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公开(公告)号：US10017506B2
公开(公告)日：2018-07-10
申请号：US15296601
申请日：2016-10-18
Applicant: BIOGEN MA INC.
Inventor： Kevin M. Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur G. Taveras , Deping Wang , Zhili Xin , Lei Zhang
IPC: A61K31/015 , A61K31/4375 , A61K31/44 , C07D451/02 , C07D217/22 , A61K31/472 , A61K45/06 , A61K31/4725 , C07D401/06
CPC classification number: C07D451/02 , A61K31/136 , A61K31/196 , A61K31/439 , A61K31/445 , A61K31/46 , A61K31/472 , A61K31/4725 , A61K31/5375 , A61K31/55 , A61K45/06 , C07B2200/07 , C07C217/22 , C07C229/46 , C07C229/48 , C07C255/59 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/42 , C07D209/52 , C07D211/34 , C07D211/62 , C07D217/22 , C07D221/22 , C07D223/06 , C07D295/096 , C07D401/06 , C07D471/08 , Y02A50/401
Abstract: Disclosed are bicyclic aryl compounds of formula (I), that can modulate the activity of the autotaxin (ATX) enzyme. This invention further relates to compounds that are ATX inhibitors, and methods of making and using such compounds in the treatment of demyelination due to injury or disease, as well as for treating proliferative disorders such as cancer.
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公开(公告)号：US20180133233A1
公开(公告)日：2018-05-17
申请号：US15783809
申请日：2017-10-13
Applicant: BIOGEN MA INC.
Inventor： Jermaine Thomas , Xiaogao Liu , Edward Yin-Shiang Lin , Guo Zhu Zheng , Bin Ma , Richard D. Caldwell , Kevin M. Guckian , Gnanasambandam Kumaravel , Arthur G. Taveras
IPC: A61K31/695 , A61K31/11 , C07F7/08 , C07D401/06 , C07D277/64 , C07D239/74 , C07D217/04 , C07D215/227 , C07C255/54 , C07C47/575 , C07C43/247 , A61K45/06 , A61K31/683 , A61K31/662 , A61K31/517 , A61K31/472 , A61K31/4709 , A61K31/47 , A61K31/445 , A61K31/428 , A61K31/41 , A61K31/404 , A61K31/40 , A61K31/397 , A61K31/337 , A61K31/277 , A61K31/216 , A61K31/197 , A61K31/18 , C07F9/38 , A61K31/085 , C07F9/40 , C07D417/06 , C07D403/06 , C07D305/08 , C07D257/04 , C07D217/24 , C07D215/20 , C07D211/62 , C07D211/60 , C07D209/08 , C07D207/16 , C07D205/04 , C07C311/51 , C07C309/14 , C07C237/52 , C07C237/08 , C07C229/48 , C07C229/46 , C07C229/22 , C07C229/14 , A61K31/401 , A61K31/185 , A61K31/198 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/137 , A61K31/165
CPC classification number: A61K31/695 , A61K31/085 , A61K31/11 , A61K31/137 , A61K31/165 , A61K31/18 , A61K31/185 , A61K31/197 , A61K31/198 , A61K31/216 , A61K31/222 , A61K31/223 , A61K31/235 , A61K31/277 , A61K31/337 , A61K31/397 , A61K31/40 , A61K31/401 , A61K31/404 , A61K31/41 , A61K31/428 , A61K31/445 , A61K31/47 , A61K31/4709 , A61K31/472 , A61K31/517 , A61K31/662 , A61K31/683 , A61K45/06 , C07C43/247 , C07C47/575 , C07C229/14 , C07C229/22 , C07C229/46 , C07C229/48 , C07C237/08 , C07C237/52 , C07C255/54 , C07C309/14 , C07C311/51 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/16 , C07D205/04 , C07D207/16 , C07D209/08 , C07D211/60 , C07D211/62 , C07D215/20 , C07D215/227 , C07D217/04 , C07D217/24 , C07D239/74 , C07D257/04 , C07D277/64 , C07D305/08 , C07D401/06 , C07D403/06 , C07D417/06 , C07F7/081 , C07F9/3808 , C07F9/3834 , C07F9/4006
Abstract: Compounds that have agonist activity at one or more of the S1P receptors are provided. The compounds are sphin-gosine analogs that, after phosphorylation, can behave as agonists at S1P receptors.
