公开(公告)号：US20050168663A1

公开(公告)日：2005-08-04

申请号：US11015771

申请日：2004-12-20

申请人： Koichi Miyachi ,  Seiji Shibahara ,  Iichiro Inoue ,  Shoichi Ishihara ,  Takako Koide

发明人： Koichi Miyachi ,  Seiji Shibahara ,  Iichiro Inoue ,  Shoichi Ishihara ,  Takako Koide

IPC分类号： G02F1/135 ,  G02F1/07 ,  G02F1/133 ,  G02F1/1335 ,  G02F1/137 ,  G09G3/36

CPC分类号： G02F1/137 ,  G02F1/07

摘要： A display element includes a dielectric material layer 3, provided between a pair of substrates (substrates 1 and 2), which is made of a medium showing optical isotropy when no electric field is applied and showing optical anisotropy when an electric field is applied. Further, comb-shaped electrodes 4 and 5 are provided face to face on the substrate 1 so as to be positioned in a surface which faces the substrate 2. Furthermore, polarizing plates 6 and 7 are respectively provided on rear surfaces with respect to the counter surfaces of the substrates 1 and 2. Thus, it is possible to realize the display element which has a wide driving temperature range, a wide viewing angle property, and a high-speed response property.

摘要翻译： 显示元件包括设置在一对基板（基板1和2）之间的电介质材料层3，其在不施加电场时显示光学各向同性的介质，并且当施加电场时显示出光学各向异性。 此外，梳状电极4和5面对面地设置在基板1上，以位于与基板2相对的表面中。此外，偏振片6和7分别设置在相对于计数器的后表面 因此，可以实现具有宽驱动温度范围，宽视角特性和高速响应特性的显示元件。

公开(公告)号：US20050162607A1

公开(公告)日：2005-07-28

申请号：US11035400

申请日：2005-01-14

申请人： Koichi Miyachi ,  Iichiro Inoue ,  Seiji Shibahara ,  Shoichi Ishihara

发明人： Koichi Miyachi ,  Iichiro Inoue ,  Seiji Shibahara ,  Shoichi Ishihara

IPC分类号： G02F1/1337 ,  C09K19/18 ,  C09K19/20 ,  C09K19/58 ,  G02F1/1343 ,  G02F1/1368 ,  G02F1/139 ,  C09K19/02

CPC分类号： C09K19/586 ,  C09K19/18 ,  C09K19/2007 ,  G02F1/133784 ,  G02F1/134363 ,  G02F1/1368 ,  G02F1/1393 ,  G02F1/1396

摘要： An electrode is provided on one surface of each of a pair of substrates. On the other surface of each of the substrates, a polarizer is provided. The substrates are assembled together so that their surfaces on which the electrodes are formed face each other. Then, a medium is introduced between the substrates, to form a dielectric material layer. The medium is prepared by mixing a chiral agent in a negative type liquid crystalline compound.

摘要翻译： 在一对基板的一个表面上设置电极。 在每个基板的另一个表面上设有偏振器。 将基板组装在一起，使得其上形成有电极的表面彼此面对。 然后，在基板之间引入介质，形成电介质材料层。 通过将手性试剂混合在负型液晶化合物中来制备培养基。

公开(公告)号：US5602106A

公开(公告)日：1997-02-11

申请号：US271996

申请日：1994-07-08

申请人： Keiichi Ajito ,  Osamu Hara ,  Ken-ichi Kurihara ,  Nobue Kikuchi ,  Minako Araake ,  Akira Shimizu ,  Tsuneo Okonogi ,  Shigeharu Inouye ,  Seiji Shibahara

发明人： Keiichi Ajito ,  Osamu Hara ,  Ken-ichi Kurihara ,  Nobue Kikuchi ,  Minako Araake ,  Akira Shimizu ,  Tsuneo Okonogi ,  Shigeharu Inouye ,  Seiji Shibahara

IPC分类号： C07H17/08 ,  A61K31/70

CPC分类号： C07H17/08

摘要： 16-membered macrolide derivatives represented by the formula (I): ##STR1## wherein R.sup.1 represents a hydrogen atom or a substituent group which protects a hydroxyl group; R.sup.2 represents a hydrogen atom or a substituent group which protects a hydroxyl group; R.sup.3 represents a hydrogen atom or a straight-chain aliphatic acyl group having 2 to 4 carbon atoms; and R.sup.4 represents a hydrogen atom or a straight-chain aliphatic or aromatic acyl group having 1 to 10 carbon atoms;or a pharmaceutically acceptable salt thereof are disclosed.A novel process for producing these 16-membered macrolide derivatives is also disclosed.

