公开(公告)号：US20170172717A1

公开(公告)日：2017-06-22

申请号：US15385817

申请日：2016-12-20

Applicant: Taipei Medical University ,  Industrial Technology Research Institute

Inventor： WIN-PING DENG ,  HENG-YU LIU ,  HSIN-HUA CHOU ,  CHIN-YU TSAI ,  CHIUNG-FANG HUANG ,  CHUN-HSIANG WEN ,  PING-CHEN CHEN ,  CHING-SUNG CHEN ,  CHENG-HUSAN LIN ,  KAI-HAN LIAO

IPC: A61C19/06

CPC classification number: A61C19/066 ,  A61C7/08 ,  A61C9/0006 ,  A61C19/063 ,  A61C2201/00 ,  A63B71/085 ,  A63B2071/086

Abstract: A dental carrier comprises a thermoplastic carrier. The thermoplastic carrier has a pattern structure. After heating the thermoplastic carrier, the thermoplastic carrier is provided with a user to be impressed by teeth or alveolar ridge for forming teeth or alveolar ridge model of the user. Compared to the prior art, the dental carrier of the present invention can provide the dental medicament contained in the pattern structure to be precisely applied and hold onto the treatment area and the medicament can be evenly coated on the teeth, root, or periodontal tissue for the treatment of teeth. When the dental carrier is not used to carry medicament, the pattern structure can improve the mechanical strength and fitness of the dental carrier to be used as a biteplate, orthodontic retainer, periodontal dressing for treatment or protection or mouth guard in sports.

公开(公告)号：US20160355493A1

公开(公告)日：2016-12-08

申请号：US14730430

申请日：2015-06-04

Applicant: Taipei Medical University ,  China Medical University

Inventor： Chieh-Hsi Wu ,  Yueh-Hsiung Kuo ,  Chun-Hsu Pan

IPC: C07D307/80 ,  A61K31/343 ,  A61N5/10 ,  A61K45/06

CPC classification number: C07D307/80 ,  A61K31/343 ,  A61K45/06

Abstract: The present invention develops a series of methyl caffeate derivatives having biological activity in anti-angiogenesis. The present invention suggests that the compounds of the invention possess inhibiting angiogenesis through regulation of VEGF/VEGFR-2 and its downstream signaling cascades in the vascular endothelial cells (VECs).

Abstract translation: 本发明开发了一系列在抗血管生成中具有生物学活性的咖啡酸甲酯衍生物。 本发明提出本发明的化合物通过调节VEGF / VEGFR-2及其在血管内皮细胞（VECs）中的下游信号级联来抑制血管生成。

公开(公告)号：US20160145312A1

公开(公告)日：2016-05-26

申请号：US14920283

申请日：2015-10-22

Applicant: Taipei Medical University

Inventor： Jaulang HWANG

IPC: C07K14/47 ,  C07K16/18 ,  A61K39/00 ,  A61K38/17 ,  A61K45/06

CPC classification number: C07K14/47 ,  A61K38/00 ,  A61K39/0005 ,  A61K45/06 ,  C07K16/18 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2319/30

Abstract: The disclosure provides an antigenic peptide targeting the extracellular, but not the intracellular, form of CETP to reduce the level of LDL (including oxLDL and other derivatives of LDL) and increase the level of HDL. Accordingly, the disclosure provides a CETP vaccine to overcome the low immunogenicity of CETP and for long-term inhibition of CETP activity to prevent or treat oxLDL or other LDL derivative-related diseases/symptoms.