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公开(公告)号：US09765016B2
公开(公告)日：2017-09-19
申请号：US14763893
申请日：2014-01-29
Applicant: BIOGEN MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Xiaogao Liu , Bin Ma , Hairuo Peng
IPC: C07C229/14 , C07C229/48 , C07C229/50 , C07D205/04 , C07D207/08 , C07D207/16 , C07D211/34 , C07D211/62 , A61K31/196 , A61K31/197 , A61K31/198 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/695 , A61K45/06 , C07F7/08
CPC classification number: C07C229/14 , A61K31/196 , A61K31/197 , A61K31/198 , A61K31/397 , A61K31/40 , A61K31/445 , A61K31/695 , A61K45/06 , C07C229/48 , C07C229/50 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2602/26 , C07C2602/44 , C07D205/04 , C07D207/08 , C07D207/16 , C07D211/34 , C07D211/62 , C07F7/0812 , Y02A50/401
Abstract: Compounds of formula (I) can modulate the activity of one or more S 1P receptors. Sphingosine 1-phosphate (S IP) is a lysophospholipid mediator that evokes a variety of cellular responses by stimulation of five members of the endothelial cell differentiation gene (EDG) receptor family, namely S1P1, S1P2, S1P3, S1P4, and S1P5 (formerly EDG1, EDG5, EDG3, EDG6 and EDG8). The EDG receptors are G-protein coupled receptors (GPCRs) and on stimulation propagate second messenger signals via activation of heterotrimeric G-protein alpha (Ga.) subunits and beta-gamma (G( )y) dimers.
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44.发明授权公开(公告)号：US09550798B2
公开(公告)日：2017-01-24
申请号：US14417293
申请日：2013-07-26
Applicant: BIOGEN MA INC.
Inventor： Kevin Guckian , Gnanasambandam Kumaravel , Bin Ma , Sha Mi , Hairuo Peng , Zhaohui Shao , Lihong Sun , Arthur Taveras , Zhili Xin , Lei Zhang
IPC: C07C229/48 , C07D223/06 , C07D221/22 , C07D209/52 , C07D211/62 , C07D295/096 , A61K31/5375 , A61K31/439 , A61K31/46 , A61K31/445 , A61K31/196 , A61K31/136 , C07F7/08 , A61K45/06 , A61K31/195 , A61K31/41 , A61K31/4709 , A61K31/4725 , A61K31/5513 , C07D215/38 , C07D217/22 , C07D401/04 , C07D471/08 , C07C217/58 , C07C229/46 , C07C233/61 , C07C235/66 , A61K31/397 , A61K31/4545 , A61K31/47 , A61K31/495 , A61K31/496 , A61K31/506 , A61K31/551 , A61K31/695 , C07C211/38 , C07D205/04 , C07D213/74 , C07D215/20 , C07D401/06
CPC classification number: C07F7/081 , A61K31/195 , A61K31/196 , A61K31/397 , A61K31/403 , A61K31/41 , A61K31/439 , A61K31/451 , A61K31/4545 , A61K31/47 , A61K31/4709 , A61K31/4725 , A61K31/495 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/551 , A61K31/5513 , A61K31/695 , A61K45/06 , C07C211/38 , C07C217/58 , C07C229/46 , C07C229/50 , C07C233/60 , C07C233/61 , C07C235/66 , C07C2102/10 , C07C2102/42 , C07C2102/44 , C07C2102/50 , C07C2103/62 , C07C2601/10 , C07C2601/14 , C07C2602/08 , C07C2602/10 , C07C2602/42 , C07C2602/44 , C07C2602/46 , C07C2602/50 , C07C2603/62 , C07C2603/74 , C07D205/04 , C07D209/52 , C07D211/14 , C07D213/74 , C07D215/12 , C07D215/20 , C07D215/38 , C07D217/22 , C07D239/42 , C07D241/20 , C07D295/096 , C07D401/04 , C07D401/06 , C07D451/02 , C07D451/14 , C07D471/08 , C07D491/107 , C07F7/0805 , A61K2300/00
Abstract: Compounds of formula (I) can modulate the activity of one or more SIP receptors and/or the activity of autotaxin (ATX).