摘要翻译： 由式（I）表示的16元大环内酯衍生物：其中R 1表示氢原子或保护羟基的取代基; R2表示氢原子或保护羟基的取代基; R3表示氢原子或碳原子数2〜4的直链脂肪族酰基， R 4表示氢原子或碳原子数1〜10的直链脂肪族或芳香族酰基， 或其药学上可接受的盐。 还公开了一种制备这些16元大环内酯衍生物的新方法。

公开(公告)号：US5232947A

公开(公告)日：1993-08-03

申请号：US754393

申请日：1991-09-04

申请人： Yasuo Sato ,  Shinsuke Katoh ,  Kunio Atsumi ,  Mitsugu Hachisu ,  Seiji Shibahara

发明人： Yasuo Sato ,  Shinsuke Katoh ,  Kunio Atsumi ,  Mitsugu Hachisu ,  Seiji Shibahara

IPC分类号： A61K31/19 ,  C07C233/56

CPC分类号： C07C233/56 ,  A61K31/19 ,  Y10S514/921

摘要： New N,N-di-alkyl- or alkenyl-substituted derivatives of oxamic acid of which the two alkyl or alkenyl groups are different from each other are now produced and found to exhibit the cerebral protective effect against cerebral anoxia in the brain of a mammalian animal, including human, and to be useful as an agent for improving or ameliorating the damaged or disturbed functions of the brain. Some known N,N-di-alkyl-substituted derivatives of oxamic acid or which the two alkyl groups are identical to each other are now also found to have similar, cerebral protective effect against cerebral anoxia and to be useful as an agent for improving the damaged functions of the brain.

摘要翻译： 现在产生两个烷基或链烯基彼此不同的新的N，N-二 - 烷基 - 或链烯基取代的衍生物，并发现它们在哺乳动物脑中表现出对脑缺氧的脑保护作用 动物，包括人类，并且可用作改善或改善大脑受损或紊乱功能的药剂。 现在还发现一些已知的氧杂酸的N，N-二烷基取代的衍生物或两个烷基彼此相同，对脑缺氧具有相似的脑保护作用，并且可用作改善 损坏大脑功能。

公开(公告)号：US5132454A

公开(公告)日：1992-07-21

申请号：US662192

申请日：1991-02-28

申请人： Yasuo Sato ,  Shinsuke Kato ,  Takako Taniguchi ,  Kunio Atsumi ,  Mitsugu Hachisu ,  Seiji Shibahara

发明人： Yasuo Sato ,  Shinsuke Kato ,  Takako Taniguchi ,  Kunio Atsumi ,  Mitsugu Hachisu ,  Seiji Shibahara

IPC分类号： A61K31/19 ,  A61P9/00 ,  A61P25/28 ,  C07C231/12 ,  C07C233/36 ,  C07C233/56

CPC分类号： C07C233/56

摘要： A method of inhibiting the abnormal postnatal axial growth of the eye of a maturing animal during conditions ordinarily leading to said abnormal growth, which comprises (1) determining the neurochemical present in the retina of said eye, e.g., dopamine, the concentration of which is reduced during said conditions, and (2) administering to said eye during postnatal maturation effective amounts of said neurochemical, its agonist or its antagonist.

