公开(公告)号：US20120116486A1

公开(公告)日：2012-05-10

申请号：US13281244

申请日：2011-10-25

申请人： Karun D. Naga ,  Roman Turovskiy ,  Denise Zarins ,  Mark Gelfand ,  Arye Rosen

发明人： Karun D. Naga ,  Roman Turovskiy ,  Denise Zarins ,  Mark Gelfand ,  Arye Rosen

IPC分类号： A61N5/02

CPC分类号： A61B18/1815 ,  A61B2018/00023 ,  A61B2018/0022 ,  A61B2018/00404 ,  A61B2018/00434 ,  A61B2018/00511 ,  A61B2018/00577 ,  A61B2018/00791 ,  A61B2018/1861

摘要： Microwave catheter apparatuses, systems, and methods for achieving renal neuromodulation by intravascular access are disclosed herein. One aspect of the present application, for example, is directed to apparatuses, systems, and methods that incorporate a catheter treatment device comprising an elongated shaft. The elongated shaft is sized and configured to deliver a microwave transmission element to a renal artery via an intravascular path. Renal neuromodulation may be achieved via dielectric heating in the presence of microwave irradiation that modulates neural fibers that contribute to renal function or alters vascular structures that feed or perfuse the neural fibers.

摘要翻译： 本文公开了通过血管内通路实现肾脏神经调节的微波导管装置，系统和方法。 本申请的一个方面，例如，涉及包括细长轴的导管治疗装置的装置，系统和方法。 细长轴的尺寸和构造适于通过血管内路径将微波传输元件输送到肾动脉。 肾微血管调节可以通过在微波照射的存在下通过介电加热来实现，其调节有助于肾功能的神经纤维或改变进食或灌注神经纤维的血管结构。

公开(公告)号：US20110066072A1

公开(公告)日：2011-03-17

申请号：US12558157

申请日：2009-09-11

申请人： Usmah Kawoos ,  Arye Rosen ,  Harel D. Rosen ,  Francis A. Kralick

发明人： Usmah Kawoos ,  Arye Rosen ,  Harel D. Rosen ,  Francis A. Kralick

IPC分类号： A61B5/03 ,  A61M1/00

CPC分类号： A61B5/031

摘要： An intracranial pressure device for measuring CSF pressure in a skull includes a housing located between the scalp and the skull containing pressure device circuitry and a conduit extending downwardly from the housing to the vicinity of the CSF. A pressure sensor is coupled to the conduit and located in communication with the CSF wherein the pressure sensor directly senses the pressure of the CSF and provides a signal representative of the pressure of the CSF to the pressure device circuitry by way of the conduit. The skull has a dura and the conduit extends by way of an opening through the skull and an opening through the dura to position the sensor in direct contact with the CSF. A fluid reservoir can be in communication with the CSF by way of a tube and by way of the housing. The fluid reservoir contains CSF.

摘要翻译： 用于测量颅骨中的CSF压力的颅内压装置包括位于头皮和颅骨之间的壳体，其包含压力装置电路和从壳体向下延伸到CSF附近的导管。 压力传感器耦合到管道并且与CSF连通，其中压力传感器直接感测CSF的压力，并且通过导管将代表CSF的压力的信号提供给压力装置电路。 颅骨具有硬脑膜，导管通过穿过颅骨的开口和通过硬脑膜的开口延伸，以使传感器与CSF直接接触。 流体储存器可以通过管和通过壳体与CSF连通。 流体储存器包含CSF。

公开(公告)号：US20070168000A1

公开(公告)日：2007-07-19

申请号：US11331947

申请日：2006-01-13

申请人： Gemunu S. Happawana ,  Arye Rosen ,  Walter M. Janton ,  Gary A. Evans

发明人： Gemunu S. Happawana ,  Arye Rosen ,  Walter M. Janton ,  Gary A. Evans

IPC分类号： A61N5/06

CPC分类号： H01S5/024 ,  A61B2018/00023 ,  A61N5/0601 ,  A61N5/062 ,  A61N2005/005 ,  A61N2005/0609 ,  A61N2005/0652 ,  A61N2005/067 ,  H01S5/0243 ,  H01S5/4037

摘要： A semiconductor device system includes a chamber, one or more semiconductor devices disposed within the chamber and operable to emit light, and an insulator fluid disposed within the chamber. The insulator fluid may be in contact with the semiconductor devices and operable to decrease the temperature of the semiconductor devices. The insulator fluid may comprise deionized water.

