公开(公告)号：US20220119388A1

公开(公告)日：2022-04-21

申请号：US17503516

申请日：2021-10-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Guanglin Luo ,  Jie Chen ,  Carolyn Diane Dzierba ,  David B. Frennesson ,  Junqing Guo ,  Amy C. Hart ,  Xirui Hu ,  Michael C. Mertzman ,  Matthew Reiser Patton ,  Jianliang Shi ,  Steven H. Spergel ,  Brian Lee Venables ,  Yong-Jin Wu ,  Zili Xiao ,  Michael G. Yang

IPC: C07D471/04

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

公开(公告)号：US20210309633A1

公开(公告)日：2021-10-07

申请号：US17274227

申请日：2019-09-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Junqing Guo ,  Carolyn Diane Dzierba ,  Amy C. Hart ,  John E. Macor ,  William J. Pitts

IPC: C07D401/04 ,  C07D403/04 ,  C07D413/04 ,  C07D401/14 ,  C07D413/14

Abstract: Compounds having formula (I), and enantiomers, and diastereomers, stereoisomers, pharmaceutically-acceptable salts thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein.

公开(公告)号：US10723734B2

公开(公告)日：2020-07-28

申请号：US16443929

申请日：2019-06-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Guanglin Luo ,  Carolyn Diane Dzierba ,  John E. Macor

IPC: C07D401/04 ,  A61K31/4427 ,  A61P25/28 ,  C07D471/04 ,  C07D401/14 ,  C07D213/74 ,  C07D309/18 ,  C07D237/08 ,  A61K31/50 ,  C07C233/25 ,  C07D213/30 ,  C07D213/34 ,  C07D213/57 ,  C07D213/61 ,  C07D213/64 ,  C07D213/73 ,  C07D213/75 ,  C07D213/80 ,  C07D215/14 ,  C07D239/26 ,  C07D309/22 ,  C07D413/10

Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

公开(公告)号：US20190389859A1

公开(公告)日：2019-12-26

申请号：US16484604

申请日：2018-02-12

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Junqing Guo ,  Amy C. Hart ,  John E. Macor ,  Michael E. Mertzman ,  William J. Pitts ,  Steven H. Spergel ,  Scott Hunter Watterson ,  Murugaiah Andappan Murugaiah Subbaiah ,  Jie Chen ,  Carolyn Diane Dzierba ,  Guanglin Luo ,  Jianliang Shi ,  Sing-Yuen Sit

IPC: C07D471/04

Abstract: Compounds having formula (I) (IX), and enantiomers, and diastereomers, stereoisomers, pharmaceutically acceptable salts and prodrugs thereof, are useful as kinase modulators, including RIPK1 modulation. All the variables are as defined herein: (I), (II), (III), (IV), (V), (VI), (VII), (VIII), (IX).

公开(公告)号：US20180346440A1

公开(公告)日：2018-12-06

申请号：US15763280

申请日：2016-09-29

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Joanne J. Bronson ,  Ling Chen ,  Jonathan L. Ditta ,  Carolyn Diane Dzierba ,  Prasada Rao Jalagam ,  Guanglin Luo ,  John E. Macor ,  Tarun Kumar Maishal ,  Susheel Jethanand Nara ,  Ramkumar Rajamani ,  Ramesh Kumar Sistla ,  Soodamani Thangavel

IPC: C07D401/04 ,  C07D413/14 ,  A61P25/16 ,  A61P25/28 ,  A61P25/18 ,  A61P25/02

Abstract: The present disclosure is directed to biaryl compounds of formula (I) which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds and their use for treating e.g. pain, Alzheimer's disease, Parkinson's disease and schizophrenia.

公开(公告)号：US20180134704A1

公开(公告)日：2018-05-17

申请号：US15865848

申请日：2018-01-09

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Guanglin Luo ,  Ling Chen ,  Carolyn Diane Dzierba ,  Jonathan L. Ditta ,  John E. Macor ,  Joanne J. Bronson

IPC: C07D471/04 ,  C07D413/10 ,  A61K31/50 ,  C07D401/04 ,  C07D309/22 ,  C07D239/26 ,  C07D237/08 ,  C07D215/14 ,  C07D213/80 ,  C07D213/75 ,  C07D213/73 ,  C07D213/64 ,  C07D213/61 ,  C07D213/57 ,  C07D213/34 ,  C07D213/30 ,  C07C233/25 ,  C07D401/14

