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公开(公告)号：US20240325088A1
公开(公告)日：2024-10-03
申请号：US18578948
申请日：2022-07-12
IPC分类号： A61B34/20 , A61B90/00 , A61N5/10 , G01R33/561
CPC分类号： A61B34/20 , A61B90/37 , A61N5/1007 , A61N5/1049 , G01R33/5615 , A61B2034/2051 , A61B2090/365 , A61B2090/372 , A61N2005/1055
摘要： Described here are systems and methods for guiding interventional procedures, in which the guidance is driven by a virtual reality, augmented reality, augmented virtuality, and/or other mixed reality systems. The virtual/mixed reality guidance can be based on magnetic resonance images that are acquired in real-time and presented to a user in a virtual/mixed reality environment.
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公开(公告)号：US12076344B2
公开(公告)日：2024-09-03
申请号：US17296859
申请日：2019-11-27
IPC分类号： A61K35/17 , C12N5/0783
CPC分类号： A61K35/17 , C12N5/0636 , C12N2501/04 , C12N2501/2302 , C12N2501/24 , C12N2510/00
摘要： The present disclosure provides chimeric antigen receptor (CAR)-T-Rapa cells and methods of making and using them. Specifically, methods of producing T-Rapa cells that can express chimeric antigen receptors is provided.
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公开(公告)号：US12076130B2
公开(公告)日：2024-09-03
申请号：US16982821
申请日：2019-03-20
发明人： Nikolai Mickevicius , Eric Paulson
IPC分类号： A61B5/055 , G01R33/48 , G01R33/483 , G01R33/561 , G01R33/565 , G01R33/567
CPC分类号： A61B5/055 , G01R33/4808 , G01R33/4835 , G01R33/5611 , G01R33/56509 , G01R33/5676
摘要： Systems and methods for providing image guidance for motion tracking and compensation in magnetic resonance imaging (“MRI”) guided therapies, such as MRI-guided radiation therapies using an MR-linac or other MRI-guided radiation therapy system, are described. Simultaneous orthogonal plane imaging (“SOPI”) is used to acquire images from a first slice that remains static throughout the acquisition, and from a plurality of slices that are orthogonal to the first slice. This first slice can be referred to in some instances as a “tracking” or “navigator” slice, and the plurality of slices that are orthogonal to the first slice can be referred to as “imaging” slices. The tracking slice images can be used to estimate motion of the subject that occurred during the data acquisition, and to track the position of targets (e.g., anatomical targets) during the delivery of radiation treatment.
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44.发明公开公开(公告)号：US20240254087A1
公开(公告)日：2024-08-01
申请号：US18560113
申请日：2022-05-11
申请人： Saint Joseph's University , The Medical College of Wisconsin, Inc. , The Regents of the University of California
发明人： Jason WALLACH , John MCCORVY , Adam HALBERSTADT
IPC分类号： C07D215/12 , A61K31/135 , A61K31/341 , A61K31/343 , A61K31/357 , A61K31/381 , A61K31/415 , A61K31/44 , A61K31/472 , A61K45/06 , C07C217/60 , C07D213/38 , C07D217/04 , C07D231/12 , C07D307/52 , C07D307/91 , C07D317/64 , C07D333/20 , C07D333/76 , C07D493/04
CPC分类号： C07D215/12 , A61K31/135 , A61K31/341 , A61K31/343 , A61K31/357 , A61K31/381 , A61K31/415 , A61K31/44 , A61K31/472 , A61K45/06 , C07C217/60 , C07D213/38 , C07D217/04 , C07D231/12 , C07D307/52 , C07D307/91 , C07D317/64 , C07D333/20 , C07D333/76 , C07D493/04 , C07C2602/08 , C07C2602/10
摘要： Disclosed herein are novel serotonin 5-HT2A receptor agonists with selectivity for the 5-HT2A receptor subtype over other serotonin receptors. Some of these 5-HT2A agonists exhibit functional selectivity and preferentially activate arrestin signaling over G protein-mediated signaling. Also disclosed are pharmaceutical compositions of the compounds and methods of treating certain diseases or conditions.
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公开(公告)号：US12012602B2
公开(公告)日：2024-06-18
申请号：US16492878
申请日：2018-03-09
发明人： Daniel M. Lipinski , Chris A. Reid
IPC分类号： C12N15/115 , A61K48/00 , C12N15/67
CPC分类号： C12N15/115 , A61K48/005 , A61K48/0075 , C12N15/67 , C12N2310/141 , C12N2310/16 , C12N2310/3519 , C12N2320/50 , C12N2750/14143 , C12N2830/00
摘要： The present invention provides constructs comprising modified riboswitches to regulate expression of a transgene within a subject. Methods of treating a disease, specifically an eye disease, are also contemplated.
