公开(公告)号：US11814626B2

公开(公告)日：2023-11-14

申请号：US16612734

申请日：2018-05-11

Applicant: The Research Foundation for The State University of New York

Inventor： Juliane Nguyen ,  Scott Ferguson

IPC: C12N15/63 ,  A61K9/50 ,  A61K31/713 ,  C12N15/11

CPC classification number: C12N15/63 ,  A61K9/5068 ,  A61K31/713 ,  C12N15/111 ,  C12N2310/141 ,  C12N2310/20 ,  C12N2310/3519 ,  C12N2320/32

Abstract: Presented are RNA nucleotide sequences referred to as EXO-Codes, and longer RNA polynucleotides that contain the EXO-Codes. EXO-Codes provide RNA with the ability to a) be selectively sorted to extracellular vesicles such as exosomes, and b) deliver a variety of cargo types to program or reprogram the extracellular vesicles, and cells that receive the exosomes. Also presented are methods of making the EXO-Codes, modifying cells using the EXO-Codes, expression vectors encoding the EXO-Codes, and exosomes and other secreted vesicles that include RNA polynucleotides that contain the EXO-Codes.

公开(公告)号：US20230348592A1

公开(公告)日：2023-11-02

申请号：US17998634

申请日：2021-05-10

Applicant: Memorial Sloan Kettering Cancer Center ,  Institute for Advanced Study ,  The Research Foundation for The State University of New York

Inventor： James C. Mathews ,  Saad Nadeem ,  Maryam Pouryahya ,  Zehor Belkhatir ,  Joseph O. Deasy ,  Allen Robert Tannenbaum ,  Arnold Levine

IPC: C07K16/28 ,  A61K39/395 ,  A61K39/00 ,  A61K35/76 ,  A61K38/21 ,  A61K38/20 ,  A61K38/19 ,  A61P35/00 ,  C12N15/115 ,  C12N15/113

CPC classification number: C07K16/2803 ,  A61K39/3955 ,  A61K39/0011 ,  A61K35/76 ,  A61K39/4611 ,  A61K39/4613 ,  A61K39/4631 ,  A61K38/212 ,  A61K38/215 ,  A61K38/217 ,  A61K38/208 ,  A61K38/195 ,  A61K38/2086 ,  A61K38/2013 ,  A61K38/191 ,  A61P35/00 ,  C12N15/115 ,  C12N15/1135 ,  C12N2310/14 ,  C12N2310/531 ,  C12N2310/11 ,  C07K2317/22 ,  C07K2317/31 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/569

Abstract: Disclosed are treatments for cancer that enhance a patient immune systems' ability to detect and attack cancer. The present disclosure provides methods for treating cancer in a subject in need thereof comprising administering to the subject an effective amount of a pregnancy specific glycoprotein (PSG) inhibitor.

公开(公告)号：US11799035B2

公开(公告)日：2023-10-24

申请号：US16846052

申请日：2020-04-10

Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

Inventor： Supriyo Karmakar

IPC: H01L29/66 ,  H01L29/12 ,  H01L29/423 ,  H01L29/786 ,  H01L29/49 ,  H01L29/778 ,  B82Y10/00 ,  H01L29/08

CPC classification number: H01L29/78696 ,  H01L29/127 ,  H01L29/42392 ,  H01L29/49 ,  H01L29/66977 ,  H01L29/778 ,  H01L29/78618 ,  H01L29/78642 ,  B82Y10/00 ,  H01L29/0847

Abstract: Various gate all-around field effect transistors (GAAFET) including quantum-based features are disclosed. GAAFET may include a center core including a first end and a second end, a source region positioned circumferentially around the first end of the center core, and a drain region positioned circumferentially around the second end of the center core. The drain region may also be positioned axially opposite the source region. The GAAFET may also include a gate portion axially positioned between the source region and the drain region. The gate portion may include at least one quantum-based feature circumferentially disposed around the center core, and a gate contact circumferentially disposed around the quantum-based feature(s). The quantum-based feature(s) may include a plurality of quantum dots (QD) or at least one quantum well channel.