摘要翻译： 半导体器件系统包括腔室，设置在腔室内并可操作以发光的一个或多个半导体器件以及设置在腔室内的绝缘体流体。 绝缘体流体可以与半导体器件接触并且可操作以降低半导体器件的温度。 绝缘体流体可以包括去离子水。

公开(公告)号：US06749623B1

公开(公告)日：2004-06-15

申请号：US09591947

申请日：2000-06-12

申请人： Richard A Hsi ,  Arye Rosen ,  Carmen E Rodriguez

发明人： Richard A Hsi ,  Arye Rosen ,  Carmen E Rodriguez

IPC分类号： A61K500

CPC分类号： A61N5/062 ,  A61B2017/00057 ,  A61N5/0601

摘要： A photodynamic therapy method administers, to a patient to be treated, a photosensitive medication which fluoresces when illuminated. The fluorescent light is an indication of the instantaneous phototherapy dose. A catheter according to the invention includes a probe or sensor arrangement for generating a signal representing the instantaneous amplitude of the fluorescence or the incident illumination. The signal is integrated to produce a signal representing the total dose of phototherapy. The photodynamic therapy is terminated when the integrated signal indicates a particular value. The catheter in one embodiment includes an array of semiconductor light sources near its distal end, energized from the proximal end. In another embodiment, the light source is external to the patient, and the light is conducted to the distal end of the catheter by one or more optical fibers. The light sensor may be an optical fiber extending from the proximal to the distal end of the catheter, with a probe end which is directive or omnidirectional. In this case, the dose signal is detected by a photodiode exterior to the catheter and the detected signal is integrated to generate a signal indicative of cumulative dose. In another embodiment, the photodiode is located near the distal end of the catheter.

摘要翻译： 光动力学治疗方法向待治疗的患者施用照射时发荧光的光敏药物。 荧光灯是瞬时光疗剂量的指示。 根据本发明的导管包括用于产生表示荧光或入射照明的瞬时幅度的信号的探针或传感器装置。 信号被整合以产生表示光疗总剂量的信号。 当积分信号表示特定值时，光动力疗法终止。 一个实施例中的导管包括从其近端附近的半导体光源的阵列，从近端激励。 在另一个实施例中，光源在患者外部，并且光通过一根或多根光纤传导到导管的远端。 光传感器可以是从导管的近端延伸到远端的光纤，探针端是指导性的或全向的。 在这种情况下，剂量信号由导管外部的光电二极管检测，并且检测到的信号被积分以产生指示累积剂量的信号。 在另一个实施例中，光电二极管位于导管的远端附近。