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公开(公告)号：US11974812B2
公开(公告)日：2024-05-07
申请号：US18550776
申请日：2022-03-21
CPC分类号： A61B3/1241 , A61B3/14
摘要： Laser-Speckle Contrast imaging apparatus configured to assess and quantify motion associated with an object and, in a specific case of an eye—retinal vascular anatomy and hemodynamics and generate substantially contrast-free maps of retinal blood flow over a wide field-of-view at up to 590 fps and under short exposure durations (>50 μs), is applicable for diagnosis, study, and management of neurodegenerative conditions (i.e. mild cognitive impairment and Alzheimer's disease) and systemic cardiovascular diseases (i.e. athero- and arteriosclerosis, coronary artery occlusion, and hypertension). The apparatus employs a) a set of apertures substantially blocking light, delivered from a source of light to an illumination arm of the apparatus, from impinging onto an axial point of the front surface of the lens of the illumination arm, and b) polarization gating between the illumination and light-collecting arms of the apparatus. In one implementation, the apparatus is configured to allow for irradiation of the object with an optical field a degree of coherence and/or spectral content of which are varied delivered through the same optical train including the set of apertures.
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公开(公告)号：US11959096B2
公开(公告)日：2024-04-16
申请号：US17025057
申请日：2020-09-18
IPC分类号： C12N5/00 , A61K35/545 , C12N5/0735 , C12N5/074 , C12N5/077
CPC分类号： C12N5/0081 , A61K35/545 , C12N5/0606 , C12N5/0657 , C12N5/0696 , C12N2500/38 , C12N2501/72 , C12N2501/724 , C12N2506/45
摘要： Provided herein are methods of reducing or eliminating undifferentiated pluripotent stem cells, where the methods comprise contacting an effective amount of a compound to a heterogeneous cell population or sample comprising or suspected of comprising differentiated cell types and undifferentiated pluripotent stem cells, whereby the contacting selectively reduces or eliminates undifferentiated pluripotent stem cells from the cell population or sample. Also provided are methods for obtaining a population of stem cell-derived cell types substantially free of undifferentiated pluripotent stem cells as well as isolated populations of such of stem cell-derived cell types.
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48.发明公开公开(公告)号：US20240055126A1
公开(公告)日：2024-02-15
申请号：US18491282
申请日：2023-10-20
CPC分类号： G16H50/20 , G06T7/143 , G16H30/20 , G16H30/40 , G06N3/08 , G06T7/0012 , G06T2207/10088 , G06T2207/20084
摘要： Systems and methods are described for segmenting medical images, such as magnetic resonance images, using a deep learning model that has been trained using random dropped inputs, standardized inputs, or both. Medical images can be segmented based on anatomy, physiology, pathology, other properties or characteristics represented in the medical images, or combinations thereof. As one example, multi-contrast magnetic resonance images are input to the trained deep learning model in order to generate multiple segmented medical images, each representing a different segmentation class.
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公开(公告)号：US11899288B2
公开(公告)日：2024-02-13
申请号：US18341661
申请日：2023-06-26
发明人： Jay Neitz , Maureen Neitz
CPC分类号： G02C7/04 , A61K9/0048 , G02C7/02 , G02C7/061 , G02C7/10 , G02C7/16 , A61B3/1005 , A61B5/107 , G02C2202/24
摘要： Certain embodiments of the present invention are directed to therapeutic intervention in patients with eye-length-related disorders to prevent, ameliorate, or reverse the effects of the eye-length-related disorders. Embodiments of the present invention include methods for early recognition of patients with eye-length-related disorders, therapeutic methods for inhibiting further degradation of vision in patients with eye-length-related disorders, reversing, when possible, eye-length-related disorders, and preventing eye-length-related disorders. Additional embodiments of the present invention are directed to particular devices used in therapeutic intervention in patients with eye-length-related disorders.
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公开(公告)号：US20240032790A1
公开(公告)日：2024-02-01
申请号：US18550776
申请日：2022-03-21
CPC分类号： A61B3/1241 , A61B3/14
摘要： Laser-Speckle Contrast imaging apparatus configured to assess and quantify motion associated with an object and, in a specific case of an eye—retinal vascular anatomy and hemodynamics and generate substantially contrast-free maps of retinal blood flow over a wide field-of-view at up to 590 fps and under short exposure durations (>50 μs), is applicable for diagnosis, study, and management of neurodegenerative conditions (i.e. mild cognitive impairment and Alzheimer's disease) and systemic cardiovascular diseases (i.e. athero- and arteriosclerosis, coronary artery occlusion, and hypertension). The apparatus employs a) a set of apertures substantially blocking light, delivered from a source of light to an illumination arm of the apparatus, from impinging onto an axial point of the front surface of the lens of the illumination arm, and b) polarization gating between the illumination and light-collecting arms of the apparatus. In one implementation, the apparatus is configured to allow for irradiation of the object with an optical field a degree of coherence and/or spectral content of which are varied delivered through the same optical train including the set of apertures.
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