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41.发明授权公开(公告)号：US12097242B2
公开(公告)日：2024-09-24
申请号：US17721569
申请日：2022-04-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Gene M. Dubowchik , Olafur S. Gudmundsson , Xiaojun Han , R. Michael Lawrence , Dasa Lipovsek , Cort S. Madsen , Claudio Mapelli , Paul E. Morin , Michael C. Myers
CPC classification number: A61K38/18 , A61K38/2221 , C07K1/1077 , C07K14/64 , A61K38/00 , A61K45/06 , A61K47/64 , A61P9/00
Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
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公开(公告)号：US12084452B2
公开(公告)日：2024-09-10
申请号：US17902618
申请日：2022-09-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY , UNIVERSITÉ DE MONTRÉAL
Inventor： Jacques Banville , Roger Rémillard , Edward H. Ruediger , Daniel H. Deon , Marc Gagnon , Laurence Dubé , Julia Guy , Eldon Scott Priestley , Shoshana L. Posy , Brad D. Maxwell , Pancras C. Wong , R. Michael Lawrence , Michael M. Miller
IPC: C07D487/04 , A61K31/433 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/5025 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61K51/04 , C07B59/00 , C07D513/04 , C07D519/00
CPC classification number: C07D487/04 , A61K31/433 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/5025 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61K51/0453 , C07B59/002 , C07D513/04 , C07D519/00 , C07B2200/05
Abstract: The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.
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公开(公告)号：US11498903B2
公开(公告)日：2022-11-15
申请号：US16639145
申请日：2018-08-16
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Shun Su , Hannguang J. Chao , Adam James Clarke , R. Michael Lawrence
IPC: C07D235/16 , C07D413/12 , C07D413/10 , C07D471/04 , C07D491/056 , C07D473/00 , C07D235/18
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification. The compounds are apelin and APJ agonists for treating cardiovascular diseases. Preferred compounds are 2-(1,1′-biphe-1H-benzo[d]imidazole derivatives. The invention further provides compositions comprising the compounds and the compounds for use in methods of medical treatment.
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44.发明授权公开(公告)号：US11364281B2
公开(公告)日：2022-06-21
申请号：US17198939
申请日：2021-03-11
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Gene M. Dubowchik , Olafur S. Gudmundsson , Xiaojun Han , R. Michael Lawrence , Dasa Lipovsek , Cort S. Madsen , Claudio Mapelli , Paul E. Morin , Michael C. Myers
Abstract: The present disclosure generally relates to modified relaxin polypeptides, such as modified human relaxin 2 polypeptides, comprising a non-naturally encoded amino acid which is linked to a pharmacokinetic enhancer, and therapeutic uses of such polypeptides, such as for the treatment of cardiovascular conditions (such as heart failure) and/or conditions relating to fibrosis.
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公开(公告)号：US10669261B2
公开(公告)日：2020-06-02
申请号：US16061365
申请日：2016-12-15
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Michael C. Myers , R. Michael Lawrence , Donna M. Bilder , Wei Meng , Zulan Pi , Robert Paul Brigance , Heather Finlay
IPC: A61K31/506 , A61K31/513 , C07D403/04 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14 , A61P9/04 , A61P9/10 , A61P9/12 , A61P9/00
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments, in particular for treating cardiovascular disorders.
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Patent Agency Ranking
公开(公告)号：US10392347B2
公开(公告)日：2019-08-27
申请号：US15767364
申请日：2016-10-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Soong-Hoon Kim , Hannguang J. Chao , Heather Finlay , Ji Jiang , James A. Johnson , R. Michael Lawrence , Michael C. Myers , Monique Phillips , George O. Tora , Wei Meng
IPC: C07D213/82 , C07D401/06 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D491/107 , C07D498/10 , C07D401/12 , C07D471/10
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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47.发明申请公开(公告)号：US20180305376A1
公开(公告)日：2018-10-25
申请号：US16020043
申请日：2018-06-27
Applicant: BRISTOL-MYERS SQUIBB COMPANY , UNIVERSITE DE MONTREAL
Inventor： Jacques Banville , Roger Remillard , Edward H. Ruediger , Daniel H. Deon , Marc Gagnon , Laurence Dube , Julia Guy , Eldon Scott Priestley , Shoshana L. Posy , Brad D. Maxwell , Pancras C. Wong , R. Michael Lawrence , Michael M. Miller
IPC: C07D513/04 , A61K31/5377 , A61K31/435 , C07D487/04 , A61K31/541 , A61K31/553 , A61K31/433 , A61K31/496 , A61K31/497 , A61K31/454 , A61K45/06 , A61K31/4439 , A61K31/5025 , C07B59/00 , A61K31/55 , A61K51/04 , A61K31/5386 , C07D519/00
CPC classification number: C07D513/04 , A61K31/433 , A61K31/435 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/497 , A61K31/5025 , A61K31/5377 , A61K31/5386 , A61K31/541 , A61K31/55 , A61K31/553 , A61K45/06 , A61K51/0453 , C07B59/002 , C07B2200/05 , C07D487/04 , C07D519/00
Abstract: The present invention provides thiazole compounds of Formula I wherein W, Y, R0, R2, R4, R5, R6, R7, X1, X2, X3 and X4 are as defined herein, or a stereoisomer, tautomer, pharmaceutically acceptable salt, prodrug ester or solvate form thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of platelet aggregation and thus can be used as medicaments for treating or preventing thromboembolic disorders.
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公开(公告)号：US20180297954A1
公开(公告)日：2018-10-18
申请号：US15767364
申请日：2016-10-13
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： Soong-Hoon Kim , Hannguang J. Chao , Heather Finlay , Ji Jang , James A. Johnson , R. Michael Lawrence , Michael C. Myers , Monique Phillips , George O. Tora , Wei Meng
IPC: C07D213/82 , C07D401/12 , C07D401/14 , C07D413/14 , C07D401/06 , C07D405/14 , C07D417/14 , C07D417/12 , C07D498/10 , C07D413/12 , C07D491/107 , C07D471/10
CPC classification number: C07D213/82 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/10 , C07D491/107 , C07D498/10
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, O and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US20180273518A1
公开(公告)日：2018-09-27
申请号：US15990855
申请日：2018-05-29
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Soong-Hoon Kim , R. Michael Lawrence , Michael C. Myers , Hannguang J. Chao , Monique Phillips , Ji Jiang
IPC: C07D413/04 , C07D417/14 , C07D498/04 , C07D401/04 , C07D413/14
CPC classification number: C07D413/04 , C07D401/04 , C07D413/14 , C07D417/14 , C07D498/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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公开(公告)号：US10011594B2
公开(公告)日：2018-07-03
申请号：US15171276
申请日：2016-06-02
Applicant: BRISTOL-MYERS SQUIBB COMPANY
Inventor： James A. Johnson , Soong-Hoon Kim , R. Michael Lawrence , Michael C. Myers , Hannguang J. Chao , Monique Phillips , Ji Jiang
IPC: C07D413/04 , C07D413/14 , C07D401/04 , C07D417/14 , C07D498/04
CPC classification number: C07D413/04 , C07D401/04 , C07D413/14 , C07D417/14 , C07D498/04
Abstract: The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments.
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