公开(公告)号：US06535722B1

公开(公告)日：2003-03-18

申请号：US09206429

申请日：1998-12-07

申请人： Arye Rosen ,  Stewart Mark Perlow ,  Raymond Louis Camisa

发明人： Arye Rosen ,  Stewart Mark Perlow ,  Raymond Louis Camisa

IPC分类号： H04B118

CPC分类号： H04N5/50 ,  H03J5/244 ,  H03J2200/10 ,  H04N21/4263

摘要： A tuning circuit, as for a television receiver or video recorder, employs switchable tuning circuits including micro-electronic electro-mechanical switches for selecting the ones of an array of capacitors and/or inductors as is useful in tunable circuits. The array of capacitors and/or inductors and micro-electro-mechanical switches of the switched tuning matrix is formed on an integrated circuit or an electronic circuit substrate along with amplifiers and other electronic elements of the tuning circuit for which the switched tuning matrix is employed. The switchable capacitance and inductance matrices are well suited for use in the resonators employed in the pre-selector filters, post-selector filters and oscillators of electronic tuners, such as those employed in television receivers and video recorders. The capacitors and micro-electro-mechanical switches may be connected to select a particular capacitor of the array of capacitors or to select ones of the capacitors of the array of capacitors to establish a particular capacitance value. The capacitors of the array of capacitors may be of like value or may be of different values, such as would advance simplified response to a digital control word, such as a 1-2-4-8 weighting or a 1-2-2-4 weighting. Similarly, the inductors and micro-electro-mechanical switches may be connected to select a particular inductor of the array of inductors or to select ones of the inductors of the array of inductors to establish a particular inductance value. The inductors of the array of inductors may be of like value or may be of different values, such as would advance simplified response to a digital control word, such as a 1-2-4-8 weighting or a 1-2-2-4 weighting.

摘要翻译： 对于电视接收机或录像机，调谐电路采用可切换调谐电路，包括微电子机电开关，用于选择电容器和/或电感器阵列中的那些，这在可调谐电路中是有用的。 开关调谐矩阵的电容器和/或电感器和微机电开关的阵列与集成电路或电子电路基板一起形成在调谐电路的放大器和其他电子元件上，其中使用开关调谐矩阵 。 可切换电容和电感矩阵非常适合用于电子调谐器的预选择器滤波器，后置选择器滤波器和振荡器中使用的谐振器，例如在电视接收机和录像机中使用的谐振器。 电容器和微机电开关可以被连接以选择电容器阵列的特定电容器或者选择电容器阵列的电容器中的一个以建立特定的电容值。 电容器阵列的电容器可以具有相同的值或者可以具有不同的值，例如可以提前对数字控制字的简化响应，例如1-2-4-8加权或者1-2-2- 4加权 类似地，电感器和微机电开关可以被连接以选择电感器阵列的特定电感器或者选择电感器阵列的电感器以建立特定的电感值。 电感器阵列的电感器可以具有相同的值或者可以具有不同的值，例如将提前对数字控制字的简化响应，例如1-2-4-8加权或1-2-2-8的加权， 4加权

公开(公告)号：US6045575A

公开(公告)日：2000-04-04

申请号：US15226

申请日：1998-01-29

申请人： Danielle Rosen ,  Arye Rosen

发明人： Danielle Rosen ,  Arye Rosen

IPC分类号： A61N5/06 ,  A61B17/36

CPC分类号： A61N5/0621 ,  A61N2005/0645 ,  A61N2005/0652 ,  Y10S2/905

摘要： An apparatus for treating neonatal jaundice is in the form of a garment (10, 40) which has semiconductor light sources (14, 214, 314) affixed thereto for radiating toward the "inside" of the garment when the infant is dressed in the garment. A portable energy source such as batteries (318) or a fuel cell (360) powers the array of light sources. A method according to the invention vests the infant in the garment, and energizes the light sources by coupling a battery to the light sources, or fueling and starting the fuel cell. The therapy is continued for as long as desired or needed.

摘要翻译： 用于治疗新生儿黄疸的装置是服装（10,40）的形式，其具有固定到其上的半导体光源（14,214,314），用于当婴儿穿着衣服时向服装的“内部”辐射 。 诸如电池（318）或燃料电池（360）的便携式能量源为光源阵列供电。 根据本发明的方法将婴儿装在衣服中，并通过将电池耦合到光源或者燃料和启动燃料电池来激励光源。 治疗持续达到需要或需要的时间。