公开(公告)号：US5079255A

公开(公告)日：1992-01-07

申请号：US544671

申请日：1990-06-27

申请人： Kiyoaki Katano ,  Tamako Tomomoto ,  Hiroko Ogino ,  Yamazaki Naoki ,  Fumiya Hirano ,  Yasukatsu Yuda ,  Fukio Konno ,  Motohiro Nishio ,  Tomoya Machinami ,  Seiji Shibahara ,  Takashi Tsuruoka ,  Shigeharu Inouye

发明人： Kiyoaki Katano ,  Tamako Tomomoto ,  Hiroko Ogino ,  Yamazaki Naoki ,  Fumiya Hirano ,  Yasukatsu Yuda ,  Fukio Konno ,  Motohiro Nishio ,  Tomoya Machinami ,  Seiji Shibahara ,  Takashi Tsuruoka ,  Shigeharu Inouye

IPC分类号： C07D487/04 ,  A61K31/435 ,  A61K31/44 ,  A61K31/445 ,  A61K31/495 ,  A61K31/535 ,  A61P1/04 ,  C07D471/04 ,  C07D498/04 ,  C07D513/04

CPC分类号： C07D471/04 ,  C07D513/04

摘要： Compounds of the general formula (I): ##STR1## and pharmaceutically acceptable salts thereof, in which A, B, C and D each represent --CH.dbd. or --N.dbd., with the proviso that at least one of them is --N.dbd.;X represents --NH--, --O-- or --S--;Y represents --(CH.sub.2).sub.p -- wherein p is an integer from 0 to 4, --C(CH.sub.3).sub.2 --, --CH.sub.2 CH.dbd.CH--, --CH.sub.2 CO--, --CF.sub.2 -- or --CH.sub.2 COCH.sub.2 --;R.sup.1 represents a hydrogen atom, a C.sub.1-4 alkyl group, a halogen atom or a C.sub.1-4 alkoxy group;R.sup.2 represents a hydrogen atom, a hydroxyl group, a saturated or unsaturated C.sub.1-6 alkyl group, a C.sub.1-6 alkoxy group, a carboxyl group, a saturated or unsaturated C.sub.1-12 alkoxycarbonyl group which may be optionally substituted, a cycloalkoxycarbonyl group, a saturated or unsaturated five- or six-membered heterocyclic group containing at least one nitrogen atom optionally with one or more nitrogen and/or oxygen atoms, which may be optionally condensed and/or substituted, --CONR.sup.3 R.sup.4, --NR.sup.3 R.sup.4, --OCOR.sup.3 or --NHCONHR.sup.3 wherein R.sup.3 and R.sup.4, which may be the same or different, represent a C.sub.1-6 alkyl group which may be optionally substituted or a cycloalkyl group, andm and n each represent an integer from 0 to 2.

公开(公告)号：US5061702A

公开(公告)日：1991-10-29

申请号：US402814

申请日：1989-09-05

申请人： Kunio Atsumi ,  Katsuyoshi Iwamatsu ,  Kenji Sakagami ,  Takashi Yoshida ,  Haruo Yamamoto ,  Seiji Shibahara ,  Shigeharu Inouye

发明人： Kunio Atsumi ,  Katsuyoshi Iwamatsu ,  Kenji Sakagami ,  Takashi Yoshida ,  Haruo Yamamoto ,  Seiji Shibahara ,  Shigeharu Inouye

IPC分类号： C07D501/22 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/04 ,  C07D501/06 ,  C07D501/24

CPC分类号： C07D501/24 ,  Y02P20/55

摘要： A novel cephem compound which has antimicrobial activity is disclosed. The cephem compound is represented by the formula: ##STR1## wherein R.sup.1 represents a hydrogen atom or a carboxyl group; R.sup.2 and R.sup.3, which may be the same or different, each represent a hydrogen atom or a lower alkyl group of 1-3 carbon atoms; and R.sup.4 and R.sup.5, which may be the same or different, each represent a hydrogen atom or an acyl group; and pharmaceutically acceptable salts thereof.

