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    MEMBRANE BOUND NUCLEIC ACID NANOPORES
    42.
    发明申请
    MEMBRANE BOUND NUCLEIC ACID NANOPORES 有权

    公开(公告)号：US20210301334A1

    公开(公告)日：2021-09-30

    申请号：US17265244

    申请日：2019-08-02

    Applicant: UCL Business Ltd

    Inventor： Stefan HOWORKA ,  Yongzheng XING

    IPC: C12Q1/6869 ,  C12Q1/6837

    Abstract: A membrane-spanning nanopore is provided, the nanopore comprising: a. one or more polynucleotide strands that provide a scaffold coma) ponent; and b. a plurality of polynucleotide strands that provide a plurality of staple components; wherein each of the plurality of staple components hybridise to the scaffold component; wherein the orientation of a major portion 7 nm of at least one polynucleotide strand comprised within the scaffold component is substantially parallel to a planar surface of a membrane as well as embedded within and substantially coplanar with the membrane; wherein the nanopore defines a channel that is suitable for perforating the membrane; the channel b) having a longitudinal axis extending along the centre thereof and a minimum internal dimension perpendicular to the longitudinal axis of at least about 3 nm. A membrane comprising the nanopore, biological sensors comprising the membrane and a method for molecular sensing using the membrane are also disclosed

    Method and apparatus for transforming physical measurement data of a biological organ
    46.
    发明授权
    Method and apparatus for transforming physical measurement data of a biological organ 有权

    公开(公告)号：US11024100B2

    公开(公告)日：2021-06-01

    申请号：US16323608

    申请日：2017-08-10

    Applicant: UCL Business LTD

    Inventor： Carole Sudre ,  M Jorge Cardoso ,  Sebastien Ourselin ,  Jonathan Rohrer

    IPC: G06T19/20 ,  G06F19/00 ,  G16H50/50 ,  G06T15/08 ,  G06T17/10

    Abstract: An apparatus is configured for performing a computer-implemented method comprising: receiving data comprising physical measurements of a biological organ across a three-dimensional (3D) volume, the organ having a hierarchical structure of elements with multiple levels; transforming the physical measurement data into a two-dimensional (2D) data representation having first and second axes, wherein the first axis corresponds to location of an element a spatial path through the three-dimensional volume based on the hierarchical structure of the organ, and the second axis corresponds to descending successive levels through said hierarchical structure; and outputting the two-dimensional data representation to an apparatus for display.

    Switching resistor and method of making such a device
    48.
    发明授权
    Switching resistor and method of making such a device 有权

    公开(公告)号：US11004506B2

    公开(公告)日：2021-05-11

    申请号：US16499698

    申请日：2018-03-29

    Applicant: UCL Business LTD

    Inventor： Anthony Kenyon ,  Adnan Mehonic ,  Wing Ng

    IPC: G11C13/00 ,  G11C11/56 ,  H01L45/00

    Abstract: A switching resistor has a low resistance state and a high resistance state. The switching resistor comprises a dielectric layer disposed between a first electrode and a second electrode. The switching resistor further comprises a textured boundary surface between the first electrode and the dielectric layer. The textured boundary surface promotes the formation of a conductive pathway in the dielectric layer between the first electrode and the second electrode.

    Marker-suicide gene useful in adoptive cell therapy
    49.
    发明授权
    Marker-suicide gene useful in adoptive cell therapy 有权

    公开(公告)号：US10925943B2

    公开(公告)日：2021-02-23

    申请号：US14391536

    申请日：2013-04-11

    Applicant: UCL BUSINESS LTD

    Inventor： Martin Pulé ,  Brian Philip

    IPC: A61K39/00 ,  G01N33/50 ,  A61K35/14 ,  C07K14/705 ,  C07K16/28 ,  A61K35/17 ,  C07K14/725 ,  C12N15/85 ,  A61K48/00

    Abstract: The present invention provides a polypeptide having the formula: St-R1-S1-Q-S2-R2 wherein St is a stalk sequence which, when the polypeptide is expressed at the surface of a target cell, causes the R and Q epitopes to be projected from the cell surface; R1 and R2 are a Rituximab-binding epitopes each having the an amino acid sequence selected from the group consisting of SEQ ID No. 1, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15 and 16 or a variant thereof which retains Rituximab-binding activity; S1 and S2 are optional spacer sequences, which may be the same or different; and Q is a QBEnd1O-binding epitope having the amino acid sequence shown as SEQ ID No. 2 or a variant thereof which QBEnd1O-binding activity. The invention also provides a nucleic acid sequence encoding such a polypeptide and uses thereof in adoptive cell transfer.

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