公开(公告)号：US5716389A

公开(公告)日：1998-02-10

申请号：US559816

申请日：1995-11-13

申请人： Paul Walinsky ,  Arnold Jack Greenspon ,  Arye Rosen

发明人： Paul Walinsky ,  Arnold Jack Greenspon ,  Arye Rosen

IPC分类号： A61B5/042 ,  A61N1/05 ,  A61N1/06 ,  A61B5/04

CPC分类号： A61N1/06 ,  A61B5/0422 ,  A61N1/056 ,  A61N1/0587 ,  A61B2562/0209 ,  A61B2562/043

摘要： The catheter sensing and ablation arrangement allows location and cardiac abalation on a patient. The arrangement includes an electrically nonconductive catheter body, with a guide-wire lumen. The guidewire is electrically conductive, and, when the guidewire is assembled with the catheter, extends through the lumen, and is slideable therein. The guidewire has an enlarged distal end which, when retracted, blocks the guidewire lumen. The distal end of the catheter body has an exposed first electrode, which is connected to a terminal located near the proximal end. An action potential sensor is adapted for, in a sensing mode of operation, coupling to the proximal end of the guide wire and to the electrical terminal, for sensing action potentials appearing between the enlarged end of the guide wire and the first electrode, so the end of the guide wire may be moved to a cardiac location identifiable by the action potentials. An electrically conductive contact plate is adapted for, in a second mode of operation of the sensing and ablation arrangement, being located on the exterior of the patient's back. An RF signal generator is provided for, in an ablation mode of operation, causing RF energy to be guided to the selected cardiac location, for causing current flow between the contact plate and the enlarged distal end of the guidewire, resulting in ablation of cardiac material at the cardiac location, but not at the contact plate.

摘要翻译： 导管感测和消融装置允许患者的位置和心脏出血。 该装置包括具有导丝管腔的非导电导管体。 导丝是导电的，并且当导丝与导管组装时延伸穿过内腔，并且可在其中滑动。 导丝具有扩大的远端，当缩回时，其阻挡导丝管腔。 导管主体的远端具有暴露的第一电极，其连接到位于近端附近的端子。 动作电位传感器适于在感测操作模式下耦合到导丝的近端和电端子，用于感测出现在导丝的扩大端和第一电极之间的动作电位，因此， 导丝的末端可以移动到由动作电位可识别的心脏位置。 导电接触板适于在感测和消融装置的第二操作模式中位于患者背部的外部。 提供RF信号发生器，用于在消融操作模式中使RF能量被引导到所选择的心脏位置，以引起接触板和导丝的扩大远端之间的电流流动，导致心脏材料的消融 在心脏位置，但不在接触板。

公开(公告)号：US5421727A

公开(公告)日：1995-06-06

申请号：US74652

申请日：1993-06-07

申请人： Barry H. Stevens ,  Arye Rosen ,  Kevin W. Choi

发明人： Barry H. Stevens ,  Arye Rosen ,  Kevin W. Choi

IPC分类号： A61C5/02 ,  A61C1/00 ,  A61C3/00

CPC分类号： A61C5/02

摘要： Dental or endodontic instruments such as drills, files, rasps, broaches, reamers, and the like are arranged to allow radiation of electromagnetic energy into a man-made or natural cavity in the tooth under treatment. The energy may be in the form of microwave or radio-frequency (RF) radiation. The energy raises the temperature of the surrounding tooth material, which tends to disinfect the material as a direct consequence of the temperature. Also, if a disinfectant material is additionally introduced into the tooth cavity, the temperature of the disinfectant material itself may be raised, which enhances its activity. In the particular application to the removal of degenerated pulp, the instrument may be introduced, and electrical or electromagnetic power applied to coagulate the pulp about the instrument, allowing more complete removal of the pulp. The dental instrument may be used with an RF energy delivery system for application of particular amounts of energy per unit time (power). The RF power may be carried through miniature coaxial cables through the dental instrument itself, to enable radiation directly into the interior of the tooth. For this purpose, in some embodiments of the invention the dental instrument includes a portion formed from a dielectric material which allows the energy to pass therethrough. In a particular embodiment, a dental drill includes an antenna near the distal end thereof, a capacitive top cap of which is made from hardened material shaped for removal of tooth material.

