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公开(公告)号:US11766439B2
公开(公告)日:2023-09-26
申请号:US17344777
申请日:2021-06-10
Applicant: FOUNDATION MEDICINE, INC. , UCL BUSINESS LTD
Inventor: Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky
IPC: A61K31/55 , A61K38/00 , A61K31/519 , C12Q1/70 , A61K31/506 , A61K31/454 , A61K31/52 , A61K31/404 , A61K31/4196 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , C12Q1/6886 , A61K31/366 , A61K31/505 , A61K31/555 , A61K33/243 , A61K33/24 , A61K31/439 , A61K31/4745 , C07K16/28 , C12Q1/6883 , G01N33/571 , A61N5/10 , A61K39/00
CPC classification number: A61K31/519 , A61K31/05 , A61K31/282 , A61K31/337 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4196 , A61K31/436 , A61K31/439 , A61K31/454 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/52 , A61K31/5377 , A61K31/555 , A61K33/24 , A61K33/243 , A61K39/39558 , A61N5/00 , A61N5/10 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q1/708 , G01N33/571 , A61K2039/505 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , A61K31/404 , A61K2300/00 , A61K31/454 , A61K2300/00 , A61K31/506 , A61K2300/00 , A61K31/513 , A61K2300/00 , A61K31/519 , A61K2300/00 , A61K31/52 , A61K2300/00 , A61K33/24 , A61K2300/00 , A61K31/436 , A61K2300/00 , A61K31/05 , A61K2300/00 , A61K31/366 , A61K2300/00 , A61K31/505 , A61K2300/00 , A61K31/555 , A61K2300/00 , A61K31/337 , A61K2300/00 , A61K31/282 , A61K2300/00 , A61K31/4196 , A61K2300/00 , A61K31/4709 , A61K2300/00 , A61K31/496 , A61K2300/00 , A61K31/5377 , A61K2300/00 , A61K31/105 , A61K2300/00
Abstract: Methods of treating a head and neck cancer are disclosed.
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公开(公告)号:US11058687B2
公开(公告)日:2021-07-13
申请号:US16654582
申请日:2019-10-16
Applicant: FOUNDATION MEDICINE, INC. , UCL BUSINESS LTD
Inventor: Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky
IPC: A61K31/551 , A61K31/505 , A61P35/00 , A61K31/519 , C12Q1/70 , A61K31/506 , A61K31/454 , A61K31/52 , A61K31/404 , A61K31/4196 , A61K33/24 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , C12Q1/6886 , A61K31/366 , A61K31/555 , A61K31/439 , A61K31/4745 , C07K16/28 , C12Q1/6883 , G01N33/571 , A61N5/10 , A61K39/00
Abstract: Methods of treating a head and neck cancer are disclosed.
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公开(公告)号:US20220096483A1
公开(公告)日:2022-03-31
申请号:US17344777
申请日:2021-06-10
Applicant: FOUNDATION MEDICINE, INC. , UCL BUSINESS LTD
Inventor: Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Garrett Michael Frampton , Roman Yelensky
IPC: A61K31/519 , C12Q1/70 , A61K31/506 , A61K31/454 , A61K31/52 , A61K31/404 , A61K31/4196 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , C12Q1/6886 , A61K31/366 , A61K31/505 , A61K31/555 , A61K33/243 , A61K33/24 , A61K31/439 , A61K31/4745 , C07K16/28 , C12Q1/6883 , G01N33/571 , A61N5/10
Abstract: Methods of treating a head and neck cancer are disclosed.
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公开(公告)号:US12274699B2
公开(公告)日:2025-04-15
申请号:US18346029
申请日:2023-06-30
Applicant: Foundation Medicine, Inc.
Inventor: Siraj Mahamed Ali , Matthew J. Hawryluk , Jie He , Doron Lipson , Vincent A. Miller , Jeffrey S. Ross , Philip James Stephens
IPC: A61K31/517 , A61K31/19 , A61K31/404 , A61K31/435 , A61K31/4412 , A61K31/4439 , A61K31/47 , A61K31/496 , A61K31/498 , A61K31/5025 , A61K31/506 , A61K31/519 , A61K31/53 , A61K31/5383 , A61K31/553 , A61K45/06 , C07K14/705 , C07K14/71 , C07K16/40 , C12N9/12 , C12N15/113 , C12Q1/6883 , C12Q1/6886 , G01N33/573
Abstract: Methods and compositions for treating cholangiocarcinoma.
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公开(公告)号:US12180540B2
公开(公告)日:2024-12-31
申请号:US17812415
申请日:2022-07-13
Applicant: Foundation Medicine, Inc.
Inventor: Doron Lipson , Geoffrey Alan Otto , Alexander Nevin Parker , Philip James Stephens , Sean R. Downing , Mirna Jarosz , Mikhail G. Shapiro , Roman Yelensky
IPC: C12Q1/6827 , C12Q1/6874 , C12Q1/6886 , G16B20/00 , G16B20/10 , G16B20/20 , G16B30/00 , G16B30/10
Abstract: A method of analyzing a tumor sample comprising: (a) acquiring a library comprising a plurality of tumor members from a tumor sample; (b) contacting the library with a bait set to provide selected members; (c) acquiring a read for a subgenomic interval from a tumor member from said library; (d) aligning said read; and (e) assigning a nucleotide value (e.g., calling a mutation) from said read for the preselected nucleotide position, thereby analyzing said tumor sample.
