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41.发明申请公开(公告)号：US20210228565A1
公开(公告)日：2021-07-29
申请号：US17022693
申请日：2020-09-16
Applicant: AbbVie Inc.
Inventor： Le Wang , George Doherty , Xilu Wang , Zhi-Fu Tao , Milan Bruncko , Aaron R. Kunzer , Michael D. Wendt , Xiaohong Song , Robin Frey , Todd M. Hansen , Gerard M. Sullivan , Andrew Judd , Andrew Souers
IPC: A61K31/4725 , C07D401/04 , C07D417/14 , C07D471/04 , C07D487/04 , C07D493/08 , C07D513/04 , A61K31/4985 , A61K31/5025 , A61K31/5377 , A61K31/541
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-xL protein.
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公开(公告)号：US20200246323A1
公开(公告)日：2020-08-06
申请号：US16412729
申请日：2019-05-15
Applicant: AbbVie Inc.
Inventor： Scott L. Ackler , Erwin R. Boghaert , Milan Bruncko , George Doherty , Andrew S. Judd , Aaron R. Kunzer , Violeta L. Marin , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-fu Tao , Xilu Wang , Dennle S. Welch
IPC: A61K31/4545 , A61K47/68
Abstract: Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
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公开(公告)号：US20200239553A1
公开(公告)日：2020-07-30
申请号：US16675784
申请日：2019-11-06
Applicant: AbbVie Inc.
Inventor： Scott L. Ackler , Nathan B. Bennett , Erwin R. Boghaert , Steve C. Cullen , George Doherty , Robin R. Frey , Anthony R. Haight , Andrew S. Judd , Aaron R. Kunzer , Xiaoqiang Shen , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch , Michael D. Wendt
IPC: C07K16/18 , C07D417/14 , C07D487/04 , C07D513/04 , A61K47/68
Abstract: Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
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44.发明申请公开(公告)号：US20190119247A1
公开(公告)日：2019-04-25
申请号：US15993521
申请日：2018-05-30
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC: C07D401/12 , C07D403/12 , C07D209/82 , A61K31/496 , C07D401/14 , C07D519/00 , C07D471/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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公开(公告)号：US20170182179A1
公开(公告)日：2017-06-29
申请号：US14963512
申请日：2015-12-09
Applicant: AbbVie Inc.
Inventor： Scott L. Ackler , Erwin R. Boghaert , Milan Bruncko , George Doherty , Andrew S. Judd , Aaron R. Kunzer , Violeta L. Marin , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Xilu Wang , Dennie S. Welch
IPC: A61K47/48 , A61K31/4545 , C07D513/04 , C07K19/00
CPC classification number: A61K31/4545 , A61K47/6803 , A61K47/6807 , A61K47/6811 , A61K47/6851 , A61K47/6855 , A61K47/6857 , A61K47/6889
Abstract: Small molecule Bcl-xL inhibitors and Antibody Drug Conjugates (ADCs) comprising small molecule Bcl-xL inhibitors are disclosed herein. The Bcl-xL inhibitors and ADCs of the disclosure are useful for, among other things, inhibiting anti-apoptotic Bcl-xL proteins as a therapeutic approach towards the treatment of diseases that involve a dysregulated apoptosis pathway.
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Patent Agency Ranking
公开(公告)号：US09359296B2
公开(公告)日：2016-06-07
申请号：US14683839
申请日：2015-04-10
Applicant: AbbVie Inc.
Inventor： Xilu Wang , Xiaohong Song , Steven W. Elmore , Milan Bruncko , David J. Madar , Andrew J. Souers , Lisa A. Hasvold , Le Wang , Zhi-Fu Tao , Aaron R. Kunzer
IPC: C07D401/06 , C07D401/14 , C07D209/42 , A61K31/5377 , C07D413/14 , C07D209/34 , C07D401/12 , C07D413/06 , C07D417/04 , C07D401/04 , C07D413/12 , C07D405/06 , C07D491/113
CPC classification number: C07D209/42 , A61K31/5377 , C07D209/34 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/06 , C07D413/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D491/113
Abstract: Compounds which inhibit the activity of anti-apoptotic Mcl-1 protein, compositions containing the compounds, and methods of treating diseases involving overexpressed or unregulated Mcl-1 protein are disclosed.
