Patent search ap:("10X GENOMICS Page INC.") AND inv:"Paul Ryvkin"

41.

发明申请
CELL POPULATION ANALYSIS USING SINGLE NUCLEOTIDE POLYMORPHISMS FROM SINGLE CELL TRANSCRIPTOMES 有权

公开(公告)号：US20210277471A1

公开(公告)日：2021-09-09

申请号：US17029756

申请日：2020-09-23

Applicant: 10X Genomics, Inc. , Fred Hutchinson Cancer Research Center

Inventor： Xinying Zheng , Jason H. Bielas , Mark T. Gregory , Benjamin Hindson , Tarjei Sigurd Mikkelsen , Ryan Wilson , Paul Ryvkin

IPC: C12Q1/6881 , C12N15/10

Abstract: The disclosure provides methods and systems for producing single cell RNA sequencing data. Single nucleotide polymorphisms (SNPs) identified in such data can be used to distinguish subpopulations of cells within a mixed population.

42.

发明申请
METHODS AND SYSTEMS FOR ANALYSIS OF MAJOR HISTOCOMPATABILITY COMPLEX 审中-公开

公开(公告)号：US20190367966A1

公开(公告)日：2019-12-05

申请号：US16375102

申请日：2019-04-04

Applicant: 10X Genomics, Inc.

Inventor： Kamila Belhocine , Jason Bell , Zachary Bent , Rajiv Bharadwaj , Christopher Hindson , Mohammad Rahimi Lenji , Bill Kengli Lin , Anthony Makarewicz , Geoffrey McDermott , Elliott Meer , Francesca Meschi , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Michael Schnall-Levin , Sarah Taylor , Jessica Michele Terry , Tobias Daniel Wheeler , Yifeng Yin , Xinying Zheng , Solongo Batjargal Ziraldo , Eswar Prasad Ramachandran Iyer , Luigi Jhon Alvarado Martinez

IPC: C12Q1/6806 , G01N33/53 , G01N33/58 , C12Q1/6804 , G01N33/50 , C12N15/10

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization from one or more cells. Such polynucleotide processing may be useful for a variety of applications, including characterization of major histocompatibility complex (MHC) molecules. The compositions, methods, systems, and devices disclosed herein generally describe peptides and barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing MHC molecules from one or more cells.

43.

发明授权
Methods and systems for processing polynucleotides 有权

公开(公告)号：US10480029B2

公开(公告)日：2019-11-19

申请号：US15933299

申请日：2018-03-22

Applicant: 10X GENOMICS, INC.

Inventor： Zachary Bent , Josephine Harada , Christopher Hindson , Elliott Meer , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Serge Saxonov , John R. Stuelpnagel , Jessica Michele Terry , Solongo Batjargal Ziraldo

IPC: C12Q1/68 , C12Q1/6874 , C12Q1/683 , C12Q1/6806

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing. Such polynucleotide processing may be useful for a variety of applications, including polynucleotide sequencing.

44.

发明申请
METHODS AND SYSTEMS FOR PROCESSING POLYNUCLEOTIDES 审中-公开

公开(公告)号：US20190338353A1

公开(公告)日：2019-11-07

申请号：US16426762

申请日：2019-05-30

Applicant: 10X GENOMICS, INC.

Inventor： Phillip Belgrader , Zachary Bent , Rajiv Bharadwaj , Vijay Kumar Sreenivasa Gopalan , Josephine Harada , Christopher Hindson , Mohammad Rahimi Lenji , Michael Ybarra Lucero , Geoffrey McDermott , Elliott Meer , Tarjei Sigurd Mikkelsen , Christopher Joachim O'Keeffe , Katherine Pfeiffer , Andrew D. Price , Paul Ryvkin , Serge Saxonov , John R. Stuelpnagel , Jessica Michele Terry , Tobias Daniel Wheeler , Indira Wu , Solongo Batjargal Ziraldo

IPC: C12Q1/6874 , C12N15/10 , C12Q1/683 , C12Q1/6806 , C12Q1/6804

Abstract: The present disclosure provides compositions, methods, systems, and devices for polynucleotide processing and analyte characterization. Such polynucleotide processing may be useful for a variety of applications, including analyte characterization by polynucleotide sequencing. The compositions, methods, systems, and devices disclosed herein generally describe barcoded oligonucleotides, which can be bound to a bead, such as a gel bead, useful for characterizing one or more analytes including, for example, protein (e.g., cell surface or intracellular proteins), genomic DNA, and RNA (e.g., mRNA or CRISPR guide RNAs). Also described herein, are barcoded labelling agents and oligonucleotide molecules useful for “tagging” analytes for characterization.

45.

发明申请
SYSTEMS AND METHODS FOR VISUALIZING A PATTERN IN A DATASET 审中-公开

公开(公告)号：US20190332963A1

公开(公告)日：2019-10-31

申请号：US16442800

申请日：2019-06-17

Applicant: 10X Genomics, Inc.

Inventor： Alexander Y. Wong , Jeffrey Mellen , Kevin J. Wu , Paul Ryvkin , Preyas Shah , Patrick Marks , Niranjan Srinivas

IPC: G06N7/00 , G06F16/28 , G06F16/904

Abstract: A visualization system comprising a persistent memory, storing a dataset, and a non-persistent memory implements a pattern visualizing method. The dataset contains discrete attribute values for each first entity of a first type in a plurality of first entities of the first type and discrete attribute values for each first entity of a second type in a plurality of first entities of the second type for each second entity in a plurality of second entities. The dataset is compressed by blocked compression and represents discrete attribute values in both compressed sparse row and column formats. The discrete attribute values are clustered to assign each second entity to a cluster in a plurality of clusters.