公开(公告)号：US11571298B2

公开(公告)日：2023-02-07

申请号：US17101787

申请日：2020-11-23

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Yelena Kasimov ,  Boaz Harari ,  Aviram Baum

IPC: A61F2/24

Abstract: An implant includes a prosthetic valve and is transitionable from a compressed to an expanded state. The implant includes a frame assembly including a plurality of struts that collectively define an upstream-frame-assembly-perimeter at an upstream end of the frame assembly and a downstream-frame-assembly-perimeter at a downstream end of the frame assembly. The frame assembly includes a valve frame that defines a lumen, and one or more appendages disposed at and extending in a downstream direction from the downstream-frame-assembly-perimeter. A plurality of prosthetic leaflets are disposed within the valve frame lumen and facilitate one-way upstream-to-downstream fluid flow through the lumen. The implant includes a fabric and, in the expanded state of the implant, the fabric obscures the one or more appendages and defines a downstream perimeter of the fabric at a downstream end of the implant. Additional embodiments are described.

公开(公告)号：US11491011B2

公开(公告)日：2022-11-08

申请号：US17307176

申请日：2021-05-04

Applicant: CARDIOVALVE LTD.

Inventor： Yonatan Kislev ,  Or Cohen ,  Meni Iamberger

IPC: A61F2/24

Abstract: A method of using a computer processor for grouping prosthetic valve leaflets of an aggregate of prosthetic valve leaflets is provided. For each leaflet of the aggregate, in response to an image parameter of the leaflet, a leaflet-flexibility value is derived. At least some of the leaflets of the aggregate are designated into leaflet groups, based on similarity between the respective leaflet-flexibility value of each leaflet of the aggregate. For each of the designated leaflet groups, the flexibility value of each leaflet in the designated leaflet group is within the intra-group tolerance with respect to the leaflet-flexibility value of each other leaflet in the designated leaflet group. An indication of the designated leaflet groups is outputted. Other embodiments are also described.

公开(公告)号：US11246704B2

公开(公告)日：2022-02-15

申请号：US16636204

申请日：2018-07-04

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Aviram Baum ,  Yelena Kasimov

IPC: A61F2/24

Abstract: A frame assembly (222) includes a tubular portion (32) that defines a lumen along an axis; a plurality of arms (46) coupled to the tubular portion at a first axial level, each of the arms extending radially outward from the tubular portion to a respective arm-tip; and a plurality of ventricular legs (50) that are coupled to the tubular portion at a second axial level, and that extend radially outward from the tubular portion. A first sheet (440) has a greater perimeter (446), and a smaller perimeter (448) that defines an opening. The first sheet is stitched onto the plurality of arms, with the opening aligned with the lumen. Subsequently, an outer perimeter (454) of a second sheet (450) is stitched to the greater perimeter of the first sheet. Subsequently, the second sheet is everted by passing an inner perimeter (452) of the second sheet around the arm-tips.

公开(公告)号：US20210093449A1

公开(公告)日：2021-04-01

申请号：US17101787

申请日：2020-11-23

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Yelena Kasimov ,  Boaz Harari ,  Aviram Baum

IPC: A61F2/24

Abstract: An implant includes a prosthetic valve and is transitionable from a compressed to an expanded state. The implant includes a frame assembly including a plurality of struts that collectively define an upstream-frame-assembly-perimeter at an upstream end of the frame assembly and a downstream-frame-assembly-perimeter at a downstream end of the frame assembly. The frame assembly includes a valve frame that defines a lumen, and one or more appendages disposed at and extending in a downstream direction from the downstream-frame-assembly-perimeter. A plurality of prosthetic leaflets are disposed within the valve frame lumen and facilitate one-way upstream-to-downstream fluid flow through the lumen. The implant includes a fabric and, in the expanded state of the implant, the fabric obscures the one or more appendages and defines a downstream perimeter of the fabric at a downstream end of the implant. Additional embodiments are described.

公开(公告)号：US10888421B2

公开(公告)日：2021-01-12

申请号：US16269328

申请日：2019-02-06

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Meni Iamberger ,  Yelena Kasimov ,  Boaz Harari ,  Aviram Baum

IPC: A61F2/24

Abstract: A valve body circumscribes a longitudinal axis and defines a lumen along the axis. Upstream arms are coupled to the valve body, and extend radially outward from the valve body to respective arm-tips. Downstream legs are coupled to the valve body, and extend radially outward from the valve body and toward the plurality of arms. A flexible pouch extends radially outward from the valve body. The arms and the legs narrow the pouch therebetween to form a narrowed portion of the pouch, thereby defining, in an interior space of the pouch: (a) an inner portion, radially inward from the narrowed portion, and in fluid communication with the lumen, and (b) an outer portion, radially outward from the narrowed portion, and in fluid communication with the inner portion via the narrowed portion. Other embodiments are also described.

公开(公告)号：US10426614B2

公开(公告)日：2019-10-01

申请号：US15899858

申请日：2018-02-20

Applicant: CARDIOVALVE LTD.