Abstract translation: 式（I）化合物可以调节一种或多种SIP受体的活性和/或自分泌素（ATX）的活性。
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公开(公告)号：US12240838B2
公开(公告)日：2025-03-04
申请号：US17610963
申请日：2020-05-15
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Robin Prince , Isaac Marx , Jürgen Schulz , Marta Nevalainen
IPC: C07D413/12 , C07D401/12 , C07D413/14 , C07D417/12
Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
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Patent Agency Ranking
公开(公告)号：US20250034150A1
公开(公告)日：2025-01-30
申请号：US18709273
申请日：2022-11-10
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Jürgen Schulz , Marta Nevalainen , TeYu Chen , Robin Prince , Harold George Vandeveer , Isaac Marx , Simone Sciabola , Zain Yousaf
IPC: C07D487/04 , A61K31/437 , A61K31/4985 , A61K31/519 , A61K31/5377 , A61K31/55 , C07D471/04 , C07D519/00
Abstract: Provided are compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein the variables in Formula (I) are as defined herein; and methods for their use and production.
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公开(公告)号：US20240327380A1
公开(公告)日：2024-10-03
申请号：US18019540
申请日：2021-08-05
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Isaac Marx , Jürgen Schulz , Harold George Vandeveer , Robin Prince , Marta Nevalainen , TeYu Chen , Zain Yousaf , Martin Himmelbauer , Vatee Pattaropong , John Howard Jones , Rab Gilfillan , Edward Yin Shiang Lin , Felix Gonzalez Lopez de Turiso , Bin Ma
IPC: C07D401/14 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/553 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D471/08 , C07D487/10
CPC classification number: C07D401/14 , A61K31/4439 , A61K31/4545 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/55 , A61K31/553 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D471/08 , C07D487/10
Abstract: Provided are compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R7, R8, R9, A1, A2, Q1, Q2, Q3, A, Z, m and n are as defined herein; pharmaceutical compositions comprising said compounds or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable excipients; and methods of treating a disorder responsive to inhibition of Bruton's tyrosine kinase using said compounds, or pharmaceutically acceptable salts thereof, or said pharmaceutical compositions.
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公开(公告)号：US20230121818A1
公开(公告)日：2023-04-20
申请号：US17788127
申请日：2020-12-23
Applicant: BIOGEN MA INC.
Inventor： Bin Ma , Brian T. Hopkins , Isaac Marx , Jürgen Schulz , George Vandeveer , Robin Prince , Marta Nevalainen , TeYu Chen , Zain Yousaf , Andrew George Capacci
IPC: C07D401/14 , C07D413/12 , C07D471/04 , C07D403/12 , C07D403/10 , C07D495/04 , C07D401/12 , C07D413/14
Abstract: Provided are compounds of Formula (I′) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R8, R9, R11A, R11B, R12, Ri, Rii, A1, A2, Q1, Q2, Q3, X, W, and n are as defined herein; pharmaceutical compositions comprising said compounds or pharmaceutically acceptable salts thereof, and pharmaceutically acceptable excipients; and methods of treating a disorder responsive to inhibition of Bruton's tyrosine kinase using said compounds, or pharmaceutically acceptable salts thereof, or said pharmaceutical compositions.
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公开(公告)号：US20230025892A1
公开(公告)日：2023-01-26
申请号：US17773418
申请日：2020-10-29
Applicant: BIOGEN MA INC.
Inventor： Isaac Marx , Jürgen Schulz , Brian T. Hopkins , Bin Ma , Robin Prince , Marta Nevalainen
IPC: C07D487/04 , C07D519/00
Abstract: Provided are compounds of Formula (I): Formula (I) or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, R4, R5, R6, A1, B1, B2, Q1 and Q2 are as defined herein; and methods for their use and production.
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公开(公告)号：US11427577B2
公开(公告)日：2022-08-30
申请号：US17183702
申请日：2021-02-24
Applicant: BIOGEN MA INC.
Inventor： Brian T. Hopkins , Bin Ma , Robin Prince , Isaac Marx , Joseph P. Lyssikatos , Fengmei Zheng , Matthew Peterson , Daniel B. Patience
IPC: C07D417/14 , C07D403/14 , C07D413/14 , C07D405/14 , C07D471/04 , A61P43/00 , A61P1/16
Abstract: Provided are compounds of Formula (I), or pharmaceutically acceptable salts thereof, and methods for their use and production.
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