公开(公告)号：US11784806B2

公开(公告)日：2023-10-10

申请号：US17061376

申请日：2020-10-01

Applicant: The Research Foundation for The State University of New York

Inventor： Eden Figueroa ,  Mehdi Namazi ,  Mael Flament ,  Sonali Gera

IPC: H04L9/08 ,  G01B9/02017 ,  H04B10/70

CPC classification number: H04L9/0858 ,  G01B9/02017 ,  H04B10/70 ,  H04L9/0855

Abstract: Quantum network devices, systems, and methods are provided to enable long-distance transmission of quantum bits (qubits) for applications such as Quantum Key Distribution (QKD), entanglement distribution, and other quantum communication applications. Such systems and methods provide for separately storing first, second, third, and fourth photons, wherein the first and second photons and the third and fourth photons are respective first and second entangled photon pairs, triggering a synchronized retrieval of the stored first, second, third, and fourth photons such that the first photon is propagated to a first node, the second and third photons are propagated to a second node, and the fourth photon is propagated to a third node, and creating a new entangled pair comprising the first and fourth photons at the first and third nodes to transmit quantum information.

公开(公告)号：US20230314221A1

公开(公告)日：2023-10-05

申请号：US18022793

申请日：2021-08-27

Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

Inventor： Wei LIN

IPC: G01J3/457 ,  A61B5/026 ,  A61B5/00

CPC classification number: G01J3/457 ,  A61B5/0261 ,  A61B5/0075

Abstract: DCS analyzer including a memory to store autocorrelation values, model parameters, fitting parameters, and simulated correlation values from a DCS model; a mean square error (MSE) module to compute MSE between theoretical autocorrelation values computed from the model parameters and measured autocorrelation values; a sorting module to sort three latest MSE values obtained from the MSE module and generate indexes of largest, medium, and smallest MSE values; a convergence checking module to determine whether convergence is reached in solving an autocorrelation equation; a search module to calculate αDB and β values at reflection, extension, contraction, and shrink locations; a comparison module to compare two latest MSE values and find new αDB and β values to replace values associated with a largest MSE; a state controller coupled with the memory and the modules to control an operation thereof; and an output buffer to present a fitted solution of the autocorrelation equation.

公开(公告)号：US11771321B2

公开(公告)日：2023-10-03

申请号：US16755702

申请日：2018-10-12

Applicant: THE RESEARCH FOUNDATION FOR THE STATE UNIVERSITY OF NEW YORK

Inventor： Yingtian Pan ,  Wei Chen ,  Congwu Du

IPC: A61B5/00 ,  A61B5/026 ,  G01B9/02004 ,  G01B9/02 ,  G01B9/02091 ,  G01B9/02015 ,  G01B9/02055 ,  A61B3/10 ,  G06T7/00

CPC classification number: A61B5/0066 ,  A61B3/10 ,  A61B3/102 ,  A61B5/0075 ,  A61B5/026 ,  G01B9/02004 ,  G01B9/02027 ,  G01B9/02044 ,  G01B9/02075 ,  G01B9/02083 ,  G01B9/02091 ,  G06T7/0012 ,  G06T2207/10101 ,  G06T2207/20056 ,  G06T2207/30104

Abstract: An exemplary system, method, and computer-accessible medium for generating an image(s) of an three-dimensional anatomical flow map(s) can include receiving an optical coherence tomography (“OCT”) signal(s), splitting the OCT signal(s) into a plurality of subspectra, averaging the plurality of subspectra, and generating the image(s) of the three-dimensional anatomical flow map(s) based on the averaged subspectra. The OCT signal(s) can be a swept-source OCT signal. The OCT signal(s) can be split into the subspectra based on a Hamming window. The Hamming distance window can be optimized to minimize a nearest side lobe for each of the subspectra. A position of at least one of the subspectra can be shifted prior to averaging the subspectra. The position of all but one of the subspectra can be shifted prior to averaging the subspectra.