Abstract translation: 本公开提供靶向细胞外但不是细胞内形式的CETP以降低LDL水平（包括oxLDL和其他LDL衍生物）并提高HDL水平的抗原肽。 因此，本公开提供了CETP疫苗以克服CETP的低免疫原性和长期抑制CETP活性以预防或治疗oxLDL或其它LDL衍生物相关疾病/症状。

公开(公告)号：US20150342719A1

公开(公告)日：2015-12-03

申请号：US14824894

申请日：2015-08-12

Applicant: TAIPEI MEDICAL UNIVERSITY

Inventor： CHIEN-CHUNG CHEN ,  JEN-CHANG YANG ,  JEN-CHIEH LU ,  SHENG-YANG LEE

IPC: A61F2/02 ,  B01D69/08 ,  D01F8/14 ,  D01F8/06 ,  D01D5/24 ,  D01D5/00

CPC classification number: A61F2/02 ,  B01D61/147 ,  B01D63/021 ,  B01D69/08 ,  B01D2323/39 ,  B29C47/0014 ,  D01D5/0069 ,  D01D5/0076 ,  D01D5/24 ,  D01F6/625 ,  D01F8/14 ,  Y10T428/249921 ,  Y10T428/249924 ,  Y10T428/268

Abstract: The invention provides a highly aligned and closely packed hollow fiber assembly, wherein the assemblies of fibrous membrane has a width-to-fiber diameter ratio (W/d) larger than 10 and the orientation of the fibers is no larger than +/−10°. Also provided is an electrospinning process for the preparation of the fiber assembly of the invention and its applications.

Abstract translation: 本发明提供了一种高度排列紧密的中空纤维组件，其中纤维膜的组件具有大于10的宽度与纤维直径之比（W / d），并且纤维的取向不大于+/- 10 °。 还提供了用于制备本发明的纤维组件及其应用的静电纺丝方法。

公开(公告)号：US20140377831A1

公开(公告)日：2014-12-25

申请号：US14068969

申请日：2013-10-31

Applicant: TAIPEI MEDICAL UNIVERSITY

Inventor： JENNIFER HUI-CHUN HO

IPC: C12N13/00

CPC classification number: C12N13/00 ,  C12M31/00 ,  C12M35/00 ,  C12M41/46 ,  C12N5/0667 ,  C12N2510/00 ,  C12N2529/10

Abstract: The invention provides a method of enhancing a directional migration of stem cells, comprising providing one or more stem cell(s) and irradiating the stem cells with an effective energy of green light thereby enhancing stem cell directionally migrating, wherein the orientation of migration of stem cells is opposite to the green light source. Also provided is a stem cell treated by the method of the invention and a device for enhancing a directional migration of stem cells.

Abstract translation: 本发明提供了增强干细胞定向迁移的方法，其包括提供一个或多个干细胞并用绿光的有效能量照射干细胞，从而增强干细胞定向迁移，其中茎的迁移取向 细胞与绿色光源相对。 还提供了通过本发明的方法处理的干细胞和用于增强干细胞的定向迁移的装置。

公开(公告)号：US20140377808A1

公开(公告)日：2014-12-25

申请号：US14309486

申请日：2014-06-19

Applicant: TAIPEI MEDICAL UNIVERSITY

Inventor： YU-CHUAN LIU

IPC: A61M1/16 ,  C01B5/00 ,  B01J19/08 ,  C12P19/34

CPC classification number: A61M1/1656 ,  A61M2202/0413 ,  A61M2205/75 ,  B01J19/088 ,  B01J2219/0894 ,  C01B5/00 ,  C02F1/005 ,  C02F1/30 ,  C02F1/48 ,  C02F2103/026 ,  C02F2305/08 ,  C02F2305/10 ,  C12P19/34

Abstract: The invention provides an apparatus of treating water to obtain small water cluster, which comprises one or more illumination devices and one or more holders holding metal particles. The invention also provides a method of preparing the small water cluster and the small water cluster prepared from the apparatus or the method.