公开(公告)号：US4970305A

公开(公告)日：1990-11-13

申请号：US413915

申请日：1989-09-28

申请人： Tsuneo Okonogi ,  Yasushi Murai ,  Masahiro Onodera ,  Toshio Nishizuka ,  Yasuhiko Abat ,  Seiji Shibahara ,  Shigeharu Inouye

发明人： Tsuneo Okonogi ,  Yasushi Murai ,  Masahiro Onodera ,  Toshio Nishizuka ,  Yasuhiko Abat ,  Seiji Shibahara ,  Shigeharu Inouye

IPC分类号： C07D501/00 ,  A61K31/545 ,  C07D501/36

CPC分类号： C07D501/36 ,  Y02P20/55

摘要： The crystalline dihydrochloride of a specific cephalosporin derivative is stable to heat and retains its antibacterial activity even after storage over long periods at high temperature. The crystalline dihydrochloride can be obtained by removing protective groups from the cephalosporin derivative wherein the amino group and carboxy groups are protected and then crystallizing the cephalosporin derivative from a hydrochloric acid aqueous solution. The crystalline dihydrochloride is useful for pharmaceutical preparations.

公开(公告)号：US4898858A

公开(公告)日：1990-02-06

申请号：US928955

申请日：1986-11-10

申请人： Seiji Shibahara ,  Tsuneo Okonogi ,  Yasushi Murai ,  Toshiaki Kudo ,  Takashi Yoshida ,  Ken Nishihata ,  Shinichi Kondo

发明人： Seiji Shibahara ,  Tsuneo Okonogi ,  Yasushi Murai ,  Toshiaki Kudo ,  Takashi Yoshida ,  Ken Nishihata ,  Shinichi Kondo

IPC分类号： A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D501/00 ,  C07D501/36

CPC分类号： C07D501/00

摘要： New cephalosporin derivatives of a general formula (I) and non-toxic salts and non-toxic esters thereof are provided: ##STR1## (wherein R represents an acyclic or cyclic lower alkyl group having 1-6 carbon atoms, which may optionally be substituted by a halogen atom; the steric configuration as asterisked (*) includes an optical-active (R)-form or (S)-form or an optical-inactive (RS)-form; n is 0 or 1, n.sup.1 is 0 to 3, n.sup.2 is 0 to 3; and when n.sup.1 is 0, n.sup.2 is 3; when n.sup.1 is 1, n.sup.2 is 2; when n.sup.1 is 2, n.sup.2 is 1; when n.sup.1 is 3, n.sup.2 is 0).The new derivatives of the formula (I) and non-toxic salts and esters thereof have high bactericidal activity with broad antibacterial spectra, and these are useful as active ingredients in bactericides.

摘要翻译： 提供了通式（I）的新型头孢菌素衍生物及其无毒盐和无毒酯：其中R表示具有1-6个碳原子的无环或环状低级烷基 ，其可以任选地被卤素原子取代;星号（*）的空间构型包括光学活性（R）形式或（S）形式或光学非活性（RS）形式; n是0或 1，n1为0〜3，n2为0〜3，n2为0时，n2为3，n1为1时n2为2，n1为2时，n2为1，n1为3时，n2为0 ）。 式（I）的新衍生物及其无毒盐和酯具有广泛的抗菌谱具有高杀菌活性，可用作杀菌剂中的活性成分。

公开(公告)号：US4556513A

公开(公告)日：1985-12-03

申请号：US627254

申请日：1984-08-15

申请人： Seiji Shibahara ,  Tsuneo Okonogi ,  Yasushi Murai ,  Shunzo Fukatsu ,  Taro Niida ,  Tadashi Wakazawa

发明人： Seiji Shibahara ,  Tsuneo Okonogi ,  Yasushi Murai ,  Shunzo Fukatsu ,  Taro Niida ,  Tadashi Wakazawa

IPC分类号： C07D205/085 ,  C07D505/00 ,  C07D205/08 ,  C07D498/04

CPC分类号： C07D505/00 ,  C07D205/085 ,  Y02P20/55

摘要： Disclosed is a process for preparing antibiotic 1-oxadethiacephalosporins via diazo-species I: ##STR1## wherein: A is acyl; R.sup.1 is H or OCH.sub.3 ; and R.sup.2 is a protecting group.

摘要翻译： 本发明公开了一种通过重氮种I制备抗生素1-恶二硫醚类的方法：其中：A为酰基; R1是H或OCH3; R2是保护基。