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公开(公告)号:US20180280391A1
公开(公告)日:2018-10-04
申请号:US15839560
申请日:2017-12-12
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Sean R. Downing , Matthew J. Hawryluk , Doron Lipson , Alexander N. Parker , Philip James Stephens
IPC: A61K31/517 , C12N15/113 , A61K31/513 , C07K14/82 , A61K31/4412 , A61K31/404 , A61K31/47 , C12Q1/6886 , C12N9/14 , A61K31/444
Abstract: Novel RET fusion molecules and uses are disclosed.
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公开(公告)号:US09861633B2
公开(公告)日:2018-01-09
申请号:US14333368
申请日:2014-07-16
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Siraj Mahamed Ali , Matthew J. Hawryluk , Jeffrey S. Ross , Philip James Stephens
IPC: C12Q1/68 , A61K31/517 , A61K47/48 , A61K31/5365 , C07K14/82 , C07K16/32 , A61K45/06 , A61K31/475 , A61K31/519 , A61K31/704 , A61K31/7105 , A61K31/713 , A61K33/24
CPC classification number: A61K31/517 , A61K31/475 , A61K31/519 , A61K31/5365 , A61K31/704 , A61K31/7105 , A61K31/713 , A61K33/24 , A61K45/06 , A61K47/6803 , A61K47/6851 , A61K47/6855 , C07K14/82 , C07K16/32 , C12Q1/6886 , C12Q2600/106 , A61K2300/00
Abstract: Methods and compositions for treating a urothelial and/or a micropapillary carcinoma, such as a micropapillary urothelial carcinoma are disclosed.
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公开(公告)号:US20160145691A1
公开(公告)日:2016-05-26
申请号:US14753397
申请日:2015-06-29
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Maureen T. Cronin , Garrett Michael Frampton , Doron Lipson , Vincent A. Miller , Gary Palmer , Jeffrey S. Ross , Philip James Stephens , Roman Yelensky
IPC: C12Q1/68 , A61K45/06 , C07K16/28 , C07K14/72 , A61K31/5415 , A61K31/437 , A61K31/423 , A61K31/428 , A61K31/472 , A61K31/536 , A61K31/416 , A61K31/4439
CPC classification number: C12Q1/6886 , A61K31/416 , A61K31/4196 , A61K31/423 , A61K31/428 , A61K31/436 , A61K31/437 , A61K31/439 , A61K31/4439 , A61K31/472 , A61K31/536 , A61K31/5415 , A61K31/565 , A61K31/567 , A61K31/675 , A61K45/06 , C07K14/72 , C07K16/2869 , C07K2317/34 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156
Abstract: Novel mutant ESR1 molecules and uses are disclosed.
Abstract translation: 公开了新型突变体ESR1分子和用途。
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9.
公开(公告)号:US20140037622A1
公开(公告)日:2014-02-06
申请号:US13958502
申请日:2013-08-02
Applicant: UCL Business PLC , FOUNDATION MEDICINE, INC.
Inventor: Chris Hendrik Boshoff , Timothy Robert Fenton , Matthias Alexander Lechner , Philip James Stephens , Matthew J. Hawryluk , Roman Yelensky , Garrett Michael Frampton
IPC: C12Q1/70 , A61K31/519 , A61K31/454 , A61K31/52 , A61K31/404 , A61K31/4196 , A61K33/24 , A61K31/282 , A61K31/337 , A61K31/513 , A61K39/395 , A61K31/436 , A61K31/05 , A61K31/4709 , A61K31/496 , A61K31/5377 , A61K31/352 , A61N5/00 , A61K31/506
CPC classification number: A61K31/519 , A61K31/05 , A61K31/282 , A61K31/337 , A61K31/352 , A61K31/366 , A61K31/404 , A61K31/4196 , A61K31/436 , A61K31/439 , A61K31/454 , A61K31/4709 , A61K31/4745 , A61K31/496 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/52 , A61K31/5377 , A61K31/555 , A61K33/24 , A61K39/39558 , A61K2039/505 , A61N5/00 , A61N5/10 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q1/708 , C12Q2600/106 , C12Q2600/118 , C12Q2600/156 , C12Q2600/158 , C12Q2600/16 , G01N33/571 , A61K2300/00
Abstract: Methods of treating a head and neck cancer are disclosed.
Abstract translation: 公开了治疗头颈癌的方法。
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公开(公告)号:US10980804B2
公开(公告)日:2021-04-20
申请号:US14761518
申请日:2014-01-17
Applicant: FOUNDATION MEDICINE, INC.
Inventor: Siraj Mahamed Ali , Matthew J. Hawryluk , Jie He , Doron Lipson , Vincent A. Miller , Jeffrey S. Ross , Philip James Stephens
IPC: A61K31/517 , A61K31/498 , A61K31/19 , A61K31/5025 , C12N9/12 , A61K31/4412 , A61K45/06 , A61K31/47 , A61K31/435 , A61K31/506 , A61K31/519 , A61K31/4439 , A61K31/53 , A61K31/404 , A61K31/5383 , A61K31/496 , C12Q1/6886 , A61K31/553 , C07K14/705 , C07K14/71 , C07K16/40 , C12N15/113 , C12Q1/6883 , G01N33/573
Abstract: Methods and compositions for treating cholangiocarcinoma.
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