Abstract translation: 本发明提供了一种处理水以获得小水簇的装置，其包括一个或多个照明装置和一个或多个保持金属颗粒的保持器。 本发明还提供了一种从该装置或方法制备的小水簇和小水簇的制备方法。

公开(公告)号：US20140199748A1

公开(公告)日：2014-07-17

申请号：US14212995

申请日：2014-03-14

Applicant: TAIPEI MEDICAL UNIVERSITY

Inventor： RICHARD LI-CHERN PAN ,  FANG-CHI HSU

IPC: C12N5/09

CPC classification number: C12N5/0693 ,  C12N5/0697 ,  C12N2502/1135 ,  C12N2502/28 ,  C12N2502/30

Abstract: The invention relates to a kit and method for the capture of tumor cells in a body fluid sample. The kit and method of the invention can capture living tumor cells but not non-living tumor cells or cell fragments so that the tumor species can be further identified by further culture of the captured tumor cells. Also, the kit and method of the invention can readily identify whether a sample contains tumor cells and collect these tumor cells for further identification so that the presence of cancer and development of the metastasis and early relapse can be found.

Abstract translation: 本发明涉及用于在体液样品中捕获肿瘤细胞的试剂盒和方法。 本发明的试剂盒和方法可以捕获活肿瘤细胞，而不是非活体肿瘤细胞或细胞片段，从而可以通过进一步培养所捕获的肿瘤细胞进一步鉴定肿瘤物种。 此外，本发明的试剂盒和方法可以容易地鉴定样品是否含有肿瘤细胞并收集这些肿瘤细胞用于进一步鉴定，从而可以发现癌症的存在和转移和早期复发的发展。

公开(公告)号：US20240350521A1

公开(公告)日：2024-10-24

申请号：US18641154

申请日：2024-04-19

Applicant: TAIPEI MEDICAL UNIVERSITY

Inventor： Yang-Ching CHEN

IPC: A61K31/704 ,  A61P5/24 ,  A61P15/00

CPC classification number: A61K31/704 ,  A61P5/24 ,  A61P15/00

Abstract: Provided is a method for preventing or treating precocious puberty in a subject in need thereof. The method includes administering to the subject an effective amount of glycyrrhizin or a salt or derivative thereof and an acceptable excipient thereof. Also provided is a composition for use in preventing or treating precocious puberty in a subject in need thereof.

公开(公告)号：US20240341701A1

公开(公告)日：2024-10-17

申请号：US18493080

申请日：2023-10-24

Applicant: Taipei Medical University (TMU) ,  Taipei Veterans General Hospital

Inventor： Syu-Jyun PENG ,  Tse-Hao LEE ,  Jong-Ling FUH

IPC: A61B6/03 ,  A61B5/00 ,  A61B5/055 ,  G01N33/68

CPC classification number: A61B6/037 ,  A61B5/055 ,  A61B5/4088 ,  G01N33/6896

Abstract: An operation method of a brain amyloid PET processing system includes steps as follows. The whole brain white matter amyloid PET image is extracted from the smoothed amyloid PET image in the range of the whole brain white matter mask of the normalized brain space, and the uptake value with the preset maximum ratio in the whole brain white matter amyloid PET image is calculated; in the smoothed amyloid PET image of the normalized brain space, one or more voxels in the range of the whole brain gray matter mask are marked and counted, in which each voxel uptake value of the one or more voxels is greater than the uptake value of the preset maximum ratio of the whole brain white matter amyloid PET image, and the one or more voxels are used for interpretation training and test of the classification of the machine learning.

公开(公告)号：US20240100517A1

公开(公告)日：2024-03-28

申请号：US17935917

申请日：2022-09-27

Applicant: National Taiwan University ,  Taipei Medical University

Inventor： HORN-JIUNN SHEEN ,  PEI-KUEN WEI ,  YU-JUI FAN ,  PO-HAN JUAN ,  YUNG-YU HUANG

IPC: B01L3/00 ,  B01L7/00 ,  C12M1/38

CPC classification number: B01L3/5027 ,  B01L3/50851 ,  B01L7/52 ,  C12M1/38 ,  B01L2300/1827

Abstract: The present disclosure provide a detection device of microfluidic polymerase chain reaction (PCR) and a detection system including the same. This all-in-one device and system may be used to detect at least one biological detection chip, so that can amplify gene fragments at the front-end and detect them at the back-end immediately, decreasing the time required for the analysis, enabling real-time, low-cost, and rapid detection of various viruses, such as EBV and COVID-19, without compromising accuracy or sensitivity.