摘要翻译： 布置了诸如钻，文件，锉刀，拉刀，铰刀等的牙科或牙髓器械，以便将电磁能辐射到被处理的牙齿中的人造或自然腔中。 能量可以是微波或射频（RF）辐射的形式。 能量提高了周围的牙齿材料的温度，这是由于温度的直接后果而倾向于对材料进行消毒。 此外，如果将消毒剂材料另外引入到牙腔中，则可以提高消毒剂材料本身的温度，这增强了其活性。 在去除退化的纸浆的具体应用中，可以引入仪器，并且施加电或电磁力以使纸浆围绕仪器凝结，允许更完全地除去纸浆。 牙科器械可以与RF能量递送系统一起使用，以在每单位时间（功率）下施加特定量的能量。 RF功率可以通过微型同轴电缆通过牙科仪器本身进行，以使辐射能够直接进入牙齿的内部。 为此，在本发明的一些实施例中，牙科器械包括由介电材料形成的部分，其允许能量通过。 在特定实施例中，牙钻包括在其远端附近的天线，其电容式顶盖由形状为用于移除牙齿材料的硬化材料制成。

公开(公告)号：US5150717A

公开(公告)日：1992-09-29

申请号：US584061

申请日：1990-09-18

申请人： Arye Rosen ,  Paul Walinsky

发明人： Arye Rosen ,  Paul Walinsky

IPC分类号： A61B17/22 ,  A61B18/18 ,  A61M29/02

CPC分类号： A61B18/18 ,  A61B17/22 ,  A61B18/1815 ,  A61B2017/22058 ,  A61B2018/1861 ,  A61M25/104

摘要： An angioplasty catheter includes a coaxial transmission line with an elongated center conductor and outer conductor. The transmission line terminates at the distal end in an antenna and a balloon. A longitudinal central bore through the center conductor is dimensioned to accept the guide filament. The center conductor is made from a metallized TEFLON polytetrafluoroethylene fluorocarbon tube.

摘要翻译： 血管成形术导管包括具有细长中心导体和外导体的同轴传输线。 传输线在天线和气球的末端终止。 通过中心导体的纵向中心孔的尺寸被设计成接受导丝。 中心导体由金属化的TEFLON聚四氟乙烯氟碳管制成。

公开(公告)号：US4805084A

公开(公告)日：1989-02-14

申请号：US185561

申请日：1988-04-25

申请人： Arye Rosen ,  Chi H. Lee

发明人： Arye Rosen ,  Chi H. Lee

IPC分类号： H03B9/14 ,  H02M1/00

CPC分类号： H03B9/147

摘要： A device for converting DC to RF has a monolithic PIN diode adapted to be coupled to a DC supply. The diode receives light switching pulses and is coupled to a monolithic resonator. The monolithic form provides compactness and reliability, while the diode, which is reversed biased when OFF, prevents substrate leakage currents. The diode and the resonator can be made in a single substrate, e.g., silicon, or in different substrates, e.g., silicon for the diode to obtain a long carrier lifetime and, thus, minimize the light pulse repetition rate, and GaAs for the resonator to obtain a high Q. The resonator can also act as an impedance transformer.

摘要翻译： 用于将DC转换成RF的装置具有适于耦合到DC电源的单片PIN二极管。 二极管接收光开关脉冲并耦合到单片谐振器。 单片形式提供紧凑性和可靠性，而在OFF时反向偏置的二极管可防止衬底漏电流。 二极管和谐振器可以制成在单个衬底（例如硅）中，或者在不同的衬底（例如用于二极管的硅）中制成，以获得长的载流子寿命，并因此使光脉冲重复率最小化，并且用于谐振器的GaAs 以获得高Q值。谐振器也可以用作阻抗变换器。