉积装置可连接到所述隔离装置，用于在接收所述内皮细胞产物期间维持无菌条件，并将所述细胞沉积在待植入患者体内的移植物表面上，并便于将所述内皮移植物植入患者体内。