Inventor： Ilia Hariton ,  Boaz Harari ,  Maxim Karalnik ,  Michael Albitov ,  Meni Iamberger

IPC: A61F2/24 ,  A61F2/966 ,  A61F2/958

Abstract: A tool is configured for transluminal delivery of an implant. The tool has a proximal part and a distal part, and comprises a shaft, a nosepiece, a sheath, and a balloon. The nosepiece is fixed to the shaft, and is arranged with respect to the implant such that the implant extends proximally away from the nosepiece and over the shaft. The sheath houses the implant. The balloon is disposed at the distal part of the tool, and is in fluid communication with the proximal part of the tool. When maximally inflated, the balloon has (i) a widest part that has an inflated diameter that is less than the diameter of the sheath or at most 10 percent greater than the diameter of the sheath, and (ii) a tapered portion that tapers longitudinally away from the widest part and from the nosepiece.

公开(公告)号：US20190167423A1

公开(公告)日：2019-06-06

申请号：US16269328

申请日：2019-02-06

Applicant: Cardiovalve Ltd.

Inventor： Ilia HARITON ,  Meni Iamberger ,  Yelena Kasimov ,  Boaz Harari ,  Aviram Baum

IPC: A61F2/24

Abstract: A valve body circumscribes a longitudinal axis and defines a lumen along the axis. Upstream arms are coupled to the valve body, and extend radially outward from the valve body to respective arm-tips. Downstream legs are coupled to the valve body, and extend radially outward from the valve body and toward the plurality of arms. A flexible pouch extends radially outward from the valve body. The arms and the legs narrow the pouch therebetween to form a narrowed portion of the pouch, thereby defining, in an interior space of the pouch: (a) an inner portion, radially inward from the narrowed portion, and in fluid communication with the lumen, and (b) an outer portion, radially outward from the narrowed portion, and in fluid communication with the inner portion via the narrowed portion. Other embodiments are also described.

公开(公告)号：US12053380B2

公开(公告)日：2024-08-06

申请号：US17841912

申请日：2022-06-16

Applicant: CARDIOVALVE LTD.

Inventor： Tal Hammer ,  Meni Iamberger ,  Yaron Herman ,  Yuval Zipory ,  Eran Hoffer ,  Michael Albitov ,  Natalia Kruglova ,  Tal Reich ,  Ilia Hariton ,  Aviram Baum

IPC: A61F2/24 ,  A61F2/82

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2002/828 ,  A61F2220/0025 ,  A61F2230/001 ,  A61F2230/0067 ,  A61F2250/0039

Abstract: A prosthetic valve includes a tubular valve body, snares, and an upstream support. A native valve of a heart of a subject is disposed between an atrium and a ventricle of the heart, and has an annulus and leaflets. The prosthetic valve is advanced to the heart while in a compressed state. The prosthetic valve is positioned within the heart such that the snares are disposed upstream of the annulus and leaflets. The snares are expanded radially outwardly upstream of the leaflets. Subsequently, the prosthetic valve is moved in a downstream direction such that the snares become disposed downstream of the leaflets. While the snares remain downstream of the leaflets, the upstream support is expanded within the atrium, and the upstream support is placed against an upstream surface of the annulus. Other embodiments are also described.

公开(公告)号：US11883293B2

公开(公告)日：2024-01-30

申请号：US17956319

申请日：2022-09-29

Applicant: CARDIOVALVE LTD.

Inventor： Yonatan Kislev ,  Or Cohen ,  Meni Iamberger

IPC: A61F2/24

CPC classification number: A61F2/2472 ,  A61F2/2415

Abstract: A method for grouping prosthetic valve leaflets of an aggregate of prosthetic valve leaflets is provided. Using a computer processor, for each leaflet of the aggregate, a leaflet-flexibility value is derived. A group size value is provided to the processor. Using the processor, at least some of the leaflets of the aggregate are designated into leaflet groups, based on similarity between the respective leaflet-flexibility value of each leaflet of the aggregate. Each of the leaflet groups includes a number of leaflets equal to the group size value. Using the processor, an indication of the designated leaflet groups is outputted. Other embodiments are also described.

公开(公告)号：US11872130B2

公开(公告)日：2024-01-16

申请号：US16656790

申请日：2019-10-18

Applicant: CARDIOVALVE LTD.

Inventor： Tal Hammer ,  Meni Iamberger ,  Yaron Herman ,  Yuval Zipory ,  Eran Hoffer ,  Michael Albitov ,  Natalia Kruglova ,  Tal Reich ,  Ilia Hariton ,  Aviram Baum

IPC: A61F2/24 ,  A61F2/848 ,  A61F2/82

CPC classification number: A61F2/2436 ,  A61F2/2418 ,  A61F2/2439 ,  A61F2002/828 ,  A61F2220/0025 ,  A61F2230/001 ,  A61F2230/0067 ,  A61F2250/0039

Abstract: A prosthetic heart valve implant is provided including a frame shaped so as to define upstream and downstream openings at upstream and downstream ends of the frame, respectively, when the implant is in an expanded state for implantation at a heart native valve. A sheet is coupled to the frame. When the implant is in the expanded state, the frame is shaped so as to define the following longitudinal portions arranged along a central longitudinal axis of the prosthetic heart valve implant: a substantially cylindrical mid portion having a diameter greater than respective diameters of the upstream and the downstream ends of the frame; an upstream portion, extending upstream and radially inward from the mid portion; and a downstream portion, extending downstream and radially inward from the mid portion. Other embodiments are also described.