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47.发明申请APOPTOSIS-INDUCING AGENT FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES 审中-公开用于治疗癌症和免疫和自发性疾病的病毒诱导剂公开(公告)号：US20160002187A1
公开(公告)日：2016-01-07
申请号：US14855176
申请日：2015-09-15
Applicant: AbbVie Inc.
Inventor： Aaron R. Kunzer , Steven W. Elmore , Laura A. Hexamer , Cheol-Min Park , Andrew J. Souers , Gerard M. Sullivan , Gary T. Wang , Xilu Wang , Michael D. Wendt
IPC: C07D277/54
CPC classification number: C07D277/54 , C07C311/00 , C07C311/51 , C07D207/36 , C07D211/96 , C07D231/18 , C07D261/10 , C07D275/03 , C07D277/36 , C07D277/60 , C07D285/125 , C07D285/135 , C07D295/155 , C07D295/26 , C07D333/34 , C07D333/36 , C07D333/42 , C07D333/62 , C07D409/12 , C07D413/04 , C07D413/06 , C07D417/14 , C07D487/04 , C07D513/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2蛋白活性的化合物，含有化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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48.发明授权BCL-2-selective apoptosis-inducing agents for the treatment of cancer and immune diseases 有权用于治疗癌症和免疫疾病的BCL-2选择性细胞凋亡诱导剂公开(公告)号：US09072748B2
公开(公告)日：2015-07-07
申请号：US14058164
申请日：2013-10-18
Applicant: AbbVie Inc.
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa Hasvold , Laura A. Hexamer , Aaron R. Kunzer , Robert A. Mantei , William J. McClellan , Chang H. Park , Cheol-Min Park , Andrew M. Petros , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt
IPC: C07D405/06 , C07D413/06 , C07D487/04 , C07D241/04 , C07D401/06 , A61K31/5377 , C07D209/32 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D249/04 , C07D295/125 , C07D295/14 , C07D309/14 , C07D401/12 , C07D405/12 , C07D405/14 , C07D417/12 , C07D471/04 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K45/06 , C07D403/06
CPC classification number: C07D401/12 , A61K31/407 , A61K31/495 , A61K31/496 , A61K31/501 , A61K31/5377 , A61K45/06 , C07D209/08 , C07D209/32 , C07D211/58 , C07D211/96 , C07D213/64 , C07D215/20 , C07D217/16 , C07D231/56 , C07D235/26 , C07D241/04 , C07D249/04 , C07D295/125 , C07D295/14 , C07D295/155 , C07D309/04 , C07D309/14 , C07D401/06 , C07D403/06 , C07D405/06 , C07D405/12 , C07D405/14 , C07D413/06 , C07D417/12 , C07D471/04 , C07D487/04
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 or Bcl-xL proteins, compositions containing the compounds and methods of treating diseases during which are expressed anti-apoptotic Bcl-2 protein.
Abstract translation: 公开了抑制抗凋亡Bcl-2或Bcl-xL蛋白的活性的化合物，含有该化合物的组合物和治疗疾病的方法，其中表达抗凋亡Bcl-2蛋白。
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49.发明申请公开(公告)号：US20140094471A1
公开(公告)日：2014-04-03
申请号：US14038304
申请日：2013-09-26
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert A. Mantei , Todd M. Hansen
IPC: C07D471/04 , C07D403/12 , C07D209/82
CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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50.发明申请公开(公告)号：US20130267534A1
公开(公告)日：2013-10-10
申请号：US13830926
申请日：2013-03-14
Applicant: ABBVIE INC.
Inventor： Milan Bruncko , Hong Ding , George A. Doherty , Steven W. Elmore , Lisa A. Hasvold , Laura Hexamer , Aaron R. Kunzer , Xiaohong Song , Andrew J. Souers , Gerard M. Sullivan , Zhi-Fu Tao , Gary T. Wang , Le Wang , Xilu Wang , Michael D. Wendt , Robert Mantei , Todd M. Hansen
IPC: C07D471/04
CPC classification number: C07D401/12 , A61K31/496 , C07D209/82 , C07D401/14 , C07D403/12 , C07D471/04 , C07D519/00 , Y02A50/463
Abstract: Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.
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