CPC classification number: C07D471/04 ,  A61K31/4427 ,  A61K31/50 ,  A61P25/28 ,  C07C233/25 ,  C07D213/30 ,  C07D213/34 ,  C07D213/57 ,  C07D213/61 ,  C07D213/64 ,  C07D213/73 ,  C07D213/74 ,  C07D213/75 ,  C07D213/80 ,  C07D215/14 ,  C07D237/08 ,  C07D239/26 ,  C07D309/18 ,  C07D309/22 ,  C07D401/04 ,  C07D401/14 ,  C07D413/10

Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

公开(公告)号：US20170183340A1

公开(公告)日：2017-06-29

申请号：US15300618

申请日：2015-04-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Guanglin Luo ,  Ling Chen ,  Carolyn Diane Dzierba ,  Jonathan L. Ditta ,  John E. Macor ,  Joanne J. Bronson

IPC: C07D471/04 ,  C07D213/73 ,  C07D413/10 ,  C07D213/57 ,  C07D213/64 ,  C07D213/30 ,  C07D213/61 ,  C07D215/14 ,  C07D401/04 ,  C07D401/14 ,  C07D237/08 ,  C07D213/80 ,  C07D213/34 ,  C07D239/26 ,  C07D309/22 ,  C07C233/25 ,  C07D213/75

CPC classification number: C07D471/04 ,  A61K31/4427 ,  A61K31/50 ,  A61P25/28 ,  C07C233/25 ,  C07D213/30 ,  C07D213/34 ,  C07D213/57 ,  C07D213/61 ,  C07D213/64 ,  C07D213/73 ,  C07D213/74 ,  C07D213/75 ,  C07D213/80 ,  C07D215/14 ,  C07D237/08 ,  C07D239/26 ,  C07D309/18 ,  C07D309/22 ,  C07D401/04 ,  C07D401/14 ,  C07D413/10

Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

公开(公告)号：US20160243125A1

公开(公告)日：2016-08-25

申请号：US15027585

申请日：2014-10-08

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Carolyn Diane Dzierba ,  Bireshwar Dasgupta ,  John E. Macor ,  Joanne J. Bronson ,  Ramkumar Rajamani ,  George N. Karageorge

IPC: A61K31/53 ,  A61K31/5377

CPC classification number: A61K31/53 ,  A61K31/5377

Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

Abstract translation: 本公开一般涉及可以抑制AAK1（衔接子相关激酶1），包含这些化合物的组合物和抑制AAK1的方法的化合物。

公开(公告)号：US20160222021A1

公开(公告)日：2016-08-04

申请号：US14917306

申请日：2013-09-11

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Vivekananda M. Vrudhula ,  Senliang Pan ,  Ramkumar Rajamani ,  John E. Macor ,  Joanne J. Bronson ,  Carolyn Diane Dzierba ,  Susheel Jethanand Nara ,  Maheswaran Sivasamban Karatholuvhu

IPC: C07D491/052 ,  C07D491/20

CPC classification number: C07D491/052 ,  C07D491/04 ,  C07D491/20

Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

Abstract translation: 本公开一般涉及可以抑制AAK1（衔接子相关激酶1），包含这些化合物的组合物和抑制AAK1的方法的化合物。

公开(公告)号：US20160152621A1

公开(公告)日：2016-06-02

申请号：US14902868

申请日：2014-07-01

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Richard A. Hartz ,  Vijay T. Ahuja ,  Joanne J. Bronson ,  Carolyn Diane Dzierba ,  John E. Macor ,  Susheel Jethanand Nara ,  Ramkumar Rajamani

IPC: C07D487/04 ,  C07D413/12 ,  C07D409/10 ,  C07D249/06 ,  C07D213/56 ,  C07D277/30 ,  C07D237/08 ,  C07D285/12 ,  C07D231/12 ,  C07D233/61 ,  C07D249/08 ,  C07D213/65 ,  C07D213/73 ,  C07D417/12 ,  C07D401/10 ,  C07D401/12 ,  C07D263/32

CPC classification number: C07D487/04 ,  C07D213/16 ,  C07D213/56 ,  C07D213/61 ,  C07D213/62 ,  C07D213/65 ,  C07D213/72 ,  C07D213/73 ,  C07D231/12 ,  C07D233/54 ,  C07D233/61 ,  C07D237/08 ,  C07D249/06 ,  C07D249/08 ,  C07D263/30 ,  C07D263/32 ,  C07D277/20 ,  C07D277/30 ,  C07D285/08 ,  C07D285/12 ,  C07D401/10 ,  C07D401/12 ,  C07D409/10 ,  C07D413/12 ,  C07D417/12

Abstract: The present disclosure is generally directed to compounds which can inhibit AAK1 (adaptor associated kinase 1), compositions comprising such compounds, and methods for inhibiting AAK1.

Abstract translation: 本公开一般涉及可以抑制AAK1（衔接子相关激酶1），包含这些化合物的组合物和抑制AAK1的方法的化合物。