公开(公告)号：US20230244029A1

公开(公告)日：2023-08-03

申请号：US18151900

申请日：2023-01-09

Applicant: The Research Foundation for The State University of New York

Inventor： William CHARLES ,  Douglas COOLBAUGH ,  Douglas LA TULIPE ,  Gerald L. LEAKE, Jr.

IPC: G02B6/12 ,  G02B6/42 ,  G02B6/43 ,  H01S5/026 ,  G02B6/13

CPC classification number: G02B6/12004 ,  G02B6/428 ,  G02B6/43 ,  H01S5/026 ,  G02B6/4245 ,  G02B6/4283 ,  G02B6/12002 ,  G02B6/12 ,  G02B6/13 ,  H01L31/101

Abstract: There is set forth herein a method including building a first photonics structure using, wherein the building the first photonics structure includes fabricating one or more photonics device.

公开(公告)号：US20230233712A1

公开(公告)日：2023-07-27

申请号：US18174793

申请日：2023-02-27

Applicant: The Research Foundation for The State University of New York

Inventor： Wadie F. BAHOU ,  Song WU

IPC: A61K48/00 ,  G01N33/48 ,  A61K31/713 ,  A61P7/02 ,  A61K35/19

CPC classification number: A61K48/0066 ,  G01N33/48 ,  A61K31/713 ,  A61P7/02 ,  A61K35/19 ,  A61K48/0016 ,  A61K48/0083 ,  C12Y103/01024

Abstract: The present disclosure provides methods of treating a human having a disease or disorder that would benefit from increasing platelet counts. The method involves inhibiting the enzyme activity of biliverdin IXβ reductase (BLVRB) activity or inhibiting the expression of BLVRB gene.

公开(公告)号：US20230233695A1

公开(公告)日：2023-07-27

申请号：US17890125

申请日：2022-08-17

Applicant: The Research Foundation for the State University of New York

Inventor： Juntao Luo ,  Jason Horton ,  Dandan Guo ,  Mei Yun Lin

IPC: A61K47/60 ,  A61K9/51 ,  A61K47/69 ,  A61P19/08 ,  A61P35/00

CPC classification number: A61K47/60 ,  A61K9/51 ,  A61K47/6907 ,  A61P19/08 ,  A61P35/00

Abstract: The present disclosure relates to a nanoparticle compound, including: a hydrophilic polymer, a linker, and a drug, wherein the drug is linked to the hydrophilic polymer by the linker, wherein the drug is mithramycin A or a derivative thereof, and wherein the linker is boronic acid or a boronic acid derivative. For example, the present disclosure includes one or more nanoparticles including one or more conjugates, and methods of using the nanoparticles for drug delivery, and treating a disease such as Ewing sarcoma or osteosarcoma.

公开(公告)号：US20230226228A1

公开(公告)日：2023-07-20

申请号：US17997908

申请日：2021-05-04

Applicant: The Research Foundation for the State University of New York

Inventor： Peter J. Tonge ,  Yong Li ,  Fareidoon Daryaee ,  Peter Michael Smith-Jones ,  Labros Meimetis

IPC: A61K51/04 ,  C07C201/12 ,  A61P31/04

CPC classification number: A61K51/0402 ,  C07C201/12 ,  A61P31/04

Abstract: This invention provides a composition comprising the compound having the structure:




ethyl 2-[19F]F-4-nitrobenzoate, and at least one acceptable carrier.
This invention also provides a method of detecting the presence of or location of bacteria cells in a subject which comprises determining if an amount of the compound or determining where an amount of the compound having the structure:




is present in the subject at a period of time after administration of the compound or salt thereof to the subject, thereby detecting the presence of or location of the bacteria cells based on the amount of the compound determined to be present in the subject or detecting the location of the bacteria cells based on the location of the compound determined to be present in the subject.